Studies on the antimicrobial defence of human hair follicle epithelium
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... jedermann benutzt werden dürfen. This document is protected by copyright law. No part of this document may be reproduced in any form by any means without prior written authorization of the publisher. ...
Phagocytosis: a repertoire of receptors and Ca as a key second
... Professional phagocytes mainly encompass cells of the monocytic/macrophage lineage and neutrophils sentinels of the immune system that hunt and destroy senescent, apoptotic or otherwise defective host cells, pollutant particles and, perhaps, most importantly, foreign, potentially pathogenic organism ...
... Professional phagocytes mainly encompass cells of the monocytic/macrophage lineage and neutrophils sentinels of the immune system that hunt and destroy senescent, apoptotic or otherwise defective host cells, pollutant particles and, perhaps, most importantly, foreign, potentially pathogenic organism ...
Impact of Anti-Oxidized Low- Density Lipoprotein
... lipid phase of LDL, against apoB100 modified by MDA and 4-hydroxynonenal [3,12-14]. Immune defense The immune system uses the lethal effects of oxidants by making the production of oxidizing species a central part of its mechanism of killing pathogens, with activated phagocytes producing both ROS an ...
... lipid phase of LDL, against apoB100 modified by MDA and 4-hydroxynonenal [3,12-14]. Immune defense The immune system uses the lethal effects of oxidants by making the production of oxidizing species a central part of its mechanism of killing pathogens, with activated phagocytes producing both ROS an ...
TOWARDS A DETAILED UNDERSTANDING OF THE RED BLOOD
... senescent RBCs, but also with RBCs undergoing an apoptotic-like process called eryptosis. A consequence of the storage lesion is the fact that as much as 25% of stored RBCs could be rapidly removed from the circulation within 24 hours after transfusion. The mechanisms behind this rapid macrophage-me ...
... senescent RBCs, but also with RBCs undergoing an apoptotic-like process called eryptosis. A consequence of the storage lesion is the fact that as much as 25% of stored RBCs could be rapidly removed from the circulation within 24 hours after transfusion. The mechanisms behind this rapid macrophage-me ...
Toll-like receptor 4 ligand can differentially modulate the
... clarify these issues. Elzey et al (2003) showed in transfusion studies that platelet-derived CD154 alone is sufficient to induce isotype switching and augments T lymphocyte function during viral infection, thereby leading to enhanced protection against viral rechallenge. Heddle (1999) demonstrated t ...
... clarify these issues. Elzey et al (2003) showed in transfusion studies that platelet-derived CD154 alone is sufficient to induce isotype switching and augments T lymphocyte function during viral infection, thereby leading to enhanced protection against viral rechallenge. Heddle (1999) demonstrated t ...
The immune response to resistive breathing REVIEW
... diaphragm, secondary to the resistive loading, observed represents relatively abundant mRNA tissue levels, since cytokines were detected using a multi-probe ribonuclease protection assay [15], which does not amplify the RNA signal and is less sensitive than the commonly used technique to detect RNA, ...
... diaphragm, secondary to the resistive loading, observed represents relatively abundant mRNA tissue levels, since cytokines were detected using a multi-probe ribonuclease protection assay [15], which does not amplify the RNA signal and is less sensitive than the commonly used technique to detect RNA, ...
the Complete 2016 Summit Summary
... Dr. Ali Jabbari, from Columbia University Medical Center, reported on the utility of the Alopecia Areata Disease Activity Index (ALADIN) biomarker tool to track disease status and potentially predict disease response early in the course of treatment. He discussed its utility predicting and tracking ...
... Dr. Ali Jabbari, from Columbia University Medical Center, reported on the utility of the Alopecia Areata Disease Activity Index (ALADIN) biomarker tool to track disease status and potentially predict disease response early in the course of treatment. He discussed its utility predicting and tracking ...
EMERGING ROLES FOR CYSTEINE PROTEASES IN HUMAN
... classification scheme, and on this basis proteases can be grouped into four major classes: serine, cysteine, aspartate, and metallo. The latter two groups of enzymes utilize aspartate residues and heavy metals, respectively, to immobilize and polarize a water molecule so that the oxygen atom in wate ...
... classification scheme, and on this basis proteases can be grouped into four major classes: serine, cysteine, aspartate, and metallo. The latter two groups of enzymes utilize aspartate residues and heavy metals, respectively, to immobilize and polarize a water molecule so that the oxygen atom in wate ...
