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Gary B. Huffnagle, Ph. D.
Professor of Internal Medicine
Professor of Microbiology and Immunology
Division of Pulmonary and Critical Care Medicine
University of Michigan Health System
1150 W. Medical Center Drive, 6301 MSRB III
Ann Arbor, MI, 48109-0642
(734) 936-7934; fax (734) 764-2655
[email protected]
Title and Contents
1
Education and Training
2
Academic, Administrative, and Clinical Appointments
2
Research Interests
3
Grants
3
Honors and Awards
6
Memberships in Professional Societies
6
Editorial Positions, Boards, and Peer-Review Services
7
Teaching
9
Committee, Organizational, and Volunteer Services
12
Visiting Professorships, Seminars, and Extramural Invited Presentations
13
Bibliography
19
Gary B. Huffnagle, Ph.D.
October 2011
1
Gary B. Huffnagle, Ph. D.
Professor of Internal Medicine
Professor of Microbiology and Immunology
Division of Pulmonary and Critical Care Medicine
University of Michigan Health System
1150 W. Medical Center Drive, 6301 MSRB III
Ann Arbor, MI, 48109-0642
(734) 936-7934; fax (734) 764-2655
[email protected]
Education and Training
9/80-5/84
9/84-9/90
Postdoctoral Training
10/90-6/92
Pennsylvania State University, University Park, PA
B. S. (Honors in Microbiology)
University of Texas Southwestern Med. Ctr., Dallas, TX
Ph. D. (Immunology)
University of Texas Southwestern Med. Ctr., Dallas, TX;
Department of Pathology, Immunopathology
Academic, Administrative, and Clinical Appointments
Academic Appointments
6/92-8/97
8/97-8/00
9/99-8/00
9/00-8/02
9/00-8/02
9/02-9/06
9/02-9/06
9/06-current
9/06-current
Gary B. Huffnagle, Ph.D.
Research Investigator, Division of Pulmonary and Critical Care
Medicine, Department of Internal Medicine, University of Michigan
Medical Center
Assistant Research Scientist, Division of Pulmonary and Critical
Care Medicine, Dept. of Internal Medicine, University of Michigan
Assistant Research Scientist, Department of Microbiology/
Immunology, University of Michigan
Senior Associate Research Scientist & Associate Professor
(without tenure), Division of Pulmonary and Critical Care Medicine,
Department of Internal Medicine, University of Michigan
Associate Professor (without tenure), Department of Microbiology/
Immunology, University of Michigan
Associate Professor (with tenure), Div. of Pulmonary and Critical
Care Medicine, Dept. of Internal Medicine, University of Michigan
Associate Professor (with tenure), Department of Microbiology/
Immunology, University of Michigan
Professor, Division of Pulmonary and Critical Care Medicine,
Department of Internal Medicine, University of Michigan
Professor, Department of Microbiology and Imunology, University of
Michigan
October 2011
2
Research Interests
1.
2.
3.
4.
5.
6.
7.
8.
9.
10.
11.
12.
pulmonary
mucosal
gastrointestinal
immunology
inflammation
infection
allergy
asthma
microbiota
microflora
fungi
probiotics
Grants
Present and Active
National Institutes of Health (1R01HL114447) "Pulmonary bacterial
microbiome-epithelial cell interactions in COPD"
Principal Investigator (multi-PI) 6/1/2012-5/31/2016 ($1,000,000 total
direct costs)
National Institutes of Health (4UH3DK083993) “The Role of the
Microbiota in Ulcerative Colitis” Co-investigator 6/24/09-5/31/13
($8,500,000 total direct costs)
National Institutes of Health (1U01HL098961) “Understanding the
Lung Microbiome in HIV-Infected and HIV-uninfected individuals”
Co-investigator 9/23/09-7/31/14 ($2,450,000 total direct costs)
National Institutes of Health (U19AI090871) “Enteric Research
Investigational Network (ERIN) – Clostridium difficile Cooperative
Research Center”
Principal Investigator Project #3: Host Defense 7/1/10-6/30/15
($5,000,000 total direct costs for all 3 ERIN projects)
National Institutes of Health (1R21AI087869) "The role of the
microbiome in the development/prevention of food allergies"
Principal Investigator 9/1/2010-8/31/2012 ($275,000 total direct
costs)
National Institutes of Health (2 P30 DK034933) “Gastrointestinal
Hormone Research Core Center”
Microbiome and Inflammation Core Co-director
12/1/2010-11/30/2015 ($500,000 total direct costs for core)
Gary B. Huffnagle, Ph.D.
October 2011
3
Previous Grants
National Institutes of Health (R01-AI064479), “Role of Fungal
Microflora in Mucosal Tolerance/Immunity.” Principal Investigator;
4/1/05-3/31/11 ($1,250,000 total direct costs)
National Institutes of Health (1R21-AI064479) “Mucosal
Mechanisms Linking Pulmonary and Gastrointestinal
Inflammation/Immunity” Principal Investigator; 7/26/09-7/25/11
($275,000 total direct costs)
National Institutes of Health (R01-HL077417), "Regulation of
Pulmonary Host Defense by Leptin." Co-Investigator; 1/1/06 12/31/10 ($1,000,000 total direct costs)
Abbott Nutrition, "The Use of a Murine Model for Screening
Probiotics, Prebiotics and Nutritional Interventions for their
Effectiveness in Reducing the Risk of Allergic Airway Disease."
Principal Investigator; 6/30/08-12/30/09 ($63,000)
National Institutes of Health (R01-AI059201), “Oxylipins in
Cryptococcal Pathogenesis.” Principal Investigator; 2/1/04-1/31/09
($1,250,000 total direct costs)
National Institutes of Health (R01-HL51082), “Macrophage
Recruitment/ Activation in Lung Defense.” Co-Investigator; 6/1/035/30/09, ($1,250,000 total direct costs)
National Institutes of Health, (R01-HL65912), “Modulation of
Th1/Th2 Responses by Innate Immunity,” Principal Investigator,
9/1/00-8/31/05, ($1,000,000 total direct costs)
Francis Families Foundation, Parker B. Francis Pulmonary Fellowship
Mentor (Mairi Noverr, PhD, fellow) 7/1/05-6/31/08 ($132,000)
[Transferred on 10/1/05 because Dr. Noverr accepted a faculty
position at Wayne State Medical School]
National Institutes of Health, (R01-HL63670), "Chemokine receptors
in immunity to C. neoformans."Principal Investigator, 7/1/99-6/30/04,
($875,000 total direct costs)
National Institutes of Health (RO1-HL51082), “Macrophage
recruitment/ activation in lung defense.” Co-Investigator; 12/1/9711/30/02, ($1,365,113 total direct costs)
Gary B. Huffnagle, Ph.D.
October 2011
4
National Institutes of Health, (P50HL060289, SCOR in Acute Lung
Injury), “Effect of sepsis on lung antibacterial host defenses.” CoInvestigator; 12/1/98-11/30/03, ($945,000 total direct costs)
University of Michigan Department of Internal Medicine Pilot Grant
Program, “Lactobacillus-Candida Interactions: Biology and
Mechanisms.” Principal Investigator 1/01/03-12/31/04, ($40,000)
Francis Families Foundation, Parker B. Francis Pulmonary Fellowship
Mentor (Timothy Traynor, PhD, fellow) 7/1/00-6/31/03 $120,000
[Transferred on 6/15/01 because Dr. Traynor accepted a faculty
position at Washington State University Veterinary School]
Burroughs-Wellcome Fund, (New Investigator Award in Pathogenic
Mycology), “The role of melanin production by Cryptococcus
neoformans in evasion of host defenses.” Principal Investigator;
7/1/98-6/30/02, ($195,000 total direct costs)
National Institutes of Health (R29-AI38190), “The role of TNFin T
cell immunity to C. neoformans.” Principal Investigator, 9/1/958/31/00, ($350,000 total direct costs)
Michigan Memorial Phoenix Project, “The role of macrophage
inflammatory protein-1 (MIP-1) in pulmonary inflammation.”
Principal Investigator; 12/1/92-11/30/93, ($6,000)
Francis Families Foundation- Parker B. Francis Pulmonary Research
Award “The role of macrophage inflammatory protein-1 (MIP-1) in
pulmonary inflammation.” Senior Fellow, 7/1/93-6/30/96, ($102,000)
University of Michigan Geriatrics Center Pilot Grant “T cell mediated
host defenses in the lungs of aged mice.” Principal Investigator;
1/1/95-12/31/95, ($20,000)
University of Michigan Geriatrics Center Pilot Grant, “Effect of aging
on cell-mediated immunity in the lungs.” Principal Investigator;
6/1/97-8/31/98, ($20,000)
Undergraduate Fellowship Sponsor:
Biomedical Research Council (Lisa McNeil):
5/94-8/94, $2,500
Biomedical Research Council (Michael Boyd):
5/94-8/94, $2,500
Howard Hughes Medical Foundation (Lisa McNeil):
Gary B. Huffnagle, Ph.D.
October 2011
5
5/95-8/95, $2,500
Howard Hughes Medical Foundation (Michael Boyd):
5/95-8/95, $2,500
Biomedical Research Council (Ryan Fajardo):
7/95-9/95, $2,500
Biomedical Research Council (Lori Dargurz):
5/96-8/96, $2,500
Biomedical Research Council (Lauren Pray):
7/96-9/96, $2,500
Biomedical Research Council (Andrea Bediako):
5/97-8/97, $2,500
Biomedical Research Council (Deirdra Williams):
5/97-8/97, $2,500
Biomedical Research Council (Adam Dumas):
5/99-8/99, $3,500
Biomedical Research Council (Anne Hartmann):
5/99-8/99, $3,500
Biomedical Research Council (Elaine Te-Yie Huang):
5/01-8/01 $3,500
Biomedical Research Council (P. Anne Poole):
5/03-8/03 ($3,500)
Biomedical Research Council (Jeff Hopcian)
5/06-8/06 ($3,500)
Honors and Awards
1993
1993
1998
2008
2010
Clinical Immunology Society: Young Investigator Award
Parker B. Francis Pulmonary Research Award
Burroughs-Wellcome Fund, New Investigator Award in Pathogenic
Mycology
American Society for Microbiology Division F (Medical Mycology)
Lectureship
University of Michigan Faculty Recognition Award
Memberships in Professional Societies
1994-current
1995-current
2007-2008
2008-2009
2009-2010
American Association of Immunologists (AAI)
American Society for Microbiology (ASM)
Chair Elect, ASM Div F (Medical Mycology)
Chair, ASM Div F (Medical Mycology)
Advisor, ASM Div F (Medical Mycology)
Editorial Positions, Boards, and Peer-Review Services
Editorial Boards
1998-2002
2002-2006
Gary B. Huffnagle, Ph.D.
