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Mitochondrial Metabolism in Aging Heart
Mitochondrial Metabolism in Aging Heart

... acetylated proteins in each population, differences between SSM and IFM were observed. The differences included outcomes from both endogenous acetylation/deacetylation and responses to chemical/nonenzymatic acetylation.40 Of note, SIRT3 content was decreased in SSM but remained unaltered in IFM.40 I ...
03-1 Metabolism of carbohydrate
03-1 Metabolism of carbohydrate

... levels F-2,6-BP. Phosphofructokinase 2 (PFK-2) catalyzes the formation of F-2,6-BP from F-6P. F-2,6-BP is converted back to F-6P by fructose bisphosphatase 2 (FBPase-2). ...
Review: can diet influence the selective advantage of mitochondrial
Review: can diet influence the selective advantage of mitochondrial

... that efficiency of cellular respiration, as a product of mitochondrial function, underlies the associations between ornamentation and performance for a broad range of traits. Reducing the rates of oxygen consumption and ATP production may also induce a decrease in growth rate and body size [21], whi ...
cyanobacteria: a potential natural source for drug discovery and
cyanobacteria: a potential natural source for drug discovery and

... (NO2-) or nitrates (NO3-) in anaerobic conditions through specialized cells called heterocysts with the help of nitrogenase enzyme. Cyanobacteria accumulate metal ions such as Cr, Co, Cu and Zn very effectively and can utilize ammonia, nitrogenous compounds, and phosphates for their metabolism. They ...
This paper is published in a part-themed issue of Photochemical
This paper is published in a part-themed issue of Photochemical

... In contrast with the adenylation reaction, essentially clarified in the 1960s, except for the effect of oxygen concentration,13 little was known with respect to the second step, the oxidation of LH2 –AMP. In 1962, Seliger and McElroy observed a 1 : 1 stoichiometry between LH2 and O2 and proposed that ...
Slide 1
Slide 1

... Insulin, which rises subsequent to eating, stimulates the expression of phosphofructokinase and pyruvate kinase. Glucagon, which rises during starvation, inhibits the expression of these enzymes and stimulates the production of phosphoenolpyruvate carboxykinase and fructose 1,6bisphosphatase. Transc ...
The impact of sperm metabolism during in vitro storage: the stallion
The impact of sperm metabolism during in vitro storage: the stallion

... Adenosine triphosphate (ATP) is the energy molecule used by all living cells. It is an organic molecule containing high phosphate bonds. Energy is harvests from ATP through the breaking of these phosphate bonds by the ATPase enzyme, leaving behind adenosine diphosphate (ADP) which is rephosphorylate ...
Biochemistry of exercise-induced metabolic acidosis
Biochemistry of exercise-induced metabolic acidosis

... acidosis. Similarly, there is a wealth of research evidence to show that acidosis is caused by reactions other than lactate production. Every time ATP is broken down to ADP and Pi, a proton is released. When the ATP demand of muscle contraction is met by mitochondrial respiration, there is no proton ...
Instructor`s Guide to General Chemistry: Guided
Instructor`s Guide to General Chemistry: Guided

... (a) The balanced reaction equation is needed to relate the number of molecules/ions of the reactants to the number of molecules/ions that are produced as products. The number of molecules/ions is measured in units of moles. (b) Steps 2 and 3 make clear what information is given and what needs to be ...
This article is dedicated to Professor AL
This article is dedicated to Professor AL

... Destructive, degradative and adaptive rearrangements take place in mitochondria membranes in plant organs after transfer from aerobic to anaerobic environments (Figs 1B and C and 2A±D). Mitochondria of aerobic cells (Fig. 1A) are round or oval, contain several cristae and have a dense matrix. After ...
Acetyl CoA - WordPress.com
Acetyl CoA - WordPress.com

... The oxidative decarboxylation of pyruvate into acetyl-CoA commits the carbon atoms of glucose to two principle fates -oxidation to CO2 by the citric acid cycle (and energy ...
Nature template
Nature template

