NIH Public Access
... Neutrophils migrate through the endothelial cell barrier in two fashions: via a paracellular (between endothelial cells, as shown in Figure 1) or a transcellular (through endothelial cells) route. Most transmigration occurs via the paracellular route, although the transcellular route is favored when ...
... Neutrophils migrate through the endothelial cell barrier in two fashions: via a paracellular (between endothelial cells, as shown in Figure 1) or a transcellular (through endothelial cells) route. Most transmigration occurs via the paracellular route, although the transcellular route is favored when ...
cPu - Padis
... recognition receptors, which bind to so-called pathogen-associated molecular patterns (stranger signals). One class of pattern recognition receptor is exemplified by the Tolllike receptors (TLRs), which recognize a diverse set of pathogen-associated molecules that are not present in the host. For ex ...
... recognition receptors, which bind to so-called pathogen-associated molecular patterns (stranger signals). One class of pattern recognition receptor is exemplified by the Tolllike receptors (TLRs), which recognize a diverse set of pathogen-associated molecules that are not present in the host. For ex ...
NON CLASSICAL FUNCTION OF VITAMIN D – INFLUENCE ON
... leiomyoma tumors. Summarizing it, may be concerned that 1,25(OH)2D3-including therapy is an alternative and nonsurgical treatment option for uterine leiomyoma. IMMUNOLOGY The VDR is expressed in most cells of the immune system, including activated CD4+ and CD8+ T lymphocytes, as well as in antigen-p ...
... leiomyoma tumors. Summarizing it, may be concerned that 1,25(OH)2D3-including therapy is an alternative and nonsurgical treatment option for uterine leiomyoma. IMMUNOLOGY The VDR is expressed in most cells of the immune system, including activated CD4+ and CD8+ T lymphocytes, as well as in antigen-p ...
Updating the natural history of HPV and anogenital cancer
... dynamically oppose each other in each cohort of women, to produce the characteristic age distributions, as infections are transmitted sexually when women have new partners and then cleared. To the extent that we can observe using existing cohorts, viral clearance is not often followed by reappearanc ...
... dynamically oppose each other in each cohort of women, to produce the characteristic age distributions, as infections are transmitted sexually when women have new partners and then cleared. To the extent that we can observe using existing cohorts, viral clearance is not often followed by reappearanc ...
Macrophage polarization in metabolic disorders - HAL
... simplifies the in vivo situation where the full phenotypic spectrum between M1 and M2 can exist [8]. Moreover, an alternative classification of macrophage populations has been proposed based on three different macrophage homeostatic activities: host defence, wound healing and immune regulation [8]. ...
... simplifies the in vivo situation where the full phenotypic spectrum between M1 and M2 can exist [8]. Moreover, an alternative classification of macrophage populations has been proposed based on three different macrophage homeostatic activities: host defence, wound healing and immune regulation [8]. ...
Peer-Review Draft: Report on Carcinogens Monograph on Merkel Cell Polyomavirus
... In addition, for several rare endpoints, e.g., adult T-cell leukemia/lymphoma and human T-cell lymphotropic virus type 1, or primary effusion lymphoma and Kaposi sarcoma herpesvirus, the presence of the virus in the tumor cells is used as a diagnostic criterion to define the cancer, and thus evidenc ...
... In addition, for several rare endpoints, e.g., adult T-cell leukemia/lymphoma and human T-cell lymphotropic virus type 1, or primary effusion lymphoma and Kaposi sarcoma herpesvirus, the presence of the virus in the tumor cells is used as a diagnostic criterion to define the cancer, and thus evidenc ...
comparative characterization of porins from salmonella typhio
... absorbed antibodies were removed by centrifugation at confirmed with ELISA. Anti-LPS antiserum Anti-LPS antibodies were also raised in rabbits by giving 25, 50, 100 and 200 jlg ofLPS intravenously at 3-day intervals, followed by 250 jlg and 300 jlg at 7- day intervals. Finally 4 boosters of 300 jlg ...
... absorbed antibodies were removed by centrifugation at confirmed with ELISA. Anti-LPS antiserum Anti-LPS antibodies were also raised in rabbits by giving 25, 50, 100 and 200 jlg ofLPS intravenously at 3-day intervals, followed by 250 jlg and 300 jlg at 7- day intervals. Finally 4 boosters of 300 jlg ...
PSYCHOLOGY 506b Cognitive Neuroscience Core Course …
... protective proteins produced by the immune system - are formed and how they react with other substances. This theory was based on an understanding of the way in which a cell was thought to absorb and assimilate nutrients. ...
... protective proteins produced by the immune system - are formed and how they react with other substances. This theory was based on an understanding of the way in which a cell was thought to absorb and assimilate nutrients. ...
Effects of Whole Yeast Cell Product Supplementation in Chickens
... or 0.1% whole yeast cell product and challenged with live coccidial oocysts after 21 days of whole yeast feeding. Whole yeast cell product supplementation did not significantly alter body weight or feed consumption post-challenge. Supplementation with whole yeast cell product decreased intestinal co ...
