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Overview Functions of the Nervous System
Overview Functions of the Nervous System

... • 2. Voltage-gated Ca2+ channels open and Ca2+ enters the axon terminal • 3. Ca2+ entry causes neurotransmitter-containing vesicles to release their contents by exocytosis • 4. Neurotransmitter diffuses across the synaptic cleft and binds to specific receptors on the postsynaptic membrane • 5. Bindi ...
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Nervous System and Senses - Avon Community School Corporation

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action potential

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Biol 155 Human Physiology - University of British Columbia
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... These individual potentials are sub-threshold. If the transmitter opens an anion influx, the resulting hyperpolarization is called an Inhibitory Post Synaptic Potential (IPSP All these potentials are additive. ...
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Neuroanatomy PP - Rincon History Department
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... receiving neuron, thereby influencing whether it will generate a neural impulse  If the message is for arm movement, the vesicles only release neurotransmitters involved in the movement circuit.  There are dozens of different neurotransmitters. ...
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Chapter 17:

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1. Dominant Optic Atrophy (DOA): Clinical, genetic and
1. Dominant Optic Atrophy (DOA): Clinical, genetic and

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PNS Terminology
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... – essential for planning, initiating and directing sequences of voluntary movements – extend from the brain to the LMNs via two types of somatic motor pathways • 1. direct motor pathways: nerve impulses for precise voluntary movement – lateral corticospinal, anterior corticospinal and corticobulbar ...
Lesson 3 Brain Communication
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Chemical Senses
Chemical Senses

9.2 Electrochemical Impulses
9.2 Electrochemical Impulses

... 2. Na+ moves into cell following a concentration gradient (diffusion) and also an electrical potential gradient. The positive charge moving into the neuron reduces the potential difference of the membrane . This is depolarization. ...
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Neuromuscular junction



A neuromuscular junction (sometimes called a myoneural junction) is a junction between nerve and muscle; it is a chemical synapse formed by the contact between the presynaptic terminal of a motor neuron and the postsynaptic membrane of a muscle fiber. It is at the neuromuscular junction that a motor neuron is able to transmit a signal to the muscle fiber, causing muscle contraction.Muscles require innervation to function—and even just to maintain muscle tone, avoiding atrophy. Synaptic transmission at the neuromuscular junction begins when an action potential reaches the presynaptic terminal of a motor neuron, which activates voltage-dependent calcium channels to allow calcium ions to enter the neuron. Calcium ions bind to sensor proteins (synaptotagmin) on synaptic vesicles, triggering vesicle fusion with the cell membrane and subsequent neurotransmitter release from the motor neuron into the synaptic cleft. In vertebrates, motor neurons release acetylcholine (ACh), a small molecule neurotransmitter, which diffuses across the synaptic cleft and binds to nicotinic acetylcholine receptors (nAChRs) on the cell membrane of the muscle fiber, also known as the sarcolemma. nAChRs are ionotropic receptors, meaning they serve as ligand-gated ion channels. The binding of ACh to the receptor can depolarize the muscle fiber, causing a cascade that eventually results in muscle contraction.Neuromuscular junction diseases can be of genetic and autoimmune origin. Genetic disorders, such as Duchenne muscular dystrophy, can arise from mutated structural proteins that comprise the neuromuscular junction, whereas autoimmune diseases, such as myasthenia gravis, occur when antibodies are produced against nicotinic acetylcholine receptors on the sarcolemma.
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