Slide 1
... Since many iminium salts are unstable they are generally not isolate. As a result the reducing agent is added to the reaction mixture so that the iminium salt can be reduced as it is formed. Only very weak reducing agents can be used in this reaction to avoid reduction of the starting aldehyde or ke ...
... Since many iminium salts are unstable they are generally not isolate. As a result the reducing agent is added to the reaction mixture so that the iminium salt can be reduced as it is formed. Only very weak reducing agents can be used in this reaction to avoid reduction of the starting aldehyde or ke ...
THESE DOCTORAT DE L`UNIVERSITE DE TOULOUSE ET
... The chemistry of molybdenum and tungsten cyclopentadienyl complexes in higher oxidation states with oxo, imido and sulfide ligands has increased in significance. Interest in Cp* oxo molybdenum and tungsten complexes is particularly motivated by their potential in oxidation catalysis. Most advances i ...
... The chemistry of molybdenum and tungsten cyclopentadienyl complexes in higher oxidation states with oxo, imido and sulfide ligands has increased in significance. Interest in Cp* oxo molybdenum and tungsten complexes is particularly motivated by their potential in oxidation catalysis. Most advances i ...
Full-Text PDF
... mol % of tetrakis(acetonitrile)copper(I) triflate was able to efficiently catalyze the transformation of phenol 1 to the corresponding phenyl acetate 2 in 3 min and in quantitative yield. the model substrate and acetic anhydride (4 equivalents) as the acetylation agent, we found that 1 the model ...
... mol % of tetrakis(acetonitrile)copper(I) triflate was able to efficiently catalyze the transformation of phenol 1 to the corresponding phenyl acetate 2 in 3 min and in quantitative yield. the model substrate and acetic anhydride (4 equivalents) as the acetylation agent, we found that 1 the model ...
Anionic rearrangement of 2-benzyloxypyridine derivatives and a synthetic approach to aldingenin B
... [1,2]-Anionic rearrangements are important tools for altering the complexity of molecules at hand. In Part I of this dissertation, an anionic rearrangement of 2-benzyloxypyridine is described. Pyridine-directed metallation of the benzylic carbon leads to 1,2-migration of pyridine via a postulated as ...
... [1,2]-Anionic rearrangements are important tools for altering the complexity of molecules at hand. In Part I of this dissertation, an anionic rearrangement of 2-benzyloxypyridine is described. Pyridine-directed metallation of the benzylic carbon leads to 1,2-migration of pyridine via a postulated as ...
Organic synthesis and methodology related to the malaria drug artemisinin
... hindered ketone using either organocerium or acetylide nucleophiles. In addition, two alternative olefin metathesis approaches are described for the final cyclization. Problems associated with the olefination of a key intermediate in our efforts toward dihydroartemisinic acid led us to develop a two ...
... hindered ketone using either organocerium or acetylide nucleophiles. In addition, two alternative olefin metathesis approaches are described for the final cyclization. Problems associated with the olefination of a key intermediate in our efforts toward dihydroartemisinic acid led us to develop a two ...
Copper-Catalyzed Coupling Reactions Using Carbon
... Oxidative coupling reactions with C-H bonds are quite challenging due to the relative strong C-H bond, along with the associated selectivity issues with the myriad of C-H bonds that are available for the coupling reaction. ...
... Oxidative coupling reactions with C-H bonds are quite challenging due to the relative strong C-H bond, along with the associated selectivity issues with the myriad of C-H bonds that are available for the coupling reaction. ...
Polyhedral Oligomeric Silsesquioxane
... additional 1 h of activation time, probably resulting from the exchanging thials for IB.90 Comparatively, using the POSSPd(0) NPs, the reaction occurs as soon as the reactants are mixed, because the wider gaps between the bulk and thiol-functional POSS provide molecular channels for transportation ...
... additional 1 h of activation time, probably resulting from the exchanging thials for IB.90 Comparatively, using the POSSPd(0) NPs, the reaction occurs as soon as the reactants are mixed, because the wider gaps between the bulk and thiol-functional POSS provide molecular channels for transportation ...
4-Dimethylaminopyridine - Sigma
... DMAP also reacts with tert-butoxycarbonyl chloride to form the tert-butoxycarbonyl derivative, and effective reagent for preparing t-BOC amino acids in aqueous solution.15,16 ...
... DMAP also reacts with tert-butoxycarbonyl chloride to form the tert-butoxycarbonyl derivative, and effective reagent for preparing t-BOC amino acids in aqueous solution.15,16 ...
226 amines lec
... Effect of Resonance on Basicity — Aromatic amines are less basic than aliphatic amines, mostly because of resonance. The aromatic amine is more stabilized compared to its ammonium ion than an aliphatic amine is compared to its ammonium ion — ...
... Effect of Resonance on Basicity — Aromatic amines are less basic than aliphatic amines, mostly because of resonance. The aromatic amine is more stabilized compared to its ammonium ion than an aliphatic amine is compared to its ammonium ion — ...