... stoichiometries of a metabolic network, all possible distinct routes by which substrates can flow through the network are described and all feasible metabolic conversions can be described by linear combinations of the flux vectors of the resulting elementary modes. Elementary-modes analysis of oil s ...
Drosophila Sirt2/mammalian SIRT3 deacetylates ATP synthase and
Drosophila Sirt2/mammalian SIRT3 deacetylates ATP synthase and

... We performed metabolomic profiling on sphingolipid mutants that accumulate ceramide to gain insight into metabolic pathways that could be altered in these mutants. Our earlier study combined metabolomic profiling with genetic and biochemical approaches and demonstrated that dcerk1 mutants show an in ...
The role of the C8 proton of ATP in the catalysis of shikimate kinase
The role of the C8 proton of ATP in the catalysis of shikimate kinase

... acid [6]. SK (EC 2.7.1.71), the fifth enzyme in the shikimate biosynthetic pathway, catalyzes phosphate transfer from ATP to the 3-hydroxy group of shikimate, forming shikimate-3-phosphate. Adenylate kinases (AKs) contribute to the homeostasis of adenine nucleotides by maintaining intracellular nucl ...
PDF
PDF

... citryl-CoA lyase; CCS, citryl-CoA synthetase; (Re)/(Si)-CS, (Re)/(Si)-citrate synthase; ED, Entner–Doudoroff; EMP, Emden–Meyerhof–Parnas; FAPs, filamentous anoxygenic phototrophs; FBP, fructose 1,6-bisphosphate; Fd, ferredoxin; GAP, d-glyceraldehyde-3-phosphate; Glc, glucose; GSBs, green sulfur bacte ...
PDF
PDF

... citryl-CoA lyase; CCS, citryl-CoA synthetase; (Re)/(Si)-CS, (Re)/(Si)-citrate synthase; ED, Entner–Doudoroff; EMP, Emden–Meyerhof–Parnas; FAPs, filamentous anoxygenic phototrophs; FBP, fructose 1,6-bisphosphate; Fd, ferredoxin; GAP, d-glyceraldehyde-3-phosphate; Glc, glucose; GSBs, green sulfur bacte ...
THE ATP SYNTHASE—A SPLENDID MOLECULAR MACHINE
THE ATP SYNTHASE—A SPLENDID MOLECULAR MACHINE

... and chemical derivatization studies. Crystallization was in the presence of Mg2+ , 5 µM ADP, and 250 µM AMP-PNP. One catalytic site is filled with ADP, another with AMP-PNP, and a third site is empty. All three noncatalytic sites have bound AMP-PNP. Below a central dimple of about 15 Å, the core is ...
Review of N and Metal co-Doped TiO for Water Purification under
Review of N and Metal co-Doped TiO for Water Purification under

... In last years, various attempts have been carried out by introduction of non-metals, such as carbon [6], nitrogen [7], sulfur [8], fluorine [9], iodine [10] and boron [11] into the TiO2 bulk to successfully cause the red shift of the absorption onset of TiO2 to the visible region and enhance the pho ...
Mitochondrial Functions in Mood Disorders
Mitochondrial Functions in Mood Disorders

... dative stress and/or altered calcium homeostasis [25]. An excess of glutamate in the synapse [26] leads to an excess of cytosolic calcium, which produces overactivity of calcium-depend‐ ent enzymes and an overload of mitochondria by calcium; it leads to cytoskeletal degrada‐ tion, protein malformati ...
Cytochrome P450-enzymes involved in the biosynthesis of mono
Cytochrome P450-enzymes involved in the biosynthesis of mono

... et al. 2011). This finding was not only unexpected because of the low sequence identity with other flavonoid 30 -hydroxylases (35–37 % identity on amino acid level), but also because of the different locations of the biosynthesis of flavonoids and monoterpenoids in planta (Kaltenbach et al. 1999; Ou ...
Fermentation metabolism and its evolution in algae
Fermentation metabolism and its evolution in algae

... organisms to maintain viability can only be met if they can stay far from equilibrium. To achieve this situation, they must use energy to satisfy their metabolic demands, which includes continuous synthesis of the cellular energy currency (mostly ATP) along with maintenance of redox and ionic balanc ...
Metabolism, Lectures 25-27 Quadrant – 2 - vtu-nptel
Metabolism, Lectures 25-27 Quadrant – 2 - vtu-nptel

