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Nervous_System - Ms. Kingery`s Class
Nervous_System - Ms. Kingery`s Class

... THE NERVOUS SYSTEM ...
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Drugs Change the way Neurons communicate

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... current sink created by this local potential depolarizes the adjacent muscle membrane to its firing level. Action potentials are generated on either side of the end plate and are conducted away from the end plate in both directions along the muscle fiber. The muscle action potential, in turn, initia ...
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Neurotoxins and the Neuromuscular Junction

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Bio 3411 Problem Set 9 Name: (Due Monday, November 28th 2011

... 3. a. The reversal potential for an acetylcholine-gated channel is +20mV. Assume that it is only permeable to Na+ and K+. Given that EK is -100mV and ENa is +100mV, which ion does the channel have a greater conductance for? (.5) ...
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... now focusing on the post-synaptic cell. The early change for explicit memory storage is going to have a pull synaptic target rather than a p synaptic target. The Schaffer collaterals come in, they release glutamate just as we saw in the sensory neurons in aplysia. They act on two different kinds ...
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Neuron Function notes

... SEQUENCE OF EVENTS [AT CHOLINERGIC SYNAPSE(acetylcholine is neurotransmitter)] 1. Arriving AP depoliarizes the synaptic knob and the presynaptic membrane 2. Ca+2 ions enter the cytoplasm of the synaptic knob – membrane channels in synaptic vesicles – release Ach 3. Ach diffuses across synaptic cleft ...
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File - Mrs. LeCompte

... The (electrical) impulse itself cannot cross the synaptic cleft, so it must use instead neurotransmitters = molecules that can carry the signal across a synaptic cleft ...
Locandina Slater.cdr - univr dsnm - Università degli Studi di Verona
Locandina Slater.cdr - univr dsnm - Università degli Studi di Verona

... this structure of fundamental importance for our movements but it also represents a classic model synapse in which basic properties of the communications between nerve cells are investigated. In particular it is a model of chemical communication (as opposed to electrical) where particular molecules, ...
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Neuromuscular junction



A neuromuscular junction (sometimes called a myoneural junction) is a junction between nerve and muscle; it is a chemical synapse formed by the contact between the presynaptic terminal of a motor neuron and the postsynaptic membrane of a muscle fiber. It is at the neuromuscular junction that a motor neuron is able to transmit a signal to the muscle fiber, causing muscle contraction.Muscles require innervation to function—and even just to maintain muscle tone, avoiding atrophy. Synaptic transmission at the neuromuscular junction begins when an action potential reaches the presynaptic terminal of a motor neuron, which activates voltage-dependent calcium channels to allow calcium ions to enter the neuron. Calcium ions bind to sensor proteins (synaptotagmin) on synaptic vesicles, triggering vesicle fusion with the cell membrane and subsequent neurotransmitter release from the motor neuron into the synaptic cleft. In vertebrates, motor neurons release acetylcholine (ACh), a small molecule neurotransmitter, which diffuses across the synaptic cleft and binds to nicotinic acetylcholine receptors (nAChRs) on the cell membrane of the muscle fiber, also known as the sarcolemma. nAChRs are ionotropic receptors, meaning they serve as ligand-gated ion channels. The binding of ACh to the receptor can depolarize the muscle fiber, causing a cascade that eventually results in muscle contraction.Neuromuscular junction diseases can be of genetic and autoimmune origin. Genetic disorders, such as Duchenne muscular dystrophy, can arise from mutated structural proteins that comprise the neuromuscular junction, whereas autoimmune diseases, such as myasthenia gravis, occur when antibodies are produced against nicotinic acetylcholine receptors on the sarcolemma.
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