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carboxylic acids esters amides (R
carboxylic acids esters amides (R

notes 11/28/16 Monday
notes 11/28/16 Monday



... (R1 = Cl, Br) to the reaction conditions, providing a handle for further functionalization, is worthy of note. Two examples of spirocyclic dihydrobenzofurans (a model system for the core structure of the natural product stachybotrylactam) were also prepared in high yield. ...
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... Biocatalysis is a convenient method for the kinetic resolution of alcohols. There are many reports in the literature on the resolution of secondary alcohols in ionic liquids [3], [4], [5-8]. Of these, only a few refer to aliphatic alcohols, in particular of longer alkyl chain lengths [3], [5], [8]. ...
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Hydroformylation



Hydroformylation, also known as oxo synthesis or oxo process, is an important homogeneously catalyzed industrial process for the production of aldehydes from alkenes. This chemical reaction entails the addition of a formyl group (CHO) and a hydrogen atom to a carbon-carbon double bond. This process has undergone continuous growth since its invention in 1938: Production capacity reached 6.6×106 tons in 1995. It is important because the resulting aldehydes are easily converted into many secondary products. For example, the resulting aldehydes are hydrogenated to alcohols that are converted to plasticizers or detergents. Hydroformylation is also used in specialty chemicals, relevant to the organic synthesis of fragrances and natural products. The development of hydroformylation, which originated within the German coal-based industry, is considered one of the premier achievements of 20th-century industrial chemistry.The process typically entails treatment of an alkene with high pressures (between 10 to 100 atmospheres) of carbon monoxide and hydrogen at temperatures between 40 and 200 °C. Transition metal catalysts are required.
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