![The Role of Inflammatory Mediators in the Pathogenesis of Otitis](http://s1.studyres.com/store/data/005037032_1-31cd5dc1d3009f4e62a622e5ca5ab6e2-300x300.png)
Innate immune responses of human tracheal epithelium to
... 2005; doi:10.1152/ajpcell.00166.2005.—We measured innate immune responses by primary human tracheal epithelial (HTE) cells grown as confluent, pseudostratified layers during exposure to inflammatory activators on apical vs. basolateral surfaces. Apical Pseudomonas aeruginosa strain PAK (but not flag ...
... 2005; doi:10.1152/ajpcell.00166.2005.—We measured innate immune responses by primary human tracheal epithelial (HTE) cells grown as confluent, pseudostratified layers during exposure to inflammatory activators on apical vs. basolateral surfaces. Apical Pseudomonas aeruginosa strain PAK (but not flag ...
Neonatal Chlamydial Infection Induces Mixed T-Cell
... Chlamydial infection is clinically associated with the onset and exacerbation of asthma in adults and children. However, it is unknown how this Th1-inducing infection is linked with Th2-driven asthma. What This Study Adds to the Field ...
... Chlamydial infection is clinically associated with the onset and exacerbation of asthma in adults and children. However, it is unknown how this Th1-inducing infection is linked with Th2-driven asthma. What This Study Adds to the Field ...
WHO Meeting on Immunological Endpoints for TB Vaccine Trials
... studies of BCG-induced immunity[13,14], and is currently the primary screening assay to test multiple novel TB antigens in large Gates-funded consortiums[15]. Both these applications have involved measuring IFN-γ as the primary endpoint. IFN-γ is an example of a cytokine that is stable in culture an ...
... studies of BCG-induced immunity[13,14], and is currently the primary screening assay to test multiple novel TB antigens in large Gates-funded consortiums[15]. Both these applications have involved measuring IFN-γ as the primary endpoint. IFN-γ is an example of a cytokine that is stable in culture an ...
Fatty acids and lymphocyte functions
... These are a class of lymphocyte which do not express surface markers identifying them as either T- or B-lymphocytes. They are capable of lysing tumour or virus-infected cells and have a role in graft rejection. NK cells are activated by IL-2, IL-12, IFN-g and tumour necrosis factor (TNF)-a. Lymphocy ...
... These are a class of lymphocyte which do not express surface markers identifying them as either T- or B-lymphocytes. They are capable of lysing tumour or virus-infected cells and have a role in graft rejection. NK cells are activated by IL-2, IL-12, IFN-g and tumour necrosis factor (TNF)-a. Lymphocy ...
Interaction of human mesenchymal stem cells with cells involved in
... of both naive and memory antigen-specific T cells in response to their cognate peptide.15 This immunosuppressive activity of mouse MSC was not dependent on the secretion of inhibitory soluble factors and did not require the presence of CD4+CD25+ regulatory cells.15 However, recently published data d ...
... of both naive and memory antigen-specific T cells in response to their cognate peptide.15 This immunosuppressive activity of mouse MSC was not dependent on the secretion of inhibitory soluble factors and did not require the presence of CD4+CD25+ regulatory cells.15 However, recently published data d ...
Induced CD4+Foxp3+ Regulatory T Cells in Immune Tolerance
... a decisive factor in Helios expression on iTreg cells, rather than in nTreg or iTreg cell origin (30). In this case, the authors used T cells from TCR–transgenic RAG-deficient mice (which lack nTreg cells) and differentiated them to iTreg cells in vitro using TGF-β and IL-2 and two different activati ...
... a decisive factor in Helios expression on iTreg cells, rather than in nTreg or iTreg cell origin (30). In this case, the authors used T cells from TCR–transgenic RAG-deficient mice (which lack nTreg cells) and differentiated them to iTreg cells in vitro using TGF-β and IL-2 and two different activati ...
Thesis - KI Open Archive
... provides a ready source of cells, since this tissue is normally discarded after delivery. Stromal cells were isolated from different parts of the term placenta, specifically chorionic villi, umbilical cord, and the fetal membranes. DSCs isolated from the fetal membranes had a consistent immunosuppre ...