Cyclin-Dependent Kinase 2 Regulates Foxp3 and Regulatory T Cell
... The cyclin dependent kinase family & the classical view of cell cycle progression The cyclin dependent kinases (CDK) are a family of serine/threonine, proline-directed kinases engaged in a large number of different cellular processes. Full-length CDK3 is absent from all inbred mouse strains due to ...
... The cyclin dependent kinase family & the classical view of cell cycle progression The cyclin dependent kinases (CDK) are a family of serine/threonine, proline-directed kinases engaged in a large number of different cellular processes. Full-length CDK3 is absent from all inbred mouse strains due to ...
National Institute of Allergy and Infectious Diseases
... It is now well established that both the innate and adaptive immune systems undergo rapid evolution and diversification; consequently, non-mammalian vertebrate animal models that are experimentally tractable alternatives to murine systems are essential, as they will allow us better distinguish impor ...
... It is now well established that both the innate and adaptive immune systems undergo rapid evolution and diversification; consequently, non-mammalian vertebrate animal models that are experimentally tractable alternatives to murine systems are essential, as they will allow us better distinguish impor ...
Thiol-Reactive Metal Compounds Inhibit NF
... for the overexpression of TNF in rheumatoid joints and RA disease activity. Blockade of NF-B activation by adenoviral transfer of IB␣ suppressed expression of TNF in cultured synoviocytes (8), and intraarticular injection of an oligodeoxynucleotide-containing B-binding sequence (NF-B decoy) inhi ...
... for the overexpression of TNF in rheumatoid joints and RA disease activity. Blockade of NF-B activation by adenoviral transfer of IB␣ suppressed expression of TNF in cultured synoviocytes (8), and intraarticular injection of an oligodeoxynucleotide-containing B-binding sequence (NF-B decoy) inhi ...
Sperm Agglutination, Sperm Shaky Head
... [11]. However, the BTB is commonly breached by physiological leakage of normally sequestered sperm antigens. ...
... [11]. However, the BTB is commonly breached by physiological leakage of normally sequestered sperm antigens. ...
LACTOBACILLUS ACIDOPHILUS = Not good, and for - Nutri-Spec
... gastrointestinal bacterial colonization in premature infants. Pediatr Infect Dis, November 1986. Studies were carried out on premature infants to determine the effect of feeding L. acidophilus in an attempt to prevent gram-negative infections in these immunodeficient premature infants. Administratio ...
... gastrointestinal bacterial colonization in premature infants. Pediatr Infect Dis, November 1986. Studies were carried out on premature infants to determine the effect of feeding L. acidophilus in an attempt to prevent gram-negative infections in these immunodeficient premature infants. Administratio ...
(CD32) Phenotype and Level of Expression
... a c t i v a t ~ r s . ~InJ ~general, MoAb-induced transmembrane signalling requires an intact IgG Fc domain and can be blocked by MoAb IV.3 specific for the FcyRII receptor (CD32), implying that binding of monoclonal Fc to that receptor is important in the process of a~tivation!,~-~~ It has been obs ...
... a c t i v a t ~ r s . ~InJ ~general, MoAb-induced transmembrane signalling requires an intact IgG Fc domain and can be blocked by MoAb IV.3 specific for the FcyRII receptor (CD32), implying that binding of monoclonal Fc to that receptor is important in the process of a~tivation!,~-~~ It has been obs ...
The Role of Macrophages in Murine Intraocular - Ti
... Local treatment of the primary tumour is very promising and depends on tumour characteristics such as size and localisation (reviewed in (Singh and Singh 2012)). It ranges from enucleation of the globe to eye-saving strategies like local radiation therapy (brachytherapy), thermotherapy or proton bea ...
... Local treatment of the primary tumour is very promising and depends on tumour characteristics such as size and localisation (reviewed in (Singh and Singh 2012)). It ranges from enucleation of the globe to eye-saving strategies like local radiation therapy (brachytherapy), thermotherapy or proton bea ...
Plaque reduction test: an alternative method to assess specific
... vaccine, it is necessary to evaluate the antibody response specifically directed at the displayed peptide. Enzyme-linked immunosorbent assays (ELISAs) and Western blot analysis are commonly used for this purpose. However, using these methods, it is not easy to distinguish the antibody response again ...
... vaccine, it is necessary to evaluate the antibody response specifically directed at the displayed peptide. Enzyme-linked immunosorbent assays (ELISAs) and Western blot analysis are commonly used for this purpose. However, using these methods, it is not easy to distinguish the antibody response again ...
Ketamine and Peripheral Inflammation
... major component of the innate immunity. They significantly contribute to the first line defense against viral infection and tumor cells growth [54]. Consequently, impairment of their cytotoxic properties, for example, in the perioperative period, is suspected to favor postoperative infections and me ...
