IMMUNOREACTIONS INVOLVING PLATELETS. VI. REACTIONS OF
... which differs (see below) from PlAl. The antiglobulin consumption test, using Mother K's serum alone, was consistently but weakly positive with PlA(1,1) platelets, but negative with PlA(-,-) platelets. The amount of antiglobulin consumed by PlA(1,1) platelets exposed to Mother K's serum was similar ...
... which differs (see below) from PlAl. The antiglobulin consumption test, using Mother K's serum alone, was consistently but weakly positive with PlA(1,1) platelets, but negative with PlA(-,-) platelets. The amount of antiglobulin consumed by PlA(1,1) platelets exposed to Mother K's serum was similar ...
Construction of a new peptide insertion site in the top
... The non-structural proteins are thought to be involved in various facets of viral morphogenesis, including virus assembly and release from infected cells. NS1 , encoded by genome segment M5, is synthesised in large quantities and polymerises into NS1 tubules in AHSV-infected cells (Huismans, 1979; U ...
... The non-structural proteins are thought to be involved in various facets of viral morphogenesis, including virus assembly and release from infected cells. NS1 , encoded by genome segment M5, is synthesised in large quantities and polymerises into NS1 tubules in AHSV-infected cells (Huismans, 1979; U ...
The Lymphoid System and Immunity
... Immunoglobulin Proteins (Antibodies) The binding of a specific antibody to its specific target antigen initiates antibody-mediated immunity Copyright © 2009 Pearson Education, Inc., publishing as Pearson Benjamin Cummings ...
... Immunoglobulin Proteins (Antibodies) The binding of a specific antibody to its specific target antigen initiates antibody-mediated immunity Copyright © 2009 Pearson Education, Inc., publishing as Pearson Benjamin Cummings ...
Molecular cloning, characterization and expression analysis of
... protozoa, which may result from its functional significance. Correlation between mechanism of action and role in diseases reveals that MIF is in a cytokine network not only as an effector molecular but also as a proinflammatory mediator and serves as a potential therapeutic target [34]. The presence o ...
... protozoa, which may result from its functional significance. Correlation between mechanism of action and role in diseases reveals that MIF is in a cytokine network not only as an effector molecular but also as a proinflammatory mediator and serves as a potential therapeutic target [34]. The presence o ...
Epidemiology of Cervical Cancer
... The strength of the association between infection of the cervix with high-risk types of HPV and invasive cervical cancer is almost unprecedented in cancer epidemiology, with odds ratios (OR) over 50 in most studies91, 92. HPV types are stratified into low-, intermediate-, and high-risk categories ba ...
... The strength of the association between infection of the cervix with high-risk types of HPV and invasive cervical cancer is almost unprecedented in cancer epidemiology, with odds ratios (OR) over 50 in most studies91, 92. HPV types are stratified into low-, intermediate-, and high-risk categories ba ...
Cutaneous Lupus Erythematosus
... Finally, some think the term comes from the French word for wolf (loup), related to a French style of mask women wore to conceal their faces. Neoclassic: 1872 Móric Kaposi recognized systemic manifestations of disease Modern: 1948 – the Lupus Erythematosus cell was described (PMN with ingestion of t ...
... Finally, some think the term comes from the French word for wolf (loup), related to a French style of mask women wore to conceal their faces. Neoclassic: 1872 Móric Kaposi recognized systemic manifestations of disease Modern: 1948 – the Lupus Erythematosus cell was described (PMN with ingestion of t ...
Antimicrobial peptides in lung transplant recipients with bronchiolitis obliterans syndrome
... found in human airways include a human cathelicidin (hCAP)18/LL-37, a- and b-defensins, and the proteinase inhibitors secretory leukoprotease inhibitor (SLPI) and elafin [12, 13]. Their release is stimulated by inflammatory cytokines and microbial products and they act directly as endogenous antibio ...
... found in human airways include a human cathelicidin (hCAP)18/LL-37, a- and b-defensins, and the proteinase inhibitors secretory leukoprotease inhibitor (SLPI) and elafin [12, 13]. Their release is stimulated by inflammatory cytokines and microbial products and they act directly as endogenous antibio ...
