T-Cell Subset Analysis of Lewis Lung Carcinoma
... H-2K restriction elements (H-2K bin1, H-2K a, and H-2K k) dem- mean expression of V~33 TCR on CD4- and CD8-positive Tonstrated a similar pattern of the T-cell heterogeneity induced lymphocytes in normal PBL of C57BL/6J mice averages 3% by the 3LL A9 tumor clone expressing the normal syngeneic (38), ...
... H-2K restriction elements (H-2K bin1, H-2K a, and H-2K k) dem- mean expression of V~33 TCR on CD4- and CD8-positive Tonstrated a similar pattern of the T-cell heterogeneity induced lymphocytes in normal PBL of C57BL/6J mice averages 3% by the 3LL A9 tumor clone expressing the normal syngeneic (38), ...
Licentiate thesis from the Department of Immunology,
... Immunity to malaria is complex and is both stage and species specific. The liver-stage specific antigens have been suggested to be processed and presented on the surface of infected hepatocytes in combination with MHC class I and then presented to T cells. This presentation results in killing of inf ...
... Immunity to malaria is complex and is both stage and species specific. The liver-stage specific antigens have been suggested to be processed and presented on the surface of infected hepatocytes in combination with MHC class I and then presented to T cells. This presentation results in killing of inf ...
Distinct lines of chickens express different splenic cytokine profiles
... The splenic cytokine and chemokine mRNA expression levels observed in the current study support the concept that distinct lines of chickens utilize different systemic immune mechanisms. The broiler hens expressed IFN-γ mRNA, which is involved in macrophage and natural killer thymic (T) cell activati ...
... The splenic cytokine and chemokine mRNA expression levels observed in the current study support the concept that distinct lines of chickens utilize different systemic immune mechanisms. The broiler hens expressed IFN-γ mRNA, which is involved in macrophage and natural killer thymic (T) cell activati ...
Autoimmune Responses to the Brain After Stroke Are Associated
... human glial fibrillary acidic protein (GFAP 5 g/mL; CalbiochemEMD BioSci) and incubated for 24 hours. The response to tetanus toxin (TT 5 g/mL; Sigma-Aldrich) was also assessed as a control. Experiments were performed in triplicate; spots were counted using a semiautomated system (MetaMorph). The ...
... human glial fibrillary acidic protein (GFAP 5 g/mL; CalbiochemEMD BioSci) and incubated for 24 hours. The response to tetanus toxin (TT 5 g/mL; Sigma-Aldrich) was also assessed as a control. Experiments were performed in triplicate; spots were counted using a semiautomated system (MetaMorph). The ...
3 - bioRxiv
... they are equipped with a diversity of innate receptors, including pattern recognition receptors such as Toll Like Receptors (TLRs). Engagement of TLRs by TLR ligands leads to DC maturation, a complex process which includes migration to draining lymph nodes, secretion of a diversity of chemokines and ...
... they are equipped with a diversity of innate receptors, including pattern recognition receptors such as Toll Like Receptors (TLRs). Engagement of TLRs by TLR ligands leads to DC maturation, a complex process which includes migration to draining lymph nodes, secretion of a diversity of chemokines and ...
CD4+ T Cells Targeting Dominant and Cryptic Epitopes from
... Despite the preponderance of studies that focus on the importance of PA in developing vaccination strategies against anthrax infection, it has lately become clear that LF may represent a major target not only for antibody responses, but also T cell immunity in naturally exposed individuals. Our prev ...
... Despite the preponderance of studies that focus on the importance of PA in developing vaccination strategies against anthrax infection, it has lately become clear that LF may represent a major target not only for antibody responses, but also T cell immunity in naturally exposed individuals. Our prev ...
fulltext
... antigen presenting cells (APC). T-cells are further divided into T helper (TH) cells and cytotoxic T-cells (CTL) depending on the expression of the glycoproteins CD4 (TH) and CD8 (CTL). T helper cells TH cells become activated when they are presented with peptide antigens by MHC class II on APCs. On ...
