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... of specific birth defects. In addition, because most studies do not specify whether antidepressant use was started because of maternal depression about an existing pregnancy complication or whether the complication occurred after drug therapy was initiated for other reasons, it is difficult to ascri ...
mechanism of action of antidepressants and mood stabilizers
mechanism of action of antidepressants and mood stabilizers

... lithium and neurotransmission, the effect of lithium has been extensively studied in virtually every neurotransmitter system. Earlier studies focused on the modulation of presynaptic components, including the synthesis, release, turnover, and reuptake of neurotransmitters. In recent years, the focus ...
EFNS guidelines on management of narcolepsy
EFNS guidelines on management of narcolepsy

... Management of narcolepsy with or without cataplexy relies on several classes of drugs, namely stimulants for excessive daytime sleepiness and irresistible episodes of sleep, antidepressants for cataplexy and hypnosedative drugs for disturbed nocturnal sleep. In addition, behavioral measures can be o ...
Effects of Self-Administered Cocaine on Plasma Adrenocorticotropic
Effects of Self-Administered Cocaine on Plasma Adrenocorticotropic

... Although it is generally accepted that passive cocaine administration stimulates activity of the HPA axis, there are very little published data demonstrating the effects of selfadministered cocaine on HPA activity. The only exception was in a study done by Goeders and Guerin (1996b) where single sam ...
Ergot Alkaloids: A Review on Therapeutic Applications (PDF
Ergot Alkaloids: A Review on Therapeutic Applications (PDF

... Ergot of Rye is a plant disease caused by the fungus Claviceps purpurea which infects the grains of cereals and grasses but it is being used for ages for its medicinal properties. All the naturally obtained ergot alkaloids contain tetracyclic ergoline ring system, which makes them structurally simil ...
Theophylline Revisited
Theophylline Revisited

... § GI toxic effects • Symptoms do not always correlate to serum-level • Life threatening effects may occur with out warning ...
Cognitive and psychomotor effects of antidepressants with emphasis
Cognitive and psychomotor effects of antidepressants with emphasis

... problem solving. Clinical studies have described impairment in patients with frontal lobe dysfunction on a range of tasks of this nature. Interestingly, there is neuroimaging evidence of frontal lobe dysfunction in depression (see Soares & Mann, 1997 for review). Neuropsychological deficits in depre ...
1158-1161 Lovelyn Joseph 317 - International Journal of Bioassays
1158-1161 Lovelyn Joseph 317 - International Journal of Bioassays

... electroshock seizure model in mice. Phytochemical profile of Valeriana wallichii suggests many active constituents with more than one possible mechanism of action. The interaction could be pharmacokinetic or pharmacodynamic. Large scale studies at various dose ratios and with more parameters includi ...
Childhood Predictors of Adolescent Substance Use in a
Childhood Predictors of Adolescent Substance Use in a

... Studies that have separated the ADHD symptoms into the two DSM–IV dimensions have shown differential relationships with later substance use. For example, Burke et al. (2001) found the inattention dimension to be significantly associated with concurrent tobacco use but not alcohol or other substance ...
Serotonin Syndrome Caused by Moclobemide
Serotonin Syndrome Caused by Moclobemide

... there was any use of single or combined serotomimetic treatments. Of the 226 cases, 105 fulfilled the Sternbach criteria for seratonin syndrome. However, moclobemide, a RIMA, was represented in only 9 of the 226 published cases and 3 of the 105 defined serotonin syndromes, either in multi-drug combi ...
pdf
pdf

... toward understanding tinnitus have been proposed recently.17 In particular, the high-throughput analysis of drug side-effect information to predict targets leading to this pathology might result informative. The strategy is based on the notion that treatment of patients with drugs is an in vivo chem ...
Effects of ()-HA-966, CGS-19755, Phencyclidine, and Dizocilpine on
Effects of ()-HA-966, CGS-19755, Phencyclidine, and Dizocilpine on

... key lights, a correct response turned all the keys blue and a correct response in the presence of the blue key lights produced a 0.5-s flash of the hopper light and restarted the cycle in red. On the fifth time through the cycle (FR5), a correct response in the presence of the blue light resulted in ...
university of california student prescription drug plan
university of california student prescription drug plan

... Prescription Drug Covered Expenses will always be the lesser of the billed charge or the Prescription Drug Maximum Allowed Amount. The expense is incurred on the date you receive the drug for which the charge is made. You will not be responsible for any amount in excess of the Prescription Drug Maxi ...
Mood stabilizers
Mood stabilizers

