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here - York University
here - York University

... vesicles and the proteins for exocytosis of the vesicles reside. One of these proteins are SNARE proteins that are used to bind the vesicles to the membrane and then facilitate their fusion causing the release of the neurotransmitters. When an action potential invades an axonal terminal, voltage-gat ...
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...  Physical therapy, massage, exercise, stress reduction  Medication to relax muscles and relieve pain ...
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Receptors and Neurotransmitters

... . In the CNS, this neurotransmitter creates a sense of feeling good, but in low doses it can cause feelings of depression. Depending on the receptor located in the PNS, this neurotransmitter can inhibit or excite ANS actions. Acetylcholine can combine with two different types of cholinergic receptor ...
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Slide ()

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456 ss 96 final - People Server at UNCW

... 28. Which of the following is true of the primary visual cortex : a) it gives meaning to complex stimuli like faces b) it allocates a small proportion of its area to processing foveal vision c) it is not layered d) it is not organized in columns e) LGN inputs terminate at layer 4 29. The optic radia ...
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Neuromuscular junction



A neuromuscular junction (sometimes called a myoneural junction) is a junction between nerve and muscle; it is a chemical synapse formed by the contact between the presynaptic terminal of a motor neuron and the postsynaptic membrane of a muscle fiber. It is at the neuromuscular junction that a motor neuron is able to transmit a signal to the muscle fiber, causing muscle contraction.Muscles require innervation to function—and even just to maintain muscle tone, avoiding atrophy. Synaptic transmission at the neuromuscular junction begins when an action potential reaches the presynaptic terminal of a motor neuron, which activates voltage-dependent calcium channels to allow calcium ions to enter the neuron. Calcium ions bind to sensor proteins (synaptotagmin) on synaptic vesicles, triggering vesicle fusion with the cell membrane and subsequent neurotransmitter release from the motor neuron into the synaptic cleft. In vertebrates, motor neurons release acetylcholine (ACh), a small molecule neurotransmitter, which diffuses across the synaptic cleft and binds to nicotinic acetylcholine receptors (nAChRs) on the cell membrane of the muscle fiber, also known as the sarcolemma. nAChRs are ionotropic receptors, meaning they serve as ligand-gated ion channels. The binding of ACh to the receptor can depolarize the muscle fiber, causing a cascade that eventually results in muscle contraction.Neuromuscular junction diseases can be of genetic and autoimmune origin. Genetic disorders, such as Duchenne muscular dystrophy, can arise from mutated structural proteins that comprise the neuromuscular junction, whereas autoimmune diseases, such as myasthenia gravis, occur when antibodies are produced against nicotinic acetylcholine receptors on the sarcolemma.
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