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UNC-119 suppresses axon branching
UNC-119 suppresses axon branching

... epileptic seizures in experimental animals results in overproduction of axon collateral sprouts (reviewed by McNamara, 1999). While a variety of molecules stimulate branching during regeneration (Ernfors et al., 1991; Bendotti et al., 1993; Aguayo et al., 1996; Caroni, 1998), the molecular mechanism ...
On the Biological Plausibility of Grandmother Cells
On the Biological Plausibility of Grandmother Cells

... preference), with adjacent hypercolumns coding for adjacent retinal locations. In this way, V1 codes for a range of line orientations in a range of retinal locations. Most important for present purposes, Hubel and Wiesel (1968) also found that information is coded in a hierarchical fashion, with com ...
New Concepts of the Neuroendocrine Regulation of Gonadotropin
New Concepts of the Neuroendocrine Regulation of Gonadotropin

... release pattern has been found to be critically important in sustaining gonadotropin secretion [14, 15]. The cellular mechanisms that govern the pulsatile LHRH release process, however, remain poorly understood. Electrophysiological correlates of pulse generator activity have been characterized usin ...
Amphetamine-induced release of dopamine from the substantia
Amphetamine-induced release of dopamine from the substantia

... and the brains quickly removed. The substantia nigra was dissected bilaterally by knife cuts made just caudal to the mammillary bodies, just rostral to the pons, lateral to the interpeduncular nucleus, and along a line extending through the medial lemniscus to the lateral edge of the brain stem vent ...
Changes in Monoamine Release in the Ventral Horn and
Changes in Monoamine Release in the Ventral Horn and

... and a reduction of muscle tone in the respiratory related musculature occur in rapid eye movement (REM) sleep. Previous studies have emphasized the role of glycine in generating these changes. Because the activity of norepinephrine- and serotonin-containing neurons is known to decrease in REM sleep, ...
Assembly and Function of Spinal Circuits for Motor Control
Assembly and Function of Spinal Circuits for Motor Control

... 1992, Jung & Dasen 2015). A major focus in recent years has been linking the organization and function of spinal and supraspinal neural networks with specific types of behaviors. Our current understanding of how motor circuits are assembled derives from classical studies on development and neuroanat ...
- Wiley Online Library
- Wiley Online Library

... imal fragment attached to the cell body confronts two potential fates: degenerate in a dying back fashion or attempt to reconnect with its target by regeneration. Successful axonal regeneration can be defined as the ability of a severed axon to re-establish connectivity with its target. This can happ ...
Alexander et al., 2009
Alexander et al., 2009

Reward and Aversion
Reward and Aversion

... questions have arisen: Which brain sites produce the rewarding effects? Which drugs block them? Attempts to address these questions have provided initial clues regarding the characteristics of neuromodulatory systems and neural circuits involved in reward (Wise 2004). Enormous advances have since be ...
Behavioral and Neural Changes after Gains and Losses of
Behavioral and Neural Changes after Gains and Losses of

... (Barraclough et al., 2004; Lee et al., 2004). During this game, the computer opponent simulated a rational decision maker who chooses its target so as to minimize the payoff of the animal, and the animal gained a token only when it chose the same target as the computer. When the animal’s choice was ...
Functional organization of inferior parietal lobule convexity in the
Functional organization of inferior parietal lobule convexity in the

... IPL. Only sites located between the cortical surface and a depth of 3000 lm were included in the database. This depth was chosen in order to include the cortex lying inside the dimples present in the IPL convexity (mainly in PF and PFG, see Fig. 1A). Thus, seven was the maximum number of recording s ...
Dynamics and Synchronization of Motifs of Neuronal Populations in the Presence
Dynamics and Synchronization of Motifs of Neuronal Populations in the Presence

... This mixture distinctly prevails in the brain structure and its function. ...
The Role Of The Cervical Spine In Sports Concussion And Post
The Role Of The Cervical Spine In Sports Concussion And Post

... neurotransmitters and nociceptive neuromodulators and can play a role in pain modulation as well.22 Injury to the facets is via two mechanisms; from excessive rotation of the cervical vertebrae resulting in pinning of the synovial fluid and/or excessive strain on the capsule (i.e. via cervical hyper ...
FEATURE ARTICLE Coding of Object Location in
FEATURE ARTICLE Coding of Object Location in