Modulation of AAV vector dosing and avoidance of capsid immune
... • Gene therapy in pediatric patients may require vector readministration • Vector re-dosing may be necessary to achieve full therapeutic efficacy ...
... • Gene therapy in pediatric patients may require vector readministration • Vector re-dosing may be necessary to achieve full therapeutic efficacy ...
Fc lessons from murine mercury-induced autoimmunity. -receptors in systemic autoimmune conditions -
... self-antigens is defined as “tolerance” and is achieved by central and peripheral mechanisms. The central tolerance occurs in the primary lymphoid organs (thymus and bone-marrow) and involves positive and negative selection. Positive selection yields functional T cells that have the potential to rec ...
... self-antigens is defined as “tolerance” and is achieved by central and peripheral mechanisms. The central tolerance occurs in the primary lymphoid organs (thymus and bone-marrow) and involves positive and negative selection. Positive selection yields functional T cells that have the potential to rec ...
prolactin and autoimmune diseases prolakt
... Lymphocytes snythesize and release a biologically active form of prolactin (28) which is employed by the cells as an autocrine and paracrine growth factor. The mechanisms that control production of lymphocyte prolactin are not completely understood, and it is not known if lymphocyte prolactin is aff ...
... Lymphocytes snythesize and release a biologically active form of prolactin (28) which is employed by the cells as an autocrine and paracrine growth factor. The mechanisms that control production of lymphocyte prolactin are not completely understood, and it is not known if lymphocyte prolactin is aff ...
EFFECTS OF PSYCHOLOGICAL STRESS ON GLUCOCORTICOID
... It is with the highest admiration and most sincere gratitude that I acknowledge Dr. Jeremy Neal as my advisor and mentor. His constant leadership, support, and relentless encouragement during the course of my doctoral studies helped me to step outside of my comfort-zone and grow in many ways that I ...
... It is with the highest admiration and most sincere gratitude that I acknowledge Dr. Jeremy Neal as my advisor and mentor. His constant leadership, support, and relentless encouragement during the course of my doctoral studies helped me to step outside of my comfort-zone and grow in many ways that I ...
Adverse Transfusion Reactions
... Adverse - 1 Contrary in purpose or effect, opposite. 2. Harmful to one’s interest; unfortunate Transfusion - A transfer of blood from one person to another Reaction - An opposed or return action A patient receives blood products to get better, not to become increasingly ill or in some cases expire. ...
... Adverse - 1 Contrary in purpose or effect, opposite. 2. Harmful to one’s interest; unfortunate Transfusion - A transfer of blood from one person to another Reaction - An opposed or return action A patient receives blood products to get better, not to become increasingly ill or in some cases expire. ...
FONGAnti-inflammatoryRole2010
... mice treated with anti-TNF antibody show increased STAT1 activation and IL12 expression after LPS and IFN stimulation. BMDM infected with adenovirus expressing IKKβ dominant negative rescued the inhibitory effect of TNFα on IL12p40 production, indicating TNFα inhibits IL-12p40 via IKKβ activation. ...
... mice treated with anti-TNF antibody show increased STAT1 activation and IL12 expression after LPS and IFN stimulation. BMDM infected with adenovirus expressing IKKβ dominant negative rescued the inhibitory effect of TNFα on IL12p40 production, indicating TNFα inhibits IL-12p40 via IKKβ activation. ...
Definition of the disease
... interest for genotyping methods (Massung et al., 2012; Sidi-Boumedine & Rousset, 2011). Unlike rickettsiae, C. burnetii produces a small, dense, highly resistant spore-like form (Heinzen et al., 1999; Minnick & Raghavan, 2012). This ability has been attributed to the existence of C. burnetii develop ...
... interest for genotyping methods (Massung et al., 2012; Sidi-Boumedine & Rousset, 2011). Unlike rickettsiae, C. burnetii produces a small, dense, highly resistant spore-like form (Heinzen et al., 1999; Minnick & Raghavan, 2012). This ability has been attributed to the existence of C. burnetii develop ...
