mRNA-based therapeutics — developing a new class of drugs
... a particular disease state. In principle, two approaches of using IVT mRNA are being pursued. One is to transfer it into the patient’s cells ex vivo; these transfected cells are then adoptively administered back to the patient. This method is being investigated for genome engineering, genetic reprog ...
... a particular disease state. In principle, two approaches of using IVT mRNA are being pursued. One is to transfer it into the patient’s cells ex vivo; these transfected cells are then adoptively administered back to the patient. This method is being investigated for genome engineering, genetic reprog ...
Lymphatic System
... QUESTION. 3 Which is the correct statement about the Lymphatic system? A. It Reabsorbs excess interstitial fluid and returns it to the venous circulation. ...
... QUESTION. 3 Which is the correct statement about the Lymphatic system? A. It Reabsorbs excess interstitial fluid and returns it to the venous circulation. ...
Nestlé Purina PetCare PTC
... • Less than optimal performance in any one of these three systems will lead to problems affecting the other systems • Optimal performance in an individual system will enable the other systems to operate to their full potential • Each of the 3 systems operates at peak efficiency together only when su ...
... • Less than optimal performance in any one of these three systems will lead to problems affecting the other systems • Optimal performance in an individual system will enable the other systems to operate to their full potential • Each of the 3 systems operates at peak efficiency together only when su ...
dendritic cell-specific ICAM- grabbing non-integrin
... C-type lectins are calcium-dependent carbohydrate-binding proteins with a wide range of biological functions, many of which are related to immunity. DC-SIGN (dendritic cell-specific ICAM-grabbing non-integrin, where ICAM is intercellular adhesion molecule) is a recently described mannose-specific C- ...
... C-type lectins are calcium-dependent carbohydrate-binding proteins with a wide range of biological functions, many of which are related to immunity. DC-SIGN (dendritic cell-specific ICAM-grabbing non-integrin, where ICAM is intercellular adhesion molecule) is a recently described mannose-specific C- ...
from um.ac.ir
... Clearly the challenge is to establish new protocols that allow the successful differentiation of these cells into lineage committed cells. A lot of progress has now been made in mouse cells. For example, it is now feasible to efficiently derive hematopoietic cells from mouse ES cells [9–11]. These c ...
... Clearly the challenge is to establish new protocols that allow the successful differentiation of these cells into lineage committed cells. A lot of progress has now been made in mouse cells. For example, it is now feasible to efficiently derive hematopoietic cells from mouse ES cells [9–11]. These c ...
24. Lymphatic System
... the venous circulation. If this excess fluid were not removed, body tissues would swell, a condition called edema (e-dē ́mă; oidema = a swelling). Further, this excess fluid would accumulate outside the bloodstream, causing blood levels to drop precipitously. Thus, the lymphatic system prevents i ...
... the venous circulation. If this excess fluid were not removed, body tissues would swell, a condition called edema (e-dē ́mă; oidema = a swelling). Further, this excess fluid would accumulate outside the bloodstream, causing blood levels to drop precipitously. Thus, the lymphatic system prevents i ...
of the TLR2/MyD88 Pathway in Microglia by Group B Streptococci
... GBS and GBS-F induced a significant reduction in numbers of neurons. Also, treatment with GBS or GBS-F resulted in a diminishment of the numbers of microglia compared with control conditions. In contrast, purified neurons alone were not affected by treatment with GBS or GBS-F. The loss of cells was ...
... GBS and GBS-F induced a significant reduction in numbers of neurons. Also, treatment with GBS or GBS-F resulted in a diminishment of the numbers of microglia compared with control conditions. In contrast, purified neurons alone were not affected by treatment with GBS or GBS-F. The loss of cells was ...
The evolution of costly acquired immune memory
... use a mathematical model to explore the role of ecological and epidemiological processes in shaping selection for costly acquired immune memory. Applying the framework of adaptive dynamics to the classic SIR (Susceptible-InfectedRecovered) epidemiological model, we focus on the conditions that may l ...
... use a mathematical model to explore the role of ecological and epidemiological processes in shaping selection for costly acquired immune memory. Applying the framework of adaptive dynamics to the classic SIR (Susceptible-InfectedRecovered) epidemiological model, we focus on the conditions that may l ...
Stress Hormone and Skin Disease
... is a causal relationship between stressors and their disease outcome. Earlier retrospective studies have suggested that exacerbation of psoriasis occur a few weeks to months after a stressful event (Gupta et al., 1988). Recently, Verhoeven et al. have found a positive significant correlation between ...
... is a causal relationship between stressors and their disease outcome. Earlier retrospective studies have suggested that exacerbation of psoriasis occur a few weeks to months after a stressful event (Gupta et al., 1988). Recently, Verhoeven et al. have found a positive significant correlation between ...
