A Brief History of Great Discoveries in Pharmacology: In Celebration
... vignettes embedded in these essays are meant to express a reverence for the gifted scientists with whom I have had the fortune to interact. But my overall objective relates to the fervent hope that the reader will achieve deeper insight into the cultural heritage of present day science, and of pharm ...
... vignettes embedded in these essays are meant to express a reverence for the gifted scientists with whom I have had the fortune to interact. But my overall objective relates to the fervent hope that the reader will achieve deeper insight into the cultural heritage of present day science, and of pharm ...
Suboxone Contract
... been using; and whether I have become pregnant or have developed hepatitis. I agree to cooperate with urine drug testing whenever requested by Dr Mian, to confirm if I have been using any alcohol, prescription drugs, or street drugs. I have been informed that buprenorphine, as found in Suboxone, ...
... been using; and whether I have become pregnant or have developed hepatitis. I agree to cooperate with urine drug testing whenever requested by Dr Mian, to confirm if I have been using any alcohol, prescription drugs, or street drugs. I have been informed that buprenorphine, as found in Suboxone, ...
Selective serotonin reuptake inhibitors and risk for gastrointestinal
... Selective serotonin reuptake inhibitors (SSRIs) are effective drugs partly due to their ability to block the proteins responsible for the transport of serotonin back into the presynaptic neuron. Most of the known effects of SSRIs, beneficial or harmful, are associated with the inhibitory action of t ...
... Selective serotonin reuptake inhibitors (SSRIs) are effective drugs partly due to their ability to block the proteins responsible for the transport of serotonin back into the presynaptic neuron. Most of the known effects of SSRIs, beneficial or harmful, are associated with the inhibitory action of t ...
Clinical pharmacology of anti-infectives and nonsteroidal_англ
... 21. Isoniazid-induced liver damage: A. occurs primarily in patients under 30 years of age B. occurs with increased frequency in patients receiving concomitant ethambutol therapy C. *is probably due to the formation of a toxic hydrazine metabolite that binds to liver protein D. is frequently associat ...
... 21. Isoniazid-induced liver damage: A. occurs primarily in patients under 30 years of age B. occurs with increased frequency in patients receiving concomitant ethambutol therapy C. *is probably due to the formation of a toxic hydrazine metabolite that binds to liver protein D. is frequently associat ...
5-meo-dmt.5ht1a.para..
... is strongly involved. . .” Although it is true that a number of investigators have suggested that 5-HT1A–mediated events are factors in the behavioral effects of phenethylamine and indoleamine hallucinogens (1,5,19,32,41), this receptor appears to play a modulatory role rather than be directly invol ...
... is strongly involved. . .” Although it is true that a number of investigators have suggested that 5-HT1A–mediated events are factors in the behavioral effects of phenethylamine and indoleamine hallucinogens (1,5,19,32,41), this receptor appears to play a modulatory role rather than be directly invol ...
Impact of amiodarone and cisapride on simulated human ventricular
... effects were strongest in epicardial cells due to the higher sensitivity of IK,ATP, the resulting APs of this cell type are shown in Figure 1. In endocardial and M cells, similar but less pronounced ischaemia effects could be observed. Effects of the investigated drugs on electrophysiological proper ...
... effects were strongest in epicardial cells due to the higher sensitivity of IK,ATP, the resulting APs of this cell type are shown in Figure 1. In endocardial and M cells, similar but less pronounced ischaemia effects could be observed. Effects of the investigated drugs on electrophysiological proper ...
hydromorphone hydrochloride ciir
... Central Nervous System: Sedation, drowsiness, mental clouding, lethargy, impairment of mental and physical performance, anxiety, fear, dysphoria, dizziness, psychic dependence, mood changes. Gastrointestinal System: Nausea, and vomiting occur infrequently; they are more frequent in ambulatory than i ...
... Central Nervous System: Sedation, drowsiness, mental clouding, lethargy, impairment of mental and physical performance, anxiety, fear, dysphoria, dizziness, psychic dependence, mood changes. Gastrointestinal System: Nausea, and vomiting occur infrequently; they are more frequent in ambulatory than i ...
Essential Tremor
... reviewing the prescribing information for tranylcypromine, you note that tremor is a rare but potential side effect of this medication. It would be important to review the history of his generalized anxiety and panic disorder and the need for ongoing treatment. Possible options might include a trial ...
... reviewing the prescribing information for tranylcypromine, you note that tremor is a rare but potential side effect of this medication. It would be important to review the history of his generalized anxiety and panic disorder and the need for ongoing treatment. Possible options might include a trial ...
Constipation - Australian Medicines Handbook
... – fruit and vegetables may be too expensive – they believe increased fluid intake may worsen urinary incontinence cost may be a problem, especially if long-term laxative use is needed; not all laxatives are subsidised by the PBS and restrictions may apply to those that are there is no convincing evi ...