Associate Editor, the Journal of Immunology
Section Editor, the Journal of Immunology
October 2011
6
2003-2008
2004
Editorial Board, Infection and Immunity
Associate Editor, Medical Mycology
Manuscript Reviewer (approximately 30/year):
Journal of Immunology, American Journal of Respiratory Cell and
Molecular Biology, American Journal of Pathology, Journal of Infectious
Diseases, Journal of Clinical Investigation, Infection and Immunity,
Clinical and Experimental Immunology, FEMS Letters, Biochimica
Biophysica Acta, Journal of Bacteriology, Nature Reviews, Cell Host &
Microbe, Eukaryotic Cell, American Journal of Gastroenterology,
American Journal of Respiratory & Critical Care Medicine, Cell Host &
Microbe, Medical Mycology, ISMEJ, PLoS
Study Sections (Permanent member, National Institutes Of Health, Bethesda, Md)
2002-2005
NIH, Bacteriology/Mycology Study Section 2 (BM-2) and Pathogenic
Eukaryotic Microbiology (PTHE) {study section re-organized and renamed in 2004} – Review Committee, Center for Scientific Review
2010-current
Center for Scientific Review (CSR), College of Reviewers
2012-current
NIH, Immunology & Host Defense Study Section (IHD)- Review
Committee, Center for Scientific Review (appointment through 2018)
Study Sections (ad hoc, National Institutes of Health, Bethesda, MD)
1998
NIH, AIDS Research - Review Committee, National Institute of
Allergy and Infectious Diseases
1998
NIH, Mycology Program Projects - Review Committee, National
Institute of Allergy and Infectious Diseases
1999
NIH, Models of HIV Infection - Review Committee, National Heart
Lung Blood Institute
2000
NIH, Vaccine Immunology - Review Committee, National Institute of
Allergy and Infectious Diseases
2000
NIH, Immunology of Orapharyngeal Candidiasis - Review Committee,
National Institute of Dental and Craniofacial Research
2000
NIH, Members Conflict Special Emphasis Study Section - Review
Committee, Center for Scientific Review
2001 (Mar)
NIH, Bacteriology/Mycology Study Section 2 (BM-2) – Review
Committee, Center for Scientific Review
2001 (Oct)
NIH, Bacteriology/Mycology Study Section 2 (BM-2) – Review
Committee, Center for Scientific Review
2002 (Feb)
NIH, Bacteriology/Mycology Study Section 2 (BM-2) – Review
Committee, Center for Scientific Review
2003
NIH, Conflict Special Emphasis Study Section - Review Committee,
Center for Scientific Review (Chair)
2004
NIH, Mycology Program Projects - Review Committee, National
Institute of Allergy and Infectious Diseases
Gary B. Huffnagle, Ph.D.
October 2011
7
2005, 2007
2006
2007, 2008
2007, 2008
2008, 2009
2009
2009, 2010
2010
2010
2010
2010
2011
2011
2011
2011, 2012
2011
2011
Grant Reviewer (ad hoc)
1992
1993
1994-2005
1996
2000
2001-2006
2004
2007
2009
2010
2010
Gary B. Huffnagle, Ph.D.
NIH, Conflict Special Emphasis Study Section - Review Committee,
Center for Scientific Review
NIH, Conflict Special Emphasis Study Section - Review Committee,
Center for Scientific Review (Chair)
NIH, Pathogenic Eukaryotic Microbiology (PTHE) – Review
Committee, Center for Scientific Review
NIH, NHLBI P01 review study section
NIH, Special Emphasis Study Section (Microbiome Roadmap / New
Technologies RFA) - Review Committee, Center for Scientific Review
NIH, RC1 Challenge Grant remote review
NIH, AIDS & Opportunistic Diseases Study Section (AOIC) – Review
Committee, Center for Scientific Review
NIH, P01 program in Allergic Diseases, Review Committee, National
Institute of Allergy and Infectious Diseases
NIH, Metagenomics of Orapharyngeal Diseases - Review Committee,
National Institute of Dental and Craniofacial Research (Chair)
NIH, Conflict Special Emphasis Study Section - Review Committee,
Center for Scientific Review
NIH, CSR College of Reviewers
NIH, NHLBI P01 Special Emphasis Panel – Review Committee
NIH, NIAID Asthma and Allergic Diseases Cooperative Research
Centers (AADCRC) – Review Committee
NIH, NIDDK Special Emphasis Panel – Review Committee
NIH, CSR - Ad hoc reviewer, Immunology & Host Defense (IHD)
study section
NIH, NIEHS - Dietary Influence on the Human Health Effects of
Environmental Exposures - Review Committee
NIH, CSR - Population Sciences and Epidemiology (PSE) Integrated
Review Group - R15 application reviews (Ad hoc)
American Heart Association.
British Columbia Lung Association
Department of Veterans Affairs
British Columbia Health Research Foundation
Louisiana State University Board of Regents
Alberta Heritage Medical Research Foundation
Wellcome Trust, England
Singapore National Medical Research Council
Ludwig Boltzmann Institutes, Austria: “Role of the Microbiome in
Disease”- Review Committee
European Commission’s 7th Framework Programme for Research:
“Infection and dysbiosis as the triggers of the development of
inflammatory processes in allergies and autoimmune diseases” Review Committee
Natural Environmental Research Council – United Kingdom
October 2011
8
2010
2010
Biotechnology and Biological Sciences Research Council – United
Kingdom
Wellcome Trust, United Kingdom
Government Review Panels and Advisory Committees
2004
Department of Defense, Innate Immunity in Biodefenses, Center for
Technology and National Security Policy, National Defense University
2007
NIH, National Human Genome Research Institute, the Microbiome in
Health and Disease
2007
NIH, NHLBI, the Microbiome in Pulmonary Disease
2008
NIH, NIAID, Helicobacter Pylori Workshop
2011
NIH, NIHGRI Director’s Advisory and Ideas Meeting: Human
Microbiome Research Initiative
2011
NIH, NHLBI Human Lung Microbiome Workshop and Advisory
Panel
Non-government Advisory Committees
2008-2010
Ganeden Biotech, Scientific Advisory Board
Teaching
National
1986-1988
1988-1992
1998
1999
2004
2006
2009
Teaching Assistant, Medical Microbiology,
UT Southwestern Medical School, Dallas, TX
Lecturer, Tumor Immunobiology
UT Southwestern Graduate School, Dallas, TX
External Examiner: Doctoral Dissertation Committee (Rachel Syme),
University of Calgary, Alberta, Canada
Invited Lecturer, Microbial Pathogenesis Course
Duke University, Durham, NC
External Examiner: Doctoral Dissertation (Rosie Santangelo),
University of Sydney, Australia
External Examiner: Doctoral Dissertation (Joanna Zhou), University of
Nevada, Reno, NV
University of Michigan Retirees Association, "Probiotics, Prebiotics &
Human Health", Ann Arbor, MI
University Of Michigan
Undergraduate Courses
2000-2003
2005-2009
2010, 2011
Gary B. Huffnagle, Ph.D.
Microbiology 505 “Introduction to Infectious Diseases,”
Course Director and Primary Lecturer (3 cr)
Microbiology 460 / Internal Medicine 460
"Eukaryotic Microbology and Microbial Symbiosis,"
Course Director/Instructor (3 cr)
Microbiology 460 / Internal Medicine 460
October 2011
9
"Eukaryotic Microbology,"
Lecturer
Graduate Courses
2000, 2005-2008, 2010
Immunology 850 “Advanced Immunology”
Course Director and Instructor (2 cr)
2001-2004
Immunology 815 “Immunology Student Seminars”
Course Director (1 cr)
2006
Microbiology 512/Pharmacology 502 “Grant Writing"
Faculty group leader/reviewer (2 cr)
Graduate Lectures
2002
2004
2006, 2007
2007
2009
Program Membership
1999-current
1999-2010
1993-current
2004-current
Immunology 850 “Immunity to Infection”
School of Public Health - "The Epidemiological Links between
Infection and Chronic Disease”
School of Public Health - "The Hygiene Hypothesis”
Immunology 851 “Mucosal Immunology”
NHLBI T32 Basic science core curriculum: Multi-disciplinary training
program in pulmonary diseases - "Flow Cytometry" & "Cell
Culture"
Microbiology Graduate Program
Immunology Graduate Program
University of Michigan Undergraduate Research Opportunity Program
(UROP)
Interdepartmental Undergraduate Microbiology Concentration
Steering Committee (Chair, 2005-current)
Undergraduate Mentorship
1993-current
Michael Boyd (1993-96)
Ryan Fajardo (1993-96)
Lauren Pray (1995-98)
Chrystie Dronjseko (1996)
Andrea Bediako (1996-1999)
Anne Hartmann (1998-2001)
Elaine Te-Yie Huang (1998-2002)
Zack Leshen (1999-2000)
Stephanie Dionne (2001)
P. Anne Poole (2003)
DeAndrea Fedrick (2003)
David McNamara (2005-2007)
Kelly Mason (2008-2010)
Lauren Miller (2010-2011)
Gary B. Huffnagle, Ph.D.