... or 0.1% whole yeast cell product and challenged with live coccidial oocysts after 21 days of whole yeast feeding. Whole yeast cell product supplementation did not significantly alter body weight or feed consumption post-challenge. Supplementation with whole yeast cell product decreased intestinal co ...
Hydrofiber Dressing and Wound Repair: Review of the Literature
... and to contribute to the process of healing [10,11]. Skin is an active immune organ and its injury and microbial invasion trigger the activity of two important components of its innate immunity, namely epidermal dendritic cells (Langerhans cells) and antimicrobial peptides (AMPs). In humans two majo ...
... and to contribute to the process of healing [10,11]. Skin is an active immune organ and its injury and microbial invasion trigger the activity of two important components of its innate immunity, namely epidermal dendritic cells (Langerhans cells) and antimicrobial peptides (AMPs). In humans two majo ...
(2016) Innate Immunity and Asthma Risk in Amish and Hutterite
... to asthma and allergy,1,2 but the dramatic increase in the prevalence of these conditions in westernized countries in the past halfcentury suggests that the environment also plays a critical role.3 The importance of environmental exposures in the development of asthma is most exquisitely illustrated ...
... to asthma and allergy,1,2 but the dramatic increase in the prevalence of these conditions in westernized countries in the past halfcentury suggests that the environment also plays a critical role.3 The importance of environmental exposures in the development of asthma is most exquisitely illustrated ...
Vaccination - The Open University
... vaccination is not straightforward. Serious complications of injecting people with vaccinia can be expected to occur in a minority of individuals – particularly those with immunodeficiency. In the 1960s, smallpox vaccination led to an estimated 1–3 deaths per million doses, but today's population no ...
... vaccination is not straightforward. Serious complications of injecting people with vaccinia can be expected to occur in a minority of individuals – particularly those with immunodeficiency. In the 1960s, smallpox vaccination led to an estimated 1–3 deaths per million doses, but today's population no ...
Lack of Chromatin and Nuclear Fragmentation In Vivo Impairs the
... In vivo, systemic apoptosis was induced by exposure to 600 or 1500 Rads using a Cs-137 emission source of ␥ radiation. Mice were then sacrificed at 2.5 or 8 h after radiation exposure according to the experimental conditions. Organs (thymus, spleen, bone marrow, and liver) were explanted and process ...
... In vivo, systemic apoptosis was induced by exposure to 600 or 1500 Rads using a Cs-137 emission source of ␥ radiation. Mice were then sacrificed at 2.5 or 8 h after radiation exposure according to the experimental conditions. Organs (thymus, spleen, bone marrow, and liver) were explanted and process ...
Cannabidiol lowers incidence of diabetes in non - Alpha-CAT
... anti-inflammatory effects in rat paw carrageeninduced inflammation [14] associated with reduction in prostaglandin E2 (PGE2), tissue cyclooxygenase (COX) activity, and production of oxygen-derived free radicals and production of NO. Since CBD has been shown to inhibit production of IL-1b, TNF-a and ...
... anti-inflammatory effects in rat paw carrageeninduced inflammation [14] associated with reduction in prostaglandin E2 (PGE2), tissue cyclooxygenase (COX) activity, and production of oxygen-derived free radicals and production of NO. Since CBD has been shown to inhibit production of IL-1b, TNF-a and ...
Principal Investigator/Program Director (Last, First, Middle): Halonen
... Major Goal: Neural Stem Cells (NSCs) are partially differentiated pluripotent stem cells that have the ability to generate all types of cells found in the central nervous system (CNS). NSCs derived differentiated cells will be used to generate cerebral organoid cultures, 3-D brain-like masses, creat ...
... Major Goal: Neural Stem Cells (NSCs) are partially differentiated pluripotent stem cells that have the ability to generate all types of cells found in the central nervous system (CNS). NSCs derived differentiated cells will be used to generate cerebral organoid cultures, 3-D brain-like masses, creat ...
Table 1: Membrane damaging toxins
... rod-shaped, Gram-positive bacterium that can be found ubiquitously in soil and water. Under stressful conditions, these bacteria can form spores that can survive extreme conditions. These spores are destroyed when heated to 121°Celsius, whereas the toxin is destructed when heated to 85°C. Insufficie ...
... rod-shaped, Gram-positive bacterium that can be found ubiquitously in soil and water. Under stressful conditions, these bacteria can form spores that can survive extreme conditions. These spores are destroyed when heated to 121°Celsius, whereas the toxin is destructed when heated to 85°C. Insufficie ...
Differentiation of Troponin in Cardiac and Skeletal Muscles in
... are characteristic for the type of muscle from which they are prepared. The present study further showed that some of the TN components synthesized by embryonic cardiac or skeletal muscles react with antibodies raised from both adult cardiac and skeletal muscles. That is, embryonic cardiac muscle di ...