... – fruit and vegetables may be too expensive – they believe increased fluid intake may worsen urinary incontinence cost may be a problem, especially if long-term laxative use is needed; not all laxatives are subsidised by the PBS and restrictions may apply to those that are there is no convincing evi ...
Zopiclone is a drug with very similar effects
... Zopiclone is prescribed in tablet form, either as zopiclone or under the brand name Zimovane, which along with zolpidem (brand name Stilnoct) and zaleplon (brand name Sonata), are known as ‘Z drugs’ – that is, sleeping pills which begin with the letter ’z’. Zopiclone tablets go by the street names o ...
... Zopiclone is prescribed in tablet form, either as zopiclone or under the brand name Zimovane, which along with zolpidem (brand name Stilnoct) and zaleplon (brand name Sonata), are known as ‘Z drugs’ – that is, sleeping pills which begin with the letter ’z’. Zopiclone tablets go by the street names o ...
Prescribing guidelines for NSAIDs (including
... Topical NSAIDs must be systemically absorbed to have an effect. They cause similar systemic adverse effects to oral NSAIDs but only rarely and usually when used to excess. Hypersensitivity reactions e.g. asthma do occur with topical NSAIDs Photosensitivity reactions can occur with all topical NSAIDs ...
... Topical NSAIDs must be systemically absorbed to have an effect. They cause similar systemic adverse effects to oral NSAIDs but only rarely and usually when used to excess. Hypersensitivity reactions e.g. asthma do occur with topical NSAIDs Photosensitivity reactions can occur with all topical NSAIDs ...
Expert peer review No.1 Agenda item 6.1: Tramadol
... combination with serotonergic agents, tramadol may induce the serotonin syndrome. The resulting hyperthermia could be potentially fatal. As well, few cases of severe respiratory depression associated with tramadol use have been reported but these were overdoses. Seizures ha ...
... combination with serotonergic agents, tramadol may induce the serotonin syndrome. The resulting hyperthermia could be potentially fatal. As well, few cases of severe respiratory depression associated with tramadol use have been reported but these were overdoses. Seizures ha ...
EPIPRINUS MALLOTIFORMIS LEAF METHANOLIC EXTRACT Research Article
... Objective: To evaluate the antinociceptive and anti-inflammatory properties of Epiprinus mallotiformis leaf methanolic extract. Methods: Epiprinus mallotiformis Muell is traditionally well known medicinal plant, traditional medicinal practitioners use this plant to treat digestive problems, dysenter ...
... Objective: To evaluate the antinociceptive and anti-inflammatory properties of Epiprinus mallotiformis leaf methanolic extract. Methods: Epiprinus mallotiformis Muell is traditionally well known medicinal plant, traditional medicinal practitioners use this plant to treat digestive problems, dysenter ...
Local Anesthetics
... • Cocaine is the first local anesthetic (for ophthalmic use, 1884) introduced into clinical practice. Its chronic use was associated with psychological dependence (addiction). • Procaine was synthesized to improve upon the clinical properties of cocaine (1905), and became the dominant local anesthet ...
... • Cocaine is the first local anesthetic (for ophthalmic use, 1884) introduced into clinical practice. Its chronic use was associated with psychological dependence (addiction). • Procaine was synthesized to improve upon the clinical properties of cocaine (1905), and became the dominant local anesthet ...
Chronic tolerance to recreational MDMA
... follows an acute dose of MDMA, although direct vesicle depletion is also important (Mlinar and Corradetti, 2003). An acute dose of MDMA can release large amounts of serotonin in the synaptic cleft, with a 80% loss of brain serotonin (5-HT) and its metabolite 5-hydroxyindoleacetic acid (5-HIAA) withi ...
... follows an acute dose of MDMA, although direct vesicle depletion is also important (Mlinar and Corradetti, 2003). An acute dose of MDMA can release large amounts of serotonin in the synaptic cleft, with a 80% loss of brain serotonin (5-HT) and its metabolite 5-hydroxyindoleacetic acid (5-HIAA) withi ...
CRF Enhancement of GIRK Channel-Mediated
... terminal nucleus of the accessory optic tract. Physiological identification was based on the sensitivity to iontophoretically applied dopamine, a hyperpolarization-induced Ih current and the presence of spontaneous pacemaker firing of wide (E2 ms) action potentials at 1–5 Hz. The precise identificat ...
... terminal nucleus of the accessory optic tract. Physiological identification was based on the sensitivity to iontophoretically applied dopamine, a hyperpolarization-induced Ih current and the presence of spontaneous pacemaker firing of wide (E2 ms) action potentials at 1–5 Hz. The precise identificat ...
Coming Off Psychiatric Drugs
... educate people about their options if they decide to explore going off. In a culture polarized between the pro-medication propaganda of pharmaceutical companies on the one hand, and the anti-medication agenda of some activists on the other, we offer a harm reduction approach to help people make thei ...
