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EDEXCEL A LeveL - Hodder Education
EDEXCEL A LeveL - Hodder Education

... Relative atomic masses show that one atom of carbon is 12 times heavier than one atom of hydrogen. This means that 12 g of carbon contains the same number of atoms as 1 g of hydrogen. Similarly, one atom of oxygen is 16 times as heavy as one atom of hydrogen, so 16 g of oxygen also contains the same ...
Ethers, Epoxides, and Sulfides
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... functional group is of great importance in organic chemistry and there are numerous applications in fine chemical industry and laboratory1. A large number of methods including catalytic reduction2, Meerwin-ponndorff-verley reduction2, hydride transfer reagents3, homogeneous catalysis4-6 and heteroge ...
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A Crash Course In Organic Chemistry

... Addition of a halogen can reduce or eliminate flammability, and can also increase potency. Depending on the halogen, some of these compounds can cause arrhythmias and/or renal or hepatic toxicity. Compounds containing only bromine are generally not useful. Compounds containing only chlorine are subj ...
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Strychnine total synthesis



Strychnine total synthesis in chemistry describes the total synthesis of the complex biomolecule strychnine. The first reported method by the group of Robert Burns Woodward in 1954 is considered a classic in this research field. At the time it formed the natural conclusion to an elaborate process of molecular structure elucidation that started with the isolation of strychnine from the beans of Strychnos ignatii by Pierre Joseph Pelletier and Joseph Bienaimé Caventou in 1818. Major contributors to the entire effort were Sir Robert Robinson with over 250 publications and Hermann Leuchs with another 125 papers in a time span of 40 years. Robinson was awarded the Nobel Prize in Chemistry in 1947 for his work on alkaloids, strychnine included. The process of chemical identification was completed with publications in 1946 by Robinson and later confirmed by Woodward in 1947. X-ray structures establishing the absolute configuration became available between 1947 and 1951 with publications from J. M. Bijvoet and J.H. Robertson .Woodward published a very brief account on the strychnine synthesis in 1954 (just 3 pages) and a lengthy one (42 pages) in 1963.Many more methods exist and reported by the research groups of Magnus, Overman, Kuehne, Rawal, Bosch, Vollhardt, Mori, Shibasaki, Li, Fukuyama Vanderwal and MacMillan. Synthetic (+)-strychnine is also known. Racemic synthesises were published by Padwa in 2007 and in 2010 by Andrade and by Reissig.In his 1963 publication Woodward quoted Sir Robert Robinson who said for its molecular size it is the most complex substance known.
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