... Bruno and Sakmann 2006; Brecht 2007; Groh et al. 2008) embedded within a global motor-sensory closed loop (Fig. 1). In order to eliminate closed-loop effects induced by the global loop, the global loop must be artificially opened. Practically, the motor-sensory loop can be opened in several ways. In ...
University of Birmingham Drosophila neurotrophins reveal a
University of Birmingham Drosophila neurotrophins reveal a

... to target size [1]. Neurotrophins (NTs) are the major class of molecules promoting neuronal survival in vertebrates. They also control cell proliferation and neuronal differentiation, and they are required for axonal and dendritic elaborations, synaptic plasticity, excitability, and long-term potent ...
PDF file - Izhikevich
PDF file - Izhikevich

... in the number of its neurons and synapses as well as in its anatomical complexity (see Fig. 1). Nevertheless, we made efforts to preserve important ratios and relative distances found in the mammalian cortex (Braitenberg and Schuz, 1991). The ratio of excitatory to inhibitory neurons was 4/1. The sp ...
construction of a model demonstrating neural pathways and reflex arcs
construction of a model demonstrating neural pathways and reflex arcs

... Structurally, the nervous system is divided into the central nervous system (CNS) and the peripheral nervous system (PNS). The CNS consists of the brain and spinal cord. The PNS contains the spinal and cranial nerves leading into and out of the CNS. There are 12 cranial nerves. All other nerves in t ...
construction of a model demonstrating neural pathways and reflex arcs
construction of a model demonstrating neural pathways and reflex arcs

... Structurally, the nervous system is divided into the central nervous system (CNS) and the peripheral nervous system (PNS). The CNS consists of the brain and spinal cord. The PNS contains the spinal and cranial nerves leading into and out of the CNS. There are 12 cranial nerves. All other nerves in t ...
Novel approaches to explore mechanisms of
Novel approaches to explore mechanisms of

... Epilepsy comprises a family of neurological disorders characterized by recurrent seizures, which can be highly debilitating. Up to 30% of patients with temporal lobe epilepsy, the most common form of the disorder in adults, arising in the hippocampus, cannot be effectively treated by current pharmac ...
TESIS DOCTORAL Dynamics and Synchronization in Neuronal Models
TESIS DOCTORAL Dynamics and Synchronization in Neuronal Models

... to tackle questions like how are the memories stored? what is the neural code? how can the brain be so fast?... from different points of view and using different approaches. With the advent of computers and later on the increase of computational power, computational neuroscience emerged as a fundame ...
Mouse Nerve Growth Factor Prevents Degeneration of Axotomized
Mouse Nerve Growth Factor Prevents Degeneration of Axotomized

... Figure 3. Efficacy of lesion. A profound reduction in AChE staining in the hippocampus ipsilateral to the lesion (a) as compared to the control side (b) is shown. The comparison confirms the choline&c deafferentation of the hippocampus and, accordingly, the completeness of the transection of choline ...
The Effect of Ischemia on Biogenic Amine Concentrations in
The Effect of Ischemia on Biogenic Amine Concentrations in

... some physical or biochemical phenomenon must be responsible for the dysfunction. Because biogenic amines are both neurotransmitters and have potent vasoactive properties, for many years there has been considerable speculation about their influences on the development of injury to the CNS. 1 Many exp ...
Chapter 2 - IFSC-USP
Chapter 2 - IFSC-USP

Mapping Function Onto Neuronal Morphology
Mapping Function Onto Neuronal Morphology

... optimization procedure to find neuronal morphological structures for two computational tasks: first, neuronal morphologies were selected for linearly summing excitatory synaptic potentials (EPSPs); second, structures were selected that distinguished the temporal order of EPSPs. The solutions resembl ...
Planarian shows decision-making behavior in response to multiple
Planarian shows decision-making behavior in response to multiple

... Results: In the present study, we designed chemotaxis and thigmotaxis/kinesis tracking assays to measure several planarian behaviors in addition to those measured by phototaxis and thermotaxis assays previously established by our group, and used these tests to analyze planarian chemotactic and thigm ...
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Neural engineering

Neural engineering (also known as neuroengineering) is a discipline within biomedical engineering that uses engineering techniques to understand, repair, replace, enhance, or otherwise exploit the properties of neural systems. Neural engineers are uniquely qualified to solve design problems at the interface of living neural tissue and non-living constructs.
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