Cells Intestinal Lamina Propria as Regulatory T Cells in Human
... Briefly, the dissected mucosa was incubated in calcium and magnesium-free HBSS containing 2.5% FBS and 1 mM DTT (SigmaAldrich) to remove mucus. The mucosa was then incubated in medium containing 0.75 mM EDTA (Sigma-Aldrich) for 60 min at 37°C. During this treatment, intraepithelial lymphocytes and e ...
... Briefly, the dissected mucosa was incubated in calcium and magnesium-free HBSS containing 2.5% FBS and 1 mM DTT (SigmaAldrich) to remove mucus. The mucosa was then incubated in medium containing 0.75 mM EDTA (Sigma-Aldrich) for 60 min at 37°C. During this treatment, intraepithelial lymphocytes and e ...
Lesson 65. Organ transplantation
... molecules), Minor histocompatibility antigens (HLA antigens) and other alloantigens (ABO blood group, and some tissue specific antigens, etc.). Mismatch of these antigens in donor and recipient is a strong factor for graft rejection. Cell-mediated Immunity, humoral immunity and NK cells play a role ...
... molecules), Minor histocompatibility antigens (HLA antigens) and other alloantigens (ABO blood group, and some tissue specific antigens, etc.). Mismatch of these antigens in donor and recipient is a strong factor for graft rejection. Cell-mediated Immunity, humoral immunity and NK cells play a role ...
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... Peripheral processing of pro-CRH into CRH appears to be similar at the peripheral and central levels, as shown in placenta, endometrium, uterus, and immune system (49, 297, 301, 398, 456). In addition to its regulation by similar factors as in the brain (100, 166, 267, 268, 297, 299, 301, 305, 332, ...
... Peripheral processing of pro-CRH into CRH appears to be similar at the peripheral and central levels, as shown in placenta, endometrium, uterus, and immune system (49, 297, 301, 398, 456). In addition to its regulation by similar factors as in the brain (100, 166, 267, 268, 297, 299, 301, 305, 332, ...
Integrin-associated protein (CD47) and its ligands
... fibrinogen-binding integrin αIIbβ3. The CD47 agonist peptide 4N1K, the recombinant C-terminal domain of TSP1 containing the VVM sequences and intact TSP1 all stimulate platelet spreading on fibrinogen. This spreading is mediated by αIIbβ3 and is prevented by a function-blocking mAb against CD477. 4N ...
... fibrinogen-binding integrin αIIbβ3. The CD47 agonist peptide 4N1K, the recombinant C-terminal domain of TSP1 containing the VVM sequences and intact TSP1 all stimulate platelet spreading on fibrinogen. This spreading is mediated by αIIbβ3 and is prevented by a function-blocking mAb against CD477. 4N ...
and Adaptive Immunity Structure and Function
... stimulation and generation of both innate and adaptive immunity. The ability of HSPs to bind antigenic peptides and deliver them to APCs is the basis of the generation of peptide-specific T lymphocyte responses both in vitro and in vivo. The different HSP families are genetically and biochemically u ...
... stimulation and generation of both innate and adaptive immunity. The ability of HSPs to bind antigenic peptides and deliver them to APCs is the basis of the generation of peptide-specific T lymphocyte responses both in vitro and in vivo. The different HSP families are genetically and biochemically u ...
Human T lymphotropic virus type 1 uveitis
... Although the incidence of ATL and HAM/TSP was finding - that is, a trend for declining odds ratio for HTLV-I reported to be approximately 1 in 1000 to 3000 individuals with age, is important since the opposite is true for the in the HTLV-I carrier population,45 the incidence of HTLV-I carriers of HT ...
... Although the incidence of ATL and HAM/TSP was finding - that is, a trend for declining odds ratio for HTLV-I reported to be approximately 1 in 1000 to 3000 individuals with age, is important since the opposite is true for the in the HTLV-I carrier population,45 the incidence of HTLV-I carriers of HT ...
Cervarix-H-C-721-P46-0088: EPAR - EMA
... Use of concomitant medication (e.g. prophylactic use of antibiotics or antipyretics) throughout the study period (from Day 0 up to Month 36) in all groups. ...
... Use of concomitant medication (e.g. prophylactic use of antibiotics or antipyretics) throughout the study period (from Day 0 up to Month 36) in all groups. ...
The Equine Endometrial Cup Reaction
... Pieces of the Puzzle Not until 31 years after Schauder’s original description were the endometrial cups identified as the source of the high concentrations of eCG in the blood of pregnant mares (4). Professor Harold Cole (Figure 1c) and his colleagues in Davis, California, had made the startling dis ...
... Pieces of the Puzzle Not until 31 years after Schauder’s original description were the endometrial cups identified as the source of the high concentrations of eCG in the blood of pregnant mares (4). Professor Harold Cole (Figure 1c) and his colleagues in Davis, California, had made the startling dis ...