... provides a ready source of cells, since this tissue is normally discarded after delivery. Stromal cells were isolated from different parts of the term placenta, specifically chorionic villi, umbilical cord, and the fetal membranes. DSCs isolated from the fetal membranes had a consistent immunosuppre ...
Broad and direct interaction between TLR and Siglec families of
... SIGLEC fusion proteins for their interaction with human TLRs synthesized by the THP1 cell line using a sandwich capture assay. Plates were coated with recombinant SIGLEC-Fc fusion proteins or control human Fc. Lysates from the human myeloid cell line THP1 was used as the source of cellular TLRs, as ...
... SIGLEC fusion proteins for their interaction with human TLRs synthesized by the THP1 cell line using a sandwich capture assay. Plates were coated with recombinant SIGLEC-Fc fusion proteins or control human Fc. Lysates from the human myeloid cell line THP1 was used as the source of cellular TLRs, as ...
Early Life Microbiota, Neonatal Immune Maturation and
... Emerging epidemiologic data supports the hypothesis that early life colonization is a key player in development of a balanced immune system. Events in early life, as birth mode and infant diet, are shown to influence development of immune related diseases, like asthma, diabetes and inflammatory bowl ...
... Emerging epidemiologic data supports the hypothesis that early life colonization is a key player in development of a balanced immune system. Events in early life, as birth mode and infant diet, are shown to influence development of immune related diseases, like asthma, diabetes and inflammatory bowl ...
immune-strong year round! - Institute for Vibrant Living
... created more and more deadly, drug-resistant strains of bacteria. And since then... ...
... created more and more deadly, drug-resistant strains of bacteria. And since then... ...
Immunity against Mucosal Pathogens?
... Downloaded from http://www.jimmunol.org/ by guest on June 14, 2017 ...
... Downloaded from http://www.jimmunol.org/ by guest on June 14, 2017 ...
Plant-Microbe Interaction
... macromolecules that are released when pre-existing precursors come into contact with enzymes from which they are separated in the intact cell. Any kind of these DAMPs enable damaged-self recognition, inform the host on tissue disruption, initiate processes aimed at restoring homeostasis, such as sea ...
... macromolecules that are released when pre-existing precursors come into contact with enzymes from which they are separated in the intact cell. Any kind of these DAMPs enable damaged-self recognition, inform the host on tissue disruption, initiate processes aimed at restoring homeostasis, such as sea ...
Aspergillus fumigatus conidia induce interferon-b signalling in respiratory epithelial cells C. Beisswenger*
... immune functions of respiratory epithelial cells are well described in the response to bacteria and viruses, little is known about the response of these cells to fungal pathogens such as A. fumigatus and its spores, the conidia. It has been shown that surfactant found in the fluids lining the epithe ...
... immune functions of respiratory epithelial cells are well described in the response to bacteria and viruses, little is known about the response of these cells to fungal pathogens such as A. fumigatus and its spores, the conidia. It has been shown that surfactant found in the fluids lining the epithe ...
An Evaluation of the Efficiency of Lymphocytic Choriomeningitis Virus- In Vivo by
... knowledge of immunity, as well as to apply these findings to vaccine development against infectious pathogens and tumors. ...
... knowledge of immunity, as well as to apply these findings to vaccine development against infectious pathogens and tumors. ...
KUOPION YLIOPISTON JULKAISUJA C. LUONNONTIETEET JA YMPÄRISTÖTIETEET 264
... activity (IC50:1.5x10-15M), compared to 1α,25(OH)2D3 (IC50:8x10-9M). This higher anti-inflammatory potency from BXL-62 compared to 1α,25(OH)2D3 was confirmed in PBMCs from IBD patients. In addition, PBMCs from CD and UC patients activated by different TLR agonists are equally sensitive to the anti-i ...
... activity (IC50:1.5x10-15M), compared to 1α,25(OH)2D3 (IC50:8x10-9M). This higher anti-inflammatory potency from BXL-62 compared to 1α,25(OH)2D3 was confirmed in PBMCs from IBD patients. In addition, PBMCs from CD and UC patients activated by different TLR agonists are equally sensitive to the anti-i ...
the role of the c5a receptor in host defense against listeria
... macrophages (21, 24). Similarly, CD8+ T cells have bactericidal activity through some combination of cytokine production and cytolytic activity (24). While adaptive immunity is required for total clearance of Lm from the organism, a potent innate immune response must precede it to provide bacterial ...
