![Biosketch - University of Florida](http://s1.studyres.com/store/data/007988262_1-bb64643f647adfede4d3df1424d8320d-300x300.png)
Cancer immunotherapy - Italian Sarcoma Group
... CTLA-4 is a critical down-regulator of T-cell responses, and CTLA-4 blockade allows prolonged T-cell responses. PD1, another checkpoint, has a different mechanism of action. It recruits a phosphatase and seems to interfere with T-cell antigen receptor-mediated signaling. James P. Allison suggested t ...
... CTLA-4 is a critical down-regulator of T-cell responses, and CTLA-4 blockade allows prolonged T-cell responses. PD1, another checkpoint, has a different mechanism of action. It recruits a phosphatase and seems to interfere with T-cell antigen receptor-mediated signaling. James P. Allison suggested t ...
The Thymus Gland
... placed in close contact along the middle line, situated partly in the thorax, partly in the neck, and extending from the fourth costal cartilage upward, as high as the lower border of the thyroid gland. It is covered by the sternum, and by the origins of the Sternohyoidei and Sternothyreoidei. Below ...
... placed in close contact along the middle line, situated partly in the thorax, partly in the neck, and extending from the fourth costal cartilage upward, as high as the lower border of the thyroid gland. It is covered by the sternum, and by the origins of the Sternohyoidei and Sternothyreoidei. Below ...
Architecture for an Artificial Immune System
... i.e. when a lymphocyte is activated, the IS responds as if nonself were detected. This simple form of learning is known as tolerization, because the lymphocytes are trained to be tolerant of self. Lymphocytes are created with randomly generated receptors, and so could bind to either self or nonself. ...
... i.e. when a lymphocyte is activated, the IS responds as if nonself were detected. This simple form of learning is known as tolerization, because the lymphocytes are trained to be tolerant of self. Lymphocytes are created with randomly generated receptors, and so could bind to either self or nonself. ...
CD4+ T-Cell-Independent Secondary Immune Responses to
... In order to assess whether infection with Pneumocystis generates Pneumocystis-specific bone marrow plasma cells (BMPCs), BMPCs were enumerated using flow cytometry and cultured. BMPCs (CD45R−CD138+) are long-lived cells that secrete neutralizing antibody after exposure to antigen. As terminally diff ...
... In order to assess whether infection with Pneumocystis generates Pneumocystis-specific bone marrow plasma cells (BMPCs), BMPCs were enumerated using flow cytometry and cultured. BMPCs (CD45R−CD138+) are long-lived cells that secrete neutralizing antibody after exposure to antigen. As terminally diff ...
Immunomodulatory Effects of Human Immunodeficiency
... infection as the virus has adapted myriad ways to remain persistent in the host where it causes severe damage to the immune system. Both humoral and cellular immune responses are mounted against HIV-1 during the initial phase of infection but fail to control viral replication as these responses are ...
... infection as the virus has adapted myriad ways to remain persistent in the host where it causes severe damage to the immune system. Both humoral and cellular immune responses are mounted against HIV-1 during the initial phase of infection but fail to control viral replication as these responses are ...
Evolution of the innate immune system: the worm perspective
... the fact that the virulence factors relevant for infection of humans are also important for full pathogenicity during the infection of C. elegans. However, this fact must not be expected to be true in all cases. In this context, it is worth reiterating that the impact of a certain pathogen virulence ...
... the fact that the virulence factors relevant for infection of humans are also important for full pathogenicity during the infection of C. elegans. However, this fact must not be expected to be true in all cases. In this context, it is worth reiterating that the impact of a certain pathogen virulence ...
Really Essential Medical Immunology Arthur Rabson
... The macrophage These cells derive from bone marrow promonocytes which, after differentiation to blood monocytes (figure 1.2a), finally settle in the tissues as mature macrophages where they constitute the mononuclear phagocyte system (figure 1.2d). They are present throughout the connective tissue a ...
... The macrophage These cells derive from bone marrow promonocytes which, after differentiation to blood monocytes (figure 1.2a), finally settle in the tissues as mature macrophages where they constitute the mononuclear phagocyte system (figure 1.2d). They are present throughout the connective tissue a ...
The Schwann cell
... immunocompetent cells within the peripheral nervous system (PNS), which, in addition to their physiological roles, exhibit a broad spectrum of immune-related functions and might be involved in the local immune response in the PNS. ...
... immunocompetent cells within the peripheral nervous system (PNS), which, in addition to their physiological roles, exhibit a broad spectrum of immune-related functions and might be involved in the local immune response in the PNS. ...