October 2011
Lisa McNeil (1993-96)
Nicola Bolf (1995)
Lori Dargurz (1995-96)
David Petrovski (1996)
Deirdra Williams (1996-2000)
Cara Christman (1998-2000)
Adam Dumas (1998-1999)
Danielle Bracy (2000)
Nicole Robson (MS, 2001-2002)
Rishi Surana (2002-2006)
Mia Lui (2002-2004)
James Kozich (2007-2008)
Ryan Pakula (2009)
Ryan Muraglia (2012)
10
Kathryn Higdon (2012)
Charles Frank (2012-current)
Zachary Britt (2012-2013)
Chinmay Pandit (2012-current)
Medical Student Mentorship
Jeff Hopcian (2006)
Graduate Mentorship
1999-2002
2000-2003
2000-2004
2000-2005
2002-2005
2002-2007
2005-2008
2006-2010
2007-2010
2011-current
2011-current
Ph. D. Dissertation Mentor for Mairi Noverr (Microbiology/Immunology)
Ph. D. Dissertation Mentor for Yadira Hernandez
(Microbiology/Immunology)
Ph. D. Dissertation Mentor for Dennis Lindell (Immunology)
Ph. D. Dissertation Mentor for John Erb-Downward
(Microbiology/Immunology)
Ph. D. Dissertation Mentor for Shikha Arora (Immunology)
Ph. D. Dissertation Mentor for Toby Rodriguez
(Microbiology/Immunology)
Ph. D. Dissertation Mentor for Andrew Shreiner (MSTP, Immunology)
Ph. D. Dissertation Mentor for Katie Mason (Microbiology/Immunology)
Ph. D. Dissertation Mentor for Ben Murdock (Immunology)
Ph. D. Dissertation Mentor for Brittan Scales (Microbiology/Immunology)
Ph. D. Dissertation Mentor for Andrew McDermott
(Microbiology/Immunology)
Post-doctoral Fellow Mentorship
1997-1999
Research Fellowship Mentor for John Lee, M.D.
1998-2003
Research Fellowship Mentor for Michal Olszewski, D.V.M., Ph.D.
1998-2001
Research Fellowship Mentor for Tim Traynor, Ph.D.
1999-2002
Research Fellowship Mentor for Raj Pandrangi, Ph.D.
1999-2003
Research Fellowship Mentor for Amy Herring, Ph.D.
2001-2002
Research Fellowship Mentor for Jill Kolodsick, Ph.D.
2002-2005
Research Fellowship Mentor for Mairi Noverr, Ph. D.
2005-2007
Research Fellowship Mentor for Jami Milam, Ph. D.
2005-2008
Research Fellowship Mentor for John Erb-Downward, Ph. D.
2008-2009
Research Fellowship Mentor for Mary Pat Craver, Ph. D.
2009-2011
Research Fellowship Mentor for Michael Shen, M. D.
2009-2012
Research Fellowship Mentor for Merritt Gillilland III, Ph. D.
2012-current
Research Fellowship Mentor for Robert Dickson, M. D.
Graduate Program Student Committees
2000-current
Microbiology/Immunology Graduate Program, Preliminary Exam
Committees:
Nancy Beck
Becky Wiesner Brendan Thomason
Jess Siple
Nathan Fisher
Ari Molofsky
Ryan Mihalik
Lisa Gralinski
Miranda Gray
Gary B. Huffnagle, Ph.D.
October 2011
11
Patrick Virgil
Shandee Dixon
2011 exams (4 students)
2001
Will DePas
Biomedical Engineering Graduate Program, Preliminary Exam
Committee:
Seema Bajaria
2002-2005
Immunology Graduate Program, Preliminary Exam Committees:
Rebecca Henry
Katie Johnson
Matt Schaller
Kelly Seidl
Chun-Shu Wong
2001-current
Dissertation Committees:
Brendan Thomason (PhD, Micro/Imm) - defended 10/2005
Steve Cendrowski (PhD, Micro/Immun) - defended 8/2004
Sharlene Moore (MS, Epidemiology) – defended 12/2002
Gabriel Maine (PhD, Immunology) - defended 12/2004
Laura Rozen (PhD, Chemistry) – defended 12/2002
Scott Berger (PhD, Biochemistry) - defended 10/2005
Ping Ye (PhD, Microbiology/Immunology) – defended 6/2003
Seema Bajaria (PhD, Biomed. Engineering) - defended 12/2004
Rebecca Henry (PhD, Immunology) - defended 12/2004
Ari Molofsky (PhD, Micro/Immun) - defended 6/2005
Matt Schaller (PhD, Immunology) - defended 11/2005
Andrew Hsu (MS, Nutrition) - defended 4/2005
Brian Heffernan (PhD, Micro/Immun) – defended 12/2006
Megan Ballinger (PhD, Immunology) – defended 12/2006
Helen Lau (PhD, Micro/Immun) - defended 6/2007
Christian Ray (PhD, Micro/Immun)- defended 10/2007
Bryna Burrell (PhD, Immunology) - defended 12/2007
Laura Delbridge (PhD, Microbiology) - defended 1/2009
Heather O'Malley (PhD, Pharmacology) - defended 8/2009
Adam Hartigan (PhD, Immunology) - defended 6/2009
Lindsay Davis (PhD, Microbiology/Immunology) - defended 3/2010
Hemanth Ramaprakash (PhD, Immunology) - defended 4/2010
Gitanjali Kundu (PhD, Wayne State Med. School, Imm & Micro) –
defended 7/2010
Tiffany Tsang (PhD, Microbiology/Immunology) – defended 12/2010
Marta Hernandez-Gonzalez (PhD, Immunology) - defended 8/2012
Angela Hopkinson (PhD, Microbiology/Immunology) - defended
7/2012
Kelly Schwartz (PhD, Molec Cell Develop Biol)
Joe Zakular (PhD, Microbiology/Immunology)
2001-current
Additional Graduate Laboratory Research Rotations
Rebecca Wiesner
Ari Molofsky
Gary B. Huffnagle, Ph.D.
October 2011
12
Christian Ray
Megan Ballinger
Zach Dalebroux
Margarita Hernandez
Julia Wu
Eric Komuniecki
Brittany Shaw
Tiffany Tsang
Kelly Schwartz
Committee, Organizational, and Volunteer Services
National
1996-1999
2007
2007-2009
University Of Michigan
1993-current
1998-2001
2000-2004
2001
2002-2003
2002
2002
2003
2003
2004
2005, 2010
2004-2008
2008-2009
2007-2008
2004-current
2005-current
2012-current
2008-current
2009-current
American Thoracic Society Program Committee (MTPI)
American Society for Microbiology, Division F Program Committee
American Society for Microbiology, Division F Chairelect/Chair/Advisor
Undergraduate Research Opportunity Program (UROP)
Advisory Committee on Primary Research Appointments, Promotions and
Titles (APRAPT) - Chair 2000-2001
Graduate Studies Committee (Microbiology/Immunology)
Pulmonary Faculty Search Committee (Internal Medicine Dept)
Curriculum Committee (Microbiology/Immunology)
Rackham Graduate School Distinguished Dissertation Award Committee
Immunology Faculty Search Committee (Microbiology & Immunology
Dept)
Microbiology Faculty Search Committee (Dental School)
University Committee on the Use and Care of Animals (UCUCA)
Graduate Studies and Admissions (Immunology)
Immunology Faculty Search Committee (Microbiology & Immunology
Department)
The Committee for Science and Technology Recruiting to Improve
Excellence and Diversity (STRIDE)
Microbial Ecology Faculty Search Committee, Department of
Microbiology & Immunology
Medical School Dean's Faculty Compensation Committee
Interdepartmental Undergraduate Microbiology Concentration Steering
Committee (Chair, 2008-current)
Undergraduate Advisor, Microbiology Concentration, College of LS&A
Co-Director, Multidisciplinary Training Program in Lung Disease
(Division of Pulmonary and Critical Care Medicine)
Microbial Ecology University Cluster Hire, Steering Committee
UM Med School-China (Peking University) Joint Institute Lung Group
Visiting Professorships, Seminars, and Extramural Invited Presentations
International
Gary B. Huffnagle, Ph.D.
October 2011
13
6/1998
4/1999
9/1999
6/2000
9/2005
5/2006
10/2006
11/2007
9/2012
National
1/1990
1/1992
6/1993
11/1995
5/1996
6/1996
Gary B. Huffnagle, Ph.D.
“The Role of TNF, Chemokines, and Microbial Virulence Factors in
Th1/Th2 Immunity during Pulmonary Infection,” Department of
Microbiology and Infectious Diseases, the University of Calgary,
Canada
“Cells and Cytokines in Pulmonary Cryptococcosis,” VII International
Meeting on Paracoccidiomycosis, Sao Palo, Brazil
“Cytokines and Leukocyte Recruitment into the Lungs during
Cryptococcosis,” Fourth International Conference on Cryptococcus
and Cryptococcosis, London, United Kingdom
“Cryptococcosis: Knock-out to Knock-out, Mice to Yeast,”
International Society for Human and Animal Mycology (ISHAM)
Meeting, Buenos Aires, Argentina
"The Microflora Hypothesis of Allergic Disease," British Association
for the Advancement of Science, Dublin, Ireland
"The Response to Fungal Exposure in the Respiratory Tract:
Inflammation, Tolerance or Symbiosis?” McGill University, Montreal,
Canada
“Disruption of the Normal Flora: a Predisposing Factor for the
Development of Asthma,” Infectious Diseases Society of America
(IDSA) meting, Toronto, Canada
"Probiotica," Uitgeverij Thoeris workshop, Amsterdam, Natherlands
"The consequences of microbiome and pathogen dynamics for chronic
lung diseases," European Respiratory Society, Vienna, Austria
"Cell-Mediated Immunity in the Lungs during Opportunistic
Infections", Department of Microbiology, University of Oklahoma
Heath Sciences Center, Oklahoma City, OK
“Protective and Non-Protective T Cell Mediated Responses during a
Pulmonary Cryptococcus Neoformans Infection,” Division of
Pulmonary and Critical Care Medicine, Department of Internal
Medicine, the University of Michigan, Ann Arbor, MI
“Host Defenses during a Cryptococcus Infection: Michigan Update”,
Department of Pathology, The University of Texas Southwestern
Medical Center, Dallas, TX
“The Role of TNF and MCP-1 in C. neoformans Pneumonia,”
Upjohn/University of Michigan Symposium on the Use of Animals in
Biological Research involving Adhesion Molecules and Cytokines, the
University of Michigan, Ann Arbor, MI
“Host Defense in Fungal Pneumonia,” American Thoracic Society
Meeting, New Orleans, LA
“Adhesion Molecules and Cytokines”, Upjohn/University of Michigan
Symposium on the Use of Animals in Biological Research Involving
Adhesion Molecules and Cytokines
October 2011
14
5/1997
6/1997
8/1997
6/1998
4/1999
6/1999
10/1999
1/2000
2/2000
4/2000
11/2000
7/2001
10/2001
3/2002
4/2002
5/2002.