... major component of the innate immunity. They significantly contribute to the first line defense against viral infection and tumor cells growth [54]. Consequently, impairment of their cytotoxic properties, for example, in the perioperative period, is suspected to favor postoperative infections and me ...
prolongation of allograft survival in ccr7
... Ph.D., Visceral and Transplantation Surgery, Hannover Medical dawar (9). Recipients were anesthetized, shaved, and grafted with School, 30625 Hannover, Germany. Email: hoffmann.matthias@ tail skin on the back or flank. Bandages were removed after 8 days, ...
... Ph.D., Visceral and Transplantation Surgery, Hannover Medical dawar (9). Recipients were anesthetized, shaved, and grafted with School, 30625 Hannover, Germany. Email: hoffmann.matthias@ tail skin on the back or flank. Bandages were removed after 8 days, ...
Dendritic cells expand antigen-specific Foxp3+ CD25+ CD4+
... was a useful marker for Tregs, it was clear from the work of North and colleagues (20) that suppressor cells for tumor immunity were antigen specific and that these suppressors were induced in tumor-bearing mice. If the contribution of Tregs to the immune system is to be investigated in an optimal w ...
... was a useful marker for Tregs, it was clear from the work of North and colleagues (20) that suppressor cells for tumor immunity were antigen specific and that these suppressors were induced in tumor-bearing mice. If the contribution of Tregs to the immune system is to be investigated in an optimal w ...
... of the pathogens or in the tissues through physical and chemical barriers, that is, they are inducible by external molecules but at the same time are constitutive and react within a very short time scale. Relevant innate responses in fish are phagocytosis, opsonisation, lytic and cytotoxic cellular ...
IMMUNOREACTIONS INVOLVING PLATELETS. VI. REACTIONS OF
... which differs (see below) from PlAl. The antiglobulin consumption test, using Mother K's serum alone, was consistently but weakly positive with PlA(1,1) platelets, but negative with PlA(-,-) platelets. The amount of antiglobulin consumed by PlA(1,1) platelets exposed to Mother K's serum was similar ...
... which differs (see below) from PlAl. The antiglobulin consumption test, using Mother K's serum alone, was consistently but weakly positive with PlA(1,1) platelets, but negative with PlA(-,-) platelets. The amount of antiglobulin consumed by PlA(1,1) platelets exposed to Mother K's serum was similar ...
Cancer immunotherapy
Cancer immunotherapy (immuno-oncology) is the use of the immune system to treat cancer. Immunotherapies fall into three main groups: cellular, antibody and cytokine. They exploit the fact that cancer cells often have subtly different molecules on their surface that can be detected by the immune system. These molecules, known as cancer antigens, are most commonly proteins, but also include molecules such as carbohydrates. Immunotherapy is used to provoke the immune system into attacking the tumor cells by using these antigens as targets.Antibody therapies are the most successful immunotherapy, treating a wide range of cancers. Antibodies are proteins produced by the immune system that bind to a target antigen on the cell surface. In normal physiology the immune system uses them to fight pathogens. Each antibody is specific to one or a few proteins. Those that bind to cancer antigens are used to treat cancer. Cell surface receptors are common targets for antibody therapies and include the CD20, CD274, and CD279. Once bound to a cancer antigen, antibodies can induce antibody-dependent cell-mediated cytotoxicity, activate the complement system, or prevent a receptor from interacting with its ligand, all of which can lead to cell death. Multiple antibodies are approved to treat cancer, including Alemtuzumab, Ipilimumab, Nivolumab, Ofatumumab, and Rituximab.Cellular therapies, also known as cancer vaccines, usually involve the removal of immune cells from the blood or from a tumor. Immune cells specific for the tumor are activated, cultured and returned to the patient where the immune cells attack the cancer. Cell types that can be used in this way are natural killer cells, lymphokine-activated killer cells, cytotoxic T cells and dendritic cells. The only cell-based therapy approved in the US is Dendreon's Provenge, for the treatment of prostate cancer.Interleukin-2 and interferon-α are examples of cytokines, proteins that regulate and coordinate the behaviour of the immune system. They have the ability to enhance anti-tumor activity and thus can be used as cancer treatments. Interferon-α is used in the treatment of hairy-cell leukaemia, AIDS-related Kaposi's sarcoma, follicular lymphoma, chronic myeloid leukaemia and malignant melanoma. Interleukin-2 is used in the treatment of malignant melanoma and renal cell carcinoma.