... b) oxygen-forming photosynthesis c) the degradation of organic molecules with the released energy stored in ATP d) anaerobic respiration 4. The First Law of Thermodynamics states that energy can be a) created b) destroyed c) converted d) all of the above 5. The universal energy currency for all cell ...
Structure-Functional Study of Tyrosine and Methionine Dipeptides
Structure-Functional Study of Tyrosine and Methionine Dipeptides

... In the case of the ORAC assay, the additive AOC effect was revealed for all dipeptides with an exception of Trp-Tyr, where a synergic effect was indicated (3.6 vs. 5.1 µmol TE/µmol). The effect of intramolecular electron transfer in Trp-Tyr from Tyr residue to the tryptophan radical was indicated ea ...
Full-Text PDF
Full-Text PDF

... photochemical energy conversion, and calculate necessary number of photons per mole glucose fixed just by using the energy of photons [7]. The simple fact that about 1/4 (depending on assumptions and situations) of light energy absorbed by the reaction center cannot be used for performing work accor ...
Escherichia coli ATP Synthase
Escherichia coli ATP Synthase

... Overall, F1 Fo -ATP synthase is structurally and functionally similar among sources with only a few exceptions such as in chloroplasts, where there are two isoforms, and in mitochondria, where there are 7–9 additional subunits. ATP hydrolysis and synthesis occur on three catalytic sites in the F1 se ...
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Light-dependent reactions

In photosynthesis, the light-dependent reactions take place on the thylakoid membranes. The inside of the thylakoid membrane is called the lumen, and outside the thylakoid membrane is the stroma, where the light-independent reactions take place. The thylakoid membrane contains some integral membrane protein complexes that catalyze the light reactions. There are four major protein complexes in the thylakoid membrane: Photosystem II (PSII), Cytochrome b6f complex, Photosystem I (PSI), and ATP synthase. These four complexes work together to ultimately create the products ATP and NADPH.[.The two photosystems absorb light energy through pigments - primarily the chlorophylls, which are responsible for the green color of leaves. The light-dependent reactions begin in photosystem II. When a chlorophyll a molecule within the reaction center of PSII absorbs a photon, an electron in this molecule attains a higher energy level. Because this state of an electron is very unstable, the electron is transferred from one to another molecule creating a chain of redox reactions, called an electron transport chain (ETC). The electron flow goes from PSII to cytochrome b6f to PSI. In PSI, the electron gets the energy from another photon. The final electron acceptor is NADP. In oxygenic photosynthesis, the first electron donor is water, creating oxygen as a waste product. In anoxygenic photosynthesis various electron donors are used.Cytochrome b6f and ATP synthase work together to create ATP. This process is called photophosphorylation, which occurs in two different ways. In non-cyclic photophosphorylation, cytochrome b6f uses the energy of electrons from PSII to pump protons from the stroma to the lumen. The proton gradient across the thylakoid membrane creates a proton-motive force, used by ATP synthase to form ATP. In cyclic photophosphorylation, cytochrome b6f uses the energy of electrons from not only PSII but also PSI to create more ATP and to stop the production of NADPH. Cyclic phosphorylation is important to create ATP and maintain NADPH in the right proportion for the light-independent reactions.The net-reaction of all light-dependent reactions in oxygenic photosynthesis is:2H2O + 2NADP+ + 3ADP + 3Pi → O2 + 2NADPH + 3ATPThe two photosystems are protein complexes that absorb photons and are able to use this energy to create an electron transport chain. Photosystem I and II are very similar in structure and function. They use special proteins, called light-harvesting complexes, to absorb the photons with very high effectiveness. If a special pigment molecule in a photosynthetic reaction center absorbs a photon, an electron in this pigment attains the excited state and then is transferred to another molecule in the reaction center. This reaction, called photoinduced charge separation, is the start of the electron flow and is unique because it transforms light energy into chemical forms.
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