Definitions Related to the Medical Use of Opioids: Evolution
... required to produce the pharmacologic effects initially resulting from smaller doses. Tolerance may be present in addiction, but it can also occur in the absence of addiction, as when drugs are used therapeutically over a period of time. Until recently, physical dependence and tolerance were thought ...
... required to produce the pharmacologic effects initially resulting from smaller doses. Tolerance may be present in addiction, but it can also occur in the absence of addiction, as when drugs are used therapeutically over a period of time. Until recently, physical dependence and tolerance were thought ...
Inhibition of Prostaglandin Synthesis and Effects of Ethanol and
... ing (Hale et al., 1992). Overall, these animal studies suggest that some of the effects of ethanol in the brain are due to an increase in prostaglandin synthesis or release and that PGSIs diminish these effects. However, interactions between PGSIs and ethanol in human experiments have yielded mixed ...
... ing (Hale et al., 1992). Overall, these animal studies suggest that some of the effects of ethanol in the brain are due to an increase in prostaglandin synthesis or release and that PGSIs diminish these effects. However, interactions between PGSIs and ethanol in human experiments have yielded mixed ...
Iboga - Scientific Information
... interval (11), so its medical use may be limited in people suffering from premorbid cardiovascular diseases or in the presence of other medications. In fact, from 1990 through 2008, at least 15 individuals are known to have died within 1.5–76 h of taking ibogaine, although in most of them advanced c ...
... interval (11), so its medical use may be limited in people suffering from premorbid cardiovascular diseases or in the presence of other medications. In fact, from 1990 through 2008, at least 15 individuals are known to have died within 1.5–76 h of taking ibogaine, although in most of them advanced c ...
Effect of Khat chewing on the bioavailability of ampicillin and
... rate than ampicillin. Up to 70% of the dose of amoxycillin can be absorbed, compared with a maximum of about 40% for ampicillin. 6 Moreover, concurrent administration of ampicillin with food reduces its absorption significantly, whereas amoxycillin absorption is unaffected.7 The observed pronounced ...
... rate than ampicillin. Up to 70% of the dose of amoxycillin can be absorbed, compared with a maximum of about 40% for ampicillin. 6 Moreover, concurrent administration of ampicillin with food reduces its absorption significantly, whereas amoxycillin absorption is unaffected.7 The observed pronounced ...
Retrospective Review of Trend in Modafinil Overexposures
... drowsiness associated with narcolepsy, obstructive sleep apnea and shift work sleep disorder (2,3). Due to its presumed lower potential for abuse and lack of peripheral sympathomimetic effects that are associated with the amphetamine stimulants, it has also been studied and used off-label to treat s ...
... drowsiness associated with narcolepsy, obstructive sleep apnea and shift work sleep disorder (2,3). Due to its presumed lower potential for abuse and lack of peripheral sympathomimetic effects that are associated with the amphetamine stimulants, it has also been studied and used off-label to treat s ...
LSD, mushrooms and other hallucinogenic drugs
... contrast, cases of police interrogation in relation to hallucinogenic mushrooms became more and more numerous in the second half of the 1990s, although their number is still limited (approximately 150). Supply and trafficking ...
... contrast, cases of police interrogation in relation to hallucinogenic mushrooms became more and more numerous in the second half of the 1990s, although their number is still limited (approximately 150). Supply and trafficking ...
Methadone
... 1. Mu receptor agonist Major effects here 2. Delta receptor agonist 3. N-methyl-d-aspartate (NMDA) antagonist (same as NAMENDA) 4. Norepinephrine and serotonin reuptake inhibitor (like antidepressants) ...
... 1. Mu receptor agonist Major effects here 2. Delta receptor agonist 3. N-methyl-d-aspartate (NMDA) antagonist (same as NAMENDA) 4. Norepinephrine and serotonin reuptake inhibitor (like antidepressants) ...
Imovane (zopiclone)
... depression that could be intensified by hypnotic drugs. The potential for self-harm (e.g., intentional overdose) is high in patients with depression and thus, the least amount of drug that is feasible should be available to them at any one time. As with other hypnotics, IMOVANE does not constitute a ...
... depression that could be intensified by hypnotic drugs. The potential for self-harm (e.g., intentional overdose) is high in patients with depression and thus, the least amount of drug that is feasible should be available to them at any one time. As with other hypnotics, IMOVANE does not constitute a ...
... significantly inhibited the NANC component, even at 10-6 M. This inhibitory effect increased from 10-6 to 10-4 M (figs. 2 and 3). Influence of fenspiride on the concentration-response curves of ACh, SP, [Nle10]-NKA(4-10) and capsaicin Figure 4 shows that fenspiride, at concentrations of 10-4 to 10-2 ...