Endotypes and phenotypes of chronic rhinosinusitis
... complex disease with several variants caused by different cellular and molecular mechanisms. The characterization of this heterogeneity supports the concept that CRS consists of multiple biological subtypes, or endotypes, which are defined by distinct pathophysiologic mechanisms that might be identi ...
... complex disease with several variants caused by different cellular and molecular mechanisms. The characterization of this heterogeneity supports the concept that CRS consists of multiple biological subtypes, or endotypes, which are defined by distinct pathophysiologic mechanisms that might be identi ...
Common Features of Mucosal and Peripheral Antibody Responses
... for IgG; P ⫽ 0.03 for IgA) (Fig. 2B and C), suggesting that intramuscular immunization of Ad-vectored and protein HIV-1 candidate vaccines elicited immunologically coordinated antibody responses in the periphery and at mucosal sites. Follow-up studies of RV144 suggested that vaccine-elicited Env-spe ...
... for IgG; P ⫽ 0.03 for IgA) (Fig. 2B and C), suggesting that intramuscular immunization of Ad-vectored and protein HIV-1 candidate vaccines elicited immunologically coordinated antibody responses in the periphery and at mucosal sites. Follow-up studies of RV144 suggested that vaccine-elicited Env-spe ...
Microbe-induced apoptosis in phagocytic cells and its role in innate immunity Robert Blomgran
... the presence of bacterial products at the foci of infection regulate the function and life span of these cells. Modulation of neutrophil apoptosis and the subsequent clearance by scavenger cells, such as macrophages, is part of a balanced inflammatory process leading to resolution of inflammation. M ...
... the presence of bacterial products at the foci of infection regulate the function and life span of these cells. Modulation of neutrophil apoptosis and the subsequent clearance by scavenger cells, such as macrophages, is part of a balanced inflammatory process leading to resolution of inflammation. M ...
abstract supplement - Society for Mucosal Immunology
... bacterium is a key virulence factor and potential candidate for inclusion in pneumococcal subunit vaccines. In order to develop these novel vaccines it is important to understand how pneumococci and PLY interact with the host immune system. In mice, IL-17A and IFN-γ play important protective roles i ...
... bacterium is a key virulence factor and potential candidate for inclusion in pneumococcal subunit vaccines. In order to develop these novel vaccines it is important to understand how pneumococci and PLY interact with the host immune system. In mice, IL-17A and IFN-γ play important protective roles i ...
Recent developments in basophil research
... These studies clearly indicate that basophils play an important role in the induction of Th2 responses ...
... These studies clearly indicate that basophils play an important role in the induction of Th2 responses ...
Aryl Hydrocarbon Receptor Control of Adaptive Immunity
... The immune system of zebrafish shares many features with its mammalian counterpart. We reported that the zebrafish immune system can mediate self-directed inflammation and tissue destruction (Quintana et al., 2010a). This potential self-reactivity is controlled by functional FoxP3+ Tregs, suggesting ...
... The immune system of zebrafish shares many features with its mammalian counterpart. We reported that the zebrafish immune system can mediate self-directed inflammation and tissue destruction (Quintana et al., 2010a). This potential self-reactivity is controlled by functional FoxP3+ Tregs, suggesting ...
Locally delivered polyclonal antibodies potentiate the efficacy
... treatment strategy against infection. Ceftazidime is a third-generation cephalosporin and first-line antibiotic against Klebsiella pneumoniae, Serratia marcescens, Escherichia coli and Proteus mirabilis infections.36 However, emergence of ceftazidime-resistant Klebsiella and Escherichia coli strains ...
... treatment strategy against infection. Ceftazidime is a third-generation cephalosporin and first-line antibiotic against Klebsiella pneumoniae, Serratia marcescens, Escherichia coli and Proteus mirabilis infections.36 However, emergence of ceftazidime-resistant Klebsiella and Escherichia coli strains ...