... antigen presenting cells (APC). T-cells are further divided into T helper (TH) cells and cytotoxic T-cells (CTL) depending on the expression of the glycoproteins CD4 (TH) and CD8 (CTL). T helper cells TH cells become activated when they are presented with peptide antigens by MHC class II on APCs. On ...
• - Utrecht University Repository
... Several published papers link a high CD8+ T-cell activity in peripheral blood or AD lesions to increased AD disease severity. Seneviratne et al. describe a correlation between the amount of dustmite allergen specific CD8+ T-cells present in the peripheral blood of AD patients and disease severity [2 ...
... Several published papers link a high CD8+ T-cell activity in peripheral blood or AD lesions to increased AD disease severity. Seneviratne et al. describe a correlation between the amount of dustmite allergen specific CD8+ T-cells present in the peripheral blood of AD patients and disease severity [2 ...
Immunological studies on Swine Influenza Virus in Massimiliano Baratelli
... Additionally, T cells epitopes were empirically identified. Proteins M1 and NP of a human IAV were selected as target and thus dissected by using overlapping peptides and functional methods (IFN and proliferation responses) until finding T cells epitopes. The tests were performed using cells from ...
... Additionally, T cells epitopes were empirically identified. Proteins M1 and NP of a human IAV were selected as target and thus dissected by using overlapping peptides and functional methods (IFN and proliferation responses) until finding T cells epitopes. The tests were performed using cells from ...
among HLA-G, myeloid APCs, and regulatory cells
... Antigen-presenting cells (APCs) are specialized cells that process and present antigens (Ags) in the context of HLA class I and II molecules, and activate T cells. Professional APCs also provide a set of additional signals that modulate the activation of the responding cell. The most important profe ...
... Antigen-presenting cells (APCs) are specialized cells that process and present antigens (Ags) in the context of HLA class I and II molecules, and activate T cells. Professional APCs also provide a set of additional signals that modulate the activation of the responding cell. The most important profe ...
Here - European Macrophage and Dendritic Cell Society
... We are happy to welcome you to the capital of Europe for the 25th Annual Meeting of the European Macrophage and Dendritic Cell Society. We are looking forward to an exciting meeting focused around the theme of Clinical and fundamental aspects of monocyte, macrophage and dendritic cell plasticity. Th ...
... We are happy to welcome you to the capital of Europe for the 25th Annual Meeting of the European Macrophage and Dendritic Cell Society. We are looking forward to an exciting meeting focused around the theme of Clinical and fundamental aspects of monocyte, macrophage and dendritic cell plasticity. Th ...
Echinacea
... Complement lyses facilitates phagocytosis Toll-like receptors recognize microbial molecules; signal secretion of immunostimulatory cytokines ...
... Complement lyses facilitates phagocytosis Toll-like receptors recognize microbial molecules; signal secretion of immunostimulatory cytokines ...
The effects of environmental mycobacteria on VLP and MVA based vaccines against tuberculosis
... long- lived immunological memory for enhanced recall responses in order to provide life- long immunity to this pathogen. There are two APCs involved in generating a protective immune response to MTB i.e., macrophages and dendritic cells (DC).They each have a unique role to play in this response. DC ...
... long- lived immunological memory for enhanced recall responses in order to provide life- long immunity to this pathogen. There are two APCs involved in generating a protective immune response to MTB i.e., macrophages and dendritic cells (DC).They each have a unique role to play in this response. DC ...
Nature Medicine 10, 1307
... plasmacytoid DCs (PDCs) (Fig. 2a). PDCs were only recently recognized as the previously identified major producers of type 1 IFN following viral infection 89, 90, 91, 92. Further study has shown PDCs to have a complex physiology that includes differing from CDCs in genetic control of MHC class II ex ...
... plasmacytoid DCs (PDCs) (Fig. 2a). PDCs were only recently recognized as the previously identified major producers of type 1 IFN following viral infection 89, 90, 91, 92. Further study has shown PDCs to have a complex physiology that includes differing from CDCs in genetic control of MHC class II ex ...