FSC402H Forensic Toxicology of Common Pharmaceuticals
... Tolerance needs to be considered Often information on dose, not plasma (blood) concentration is available No means through law to obtain a blood sample from an individual – seized hospital samples from motor vehicle collisions ...
... Tolerance needs to be considered Often information on dose, not plasma (blood) concentration is available No means through law to obtain a blood sample from an individual – seized hospital samples from motor vehicle collisions ...
Paracetamol and codeine phosphate
... Anticholinergics: Concomitant use of codeine and anticholinergic agents may increase the risk of severe constipation and/or urinary retention. Drugs, which decrease gastric emptying, may decrease the absorption of paracetamol. Cholestyramine: Cholestyramine reduces the absorption of paracetamol if g ...
... Anticholinergics: Concomitant use of codeine and anticholinergic agents may increase the risk of severe constipation and/or urinary retention. Drugs, which decrease gastric emptying, may decrease the absorption of paracetamol. Cholestyramine: Cholestyramine reduces the absorption of paracetamol if g ...
intravenous buprenorphine in humans
... A dose-dependent miosis was evident immediately after intravenous buprenorphine administration and persisted for 24 hours after the lower doses and up to 48 hours after the high dose. In these same subjects, intravenous buprenorphine caused a long-lasting decrease in pupil size and a diminution in t ...
... A dose-dependent miosis was evident immediately after intravenous buprenorphine administration and persisted for 24 hours after the lower doses and up to 48 hours after the high dose. In these same subjects, intravenous buprenorphine caused a long-lasting decrease in pupil size and a diminution in t ...
DETC Template for Rescue College
... Hallucinogens, Club Drugs, and Steroids.” Have a separate listing for each drug that is considered to be a depressant and include all facts on origin, tolerance, withdrawal, psychoactive effects, common names and any information from the session that you feel will assist you in understanding Halluci ...
... Hallucinogens, Club Drugs, and Steroids.” Have a separate listing for each drug that is considered to be a depressant and include all facts on origin, tolerance, withdrawal, psychoactive effects, common names and any information from the session that you feel will assist you in understanding Halluci ...
Evaluation of rat ultrasonic vocalizations as predictors of the
... Again, animals that received VEH in each of the compartments showed no preference for either of the place cues while animals that were conditioned with LiCl spent less time in the drug-paired compartment than the VEH-paired compartment [F(2,21)=3.91, P<0.05]. Specifically, animals conditioned with t ...
... Again, animals that received VEH in each of the compartments showed no preference for either of the place cues while animals that were conditioned with LiCl spent less time in the drug-paired compartment than the VEH-paired compartment [F(2,21)=3.91, P<0.05]. Specifically, animals conditioned with t ...
classification of sedating antihistamines
... i.e. a continuous measure of the ability to match the varying speed of the vehicle ahead, and b) subjective drowsiness, lane keeping and emergency response to an unexpected vehicle blocking the lane. Diphenhydramine impaired coherence more than alcohol. Lane keeping was impaired after alcohol and di ...
... i.e. a continuous measure of the ability to match the varying speed of the vehicle ahead, and b) subjective drowsiness, lane keeping and emergency response to an unexpected vehicle blocking the lane. Diphenhydramine impaired coherence more than alcohol. Lane keeping was impaired after alcohol and di ...
The diffusion of Performance and Image
... in the Google search engine. These websites were monitored on a regular basis, daily (n = 32), weekly (n = 168), or monthly (n = 27) depending on relevance. Links from forums, websites, and other related material, including newspapers and magazines, were followed as well. Additional searches were ca ...
... in the Google search engine. These websites were monitored on a regular basis, daily (n = 32), weekly (n = 168), or monthly (n = 27) depending on relevance. Links from forums, websites, and other related material, including newspapers and magazines, were followed as well. Additional searches were ca ...
Management of Cocaine-Associated Chest Pain and Myocardial Infarction : A
... last 6 months of 2004, there were ⬇126 000 cocaine-related ED visits in the United States, or ⬇40% of all ED visits related to substance abuse (illicit or otherwise).9 The most frequent age group for these visits was 35 to 44 years of age; this group accounted for 37% of all cocaine-related ED encou ...
... last 6 months of 2004, there were ⬇126 000 cocaine-related ED visits in the United States, or ⬇40% of all ED visits related to substance abuse (illicit or otherwise).9 The most frequent age group for these visits was 35 to 44 years of age; this group accounted for 37% of all cocaine-related ED encou ...
Knowledge Objectives
... learning, distortion of judgement, impairment of reflexes, adverse effects on mood, etc. ...
... learning, distortion of judgement, impairment of reflexes, adverse effects on mood, etc. ...