NAME Chem 204 Spring, 1990 Final Exam FINAL EXAM: Chaps. 1
... alkyl chloride, there is NO one reaction that will convert a chiral alcohol into its alkyl chloride with "retained" configuration. Thus, it is necessary to use several reaction steps, each of 100% inversion or 100% retention of configuration, in order to convert (X) into (XI). Outlines below a serie ...
... alkyl chloride, there is NO one reaction that will convert a chiral alcohol into its alkyl chloride with "retained" configuration. Thus, it is necessary to use several reaction steps, each of 100% inversion or 100% retention of configuration, in order to convert (X) into (XI). Outlines below a serie ...
research reviews Discovering new arene-catalyzed lithiations
... followed by its hydrogen-transfer reduction [33]. The second consists of the alkylation of a methyl ketone 46 with a primary alcohol 47 to yield ketone 48 [30,31]; this is an interesting reaction from both a mechanistic (alcohol acts here as an electrophile, its normal reactivity being as a nucleoph ...
... followed by its hydrogen-transfer reduction [33]. The second consists of the alkylation of a methyl ketone 46 with a primary alcohol 47 to yield ketone 48 [30,31]; this is an interesting reaction from both a mechanistic (alcohol acts here as an electrophile, its normal reactivity being as a nucleoph ...
Investigation of the steric and electronic properties of 3
... I would like to start of by acknowledging my parents and brother. Without your love and support over the past couple of decades, I don’t think I’d be half the person that I am today. The past three years here while obtaining this degree have helped me to realize all of that. To my folks, I couldn’t ...
... I would like to start of by acknowledging my parents and brother. Without your love and support over the past couple of decades, I don’t think I’d be half the person that I am today. The past three years here while obtaining this degree have helped me to realize all of that. To my folks, I couldn’t ...
DEPARTMENT OF CHEMISTRY, UNIVERSITY OF JYVÄSKYLÄ
... modern description of chemical bonding is based on quantum theory and the atomic shell structure, which easily rationalize why bonding is typically far simpler for s- and p-block elements than for their d- and f-block counterparts. It was also long thought that chemical bonding and covalent bonding ...
... modern description of chemical bonding is based on quantum theory and the atomic shell structure, which easily rationalize why bonding is typically far simpler for s- and p-block elements than for their d- and f-block counterparts. It was also long thought that chemical bonding and covalent bonding ...
Chem 2425-Test 2 Review
... Consider the data below to answer the following question(s). Cyanohydrins are important intermediates in the synthesis of α-hydroxycarboxylic acids from ketones and aldehydes. The nitrile functional group can be hydrolyzed by aqueous acid to yield a carboxylic acid. Nitriles can also be hydrolyzed t ...
... Consider the data below to answer the following question(s). Cyanohydrins are important intermediates in the synthesis of α-hydroxycarboxylic acids from ketones and aldehydes. The nitrile functional group can be hydrolyzed by aqueous acid to yield a carboxylic acid. Nitriles can also be hydrolyzed t ...
Protection (and Deprotection) of Functional Groups in Organic
... limited thermal stability, whose manufacture generally is based on multistep synthesis performed in the liquid phase and frequently involving protectiondeprotection steps. The use of blocking functions in organic synthesis, developed for nearly 100 years, makes more complex the entire synthetic plan ...
... limited thermal stability, whose manufacture generally is based on multistep synthesis performed in the liquid phase and frequently involving protectiondeprotection steps. The use of blocking functions in organic synthesis, developed for nearly 100 years, makes more complex the entire synthetic plan ...
Kinetics Workbook - School District 67
... This workbook will allow you to demonstrate your understanding of all aspects of the kinetics unit. The minimum expectation is that you do all of these questions by the due dates given by your teacher. Do the questions. Use your notes from class to assist you. Then after you have finished go to the ...
... This workbook will allow you to demonstrate your understanding of all aspects of the kinetics unit. The minimum expectation is that you do all of these questions by the due dates given by your teacher. Do the questions. Use your notes from class to assist you. Then after you have finished go to the ...
Synthesis of Natural Products and Related Compounds using Enyne
... our group (Scheme 6).[22] Reactions of five- to sevenmembered cycloalkenes 14 having the substituent at the 3-position of the cycloalkene with 1c under ethylene gas afforded the cyclic compounds 15 in good yields. This reaction could proceed via the highly strained ruthenacyclobutane 16. In each cas ...
... our group (Scheme 6).[22] Reactions of five- to sevenmembered cycloalkenes 14 having the substituent at the 3-position of the cycloalkene with 1c under ethylene gas afforded the cyclic compounds 15 in good yields. This reaction could proceed via the highly strained ruthenacyclobutane 16. In each cas ...