VeriPrime Bulletin: Beta Glucans
... Reduced Pulls, Retreats, Dead (> 30% reduction) >40% Less CTC/OTC use ...
... Reduced Pulls, Retreats, Dead (> 30% reduction) >40% Less CTC/OTC use ...
Doctoral thesis from the Department of Immunology, the Wenner-Gren Institute,
... During infancy, before adaptive immunity has matured, innate immunity is thought to be relatively more important. Human natural killer (NK) cells are innate immune cells involved in the control of virus-infected cells and can influence adaptive immunity mainly through cytokine production. This thesi ...
... During infancy, before adaptive immunity has matured, innate immunity is thought to be relatively more important. Human natural killer (NK) cells are innate immune cells involved in the control of virus-infected cells and can influence adaptive immunity mainly through cytokine production. This thesi ...
Deep Insight Section The Fas - Fas Ligand apoptotic pathway
... that express a reduced number of Fas receptors have a defect in T-cell receptor (TCR)-induced apoptosis. Dhein et al., propose that TCR-induced apoptosis in activated T cells occurs through a FasL-mediated autocrine suicide (Dhein et al., 1995). Their results suggested a mechanism for suppression of ...
... that express a reduced number of Fas receptors have a defect in T-cell receptor (TCR)-induced apoptosis. Dhein et al., propose that TCR-induced apoptosis in activated T cells occurs through a FasL-mediated autocrine suicide (Dhein et al., 1995). Their results suggested a mechanism for suppression of ...
What the shark immune system can and cannot provide for the
... if the same antigen is seen again in the context of the actual pathogen or cancer, the kinetics, quality and amplitude of the response is much better than it would be on first encounter with the antigen. Ideally this memory effect from immunization will result in a secondary response upon challenge ...
... if the same antigen is seen again in the context of the actual pathogen or cancer, the kinetics, quality and amplitude of the response is much better than it would be on first encounter with the antigen. Ideally this memory effect from immunization will result in a secondary response upon challenge ...
10. defense mechnaism.pptx
... Capable of phagocytosing intraluminal particles Principal phagocytic cells in the distal air spaces ...
... Capable of phagocytosing intraluminal particles Principal phagocytic cells in the distal air spaces ...
Immune system
The immune system is a system of many biological structures and processes within an organism that protects against disease. To function properly, an immune system must detect a wide variety of agents, known as pathogens, from viruses to parasitic worms, and distinguish them from the organism's own healthy tissue. In many species, the immune system can be classified into subsystems, such as the innate immune system versus the adaptive immune system, or humoral immunity versus cell-mediated immunity.Pathogens can rapidly evolve and adapt, and thereby avoid detection and neutralization by the immune system; however, multiple defense mechanisms have also evolved to recognize and neutralize pathogens. Even simple unicellular organisms such as bacteria possess a rudimentary immune system, in the form of enzymes that protect against bacteriophage infections. Other basic immune mechanisms evolved in ancient eukaryotes and remain in their modern descendants, such as plants and insects. These mechanisms include phagocytosis, antimicrobial peptides called defensins, and the complement system. Jawed vertebrates, including humans, have even more sophisticated defense mechanisms, including the ability to adapt over time to recognize specific pathogens more efficiently. Adaptive (or acquired) immunity creates immunological memory after an initial response to a specific pathogen, leading to an enhanced response to subsequent encounters with that same pathogen. This process of acquired immunity is the basis of vaccination.Disorders of the immune system can result in autoimmune diseases, inflammatory diseases and cancer.Immunodeficiency occurs when the immune system is less active than normal, resulting in recurring and life-threatening infections. In humans, immunodeficiency can either be the result of a genetic disease such as severe combined immunodeficiency, acquired conditions such as HIV/AIDS, or the use of immunosuppressive medication. In contrast, autoimmunity results from a hyperactive immune system attacking normal tissues as if they were foreign organisms. Common autoimmune diseases include Hashimoto's thyroiditis, rheumatoid arthritis, diabetes mellitus type 1, and systemic lupus erythematosus. Immunology covers the study of all aspects of the immune system.