... macrophages (21, 24). Similarly, CD8+ T cells have bactericidal activity through some combination of cytokine production and cytolytic activity (24). While adaptive immunity is required for total clearance of Lm from the organism, a potent innate immune response must precede it to provide bacterial ...
Galen B - Michigan Medicine
... Program, “Lactobacillus-Candida Interactions: Biology and Mechanisms.” Principal Investigator 1/01/03-12/31/04, ($40,000) Francis Families Foundation, Parker B. Francis Pulmonary Fellowship Mentor (Timothy Traynor, PhD, fellow) 7/1/00-6/31/03 $120,000 [Transferred on 6/15/01 because Dr. Traynor acce ...
... Program, “Lactobacillus-Candida Interactions: Biology and Mechanisms.” Principal Investigator 1/01/03-12/31/04, ($40,000) Francis Families Foundation, Parker B. Francis Pulmonary Fellowship Mentor (Timothy Traynor, PhD, fellow) 7/1/00-6/31/03 $120,000 [Transferred on 6/15/01 because Dr. Traynor acce ...
28-29_Per_tolerance_Regulatory T-cells_LA
... Stimulates production of IgA antibodies by inducing B-cells to switch to this isotype. (IgA is the major antibody isotype required for mucosal immunity.) Promotes tissue repair after local inflammatory reactions (stimulate collagen synthesis and angiogenesis). Membrane-tethered TGF-β can also ...
... Stimulates production of IgA antibodies by inducing B-cells to switch to this isotype. (IgA is the major antibody isotype required for mucosal immunity.) Promotes tissue repair after local inflammatory reactions (stimulate collagen synthesis and angiogenesis). Membrane-tethered TGF-β can also ...
Dipeptidyl Peptidase IV/CD26 in T Cell Activation - diss.fu
... immune response. It has been determined that native DPPIV/CD26 not only binds to collagens but also that its binding capacity depends markedly on the type of collagen6. We then asked whether the interaction of DPPIV with specific types of collagen differentially influences the DPPIV/CD26 costimulato ...
... immune response. It has been determined that native DPPIV/CD26 not only binds to collagens but also that its binding capacity depends markedly on the type of collagen6. We then asked whether the interaction of DPPIV with specific types of collagen differentially influences the DPPIV/CD26 costimulato ...
Immune system
![](https://en.wikipedia.org/wiki/Special:FilePath/Neutrophil_with_anthrax_copy.jpg?width=300)
The immune system is a system of many biological structures and processes within an organism that protects against disease. To function properly, an immune system must detect a wide variety of agents, known as pathogens, from viruses to parasitic worms, and distinguish them from the organism's own healthy tissue. In many species, the immune system can be classified into subsystems, such as the innate immune system versus the adaptive immune system, or humoral immunity versus cell-mediated immunity.Pathogens can rapidly evolve and adapt, and thereby avoid detection and neutralization by the immune system; however, multiple defense mechanisms have also evolved to recognize and neutralize pathogens. Even simple unicellular organisms such as bacteria possess a rudimentary immune system, in the form of enzymes that protect against bacteriophage infections. Other basic immune mechanisms evolved in ancient eukaryotes and remain in their modern descendants, such as plants and insects. These mechanisms include phagocytosis, antimicrobial peptides called defensins, and the complement system. Jawed vertebrates, including humans, have even more sophisticated defense mechanisms, including the ability to adapt over time to recognize specific pathogens more efficiently. Adaptive (or acquired) immunity creates immunological memory after an initial response to a specific pathogen, leading to an enhanced response to subsequent encounters with that same pathogen. This process of acquired immunity is the basis of vaccination.Disorders of the immune system can result in autoimmune diseases, inflammatory diseases and cancer.Immunodeficiency occurs when the immune system is less active than normal, resulting in recurring and life-threatening infections. In humans, immunodeficiency can either be the result of a genetic disease such as severe combined immunodeficiency, acquired conditions such as HIV/AIDS, or the use of immunosuppressive medication. In contrast, autoimmunity results from a hyperactive immune system attacking normal tissues as if they were foreign organisms. Common autoimmune diseases include Hashimoto's thyroiditis, rheumatoid arthritis, diabetes mellitus type 1, and systemic lupus erythematosus. Immunology covers the study of all aspects of the immune system.