Minireview The Neurokinin-1 Receptor in Addictive Processes
... reinforcement, much research has focused on the impact of NK1R manipulations on stress-induced drug seeking. The preclinical findings for the NK1R system with three major classes of drugs of abuse are outlined below, followed by a conclusion relating this to the effects of CRH. Opiates. Likely owing ...
... reinforcement, much research has focused on the impact of NK1R manipulations on stress-induced drug seeking. The preclinical findings for the NK1R system with three major classes of drugs of abuse are outlined below, followed by a conclusion relating this to the effects of CRH. Opiates. Likely owing ...
Chapter 9 lesson 1 - ROP Pharmacology for Health Care
... Figure 9–3 Celecoxib (Celebrex). This is a COX-2 inhibitor drug used to treat the pain and inflammation of osteoarthritis. Celebrex is protected by a patent until 2015. When a drug company's patent expires, other drug companies begin to make their own generic versions of the drug. The generic drugs ...
... Figure 9–3 Celecoxib (Celebrex). This is a COX-2 inhibitor drug used to treat the pain and inflammation of osteoarthritis. Celebrex is protected by a patent until 2015. When a drug company's patent expires, other drug companies begin to make their own generic versions of the drug. The generic drugs ...
Effects of terbutaline and atenolol ... airways in asthmatic patients J.W.J. Lammers, Folgering,
... Ventilatory effects of P-adrenoceptor agonists and antagonists are usually assessed by routine lung function tests, such as measurement of total airway resistance, peak expiratory flow rate (PEFR), and the forced expiratory volume in one second (FEV 1 ). Although these methods give insight into chan ...
... Ventilatory effects of P-adrenoceptor agonists and antagonists are usually assessed by routine lung function tests, such as measurement of total airway resistance, peak expiratory flow rate (PEFR), and the forced expiratory volume in one second (FEV 1 ). Although these methods give insight into chan ...
Linköping University Post Print Incentive Learning Underlying Cocaine-
... enable environmental stimuli paired with natural rewards (e.g., food or water) to guide adaptive behaviors (Robinson and Berridge, 1993; Berke and Hyman, 2000; Kauer and Malenka, 2007). However, associative reward-learning can be dissociated into a variety of psychologically and neurobiologically di ...
... enable environmental stimuli paired with natural rewards (e.g., food or water) to guide adaptive behaviors (Robinson and Berridge, 1993; Berke and Hyman, 2000; Kauer and Malenka, 2007). However, associative reward-learning can be dissociated into a variety of psychologically and neurobiologically di ...
PDF - Problems of Forensic Sciences
... Clonazepam is a benzodiazepine exhibiting anticonvulsive activity. It is used in epilepsy treatment. In the practice of the Institute of Forensic Research in Krakow, 57 cases involving clonazepam in biological material were recorded from 2003 to 2006. The highest number of cases (29) associated with ...
... Clonazepam is a benzodiazepine exhibiting anticonvulsive activity. It is used in epilepsy treatment. In the practice of the Institute of Forensic Research in Krakow, 57 cases involving clonazepam in biological material were recorded from 2003 to 2006. The highest number of cases (29) associated with ...
Evidence that Diclofenac and Celecoxib are thyroid hormone
... antipyretic and anti-inflammatory properties however despite their therapeutic effectiveness, their use has been widely scrutinized due to their tendency to produce side effects. Since prostaglandins protect the gastrointestinal tract and are important in platelet aggregation, NSAID reduction of pro ...
... antipyretic and anti-inflammatory properties however despite their therapeutic effectiveness, their use has been widely scrutinized due to their tendency to produce side effects. Since prostaglandins protect the gastrointestinal tract and are important in platelet aggregation, NSAID reduction of pro ...
The Stimulus Properties of Para-Methoxyamphetamine
... Alles in 1932 [1] and its sympathomimetic properties were subsequently studied [6]. More recent investigations have emphasized the effects of PMA upon the central nervous system both in the rat.[3, 5, 13] and in man [12]. The pharmacological classification of PMA is uncertain. It is often cited as b ...
... Alles in 1932 [1] and its sympathomimetic properties were subsequently studied [6]. More recent investigations have emphasized the effects of PMA upon the central nervous system both in the rat.[3, 5, 13] and in man [12]. The pharmacological classification of PMA is uncertain. It is often cited as b ...
Stimulant
Stimulants (also referred to as psychostimulants) are psychoactive drugs that induce temporary improvements in either mental or physical functions or both. Examples of these kinds of effects may include enhanced alertness, wakefulness, and locomotion, among others. Due to their rendering a characteristic ""up"" feeling, stimulants are also occasionally referred to as ""uppers"". Depressants or ""downers"", which decrease mental and/or physical function, are in stark contrast to stimulants and are considered to be their functional opposites. Stimulants are widely used throughout the world as prescription medicines and without prescription both as legal substances and illicit substances of recreational use or abuse.