Mouse and human FcR effector functions
... (32). Multimeric immunoglobulins, however, trigger activating FcRs to mediate intracellular signaling leading to a diversity of cellular responses including phagocytosis, cell differentiation, cell migration, degranulation, secretion of mediators, antibody-dependent cellular cytotoxicity (ADCC), or ...
... (32). Multimeric immunoglobulins, however, trigger activating FcRs to mediate intracellular signaling leading to a diversity of cellular responses including phagocytosis, cell differentiation, cell migration, degranulation, secretion of mediators, antibody-dependent cellular cytotoxicity (ADCC), or ...
Palmitic Acid Activation of Dendritic Cells
... Langridge and Marino De Leon who facilitated my development into a creative and independent researcher. Their professional guidance and belief in me has fostered my love for science. I want to thank them for the incredible support of my “outside-the-box” ideas and for allowing me to chase those idea ...
... Langridge and Marino De Leon who facilitated my development into a creative and independent researcher. Their professional guidance and belief in me has fostered my love for science. I want to thank them for the incredible support of my “outside-the-box” ideas and for allowing me to chase those idea ...
Introduction to Immunoassays
... • Immunoassays are different from other types of laboratory tests, such as colorimetric tests, because they use antibody:antigen complexes to generate a signal that can be measured. • In contrast, most routine clinical chemistry tests utilize chemical reactions between the reagent (a solution of ch ...
... • Immunoassays are different from other types of laboratory tests, such as colorimetric tests, because they use antibody:antigen complexes to generate a signal that can be measured. • In contrast, most routine clinical chemistry tests utilize chemical reactions between the reagent (a solution of ch ...
Role of C-C chemokine receptor type 7 and its ligands during
... systemic nature of this infection and the presence of abundant antigen [43]. This was associated not only with delayed T-cell responses including decreased interferon-γ production, but also a significant defect in the recruitment of inflammatory macrophages [43]. This points to either a direct or in ...
... systemic nature of this infection and the presence of abundant antigen [43]. This was associated not only with delayed T-cell responses including decreased interferon-γ production, but also a significant defect in the recruitment of inflammatory macrophages [43]. This points to either a direct or in ...
Activated Monocytes Impacts Presentation by Dendritic Cells and
... CD8+ DCs excel in cross-presentation during infection with HSV and West Nile virus or after ingestion of apoptotic cells (27–29, 39, 40). However, both CD8+ and CD82 DCs can cross-present when they are incubated with high concentrations of soluble OVA (41), OVA immune complexes (42), or bacteria exp ...
... CD8+ DCs excel in cross-presentation during infection with HSV and West Nile virus or after ingestion of apoptotic cells (27–29, 39, 40). However, both CD8+ and CD82 DCs can cross-present when they are incubated with high concentrations of soluble OVA (41), OVA immune complexes (42), or bacteria exp ...
Title goes here
... of progress to AIDS •Frequency-dependent selection by host-pathogen coevolution •Pathogens adapt to the most common MHC alleles •Rare alleles have a selective advantage ...
... of progress to AIDS •Frequency-dependent selection by host-pathogen coevolution •Pathogens adapt to the most common MHC alleles •Rare alleles have a selective advantage ...
PDF - Journal of Veterinary Science
... using OMP and DNT of B. bronchiseptica as antigens. Generally, antibody titers peaked at 4 and 6 weeks in sera and egg yolks, respectively, after the first injection (Fig. 1 and 2). The titers of the vaccinated groups were three times higher than those of the control group. Antibody profiles against ...
... using OMP and DNT of B. bronchiseptica as antigens. Generally, antibody titers peaked at 4 and 6 weeks in sera and egg yolks, respectively, after the first injection (Fig. 1 and 2). The titers of the vaccinated groups were three times higher than those of the control group. Antibody profiles against ...
Locusts increase carbohydrate consumption to protect against a
... et al., 2009; Smilanich et al., 2011), known as ‘‘therapeutic medication’’ (de Roode and Lefevre, 2012). Therapeutic self-medication does not necessarily rely on the consumption of chemical substances, but may also be facilitated through the interaction between nutrition and physiological immune res ...
... et al., 2009; Smilanich et al., 2011), known as ‘‘therapeutic medication’’ (de Roode and Lefevre, 2012). Therapeutic self-medication does not necessarily rely on the consumption of chemical substances, but may also be facilitated through the interaction between nutrition and physiological immune res ...
Long Term Immunological Memory to Vaccinia Virus
... measured by ELISA and Luminex. Additionally, B-cells were stimulated and VV specific IgG antibody secreting cells (AbSCs) were enumerated by ELISPOT assays. Both VV specific B- and T-cell responses were efficiently elicited in all three groups. B-cell memory responses were found to be weaker in the ...