Elevated serum BAFF levels in patients with sarcoidosis: association
... Serum samples were obtained from 37 Japanese sarcoidosis patients (5 males and 32 females). The age (mean ± SD) of these patients was 61 ± 12 years. Fresh venous blood samples were centrifuged shortly after clot formation and all samples were stored at 80 C before use. For comparison, serum from 21 ...
... Serum samples were obtained from 37 Japanese sarcoidosis patients (5 males and 32 females). The age (mean ± SD) of these patients was 61 ± 12 years. Fresh venous blood samples were centrifuged shortly after clot formation and all samples were stored at 80 C before use. For comparison, serum from 21 ...
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... take time, there has been increased support for the development of cost-effective, point-of-care devices that can be coupled with smartphones to measure physiologically relevant nutrition biomarkers, which may enable immunonutrition support at an early intervention stage for malnourishment. Immunonu ...
... take time, there has been increased support for the development of cost-effective, point-of-care devices that can be coupled with smartphones to measure physiologically relevant nutrition biomarkers, which may enable immunonutrition support at an early intervention stage for malnourishment. Immunonu ...
Lessening Malaria Parasite Burden with Yogurt
... is a particularly significant “bacterial hot spot” within the body in terms of containing more, and more diverse, microbes along with the mouth, the skin, and the vaginal tract (7). Gut microbes help with somewhat obvious bodily functions, such as digestion. However, the gut microbiota does not sole ...
... is a particularly significant “bacterial hot spot” within the body in terms of containing more, and more diverse, microbes along with the mouth, the skin, and the vaginal tract (7). Gut microbes help with somewhat obvious bodily functions, such as digestion. However, the gut microbiota does not sole ...
Mucosal immune response in common carp (Cyprinus carpio L
... and expensive and, in some cases, unavailable due to the emergence of drug resistance in bacteria and fungi. This is why number of biological compounds, as an alternative to the drugs, has been used to reduce the risk of diseases and improve fish welfare by enhancement of non-specific defence system ...
... and expensive and, in some cases, unavailable due to the emergence of drug resistance in bacteria and fungi. This is why number of biological compounds, as an alternative to the drugs, has been used to reduce the risk of diseases and improve fish welfare by enhancement of non-specific defence system ...
ABSTRACT Title of Document: INTERFERON
... parasites to enter cells silently. Leishmania can also enter macrophages through a silent mechanism similar to the uptake of apoptotic cells (9). In this way they can establish their niche inside macrophages without activating them. Two surface molecules have been implicated in parasite’s ingestion, ...
... parasites to enter cells silently. Leishmania can also enter macrophages through a silent mechanism similar to the uptake of apoptotic cells (9). In this way they can establish their niche inside macrophages without activating them. Two surface molecules have been implicated in parasite’s ingestion, ...
Cancer immunotherapy
Cancer immunotherapy (immuno-oncology) is the use of the immune system to treat cancer. Immunotherapies fall into three main groups: cellular, antibody and cytokine. They exploit the fact that cancer cells often have subtly different molecules on their surface that can be detected by the immune system. These molecules, known as cancer antigens, are most commonly proteins, but also include molecules such as carbohydrates. Immunotherapy is used to provoke the immune system into attacking the tumor cells by using these antigens as targets.Antibody therapies are the most successful immunotherapy, treating a wide range of cancers. Antibodies are proteins produced by the immune system that bind to a target antigen on the cell surface. In normal physiology the immune system uses them to fight pathogens. Each antibody is specific to one or a few proteins. Those that bind to cancer antigens are used to treat cancer. Cell surface receptors are common targets for antibody therapies and include the CD20, CD274, and CD279. Once bound to a cancer antigen, antibodies can induce antibody-dependent cell-mediated cytotoxicity, activate the complement system, or prevent a receptor from interacting with its ligand, all of which can lead to cell death. Multiple antibodies are approved to treat cancer, including Alemtuzumab, Ipilimumab, Nivolumab, Ofatumumab, and Rituximab.Cellular therapies, also known as cancer vaccines, usually involve the removal of immune cells from the blood or from a tumor. Immune cells specific for the tumor are activated, cultured and returned to the patient where the immune cells attack the cancer. Cell types that can be used in this way are natural killer cells, lymphokine-activated killer cells, cytotoxic T cells and dendritic cells. The only cell-based therapy approved in the US is Dendreon's Provenge, for the treatment of prostate cancer.Interleukin-2 and interferon-α are examples of cytokines, proteins that regulate and coordinate the behaviour of the immune system. They have the ability to enhance anti-tumor activity and thus can be used as cancer treatments. Interferon-α is used in the treatment of hairy-cell leukaemia, AIDS-related Kaposi's sarcoma, follicular lymphoma, chronic myeloid leukaemia and malignant melanoma. Interleukin-2 is used in the treatment of malignant melanoma and renal cell carcinoma.