5/2002
Gary B. Huffnagle, Ph.D.
“Experimental Approaches to Pulmonary Host Defense”, ALA/ATS
International Conference, San Francisco, CA
“Immunity in Pulmonary Cryptococcosis”, Department of Pathology,
University of New Mexico Medical School, Albuquerque, NM
“Chemokines”, National Institute of Allergy and Infectious Diseases
Workshop: ‘Immunology in Medical Mycology: Host Defense,’ Lake
Tahoe, CA
“Pulmonary Cryptococcosis: TNF, Chemokines, and Microbial
Virulence Factors in Th1/Th2 Immunity,” Department of Pathology,
University of New Mexico Medical School, Albuquerque, NM.
“The Role of Chemokine Receptors in Leukocyte Recruitment and
Th1/Th2 Immunity during C. neoformans Infection,” Department of
Microbiology, Duke University, Durham, NC
“Modulation of Innate and Acquired Immunity by Fungal Virulence
Factors,” American Society for Microbiology Meeting, Chicago, IL
“Leukocyte Migration in Cryptococcus Infections,” Lovelace
Respiratory Research Institute Symposium on Respiratory
Immunology, Santa Fe, NM
“Role of Innate Immunity, Host Genetics, and Microbial Factors in
Modulation of Pulmonary Immunity,” University of Texas Health
Science Center at San Antonio, San Antonio, TX
“Role of Innate Defenses in Modulation of Cell-Mediated Immunity to
C. neoformans,” Louisiana State University Medical School, New
Orleans, LA
“Host-Microbe Interactions in the Development of Immunity to C.
neoformans,” Laboratory of Clinical Investigation, National Institutes
of Health, Bethesda, MD
“Microbial-Host ‘Cross Talk’ as a Mechanism for Chronic Infection,”
University of Pittsburgh School of Medicine, Pittsburg, PA
“Role of Melanin in Evasion of Host Defenses by Cryptococcus
neoformans,” Burroughs Welcome Fund New Investigators Award
Meeting, San Diego, CA
“The Dynamics of Host and Pathogen Responses to Pulmonary
Cryptococcus neoformans Infection,” Wayne State University Medical
School, Detroit, MI
“Immunity to Fungi: The Battle between Host and Parasite,” ASM
Conference on Immunity to Bacterial, Viral and Protozoal Pathogens,
Savannah, GA
“The Dynamics of Host-Pathogen Interactions during Fungal Infection
and Immunity,” Seattle Biomedical Research Institute, University of
Washington, Seatttle, WA
“Role of Innate Immunity and Fungal Virulence Factors in the
Development of Adaptive Immunity,” American Society for
Microbiology Meeting, Salt Lake City, UT
“Fungal Pathogenesis and Immunity,” National Cancer Institute,
Frederick, MD
October 2011
15
6/2002
6/2002
1/2003
1/2003
1/2003
4/2003
5/2003
8/2003
10/2003
11/2003
11/2003
12/2003
1/2004
3/2004
3/2004
3/2004
5/2004
5/2004
5/2004
8/2004
Gary B. Huffnagle, Ph.D.
“T cell Immunity to Cryptococcus neoformans,” FASEB Summer
Research Conference on Lymphocytes and Antibodies, Snowmass, CO
“Insights into the Microbiology and Immunology Underlying Chronic
Fungal Infections,” University of South Florida, Tampa, FL
"Mechanisms of Immune Deviation during Chronic Fungal Infection,”
University of North Carolina, Chapel Hill, NC
“Role of Virulence Factors in the Pathogenesis of Cryptococcus
neoformans,” Duke University, Durham, NC
“(Dys)regulation of Immune Responses during Fungal Infection,”
Penn State University, University Park, PA
"Mechanisms of Immunoregulation during Fungal Infection:
Clearance, Chronicity, or Hypersensitivity,” Medical College of Ohio,
Toledo, OH
“Update on Pulmonary Host Defense,” American Thoracic Society
Meeting, Seattle, WA
“Host-Fungus Interactions in Cryptococcus Pathogenesis”, Woods
Hole Molecular Mycology Course, MA,
“Regulation of Immunity to Fungi by Host and Microbial Factors,”
University of Oklahoma, OK
“Fungal Pathogenesis: Determinants of Clearance vs. Persistance vs.
Hypersensitivity,” University of Nevada, NV
“The Role of Fungal and Bacterial Microflora in Modulating
Pulmonary Immunity to Fungi,” Dartmouth College, NH
“Allergies, Antibiotics and the Fungal Connection,” Eastern Michigan
University, MI
“Chronic Infections and Allergies: The Connection between
Antibiotics, Immunoregulation, Fungal Oxylipins and Gastrointestinal
Microflora,” St. Louis University, MO
“Polymicrobial Interactions and Host-Microbe Dynamics in the
Regulation of Pulmonary Immunity,” Harvard University, MA
“Recipe for Airway Allergies: Immature Dendritic Cells, Fungal
Oxylipins and Antibiotics,” Columbia University, NY
“Mechanisms Underlying Chronic Fungal Infections,” Keystone
Symposium, CO
“Pulmonary Immunity to Fungi,” MBI Workshop on Immunology
Models: Cell Signaling and Immune Dynamics, Ohio State University,
Columbus, OH
“Fungal-Microflora Interactions in the Regulation of Adaptive
Immunity to Fungi in the Airways,” American Society for
Microbiology Meeting, New Orleans, LA
“Fungal Persistence: Immunological Dynamics of the Host-Pathogen
Interaction,” American Society for Microbiology Meeting, New
Orleas, LA
“Role of the Fungal Microbiota in Regulating Immune Responses in
the Airways,” FASEB Summer Research Conference on Microbial
Pathogenesis: Mechanisms of Infectious Disease, Snowmass, CO
October 2011
16
11/2004
3/2004
3/2004
6/2005
11/2005
4/2006
9/2006
12/2006
12/2006
2/2007
3/2007
4/2007
6/2007
7/2007
10/2007
11/2007
12/2007
3/2008
Gary B. Huffnagle, Ph.D.
"Innate Immunity in Control of the Microbiota," Department of
Defense Workshop on the Potential Role of Innate Immunity in
Biodefense Strategies, Washington, DC
"Regulation of Pulmonary Th2 Responses by the Gastrointestinal
Microbiota," University of Texas Southwestern Medical School,
Dallas, TX
"Adaptive Immune Responses to Fungi," University of Texas
Southwestern Medical School, Dallas, TX
"The Dynamics of Cell-Mediated Immunity to Cryptococcus
neoformans," Sixth International Conference on Cryptococcus and
Cryptococcosis, Boston, MA
"Development and Regulation of Pulmonary Immune Responses to
Fungi,” Autumn Immunology Conference, Chicago, IL
"Regulation of Anti-fungal Immunity,” University of Nevada-Reno,
Reno, NV
“Role of the Endogenous Microbiota in Host Immunity to Fungal
Exposure,” the University of Illinois, Chicago, IL
“Role of the Microbiota in Regulating Pulmonary Immune
Responses,” ULAM, University of Michigan, Ann Arbor, MI
“Role of the Microbiota in Pulmonary Immunity to Fungi” Loyola
University Medical Center, Chicago, IL
“Role of the Endogenous Microbiota in Modulating Pulmonary Fungal
Pathogenesis and the Host Response,” Mid-Atlantic Microbial
Pathogenesis Meeting, Wintergreen, VA
“Regulation of Mucosal Immunity by the Endogenous Microbiota,”
University of Wisconsin School of Medicine, Madison, WI
"Role of the Endogenous Microbiota in Modulating Host Immunity
and Health," National Human Genome Research Institute (NHGRI)
workshop on the microbiome, Bethesda, MD
"Probiotics," Dannon Institute of Nutrition, Baltimore, MD
"Role of the Endogenous Microbiota in Modulating Host Pulmonary
Immunity," National Heart, Lung and Blood Institute (NHLBI),
Bethesda, MD
"Pre-and Probiotic Strategies to Improve Immune Health," Dannisco
Probiotics Symposium, Madison, WI
"Workshop: Ethical, legal, and social implications (ELSI) of the field
of metagenomics and the Human Microbiome Project" Center for
Genetic Research Ethics and Law, Case Western Reserve University,
Cleveland, OH
"Animal Models of Immune System Development and Modulation
Throughout Lifespan," Prebiotics and Probiotics Workshop, National
Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
"The Role of Probiotics, Candida albicans and the Indigenous
Microbiota in Immune System Function," ASM Meeting on Candida
and Candidiasis, Jersey City, NJ
October 2011
17
4/2008
4/2008
4/2008
5/2008
6/2008
9/2008
10/2008
1/2009
2/2009
9/2009
12/2009
1/2010
1/2010
5/2010
10/2010
10/2010
11/2010
1/2011
Gary B. Huffnagle, Ph.D.