TUMOR NECROSIS FACTOR ALPHA (TNF-a)
... adaptor proteins TRADD, RIP1, and TRAF2, which can activate the NF-kB pathway via an I-kB kinase complex composed of I-kB kinase-a, I-kB kinase-b, and I-kB kinase-g (NEMO). Alternatively, TNFR1 signaling through TRAF2 can activate the c-Jun N-terminal kinase (JNK) pathway through the MAPK kinase, MK ...
... adaptor proteins TRADD, RIP1, and TRAF2, which can activate the NF-kB pathway via an I-kB kinase complex composed of I-kB kinase-a, I-kB kinase-b, and I-kB kinase-g (NEMO). Alternatively, TNFR1 signaling through TRAF2 can activate the c-Jun N-terminal kinase (JNK) pathway through the MAPK kinase, MK ...
Immunomodulatory effects of tick saliva
... ectoparasites are of great importance in medicine and veterinary medicine. All the biological success achieved by ticks is due to the action of bioactive components present in their saliva, which are synthesized by the salivary glands. These components have great diversity of functions such as enabl ...
... ectoparasites are of great importance in medicine and veterinary medicine. All the biological success achieved by ticks is due to the action of bioactive components present in their saliva, which are synthesized by the salivary glands. These components have great diversity of functions such as enabl ...
Plasmodium Strain Determines Dendritic Cell
... development of protective Th1-dependent immune responses [33,34]. These responses are generated by CD8 DCs during the acute phase of infection [30]. However, DCs from infected mice are unable to prime CD8þ T cells to proliferate and secrete cytokines [34,35], which impairs cross-presentation of vir ...
... development of protective Th1-dependent immune responses [33,34]. These responses are generated by CD8 DCs during the acute phase of infection [30]. However, DCs from infected mice are unable to prime CD8þ T cells to proliferate and secrete cytokines [34,35], which impairs cross-presentation of vir ...
Cancer immunotherapy
Cancer immunotherapy (immuno-oncology) is the use of the immune system to treat cancer. Immunotherapies fall into three main groups: cellular, antibody and cytokine. They exploit the fact that cancer cells often have subtly different molecules on their surface that can be detected by the immune system. These molecules, known as cancer antigens, are most commonly proteins, but also include molecules such as carbohydrates. Immunotherapy is used to provoke the immune system into attacking the tumor cells by using these antigens as targets.Antibody therapies are the most successful immunotherapy, treating a wide range of cancers. Antibodies are proteins produced by the immune system that bind to a target antigen on the cell surface. In normal physiology the immune system uses them to fight pathogens. Each antibody is specific to one or a few proteins. Those that bind to cancer antigens are used to treat cancer. Cell surface receptors are common targets for antibody therapies and include the CD20, CD274, and CD279. Once bound to a cancer antigen, antibodies can induce antibody-dependent cell-mediated cytotoxicity, activate the complement system, or prevent a receptor from interacting with its ligand, all of which can lead to cell death. Multiple antibodies are approved to treat cancer, including Alemtuzumab, Ipilimumab, Nivolumab, Ofatumumab, and Rituximab.Cellular therapies, also known as cancer vaccines, usually involve the removal of immune cells from the blood or from a tumor. Immune cells specific for the tumor are activated, cultured and returned to the patient where the immune cells attack the cancer. Cell types that can be used in this way are natural killer cells, lymphokine-activated killer cells, cytotoxic T cells and dendritic cells. The only cell-based therapy approved in the US is Dendreon's Provenge, for the treatment of prostate cancer.Interleukin-2 and interferon-α are examples of cytokines, proteins that regulate and coordinate the behaviour of the immune system. They have the ability to enhance anti-tumor activity and thus can be used as cancer treatments. Interferon-α is used in the treatment of hairy-cell leukaemia, AIDS-related Kaposi's sarcoma, follicular lymphoma, chronic myeloid leukaemia and malignant melanoma. Interleukin-2 is used in the treatment of malignant melanoma and renal cell carcinoma.