... disorder, people can also have periods where their mood is balanced. Mood stabilizers can help to keep the mood of a person with bipolar disorder within this balanced range. Bipolar disorder can make it impossible for people to keep their minds on work or school or to have a twoway relationship with ...
Essay Code D17 Heroin - Needles, Pain, and Addiction "[Users] just
Essay Code D17 Heroin - Needles, Pain, and Addiction "[Users] just

... addition, it is a cheap drug that costs less than ten dollars a dose. However, many users dislike Naloxone because it immediately elicits withdrawal symptoms that cause them to seek more heroin not long after their lives are saved by the treatment. In summary, heroin is a drug that causes significan ...
“Robo-Tripping”: Dextromethorphan Abuse and its Anesthetic
“Robo-Tripping”: Dextromethorphan Abuse and its Anesthetic

... dextromethorphan abuse, suggesting that clinically significant opioid tolerance did not occur. Finally, whether acute dextromethorphan intoxication is capable of reducing opioid requirements during and after surgery similar to subanesthetic doses of ketamine also remains to be established. Managemen ...
Chapter 16 Cholinesterase Inhibitors
Chapter 16 Cholinesterase Inhibitors

... Food reduces rate of absorption Highly bound to albumin in the blood Half-life: 12 hours Copyright © 2013, 2010 by Saunders, an imprint of Elsevier Inc. ...
Analysing the effect of I1 imidazoline receptor ligands on DSS
Analysing the effect of I1 imidazoline receptor ligands on DSS

... Imidazoline receptors (IRs) have been recognized as promising targets in the treatment of numerous diseases, and moxonidine and rilmenidine, agonists of I1-IRs are widely used as antihypertensive agents. Some evidence suggests that IR ligands may induce anti-inflammatory effects acting on I1-IRs or ...


... will undoubtedly be the subject extensive sales,marketing and physician sampling efforts, particularly in view of the void created by the recent withdrawal of Vioxx@ and Bextra@,and the genericization of Ultram@,Ultrace?, OxyContin@ and Duragesic*. Tramadol ER carries all the documented adverse effe ...
The diagnosis and management of benzodiazepine dependence
The diagnosis and management of benzodiazepine dependence

... to make them ideal medications for many common conditions (Table 1). The drugs were prescribed long term, often for many years, for complaints such as anxiety, depression, insomnia and ordinary life stresses. Benzodiazepines were undoubtedly efficacious at first for these conditions, and apparently ...
The Effects of Marijuana - Family Research Council
The Effects of Marijuana - Family Research Council

... of ideological and political persecution are far from the truth. Evaluating this area is challenging because of the way claims are made. Many people claim they have used marijuana safely. However, they may have had negative effects that they attributed to other things, like other substances they co ...
Serotonergic Modulation of Inspiratory Hypoglossal Motoneurons in
Serotonergic Modulation of Inspiratory Hypoglossal Motoneurons in

... baseline, peak Fn was measured during a preejection control period (Fcon). Then ketanserin was applied in increasing dose rates until an increase in picoejection dose rate did not result in any further decrease in peak Fn. In some neurons with relatively low Fcon, the maximum effect could not be det ...
The diagnosis and management of benzodiazepine dependence Heather Ashton
The diagnosis and management of benzodiazepine dependence Heather Ashton

... to make them ideal medications for many common conditions (Table 1). The drugs were prescribed long term, often for many years, for complaints such as anxiety, depression, insomnia and ordinary life stresses. Benzodiazepines were undoubtedly efficacious at first for these conditions, and apparently ...
Nicotine sensitization and the effects of extended withdrawal
Nicotine sensitization and the effects of extended withdrawal

... submitted manuscript. These are included as an appendix and referred to in Roman numerals (I-III) in the text Nicotine addiction and reward pathways Tobacco (Nicotiana tabacum) has been used as a recreational drug in the Americas since long before European explorers introduced it in the old world in ...
Pleiotropic Effects of Statins
Pleiotropic Effects of Statins

... might be increased. More clinical studies are needed in order to confirm the beneficial effects of coenzyme Q10 substitution in long-term statin therapy. The International College of Cardiology, in its scientific statement, recommended use of statins preferably in conjunction with coenzyme Q10 in or ...
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Stimulant



Stimulants (also referred to as psychostimulants) are psychoactive drugs that induce temporary improvements in either mental or physical functions or both. Examples of these kinds of effects may include enhanced alertness, wakefulness, and locomotion, among others. Due to their rendering a characteristic ""up"" feeling, stimulants are also occasionally referred to as ""uppers"". Depressants or ""downers"", which decrease mental and/or physical function, are in stark contrast to stimulants and are considered to be their functional opposites. Stimulants are widely used throughout the world as prescription medicines and without prescription both as legal substances and illicit substances of recreational use or abuse.
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