... are characteristic for the type of muscle from which they are prepared. The present study further showed that some of the TN components synthesized by embryonic cardiac or skeletal muscles react with antibodies raised from both adult cardiac and skeletal muscles. That is, embryonic cardiac muscle di ...
alopecia
... children suffer from at least one form of Alopecia (hair loss) or another in the United States alone. The good news is that at least 60% of children with Alopecia will "outgrow" the condition without need for treatment. As with all forms of Alopecia, a reversal and complete restoration of hair takes ...
... children suffer from at least one form of Alopecia (hair loss) or another in the United States alone. The good news is that at least 60% of children with Alopecia will "outgrow" the condition without need for treatment. As with all forms of Alopecia, a reversal and complete restoration of hair takes ...
Mechanisms underlying stress-induced hyperglycemia in critically ill
... These disturbances associate with poor prognostic events. Intensive insulin therapy and maintaining normoglycemia reduce the morbidity and mortality rate in critically ill patients. We aim to give an overview of the current insights in hyperglycemia and insulin resistance in critical illnesses. A se ...
... These disturbances associate with poor prognostic events. Intensive insulin therapy and maintaining normoglycemia reduce the morbidity and mortality rate in critically ill patients. We aim to give an overview of the current insights in hyperglycemia and insulin resistance in critical illnesses. A se ...
Combined action of anti-CD4 autoantibodies
... studies conducted have clearly identified the mechanism by which anti-CD4 autoantibodies could mediate CD4+ T cell depletion. The aim of this study is to examine the role of anti-CD4 autoantibodies induced by gp120 HIV-1 in the development of CD4+ lymphocytopenia. The model chosen for study was immu ...
... studies conducted have clearly identified the mechanism by which anti-CD4 autoantibodies could mediate CD4+ T cell depletion. The aim of this study is to examine the role of anti-CD4 autoantibodies induced by gp120 HIV-1 in the development of CD4+ lymphocytopenia. The model chosen for study was immu ...
the role of intestinal epithelial cells and the regulation
... function of IEC in regulating intestinal homeostasis and inflammation. Importantly, down-regulation of pIgR expression was a common feature in human IBD and mouse models of experimental colitis. One molecule of pIgR is consumed for every molecule of SIgA transported, thus high expression of pIgR is ...
... function of IEC in regulating intestinal homeostasis and inflammation. Importantly, down-regulation of pIgR expression was a common feature in human IBD and mouse models of experimental colitis. One molecule of pIgR is consumed for every molecule of SIgA transported, thus high expression of pIgR is ...
Parallels between Pathogens and Gluten Peptides in Celiac Sprue
... Even as new pathogens capable of causing human disease are uncovered, evidence is emerging that several diseases not previously considered to have an infectious etiology may involve pathogens. Among these are hepatocellular carcinoma and type II diabetes (hepatitis C virus [11,12]), Crohn disease (M ...
... Even as new pathogens capable of causing human disease are uncovered, evidence is emerging that several diseases not previously considered to have an infectious etiology may involve pathogens. Among these are hepatocellular carcinoma and type II diabetes (hepatitis C virus [11,12]), Crohn disease (M ...
Cancer immunotherapy
Cancer immunotherapy (immuno-oncology) is the use of the immune system to treat cancer. Immunotherapies fall into three main groups: cellular, antibody and cytokine. They exploit the fact that cancer cells often have subtly different molecules on their surface that can be detected by the immune system. These molecules, known as cancer antigens, are most commonly proteins, but also include molecules such as carbohydrates. Immunotherapy is used to provoke the immune system into attacking the tumor cells by using these antigens as targets.Antibody therapies are the most successful immunotherapy, treating a wide range of cancers. Antibodies are proteins produced by the immune system that bind to a target antigen on the cell surface. In normal physiology the immune system uses them to fight pathogens. Each antibody is specific to one or a few proteins. Those that bind to cancer antigens are used to treat cancer. Cell surface receptors are common targets for antibody therapies and include the CD20, CD274, and CD279. Once bound to a cancer antigen, antibodies can induce antibody-dependent cell-mediated cytotoxicity, activate the complement system, or prevent a receptor from interacting with its ligand, all of which can lead to cell death. Multiple antibodies are approved to treat cancer, including Alemtuzumab, Ipilimumab, Nivolumab, Ofatumumab, and Rituximab.Cellular therapies, also known as cancer vaccines, usually involve the removal of immune cells from the blood or from a tumor. Immune cells specific for the tumor are activated, cultured and returned to the patient where the immune cells attack the cancer. Cell types that can be used in this way are natural killer cells, lymphokine-activated killer cells, cytotoxic T cells and dendritic cells. The only cell-based therapy approved in the US is Dendreon's Provenge, for the treatment of prostate cancer.Interleukin-2 and interferon-α are examples of cytokines, proteins that regulate and coordinate the behaviour of the immune system. They have the ability to enhance anti-tumor activity and thus can be used as cancer treatments. Interferon-α is used in the treatment of hairy-cell leukaemia, AIDS-related Kaposi's sarcoma, follicular lymphoma, chronic myeloid leukaemia and malignant melanoma. Interleukin-2 is used in the treatment of malignant melanoma and renal cell carcinoma.