Learning Guide for Chapter 23: Amines
... Once an amine has been protonated, it is an ionic compound. Amine salts are solids, and are usually soluble in water but insoluble in organic solvents. Most biologically active amines are used as their amine salts, which dissolve to make injectable or drinkable water solutions, and are also less pro ...
... Once an amine has been protonated, it is an ionic compound. Amine salts are solids, and are usually soluble in water but insoluble in organic solvents. Most biologically active amines are used as their amine salts, which dissolve to make injectable or drinkable water solutions, and are also less pro ...
Organic Chemistry Fifth Edition
... Solvation of a chloride ion by ion-dipole attractive forces with water. The negatively charged chloride ion interacts with the positively polarized hydrogens of water. ...
... Solvation of a chloride ion by ion-dipole attractive forces with water. The negatively charged chloride ion interacts with the positively polarized hydrogens of water. ...
Chapter 23 SG5e
... The stereochemistry of the product will be determined by the stereochemistry of the starting material; if the product is racemic, the starting material must have been racemic as well. Problem 23.11 How might you bring about this conversion? OH CH3 NO2 , KOH H2 ,Pt O ethanol CH2 NO2 (Aldol reaction) ...
... The stereochemistry of the product will be determined by the stereochemistry of the starting material; if the product is racemic, the starting material must have been racemic as well. Problem 23.11 How might you bring about this conversion? OH CH3 NO2 , KOH H2 ,Pt O ethanol CH2 NO2 (Aldol reaction) ...
Oxo-molybdenum(VI) - Repositório da Universidade Nova de Lisboa
... triggers its capability to catalyze different kind of processes such as carbon-carbon bond formation, olefin metathesis or alkene epoxidation among the most relevant transformations. ...
... triggers its capability to catalyze different kind of processes such as carbon-carbon bond formation, olefin metathesis or alkene epoxidation among the most relevant transformations. ...
physicochemical properties of organic medicinal agents
... Because of their electronic character, direct nucleophilic addition reactions do not occur commonly with simple alkenes. However, if an alkenyl group is in direct conjugation with an electronic withdrawing functionality, then an alkenyl carbon may be sufficiently electrophilic to react. Such is the ...
... Because of their electronic character, direct nucleophilic addition reactions do not occur commonly with simple alkenes. However, if an alkenyl group is in direct conjugation with an electronic withdrawing functionality, then an alkenyl carbon may be sufficiently electrophilic to react. Such is the ...
Revised organic chemistry
... preferentially eliminated from the carbon atom with fewer number of hydrogen atoms.” Thus 2butene is the major product in above example. In other words Saytzeff’s rule states that “Greater the number of alkyl groups attached to the double bonded carbon atoms, the more stable is the Alkene.” Hence mo ...
... preferentially eliminated from the carbon atom with fewer number of hydrogen atoms.” Thus 2butene is the major product in above example. In other words Saytzeff’s rule states that “Greater the number of alkyl groups attached to the double bonded carbon atoms, the more stable is the Alkene.” Hence mo ...
C1 polymerization and related C-C bond forming - UvA-DARE
... polymethylene,8,9 this potentially explosive process7 is not at all practical from a synthetic point of view. Also it does not provide any advantages over traditional transition metal catalyzed ethene polymerization to linear polyethylene (which was discovered more than half a century later).10-12 T ...
... polymethylene,8,9 this potentially explosive process7 is not at all practical from a synthetic point of view. Also it does not provide any advantages over traditional transition metal catalyzed ethene polymerization to linear polyethylene (which was discovered more than half a century later).10-12 T ...
Stille reaction
The Stille reaction, or the Migita-Kosugi-Stille coupling, is a chemical reaction widely used in organic synthesis which involves the coupling of an organotin compound (also known as organostannanes) with a variety of organic electrophiles via palladium-catalyzed coupling reaction.The R1 group attached to the trialkyltin is normally sp2-hybridized, including alkenes, and aryl groups; however, conditions have been devised to incorporate both sp3-hybridized groups, such as allylic and benzylic substituents, and sp-hybridized alkynes. These organostannanes are also stable to both air and moisture, and many of these reagents are either commercially available or can be synthesized from literature precedent. However, these tin reagents tend to be highly toxic. X is typically a halide, such as Cl, Br, I, yet pseudohalides such as triflates and sulfonates and phosphates can also be used.The groundwork for the Stille reaction was laid by Colin Eaborn, Toshihiko Migita, and Masanori Kosugi in 1976 and 1977, who explored numerous palladium catalyzed couplings involving organotin reagents. John Stille and David Milstein developed a much milder and more broadly applicable procedure in 1978. Stille’s work on this area might have earned him a share of the 2010 Nobel Prize, which was awarded to Richard Heck, Ei-ichi Negishi, and Akira Suzuki for their work on the Heck, Negishi, and Suzuki coupling reactions. However, Stille died in the plane crash of United Airlines Flight 232 in 1989.Several reviews have been published on the Stille reaction.