"Role of the Indigenous Microbiota in Immune Regulation,"Cleveland
Clinic, Cleveland, OH
"The Health Benefits of Probiotics and Prebiotics," Michigan Dietetic
Association, Sterling Hts, MI
"'We are only 10% human' - The reliance of the immune system on the
indigenous microbiota," 20th Annual Buffalo Conference on Microbial
Pathogenesis, Buffalo, NY
"Regulation of Immunity by the Indigenous Microbiota'" Microbiology
Dept, Wake Forest University, Winston-Salem, NC
"Candida albicans as a Commensal: Effects on the Bacterial
Microbiota and Immune System," 2008 ASM General Meeting Division F Lecture
"The Microbiota and Immune Regulation during Chronic Pulmonary
Aspergillus Exposure," Department of Veterinary Molecular Biology,
Montana State University, Bozeman, MT
"Probiotics and Human Health," Michigan Branch of the ASM,
Eastern Michigan University, Ypsilanti, MI
"Fungi, bacterial microbiota and the regulation of mucosal immunity,"
Department of Pathology and Laboratory Medicine, The Children's
Hospital of Pennsylvania/University of Pennsylvania
"Regulation of Mucosal Immunity by the Indigenous Microbiota,"
Division of Gastroenterology, University of Chicago, Chicago, IL
“Modulation of Mucosal Immunity by the Microbiome”,
Immunopathology of Pulmonary Disease Seminars, Department of
Pathology, University of Michigan
"Insights into the interplay between the bacterial microbiota, Candida
albicans and host mucosal Immunity," Minnesota Craniofacial
Research Training Program, University of Minnesota, Minneapolis,
MN
"Mucosal Immunity and Bacterial-Yeast Interactions in the
Microbiota", Microbiology Department, Michigan State University,
East Lansing, MI
“Setting the stage for a systems biology approach to mucosal biology,
immunity, and microbiology”, Center for Computational Medicince &
Biology, University of Michigan
“Modulation of Mucosal Immunity by the Bacterial and Fungal
Microbiota”, ASM General Meeting, San Diego, CA
“Probiotics and the Role of the Microbiome in Regulating Mucosal
Immunity outside the GI tract”, Keynote Speaker, Proctor & Gamble,
Biofusion International Conference, Cincinnati, OH
“Regulation of Mucosal Immunity by the Fungal Microbiota”, ASM
Benefical Microbes Meeting, Miami, FL
“Regulation of Mucosal Immunity by the Indigenous Microbiota”,
NIEHS Workshop on the Microbiome and the Environment
“Probiotics in Health and Disease”, Washtenaw District Dental
Society, Ann Arbor, MI
October 2011
18
4/2011
5/2011
5/2011
5/2011
6/2011
10/2011
11/2011
12/2011
3/2012
3/2012
“Microbiome and Respiratory Disease”, National Academy of
Sciences Workshop:
Interplay of Microbiome, Environmental
Stressors, and Human Health, Washington, DC
“The Science Behind Probiotics”, Consumer Home Products
Association Science and Regulatory Conference, Washington, DC
“Role of Fungi in Asthma”, ATS International Meeting, Denver, CO
“The Gut Microbiota and Extra-Intestinal Disease”, ATS International
Meeting, Denver, CO
"The Lungs, the Gut and the Microbiome: A Love Story," Department
of Internal Medicine, University of Wisconsin, Madison, WI
"Microbiome-Host Interactions in Modulating Local and Distal
Mucosal Responses," Department of Embryology, Carnegie Institution
for Science, Baltimore, MD (CIS Sympoisum: Microbes- Invisible
Partners in Health)
"Dissecting Bacterial-Yeast-Host Mucosal Symbiosis," Microbiology
Department, Ohio State University, Columbus, OH
"The NHLBI, the Gut and the Microbiome," Plenary Lecture, Human
Lung Microbiome Workshop and Advisory Panel, National Heart,
Lung & Blood Institute, NIH, Bethesda, MD
"Innate and Adaptive Immunity in the Gastrointestinal Tract,"
American Academy of Allergy, Asthma and Immunology Annual
Program Meeting, Orlando, FL
"Microbiome Disturbances and Its Affect on Mucosal Host
Responses," Microbiology Program, Iowa State University, Ames IA
Bibliography
Completed Publications in Scientific Journals: Peer-Reviewed
1. Gaffney EV, Tsai S, Lingenfelter SE, Dell'Aquila ML, Huffnagle GB. Biological
response modifiers released by a mezerein-treated human monocytic leukemic cell line.
J Biol Resp Med 1985; 4:396-407.
2. Gaffney EV, Dell'Aquila ML, Lingenfelter SE, Huffnagle GB, Wiest DL.
Characterization of a colony-stimulating factor produced by the human monocytic
leukemic cell line, THP-1. J Leuk Biol 1986; 39:409-421.
3 Huffnagle GB, Ratcliffe MJH, Humphries EH. Bu-2, a novel avian cell surface antigen
on B cells and a population of non-lymphoid cells, is expressed homogeneously in
germinal centers. Hybridoma 1989; 8(6):589-604.
4. Huffnagle GB, Yates JL, Lipscomb MF. T cell-mediated immunity in the lung: a
Cryptococcus neoformans pulmonary infection model using SCID and athymic nude
mice. Infect Immun 1991; 59 (4):1423-1432.
5. Huffnagle GB, Yates JL, Lipscomb MF. Immunity to a pulmonary Cryptococcus
neoformans infection requires both CD4+ and CD8+ T cells. J Exp Med 1991; 173:793800.
6. Huffnagle GB, Lipscomb MF. Animal model of human disease: pulmonary
cryptococcosis. Am J Path 1992; 141(6):1517-1520.
Gary B. Huffnagle, Ph.D.
October 2011
19
7. Huffnagle GB, Lipscomb MF, Lovchik JA, Hoag KA, Street NE. The role of CD4+ and
CD8+ T cells in the protective inflammatory response to a pulmonary cryptococcal
infection. J Leuk Biol 1994; 55:35-42.
8. Curtis JL, Huffnagle GB, Chen GH, Warnock ML, Gyetko MR, McDonald RA, Scott PJ,
Toews GB. Experimental murine pulmonary cryptococcosis: differences in pulmonary
inflammation and lymphocyte recruitment induced by two encapsulated strains of C.
neoformans. Lab Invest 1994; 71(1): 113-126.
9. Smith RE, Strieter RM, Phan SH, Lukacs NW, Huffnagle GB, Wilke CA, Burdick MD,
Lincoln P, Evanoff H, Kunkel SL. Production and function of murine macrophage
inflammatory protein-1 in bleomycin-induced lung injury. J Immunol 1994; 153: 47044712.
10. Huffnagle GB, Chen GH, Curtis JL, McDonald RA, Strieter RM, Toews GB. Downregulation of the afferent phase of T cell-mediated pulmonary inflammation and
immunity by a high melanin-producing strain of Cryptococcus neoformans. J Immunol
1995; 155:3507-3516.
11. Hoag KE, Street NE, Huffnagle GB, Lipscomb MF. Early cytokine production in
pulmonary C. neoformans and infections distinguishes susceptible and resistant mice.
Am J Resp Cell Mol Biol 1995; 13(4): 487-495.
12. Huffnagle GB, Strieter RM, Standiford TJ, McDonald RA, Burdick MD, Kunkel SL,
Toews GB. The role of monocyte chemotactic protein-1 (MCP-1) in the recruitment of
monocytes and CD4+ T cells during a pulmonary Cryptococcus neoformans infection. J
Immunol 1995; 155:4790-4797.
13. McCoy RD, Davidson BL, Roessler BJ, Huffnagle GB, Janich SL, Laing TJ, Simon RH.
Pulmonary inflammation induced by incomplete or inactivated adenoviral particles.
Human Gene Therapy 1995; 6:1653-1660.
14. Gyetko MR, Chen GH, McDonald RA, Goodman RE, Huffnagle GB, Wilkinson CC,
Fuller JA, Toews GB. Urokinase is required for the pulmonary inflammatory response to
Cryptococcus neoformans. J Clin Invest 1996; 97:1818-1826.
15. McCoy RD, Davidson BL, Roessler BJ, Huffnagle GB, Simon RH. Expression of human
interleukin receptor-1 antagonist in mouse lungs using a recombinant adenovirus: effects
on vector induced inflammation. Gene Therapy 1996; 2:437-442.
16. Strieter RM, Standiford TJ, Huffnagle GB, Colletti LM, Lukacs NW, Kunkel SL. The
good, the bad, and the ugly: the role of chemokines in models of human disease. J
Immunol 1996; 156:3583-3586.
17. Huffnagle GB. The role of cytokines in T cell immunity to a pulmonary C. neoformans
infection. Biol Signals 1996; 5:215-222.
18. Huffnagle GB, Toews GB, Burdick MD, McAllister KS, McDonald RA, Boyd MB,
Kunkel SL, Strieter RM. Afferent phase production of TNF is required for the
development of protective T cell immunity to Cryptococcus neoformans. J Immunol
1996; 157:4529-4536.
19. Brieland J, McClain M, Heath L, Chrisp C, Huffnagle G, LeGendre M, Hurley M,
Fantone J, Engleberg C. Coinoculation with Hartmannella vermiformis enhances
replicative Legionella pneumophila lung infection in a murine model of Legionnaires’
disease. Infect Immun 1996; 64:2449-2456.
20. Brieland JK, Heath LA, Huffnagle GB, Remick DG, McClain MS, Hurley MC, Kunkel
RK, Fantone JC, Engleberg C. Humoral immunity and regulation of intrapulmonary
Gary B. Huffnagle, Ph.D.
October 2011
20
growth of Legionella pneumophila in the immunocompetent host. J Immunol 1996;
157:5002-5008.
21. Heath L, Chrisp C, Huffnagle G, LeGendre M, Osawa Y, Hurley M, Engleberg C,
Fantone J, Brieland J. Effector mechanisms responsible for gamma interferon-mediated
host resistance to Legionella pneumophila lung infection: the role of endogenous nitric
oxide differs in susceptible and resistant murine hosts. Infect Immun 1996; 64:51515160.
22. Standiford TJ, Huffnagle GB. The role of cytokines in pneumonia. J Investig Med 1997;
45:335-345.
23. Huffnagle GB, Strieter RM, McDonald RA, NcNeil LK, Burdick MD, Kunkel SL, Toews
GB. Macrophage inflammatory protein-1 (MIP-1) is required for a protective
pulmonary inflammatory response to Cryptococcus neoformans. J Immunol 1997;
159:318-327.
24. Hogaboam CM, Chensue SW, Steinhauser ML, Huffnagle GB, Lukacs NW, Strieter RM,
Kunkel SL. Alteration of the cytokine phenotype in an experimental lung granuloma
model by inhibiting nitric oxide. J Immunol 1997; 159:5585-5593.
25. Huffnagle GB, Boyd MB, Street NE, Lipscomb MF. IL-5 is required for eosinophil
recruitment, crystal deposition, and mononuclear cell recruitment during a pulmonary
Cryptococcus neoformans infection in genetically “susceptible” mice (C57BL/6). J
Immunol 1998; 160:2393-2400.