... educate people about their options if they decide to explore going off. In a culture polarized between the pro-medication propaganda of pharmaceutical companies on the one hand, and the anti-medication agenda of some activists on the other, we offer a harm reduction approach to help people make thei ...
Looking for the Edge– Dietary Supplements
... may actually negate the effects of another. One example is the combination of creatine and caffeine: Studies have shown that caffeine antagonizes the effects of creatine. • “Synergize,” or, 1+1=3. This is seen when two supplements are combined and their effect is greater than the sum of their indiv ...
... may actually negate the effects of another. One example is the combination of creatine and caffeine: Studies have shown that caffeine antagonizes the effects of creatine. • “Synergize,” or, 1+1=3. This is seen when two supplements are combined and their effect is greater than the sum of their indiv ...
ANTI-INFLAMMATORIES Alison Clode, DVM, DACVO Port City
... Ocular Bioavailability of Topical Steroid Preparations The efficacy of a topically applied ophthalmic corticosteroid depends upon multiple drug- and patientrelated factors, which influence transcorneal and intraocular penetration and anti-inflammatory activity. Of the drug-related factors, the base ...
... Ocular Bioavailability of Topical Steroid Preparations The efficacy of a topically applied ophthalmic corticosteroid depends upon multiple drug- and patientrelated factors, which influence transcorneal and intraocular penetration and anti-inflammatory activity. Of the drug-related factors, the base ...
Side Effects of Anabolic Androgenic Steroids
... Abstract Side effects of anabolic steroids with relevance in forensic medicine are mainly due to life-threatening health risks with potential fatal outcome and cases of uncertain limitations of criminal liability after steroid administration. Both problems are typically associated with long-term abu ...
... Abstract Side effects of anabolic steroids with relevance in forensic medicine are mainly due to life-threatening health risks with potential fatal outcome and cases of uncertain limitations of criminal liability after steroid administration. Both problems are typically associated with long-term abu ...
Mecamylamine (a nicotine antagonist) for smoking cessation
... 1994; Tennant 1984a; Tennant 1984b). However, at these doses, it produced significant side effects, including drowsiness, postural hypotension and constipation. Rose and colleagues have suggested that co-administration of mecamylamine and nicotine replacement might allow the use of smaller doses of ...
... 1994; Tennant 1984a; Tennant 1984b). However, at these doses, it produced significant side effects, including drowsiness, postural hypotension and constipation. Rose and colleagues have suggested that co-administration of mecamylamine and nicotine replacement might allow the use of smaller doses of ...
Facts about Marijuana - Institute for Student Achievement
... you'll be a hero. But, you're a little off. The ball grazes your glove and hits dirt. So much for your dreams of glory. Such loss of coordination can be caused by smoking marijuana. And that's just one of its many negative effects. Marijuana affects memory, judgment, and perception. Under the influe ...
... you'll be a hero. But, you're a little off. The ball grazes your glove and hits dirt. So much for your dreams of glory. Such loss of coordination can be caused by smoking marijuana. And that's just one of its many negative effects. Marijuana affects memory, judgment, and perception. Under the influe ...
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... of specific birth defects. In addition, because most studies do not specify whether antidepressant use was started because of maternal depression about an existing pregnancy complication or whether the complication occurred after drug therapy was initiated for other reasons, it is difficult to ascri ...
... of specific birth defects. In addition, because most studies do not specify whether antidepressant use was started because of maternal depression about an existing pregnancy complication or whether the complication occurred after drug therapy was initiated for other reasons, it is difficult to ascri ...
Phosphodiesterases Inhibition Enhances the Effect of Glucagon on
... test drug was applied until a cumulative concentrationresponse curve had been constructed. To ascertain the role of PDEs in regulating glucagon responses, we also determined concentration response curves for glucagon in the presence of the nonselective PDE inhibitor, 3-isobutyl-1-methylxanthine (IBM ...
... test drug was applied until a cumulative concentrationresponse curve had been constructed. To ascertain the role of PDEs in regulating glucagon responses, we also determined concentration response curves for glucagon in the presence of the nonselective PDE inhibitor, 3-isobutyl-1-methylxanthine (IBM ...
Stimulant
Stimulants (also referred to as psychostimulants) are psychoactive drugs that induce temporary improvements in either mental or physical functions or both. Examples of these kinds of effects may include enhanced alertness, wakefulness, and locomotion, among others. Due to their rendering a characteristic ""up"" feeling, stimulants are also occasionally referred to as ""uppers"". Depressants or ""downers"", which decrease mental and/or physical function, are in stark contrast to stimulants and are considered to be their functional opposites. Stimulants are widely used throughout the world as prescription medicines and without prescription both as legal substances and illicit substances of recreational use or abuse.