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Motor pathways - autonomic Nervous system
Motor pathways - autonomic Nervous system

... neurons extend from the CNS to the effector (one neuron)  Efferent pathways in the ANS are a two-neuron chain  The preganglionic (first) neuron has a lightly myelinated axon  The post-ganglionic (second) neuron extends to an effector organ ...
The Electrotonic Transformation: a Tool for Relating Neuronal Form
The Electrotonic Transformation: a Tool for Relating Neuronal Form

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to get the file

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Spinal Cord

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An Introduction to the Nervous System
An Introduction to the Nervous System

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The Autonomic Nervous System

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Sensory Pathways and the Somatic Nervous System
Sensory Pathways and the Somatic Nervous System

... poorly localized (“crude”) touch, pressure, pain, and temperature. In this pathway, the axons of first-order neurons enter the spinal cord and synapse on second-order neurons within the posterior gray horns. The axons of these interneurons cross to the opposite side of the spinal cord before ascendi ...
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Chapter 15: Sense Organs I. SENSORY RECEPTORS (Receptors)
Chapter 15: Sense Organs I. SENSORY RECEPTORS (Receptors)

... GENERAL FUNCTION Receive Stimulus(Detect Change)  Convert Stimulus to NI (NI Begins at Receptors)  The Nervous Impulse (NI) Is Carried Along Afferent Neuron into CNS; Once in CNS the Result May be ...
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chapter 11 the somatosensory system and topographic organization

... which we operate. It is often possible to find a systematic correlation between the responses of neurons to a given stimulus parameter and the locations of the neurons within a 2- or 3dimensional array in a specific area of the brain. The somatosensory and visual systems are particularly straightfor ...
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Unit One: Introduction to Physiology: The Cell and

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A Neuron Play - Web Adventures
A Neuron Play - Web Adventures

... potential is initiated. Furthermore, the magnitude of the action potential of a specific neuron is always the same. Neurons are separated by a gap (synapse) that the action potential cannot cross. Once the action potential reaches the end of an axon (its terminal), it stimulates the release of chemi ...
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Local Anesthetics
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... If the resting potential encounters the proper chemical, mechanical or electrical stimuli to reduce the membrane potential to less than -55 mV then an action potential is produced that allows the influx of sodium ions. LA act here to block the Na influx. The influx allows the membrane potential to f ...
Cardiovascular Physiology MCQ`s
Cardiovascular Physiology MCQ`s

... 51. Which of the following regarding Duchenne muscular dystrophy is incorrect? a. It is X-linked b. Dystrophin is present but reduced in amount c. It is usually fatal by the age of 30 d. Becker muscular dystrophy is a milder form of muscular dystrophe 52. The fibre type supplying sensory neurons to ...
Neuron File
Neuron File

... channels embedded in the membrane to generate intracellular-versus-extracellular concentration differences of ions such as sodium, potassium, chloride, and calcium. Changes in the cross-membrane voltage can alter the function of voltage-dependent ion channels. If the voltage changes by a large enoug ...
neuropharmacology of spasticity
neuropharmacology of spasticity

... diminishes with time Injection of mixed nerves will cause anaesthesia as well as paralysis ...
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Neuromuscular junction



A neuromuscular junction (sometimes called a myoneural junction) is a junction between nerve and muscle; it is a chemical synapse formed by the contact between the presynaptic terminal of a motor neuron and the postsynaptic membrane of a muscle fiber. It is at the neuromuscular junction that a motor neuron is able to transmit a signal to the muscle fiber, causing muscle contraction.Muscles require innervation to function—and even just to maintain muscle tone, avoiding atrophy. Synaptic transmission at the neuromuscular junction begins when an action potential reaches the presynaptic terminal of a motor neuron, which activates voltage-dependent calcium channels to allow calcium ions to enter the neuron. Calcium ions bind to sensor proteins (synaptotagmin) on synaptic vesicles, triggering vesicle fusion with the cell membrane and subsequent neurotransmitter release from the motor neuron into the synaptic cleft. In vertebrates, motor neurons release acetylcholine (ACh), a small molecule neurotransmitter, which diffuses across the synaptic cleft and binds to nicotinic acetylcholine receptors (nAChRs) on the cell membrane of the muscle fiber, also known as the sarcolemma. nAChRs are ionotropic receptors, meaning they serve as ligand-gated ion channels. The binding of ACh to the receptor can depolarize the muscle fiber, causing a cascade that eventually results in muscle contraction.Neuromuscular junction diseases can be of genetic and autoimmune origin. Genetic disorders, such as Duchenne muscular dystrophy, can arise from mutated structural proteins that comprise the neuromuscular junction, whereas autoimmune diseases, such as myasthenia gravis, occur when antibodies are produced against nicotinic acetylcholine receptors on the sarcolemma.
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