26. Laichalk LL, Bucknell KA, Huffnagle GB, Wilkowski JM, Moore TA, Romanelli RJ,
Standiford TJ. The intrapulmonary delivery of tumor necrosis factor agonist peptide
augments host defense in murine gram negative bacterial pneumonia. Infect Immun
1998; 66:2822-2826.
27. Gharaee-Kermani M, McGarry B, Lukacs N, Huffnagle G, Egan RW, Phan SH. The role
of IL-5 in bleomycin-induced pulmonary fibrosis. J Leukoc Biol 1998; 64(5):657-666.
28. Huffnagle GB, Lipscomb MF. Cells and cytokines in pulmonary cryptococcosis. Res
Immunol 1998; 149:387-396.
29. Huffnagle GB, McNeil LK. Dissemination of C. neoformans to the central nervous
system: role of chemokines, Th1 immunity, and leukocyte recruitment. J Neurovirol
1999; 5:76-81.
30. Coffey MJ, Phare SM, Peters-Golden M, Huffnagle GB. Regulation of 5-lipoxygenase
metabolism in monnuclear phagocytes by CD4 T lymphocytes. Exp Lung Res 1999; 25:
617-629.
31. Huffnagle GB, McNeil LK, McDonald RA, Murphy JW, Toews GB, Maeda N, Kuziel
WA. Cutting edge: role of CCR5 in organ-specific and innate immunity to Cryptococcus
neoformans. J Immunol 1999; 163:4642-4646.
32. Lovchik JA, Wilder JA, Huffnagle GB, Riblet R, Lyons CR, Lipscomb MF.
Development of a protective Th1 immune response in a murine cryptococcal infection is
influenced by genes linked to the Igh complex. J Immunol 1999; 163:3907-3913.
33. Traynor TR, Kuziel WA, Toews GB, Huffnagle GB. CCR2 expression determines T1 vs.
T2 polarization during pulmonary Cryptococcus neoformans infection. J Immunol 2000;
164(4):2021-2027.
34. Huffnagle GB, Traynor TR, McDonald RA, Olszewski MA, Lindell DM, Toews GB.
Leukocyte
recruitment
during
pulmonary
C.
neoformans
infection.
Immunopharmacology 2000; 48(3):231-236.
Gary B. Huffnagle, Ph.D.
October 2011
21
35. Brieland JK, Engleberg NC, Huffnagle GB, Remick DG, Fantone JC. Host pathogen
interactions in Legionnaires' disease: lessons learned from a murine animal model.
Immunopharmacology 2000; 48(3):249-52.
36. Aliberti J, Reis e Sousa C, Schito M, Hieny S, Wells T, Huffnagle GB, Sher A. CCR5
provides a signal for microbial induced production of IL-12 by CD8+ dendritic cells.
Nature Immunol 2000; 1:83-87.
37. Olszewski MA, Huffnagle GB, McDonald RA, Lindell DM, Cook DN, Toews GB. The
role of MIP-1/CCL3 in regulation of T cell-mediated immunity to Cryptococcus
neoformans infection. J Immunol 2000; 165(11):6429-36.
38. Fife BT, Huffnagle GB, Kuziel WA, Karpus WJ. CC chemokine receptor 2 is critical for
induction of experimental autoimmune encephalomyelitis. J Exp Med 2000; 192(6):899906.
39. Noverr MC, Phare SM, Toews GB, Coffey MJ, Huffnagle GB. Production of
immunomodulatory prostaglandins by the pathogenic yeast Cryptococcus neoformans
and Candida albicans. Infect Immun 2001; 69(5):2957-63.
40. Olszewski MA, Huffnagle GB, McDonald RA, Traynor, TT, Cook DN, Toews GB. MIP1/CCL3 regulatory effects on the development of immunity to Cryptococcus
neoformans depend on expression of early inflammatory cytokines. Infect Immun 2001;
69(10): 6256-6263.
41. Lindell DM, Standiford TJ, Leshen Z, Mancuso P, Huffnagle GB. MIP-1/CCL3 is
required for clearance of Klebsiella pneumoniae from the lung. Infect Immun 2001;
69(10): 6364-6369.
42. Traynor TR, Herring AC, Dorf ME, Kuziel WA, Toews GB, Huffnagle GB. Differential
roles of CCL2/MCP-1 and CCR2 in the development of T1 immunity. J Immunol 2002;
168(9):4659-66.
43. Noverr MC, Toews GB, Huffnagle GB. Production of prostaglandins and leukotrienes
by pathogenic fungi. Infect Immun 2002; 70(1):400-402.
44. Herring AC, Lee J, Toews GB, Huffnagle GB. Induction of early IL-12 and IFN
requires TNF for protective T1-cell-mediated immunity to pulmonary Cryptococcus
neoformans infection. Infect Immun 2002; 70(6):2959-64.
45. Mancuso P, Gotchalk A, Phare SM, Peters-Golden M, Lukacs NW, Huffnagle GB.
Leptin-deficient mice exhibit impaired host defense in gram-negative pneumonia. J
Immunol 2002; 168(8):4018-4024.
46. Noverr MC, Cox GM, Perfect JR, Huffnagle GB. The role of cryptococcal
phospholipase B (CnPLB1) in the pathogenesis of pulmonary Cryptococcus neoformans
infection. Infect Immun 2003; 71(3):1538-47.
47. Bauman SK, Huffnagle GB, Murphy JW. Effects of tumor necrosis factor alpha on
dendritic cell accumulation in lymph nodes draining the immunization site and the impact
on the anticryptococcal cell-mediated immune response. Infect Immun 2003; 71(1):6874.
48. Moore SI, Huffnagle GB, Chen GH, White E, Mancuso P. Leptin modulates neutrophil
phagocytosis of K. pneumoniae. Infect Immun 2003; 71(7):4182-5.
49. Noverr MC, Williamson PR, Fajardo RS, Huffnagle GB. CNLAC1 is required for extrapulmonary dissemination of Cryptococcus neoformans but not pulmonary persistence.
Infect Immun 2004; 72(3):1693-9.
Gary B. Huffnagle, Ph.D.
October 2011
22
50. Olszewski MA, Noverr MC, Chen GH, Toews GB, Cox GM, Perfect JR, Huffnagle GB.
Urease expression by Cryptococcus neoformans promotes microvascular sequestration,
thereby enhancing CNS invasion. Am J Pathol 2004; 164(5):1761-71.
51. Noverr MC, Noggle RM, Toews GB, Huffnagle GB. Role of antibiotics and fungal
microbiota in driving pulmonary allergic responses. Infect Immun 2004; 72(9):49965003.
52. Noverr MC, Huffnagle GB. Regulation of Candida albicans morphogenesis by fatty acid
metabolites Infect Immun 2004; 72(11):6206-10.
53. Speyer CL, Gao H, Rancilio NJ, Neff TA, Huffnagle GB, Sarma JV, Ward PA. Novel
chemokine responsiveness and mobilization of neutrophils during sepsis. Am J Pathol
2004; 165(6):2187-96.
54. Herring AC, Falkowski NR, Chen GH, McDonald RA, Toews GB, Huffnagle GB.
Transient neutralization of TNF
immunocompetent host: potential role of immature dendritic cells. Infect Immun 2005;
73(1):39-49.
55. Noverr MC, Falkowski NR, McDonald RA, McKenzie AN, Huffnagle GB. The
development of allergic airway disease in mice following antibiotic therapy and fungal
microbiota increase: role of genetics, antigen and IL-13. Infect Immun 2005; 73(1):30-8.
56. Hernandez YS, Arora S, McDonald RA, Toews GB, Huffnagle GB. Distinct roles for IL4 and IL-10 in regulating T2 immunity during allergic bronchopulmonary mycosis. J
Immunol 2005; 174(2):1027-36.
57. Chen GH, McDonald RA, Wells JC, Huffnagle GB, Toews GB. Interferon gamma
receptor is required for the pulmonary inflammatory response to Cryptococcus
neoformans. Infect Immun 2005; 73(3):1788-96.
58. Arora S, Hernandez YS, Erb-Downward JR, Toews GB, Huffnagle GB. Role of IFN- in
regulating T2 immunity and the development of alternatively activated macrophages
during allergic bronchopulmonary mycosis. J Immunol 2005; 174(10):6346-56.
59. Lindell DM, Moore TA, McDonald RA, Toews GB, Huffnagle GB. Generation of antifungal effector CD8+ T cells in the absence of CD4+ T cells during Cryptococcus
neoformans infection. J Immunol 2005; 174(12):7920-8.
60. Schaller MA, Lundy SK, Huffnagle GB, Lukacs NW. CD8+ T cell contributions to
allergen induced pulmonary inflammation and airway hyperreactivity. Eur J Immunol
2005; 35(7):2061-70.
61. Erb-Downward JR, Huffnagle GB. Cryptococcus neoformans produces authentic
prostaglandin E2 without a cyclooxygenase. Eukaryot Cell. 2007 Feb;6(2):346-50.
PMCID 1797952
62. Lindell DM, Moore TA, McDonald RA, Toews GB, Huffnagle GB. Distinct
compartmentalization of CD4+ T cell effector function versus proliferative capacity
during pulmonary cryptococcosis. Am J Pathol 2006; 168(3):847-55.
63. Amlie-Lefond C, Paz DA, Connelly MP, Huffnagle GB, Dunn KS, Whelan KS, Whelan
HT. Innate immunity for biodefense: a strategy whose time has come. J Allergy Clin
Immunol 2005; 116(6):1334-42.
64. Mancuso P, Huffnagle GB, Olszewski MA, Phipps J, Peters-Golden M. Leptin restores
host defense impairments following acute starvation in murine pneumococcal pneumonia.
Am J Respir Crit Care Med 2006; 173(2):212-8.
Gary B. Huffnagle, Ph.D.
October 2011
23
65. Lindell DM, Ballinger MN, McDonald RA, Toews GB, Huffnagle GB. Immunologic
homeostasis during infection: co-existence of strong pulmonary cell-mediated immunity
to secondary Cryptococcus neoformans infection while the primary infection still persists
at low levels in the lungs. J Immunol 2006; 177(7):4652-61.