... measured by ELISA and Luminex. Additionally, B-cells were stimulated and VV specific IgG antibody secreting cells (AbSCs) were enumerated by ELISPOT assays. Both VV specific B- and T-cell responses were efficiently elicited in all three groups. B-cell memory responses were found to be weaker in the ...
2003 ARS Immunology Research Workshop
... fostered “out-of-the-box” thinking enabling creative approaches to vaccine discovery. The workshop opened with two keynote presentations describing the current state of vaccinology, and then considered each of the six focus areas in turn. Two speakers, one from the US and one from the EU, led a seri ...
... fostered “out-of-the-box” thinking enabling creative approaches to vaccine discovery. The workshop opened with two keynote presentations describing the current state of vaccinology, and then considered each of the six focus areas in turn. Two speakers, one from the US and one from the EU, led a seri ...
Identification of Immunogenic Human Melanoma Antigens in a
... may increase resistance to melanoma. The most convincing evidence that this concept is correct is that immunization to melanoma vaccines can prevent this cancer in syngeneic mice (2—4).The protection conferred is specific (2), i.e., mice immu nized with control vaccine are not protected against me ...
... may increase resistance to melanoma. The most convincing evidence that this concept is correct is that immunization to melanoma vaccines can prevent this cancer in syngeneic mice (2—4).The protection conferred is specific (2), i.e., mice immu nized with control vaccine are not protected against me ...
determining the innate and adaptive immune responses to vesicular
... The purpose of a vaccine is to provide immunity to a target pathogen. How that immunity is developed depends on how the vaccine is designed. One method is to use a live attenuated virus. Current examples would be the measles, mumps, rubella vaccine, the live attenuated influenza vaccine (LAIV), and ...
... The purpose of a vaccine is to provide immunity to a target pathogen. How that immunity is developed depends on how the vaccine is designed. One method is to use a live attenuated virus. Current examples would be the measles, mumps, rubella vaccine, the live attenuated influenza vaccine (LAIV), and ...
Syddansk Universitet Immunogenicity and Immune
... cytotoxic responses by T and NK cells. Almost all cellular studies dealing with HLA class I expression have relied on a single antibody (W6/32) targeting simultaneously HLA-A, -B, -C and cross-reacting with HLA-E and –F (Uchanska-Ziegler & Ziegler, 2007). Indirect immunofluorescence assays showed th ...
... cytotoxic responses by T and NK cells. Almost all cellular studies dealing with HLA class I expression have relied on a single antibody (W6/32) targeting simultaneously HLA-A, -B, -C and cross-reacting with HLA-E and –F (Uchanska-Ziegler & Ziegler, 2007). Indirect immunofluorescence assays showed th ...
Immune system
![](https://en.wikipedia.org/wiki/Special:FilePath/Neutrophil_with_anthrax_copy.jpg?width=300)
The immune system is a system of many biological structures and processes within an organism that protects against disease. To function properly, an immune system must detect a wide variety of agents, known as pathogens, from viruses to parasitic worms, and distinguish them from the organism's own healthy tissue. In many species, the immune system can be classified into subsystems, such as the innate immune system versus the adaptive immune system, or humoral immunity versus cell-mediated immunity.Pathogens can rapidly evolve and adapt, and thereby avoid detection and neutralization by the immune system; however, multiple defense mechanisms have also evolved to recognize and neutralize pathogens. Even simple unicellular organisms such as bacteria possess a rudimentary immune system, in the form of enzymes that protect against bacteriophage infections. Other basic immune mechanisms evolved in ancient eukaryotes and remain in their modern descendants, such as plants and insects. These mechanisms include phagocytosis, antimicrobial peptides called defensins, and the complement system. Jawed vertebrates, including humans, have even more sophisticated defense mechanisms, including the ability to adapt over time to recognize specific pathogens more efficiently. Adaptive (or acquired) immunity creates immunological memory after an initial response to a specific pathogen, leading to an enhanced response to subsequent encounters with that same pathogen. This process of acquired immunity is the basis of vaccination.Disorders of the immune system can result in autoimmune diseases, inflammatory diseases and cancer.Immunodeficiency occurs when the immune system is less active than normal, resulting in recurring and life-threatening infections. In humans, immunodeficiency can either be the result of a genetic disease such as severe combined immunodeficiency, acquired conditions such as HIV/AIDS, or the use of immunosuppressive medication. In contrast, autoimmunity results from a hyperactive immune system attacking normal tissues as if they were foreign organisms. Common autoimmune diseases include Hashimoto's thyroiditis, rheumatoid arthritis, diabetes mellitus type 1, and systemic lupus erythematosus. Immunology covers the study of all aspects of the immune system.