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6.5 Nerves, Hormones and Homeostasis part 1
6.5 Nerves, Hormones and Homeostasis part 1

... Once depolarization occurs the sodium gates are closed and the potassium channels open. Potassium diffuses out of the neuron in the direction of the concentration gradient. The loss of the positive potassium ions causes the internal environment of the neuron to become negative once again and the pot ...
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... response to lowered cytoplasmic pH or elevated cytoplasmic CaH. These two properties serve to decouple damaged cells from other cells, since damaged cells contain elevated ea2+ and proton concentrations. At some specialized gap junctions the channels have voltagedependent gatesthat permit them to co ...
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... b. Chemical: a chemical neurotransmitter (NT) carries information across the gap junction. Majority of synapses are chemical synapses. i. An action potential at the synaptic terminal depolarizes the membrane, opening voltagegated channels that allow Ca2+ to diffuse into the terminal. This triggers v ...
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... Viewed from the lateral or side view, the cerebral cortex is divided into four separate areas, or lobes; the occipital lobe, the parietal lobe, the frontal lobe and the temporal lobe. The central sulcus separates the frontal lobe from the pariental lobe and the lateral sulcus separates the temporal ...
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... d) the inactivation of voltage gated sodium channels e) C and D ARE TRUE 22) Some have compared the "all or none" action potential to flushing a toilet. The relative refractory period (when the water level in the tank is below what it is at rest) is set by: a) the opening of voltage insensitive pota ...
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... Repolarization: within a millisecond Na and K return to their original state and the resting membrane potentil is restored Absolute refractory period: when the Na gates are open and the neuron is totally insensitive to additional stimuli Relative refractory period: if a very strong stimuli is able t ...
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... • In the centre of the neuron are large negatively charged units which are responsible for the net negative potential in the resting state. These units do not move even when an impulse is traveling. ...
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Neuromuscular junction



A neuromuscular junction (sometimes called a myoneural junction) is a junction between nerve and muscle; it is a chemical synapse formed by the contact between the presynaptic terminal of a motor neuron and the postsynaptic membrane of a muscle fiber. It is at the neuromuscular junction that a motor neuron is able to transmit a signal to the muscle fiber, causing muscle contraction.Muscles require innervation to function—and even just to maintain muscle tone, avoiding atrophy. Synaptic transmission at the neuromuscular junction begins when an action potential reaches the presynaptic terminal of a motor neuron, which activates voltage-dependent calcium channels to allow calcium ions to enter the neuron. Calcium ions bind to sensor proteins (synaptotagmin) on synaptic vesicles, triggering vesicle fusion with the cell membrane and subsequent neurotransmitter release from the motor neuron into the synaptic cleft. In vertebrates, motor neurons release acetylcholine (ACh), a small molecule neurotransmitter, which diffuses across the synaptic cleft and binds to nicotinic acetylcholine receptors (nAChRs) on the cell membrane of the muscle fiber, also known as the sarcolemma. nAChRs are ionotropic receptors, meaning they serve as ligand-gated ion channels. The binding of ACh to the receptor can depolarize the muscle fiber, causing a cascade that eventually results in muscle contraction.Neuromuscular junction diseases can be of genetic and autoimmune origin. Genetic disorders, such as Duchenne muscular dystrophy, can arise from mutated structural proteins that comprise the neuromuscular junction, whereas autoimmune diseases, such as myasthenia gravis, occur when antibodies are produced against nicotinic acetylcholine receptors on the sarcolemma.
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