66. Lindell DM, Ballinger MN, McDonald RA, Toews GB, Huffnagle GB. Diversity of the
T cell Response to Pulmonary Cryptococcus neoformans Infection. Infect Immun 2006;
74(8):4538-48.
67. Arora S, McDonald RA, Toews GB, Huffnagle GB. Effect of a CD4-depleting antibody
on the development of C. neoformans-induced allergic bronchopulmonary mycosis in
mice. Infect Immun 2006; 74(7):4339-48.
68. Heffernan BJ, Thomason B, Herring-Palmer A, Shaughnessy L, McDonald R, Fisher N,
Huffnagle GB, Hanna P. Bacillus anthracis phospholipases C facilitate macrophageassociated growth and contribute to virulence in a murine model of inhalation anthrax.
Infect Immun 2006; 74(7):3756-64.
69. Chen GH, Olszewski MA, McDonald RA, Wells JC, Paine R 3rd, Huffnagle GB, Toews
GB. Role of granulocyte macrophage colony-stimulating factor in host defense against
pulmonary Cryptococcus neoformans infection during murine allergic bronchopulmonary
mycosis. Am J Pathol 2007; 170(3):1028-40.
70. Milam JD, Herring AC, Pandrangi R, McDonald R, Huffnagle GB, Toews GB.
Modulation of the pulmonary T2 response to Cryptococcus neoformans by intratracheal
delivery of a TNFα-expressing adenoviral vector. Infect Immun 2007;75(10):4951-8.
71. Rodriguez TE, Falkowski NR, Harkema JR, Huffnagle GB. Analysis of the role of
neutrophils in preventing and resolving acute fungal sinusitis. Infect Immun
2007;75(12):5663-8
72. Berndt BE, Zang M, Chen GH, Huffnagle GB, Kao JY. The role of dendritic cells in the
development of acute dextran sulfate sodium colitis. J Immunol 2007;179(9):6255-62.
73. Olszewski MA, Falkowski NR, Surana R, Sonstein J, Hartman A, Moore BB, Huffnagle
GB, Toews GB. Effect of Laparotomy on Clearance and Cytokine Induction in
Staphylococcus aureus-infected Lungs. Am J Respir Crit Care Med. 2007;176(9):921-9
74. Erb-Downward JR, Noggle RM, Williamson PR, Huffnagle GB. The role of laccase in
prostaglandin production by Cryptococcus neoformans.
Mol Microbiol 2008;
68(6):1428-37.
75. Chen GH, McNamara D, Hernandez Y, McDonald RA, Toews GB, Huffnagle GB,
Olszewski MA. Inheritance of immune polarization patterns is linked to resistance
versus susceptibility to Cryptococcus neoformans in a mouse model. Infect Immun 2008;
76(6):2379-91. PMCID: PMC2423067
76. Osterholzer JJ, Polac T, Ames T, Chen GH, McDonald R, Huffnagle GB, Curtis JL,
Toews GB. CCR2 mediates conventional dendritic cell recruitment and the formation of
bronchovascular mononuclear cell infiltrates in the lungs of mice infected with
Cryptococcus neoformans. J Immunol 2008; 181(1):610-20. PMCID: PMC2735104
77. Lau HY, Huffnagle GB, Moore TA. Host and microbiota factors that control Klebsiella
pneumoniae mucosal colonization in mice. Microbes Infect 2008; 10(12-13):1283-90.
PMCID: PMC2633640
78. O'Malley HA, Shreiner AB, Chen GH, Huffnagle GB, Isom LL. Loss of Na(+) channel
beta2 subunits is neuroprotective in a mouse model of multiple sclerosis. Mol Cell
Neurosci. 2008;40(2):143-55. PMCID: PMC2670461
Gary B. Huffnagle, Ph.D.
October 2011
24
79. Osterholzer JJ, Surana R, Milam JE, Montano GT, Chen GH, Sonstein J, Curtis JL,
Huffnagle GB, Toews GB, Olszewski MA. Cryptococcal urease promotes the
accumulation of immature dendritic cells and a non-protective T2 immune response
within the lung. Am J Pathol 2009; 174(3):932-43. PMCID: PMC2665753
80. Osterholzer JJ, Milam JE, Chen GH, Toews GB, Huffnagle GB, Olszewski MA. Role of
dendritic cells and alveolar macrophages in regulating early host defense against
pulmonary infection with Cryptococcus neoformans. Infect Immun 2009;77(9):3749-58.
PMCID: in progress
81. Zhang Y, Wang F, Tompkins KC, McNamara A, Jain AV, Huffnagle GB, Olszewski,
MA. Development of robust Th1 immunity is insufficient for full protection against
highly virulent C. neoformans H99 in mouse model of pulmonary infection. Am J Pathol
2009;175(6):2489-500
82. Jain A, Zhang Y, Fields BW, McNamara DA, Choe, MY, Chen GH, Erb-Downward JR,
Osterholzer JJ, Toews GB, Huffnagle GB, and Olszewski MA. Th2 but not Th1 immune
bias results in altered lung functions in a murine model of pulmonary C. neoformans
infection. Infect Immun 2009; ;77(12):5389-99.
83. Osterholzer JJ, Chen GH, Olszewski MA, Curtis JL, Huffnagle GB, Toews GB.
Accumulation of CD11b+ lung dendritic cells in response to fungal infection results from
the CCR2-mediated recruitment and differentiation of Ly-6Chigh monocytes. J Immunol
2009;183(12):8044-53.
84. Zhang Y, Wang F, Tompkins KC, McNamara A, Jain AV, Moore BB, Toews GB,
Huffnagle GB, Olszewski MA. Robust Th1 and Th17 immunity supports pulmonary
clearance but cannot prevent systemic dissemination of highly virulent Cryptococcus
neoformans H99. Am J Pathol 2009 Dec;175(6):2489-500.
85. Milam JE, Erb-Downward JR, Chen GH, Osuchowski MF, McDonald R, Chensue SW,
Toews GB, Huffnagle GB, and Olszewski MA. CD11c+ cells are required to prevent
progression from local acute lung injury to multiple organ failure and death. Am J Pathol
2010;176(1):218-26.
86. Shetron-Rama LM, Herring-Palmer AC, Huffnagle GB, Hanna P. Transport of Bacillus
anthracis from the lungs to the draining lymph nodes is a rapid process facilitated by
CD11c+ cells. Microb Pathog. 2010; 49(1-2):38-46.
87. Reid G, Gaudier E, Guarner F, Huffnagle GB, Macklaim J, Munoz AM, Martini M,
Ringel-Kulka T, Sartor B, Unal, RR, Verbeke K, Walter J. Responders and nonresponders to probiotic interventions: how can we improve the odds? Gut Microbes
2010; 1(3):200-4
88. Chen GH, Osterholzer JJ, Choe MY, McDonald RA, Olszewski MA, Huffnagle GB,
Toews GB. Dual Roles of CD40 on Microbial Containment and the Development of
Immunopathology in Response to Persistent Fungal Infection in the Lung. Am J Pathol.
2010; 177(5):2459-71.
89. Zhang Y, Wang F, Bhan U, Huffnagle GB, Toews GB, Standiford TJ, Olszewski MA.
TLR9 signaling is required for generation of the adaptive immune protection in
Cryptococcus neoformans-infected lungs. Am J Pathol. 2010 177(2):754-65
90. Osterholzer JJ, Chen GH, Olszewski MA, Zhang YM, Curtis JL, Huffnagle GB, Toews
GB. Chemokine receptor 2-mediated accumulation of fungicidal exudate macrophages in
mice that clear cryptococcal lung infection. Am J Pathol. 2011;178(1):198-211.
Gary B. Huffnagle, Ph.D.
October 2011
25
91. Murdock BJ, Shreiner AB, McDonald RA, Osterholzer JJ, White ES, Toews GB,
Huffnagle GB. Co-evolution of TH1, TH2 and TH17 Responses During Repeated
Pulmonary Exposure to Aspergillus fumigatus Conidia. Infect Immun. 2011 79(1):12535.
92. Erb-Downward JR, Thompson DL, Han MK, Freeman CM, McCloskey L, Young VB,
Toews GB, Curtis JL, Martinez FJ, Huffnagle GB. Analysis of the Lung Microbiome in
the “Healthy” Smoker and in COPD. PLoS One 2011; 6(2):e16384.
93. Arora S, Olszewski MA, Tsang TM, McDonald RA, Toews GB, Huffnagle GB. Effect
of cytokine interplay on macrophage polarization during chronic pulmonary infection
with Cryptococcus neoformans. Infect Immun. 2011;79(5):1915-26.
94. Reeves AE, Theriot CM, Bergin IL, Huffnagle GB, Schloss PD, Young VB. The
interplay between microbiome dynamics and pathogen dynamics in a murine model of
Clostridium difficile Infection. Gut Microbes. 2011;2(3):145-58.
95. Mason KL, Erb Downward JR, Falkowski NR, Young VB, Kao JY, Huffnagle GB.
Interplay between the gastric bacterial microbiota and Candida albicans during postantibiotic recolonization and gastritis. Infect Immun. 2012; 80(1):150-8.
96. Shreiner AB, Murdock BJ, Sadighi Akha AA, Falkowski NR, Christensen PJ, White ES,
Hogaboam CM, Huffnagle GB. Repeated exposure to Aspergillus fumigatus conidia
results in CD4+ T cell-dependent and-independent pulmonary arterial remodeling in a
mixed Th1/Th2/Th17 microenvironment that requires IL-4 and IL-10. Infect Immun
2012; 80(1):388-97.
97. Gillilland III MG, Erb-Downward JR, Shen MC, Bassis CM, Toews GB, Young VB,
Huffnagle GB.
Ecological succession of bacterial communities during
conventionalization of germ-free mice. Applied Environ Micro. 2012; 78(7):2359-66.
98. Murdock BJ, Falkowski NR, Sadighi Akha AA, McDonald RA, White ES, Toews GB,
Huffnagle GB. IL-17 drives pulmonary eosinophilia following repeated Aspergillus
fumigatus conidia exposure. Infect Immun. 2012 Apr;80(4):1424-36.
99. Mason KL, Erb Downward JR, Mason KD, Falkowski NR, Eaton KA, Kao JY, Young
VB, Huffnagle GB. Candida albicans and bacterial microbiota interactions in the cecum
during re-colonization following broad spectrum antibiotic therapy. Infect Immun. 2012
80(10):3371-80
100. Sun Y, Chen C-C, Zhang M, Zhang J, Gillilland M, Huffnagle GB, Owyang C,
Gumuico DL, Hong S-C, Kao JY. Stress-induced NLRP6 inflammasome inhibition
causes intestinal dysbiosis and communicable enteritis. Gastroenterology. (in press 2013)
101. Berndt BE, Zhang M, Owyang SY, Cole TS, Wang T, Luther J, Veniaminova NA,
Merchant JL, Chen C-C, Huffnagle GB, Kao JY. Butyrate’s immunoregulatory effect on
stimulated dendritic cells and the involvement of IL-23/IL-10 axis. Am J Physiol
Gastrointest Liver Physiol. 2012 Dec 15;303(12):G1384-92
102. Miyasaka EA, Feng Y, Poroyko V, Falkowski NR, Erb-Downward JR, Gillilland M,
Mason KL, Huffnagle GB, Teitelbaum DH. Total parenteral nutrition-associated lamina
propria inflammation is mediated by a MyD88 dependent mechanism (submitted)
103. Vital M, Penton CR, Wang W, Young VB, Antonopoulos DA, Sogin MM, Morrison
HG, Raffals L, Chang FB, Huffnagle GB, Schmidt TM, Cole JR, Tiedje JM. A genetargeted approach to investigate the intestinal butyrate-producing bacterial community.
Microbiome (in press)
Gary B. Huffnagle, Ph.D.
October 2011
26
104. Sadighi Akha AA, Theriot CM, Erb-Downward JR, McDermott AJ, Falkowski NR,
Tyra HM, Rutkowski DT, Young VB and Huffnagle GB. Acute infection of mice with
Clostridium difficile leads to an innate immune response, eIF2α phosphorylation and prosurvival signaling. Immunology (in press)
105. Erb-Downward JR, Falkowski NR, Mason KL, Muraglia R and Huffnagle GB.
Modulation of post-antibiotic bacterial community reassembly and host response by
Candida albicans. (submitted)
Completed Publications in Scientific Journals: Non Peer-Reviewed
1. Lipscomb MF, Huffnagle GB, Lovchik J, Lyons CR, Pollard AM, Yates JL. The role of
T lymphocytes in pulmonary microbial defense mechanisms. Arch Path Lab Med 1993;
117:1225-1232.
2. Deepe GS, Romani L, Calich VLG, Huffnagle G, Arruda C, Molinari-Madlum EEIW,
Perfect JR. Knockout mice as experimental models of virulence. Med Mycology 2000;
38 (Suppl 1):87-98.
3. Traynor TR, Huffnagle GB. Role of chemokines in fungal infections. Med Mycology
2001; 39:41-50.
4. Huffnagle GB, Herring AC, Traynor TR. Role of fungal virulence factors in evasion of
host defenses. Annu Rev Biomed Sci 2001; 2:77-90.
5. Huffnagle GB. Investigating invasive aspergillosis. Am J Respir Crit Care Med 2002;
166(9):1159-60.
6. Huffnagle GB. Innate Immunity to fungi. EOS – J Immunol Immunopharmacol 2002; 2:
48-51.
7. Huffnagle GB, Deepe GS. Innate and adaptive determinants of host susceptibility to
medically important fungi. Curr Opin Microbiol 2003; 6(4):344-50.
8. Noverr MC, Erb-Downward JR, Huffnagle GB. Production of eicosanoids and other
oxylipins by pathogenic eukaryotic microbes. Clin Micro Rev 2003; 16(3):517-33.
9. Herring AC, Hernandez Y, Huffnagle GB, Toews GB. Role and development of
Th1/Th2 immune responses in the lungs. Sem Resp Crit Care Med 2004; 25(1):3-10.
10. Hernandez Y, Herring AC, Huffnagle GB. Pulmonary defenses against fungi. Sem Resp
Crit Care Med 2004; 25(1):63-71.
11. Arora S, Huffnagle GB. Immune regulation during allergic bronchopulmonary mycoses:
lessons taught by two fungi. Immunol Res 2005; 33(1):53-68.
12. Noverr MC, Huffnagle GB. Does the microbiota regulate immune responses outside the
gut? Trends Microbiol 2004; 12(12):562-8.
13. Noverr MC, Huffnagle GB. The "Microflora Hypothesis" of allergic diseases. Clin Exp
Allergy Immunol 2005; 35(12):1511-20.
14. Erb-Downward J, Huffnagle GB. Role of oxylipins and other lipid mediators in fungal
pathogenesis. Future Microbiol 2006; 1(2):219-227
15. Goldman DL, Huffnagle GB. Potential contribution of fungal infection and colonization
to the development of allergy. Med Mycol 2009; 22:1-12.
16. Mason KL, Huffnagle, GB. Control of mucosal polymicrobial populations by innate
immunity. Cell Microbiol 2009;11(9):1297-305.
17. Huffnagle GB. The Microbiota in Allergies/Asthma.
PLoS Pathogens 2010;
6(5):e1000549
Gary B. Huffnagle, Ph.D.
October 2011
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18. Olszewski MA, Zhang Y, Huffnagle GB. Mechanisms of cryptococcal virulence and
persistence. Future Microbiol. 2010 Aug;5:1269-88.
19. Beck JM, Young VB, Huffnagle GB. The microbiome of the lung. Transl Res. 2012 (in
press)
20. Erb-Downward JR, Huffnagle GB, Martinez FJ. The microbiota in respiratory disease.
Am J Respir Crit Care Med. 2012 May 15;185(10):1037-8.
21. Han MK, Huang YJ, Lipuma JJ, Boushey HA, Boucher RC, Cookson WO, Curtis JL,
Erb-Downward J, Lynch SV, Sethi S, Toews GB, Young VB, Wolfgang MC, Huffnagle
GB, Martinez FJ. Significance of the microbiome in obstructive lung disease. Thorax.
2012 May;67(5):456-63.
22. Scales BS, Huffnagle GB. The Microbiome in Wound Repair and Fibrosis. J Pathol
(submitted)
Chapters in Books
1. Huffnagle GB, Strieter RM, Kunkel SL, Toews GB, Standiford T. The role of
chemokines in pneumonia. The Role of Chemokines in Disease, A Koch and RM
Strieter, eds. R. G. Landes Co., Austin, TX; (1996).
2. Huffnagle GB, Toews GB. Mechanisms of macrophage recruitment to infected lungs.
Lung Macrophages and Dendritic Cells, MF Lipscomb and S Russell, eds. Marcel
Dekker Inc., NY; (1997).
3. Herring AC, Huffnagle GB. Innate immunity and fungal infections. Immunology of
Infectious Diseases, SHE Kaufmann, A Sher, R Ahmed, eds. ASM Press, Wash DC
(2001).
4. Lindell DM, Huffnagle GB. Pulmonary cell-mediated immunity to Cryptococcus
neoformans. Fungal Immunology from an Organ Perspective, Fidel PL and Huffnagle
GB, eds. Kluwer Academic/Plenum Publishers, NY (2005).
5. Rodriguez T, Huffnagle GB. Fungal sinusitis. Fungal Immunology from an Organ
Perspective, Fidel PL and Huffnagle GB, eds. Kluwer Academic/Plenum Publishers, NY
(2005).
6. Noverr MC, Lindell DM, Toews GB, Huffnagle GB. Fungal interactions with
leukocytes. Molecular Principles of Fungal Pathogenesis, Heitman J, Edwards J, Filler
S, Mitchell A, eds. ASM Press (2006).
7. Shreiner A, Huffnagle GB, Noverr MC. The “Microflora Hypothesis” of Allergic
Disease. Microbiota and Immunology, Landes Bioscience, M. Noverr & G. Huffnagle,
eds. (2008)
8. Mason KL, Huffnagle GB, Noverr MN, Kao JY. Gut Immunology. Microbiota and
Immunology, Landes Bioscience, M. Noverr & G. Huffnagle, eds. (2008).
9. Williams K, Wormley F, Geunes-Boyer S, Wright JR, Huffnagle GB. Pulmonary innate
and adaptive defenses against Cryptococcus in Cryptococcus: from human pathogen to
model yeast, ASM Press, Heitman J, Kwon-Chung J, Perfect J, Casadevall A, Kozel TR,
eds. (2010).
10. Gillilland MG, Young VB, Huffnagle GB. Gastrointestinal Microbial Ecology With
Perspectives on Health and Disease, Physiology of the Gastrointestinal Tract, 5th edition.
Johnson L, Ghishan F, Kaunitz J, Merchant J, Said H, Wood J, eds. (in press)
Book Reviews
Gary B. Huffnagle, Ph.D.
October 2011
28
1. Huffnagle GB. Review of Cryptococcus neoformans by Casadevall and Perfect (ASM
Press.) Mycopathologia, 1999; 147:59-60.
Edited Books
1. Fungal Immunology from an Organ Perspective, Fidel PL and Huffnagle GB, eds.
Kluwer Academic/Plenum Publishers, NY (2005).
2. GI Microbiota and Regulation of the Immune System. Huffnagle GB and Noverr MC,
Landes Bioscience, Austin, TX (2008)
Authored Books
1. The Probiotics Revolution, Huffnagle GB and Wernick S, Bantam (division of Random
House Publishers), NY (Hardcover, 2007)
 De probiotica-revolutie, Huffnagle GB and Wernick S, Thoeris uitgeverij,
Amsterdam, Netherlands (Hardcover, 2007) - Dutch translation
 The Probiotics Revolution, Huffnagle GB and Wernick S, Vermilion, NY
(Hardcover, 2007) - United Kingdom release
 The Probiotics Revolution (updated), Huffnagle GB and Wernick S, Bantam, NY
(Trade Paperback, 2008)
 The Probiotics Revolution, Huffnagle GB and Wernick S, Thinkingdom Media Group
LTD, China (Hardcover, 2008) - Chinese translation
 The Probiotics Revolution, Huffnagle GB and Wernick S, Matichon Publishing
House (Hardcover, 2010)- Thai translation
Gary B. Huffnagle, Ph.D.
October 2011
29