Platelets: versatile effector cells in hemostasis, inflammation, and the
... Platelets also facilitate the process of plasma coagulation and ultimate conversion of fibrinogen, which has both hemostatic and proinflammatory activities (see review by Akassoglou, this symposium) to fibrin. This complex biochemical cascade is triggered by the exposure of subendothelial collagen a ...
... Platelets also facilitate the process of plasma coagulation and ultimate conversion of fibrinogen, which has both hemostatic and proinflammatory activities (see review by Akassoglou, this symposium) to fibrin. This complex biochemical cascade is triggered by the exposure of subendothelial collagen a ...
Medical Virology of Hepatitis B: how it began and where we are now
... upon detection of the reaction of the patient’s antibodies with the viral antigen. The method most often used was the quite difficult complement fixation reaction (CFR), which was originally developed for diagnosing syphilis. In addition to the human patient serum, and the viral antigen (e.g. from i ...
... upon detection of the reaction of the patient’s antibodies with the viral antigen. The method most often used was the quite difficult complement fixation reaction (CFR), which was originally developed for diagnosing syphilis. In addition to the human patient serum, and the viral antigen (e.g. from i ...
View - OhioLINK Electronic Theses and Dissertations Center
... Francisella tularensis is a Gram-negative facultative intracellular bacterium that is a potential weapon of bioterrorism when aerosolized. Macrophage infection is necessary for disease progression and efficient phagocytosis by human macrophages requires serum opsonization by complement. Microbial co ...
... Francisella tularensis is a Gram-negative facultative intracellular bacterium that is a potential weapon of bioterrorism when aerosolized. Macrophage infection is necessary for disease progression and efficient phagocytosis by human macrophages requires serum opsonization by complement. Microbial co ...
NIH Public Access Author Manuscript The immune system and cardiac repair Abstract
... immunity and inflammation. PTX3 is induced in myocardial infarction and appears to play an important cardioprotective role possibly due to modulation of the complement cascade [23]. The diverse effects of the pentraxins in myocardial infarction highlight their complex role in the ischemic heart. The ...
... immunity and inflammation. PTX3 is induced in myocardial infarction and appears to play an important cardioprotective role possibly due to modulation of the complement cascade [23]. The diverse effects of the pentraxins in myocardial infarction highlight their complex role in the ischemic heart. The ...
Title: A longitudinal study of BCG vaccination: dynamics
... A total of 147 children were recruited into the study and blood samples were obtained before BCG vaccination was given (T0). From these children, 120 children ...
... A total of 147 children were recruited into the study and blood samples were obtained before BCG vaccination was given (T0). From these children, 120 children ...
The Innate and Adaptive Immune Response to
... Additionally, I would like to acknowledge Gui Nilaratanakul, Rachy Abraham, and Nina Martin for their presence and livelihood in the lab. Finally, I would like to thank my mother, father, and brother Ryan, as well as my extended family and friends for providing their unwavering support. As a little ...
... Additionally, I would like to acknowledge Gui Nilaratanakul, Rachy Abraham, and Nina Martin for their presence and livelihood in the lab. Finally, I would like to thank my mother, father, and brother Ryan, as well as my extended family and friends for providing their unwavering support. As a little ...
Untitled
... individuals contained substances which they called antibodies that specifically bound to the relevant pathogen. A specific immune response, such as the production of antibodies against a particular pathogen, is known as an adaptive immune response, because it occurs during the lifetime of an individ ...
... individuals contained substances which they called antibodies that specifically bound to the relevant pathogen. A specific immune response, such as the production of antibodies against a particular pathogen, is known as an adaptive immune response, because it occurs during the lifetime of an individ ...
Histones Activate the NLRP3 Inflammasome in Kupffer Cells during
... recognized as key mechanisms in liver I/R injury (3). Nucleotide-binding domain, leucine-rich repeat containing protein 3 (NLRP3), also known as NALP3 or cryopyrin, is an intracellular nucleotide-binding oligomerization domain-like receptor that functions as a danger signal sensor that becomes activ ...
... recognized as key mechanisms in liver I/R injury (3). Nucleotide-binding domain, leucine-rich repeat containing protein 3 (NLRP3), also known as NALP3 or cryopyrin, is an intracellular nucleotide-binding oligomerization domain-like receptor that functions as a danger signal sensor that becomes activ ...
LUNG FIBROSIS INDUCED BY BLEOMYCIN: STRUCTURAL
... determine the progression of lung disease during the fibrotic transformation of the organ. Cellular Changes in the Lung A variety of cells of the lung are affected by intratracheal or intravenous injection of bleomycin. Alterations in the physiology of alveolar macrophages and fibroblasts are often ...
... determine the progression of lung disease during the fibrotic transformation of the organ. Cellular Changes in the Lung A variety of cells of the lung are affected by intratracheal or intravenous injection of bleomycin. Alterations in the physiology of alveolar macrophages and fibroblasts are often ...
An Official ATS Workshop Summary: Recent Advances and Future
... CD4⫹ T cells is a prime means by which individuals become susceptible to Pneumocystis. Several mechanisms have been investigated to further characterize the importance of CD4⫹ T cells, including investigation of immunodominant epitopes, antigen presentation, costimulatory molecules, cytokine product ...
... CD4⫹ T cells is a prime means by which individuals become susceptible to Pneumocystis. Several mechanisms have been investigated to further characterize the importance of CD4⫹ T cells, including investigation of immunodominant epitopes, antigen presentation, costimulatory molecules, cytokine product ...
- Journal of Allergy and Clinical Immunology
... the asthmatic patients (n 5 20) had persistently detectable virus 2 weeks after rhinovirus inoculation than did healthy control subjects (n 5 17; 60% vs 31%, P 5 .06).63 The potential negative effects of TH2-biased immune conditions on immunity has been further demonstrated for other viruses, such a ...
... the asthmatic patients (n 5 20) had persistently detectable virus 2 weeks after rhinovirus inoculation than did healthy control subjects (n 5 17; 60% vs 31%, P 5 .06).63 The potential negative effects of TH2-biased immune conditions on immunity has been further demonstrated for other viruses, such a ...
Human norovirus transmission and evolution in a
... VP2. The capsid attaches to the cell surface through interactions between VP1 and host histo-blood group antigens (HBGAs) (step 1), and is subsequently internalized, uncoated and disassembled (steps 2,3). The (+)RNA is then transcribed and translated in the cytoplasm of the host cell. Translation is ...
... VP2. The capsid attaches to the cell surface through interactions between VP1 and host histo-blood group antigens (HBGAs) (step 1), and is subsequently internalized, uncoated and disassembled (steps 2,3). The (+)RNA is then transcribed and translated in the cytoplasm of the host cell. Translation is ...
Innate Immune Responses to Respiratory Syncytial Virus
... Figure 1. Construction of FLAG-tagged human codon-optimized vectors for transient transfection and inducible cell line construction. ....................................45 Figure 2. Procedure for live-cell tracking of polyhistidine-tagged RSV infection. ...........46 Figure 3. Subcellular localizati ...
... Figure 1. Construction of FLAG-tagged human codon-optimized vectors for transient transfection and inducible cell line construction. ....................................45 Figure 2. Procedure for live-cell tracking of polyhistidine-tagged RSV infection. ...........46 Figure 3. Subcellular localizati ...
Mycophenolate mofetil increases susceptibility to opportunistic
... Anti-proliferative agents that target lymphoid cells are common immunosuppressive agents used in the treatment of diverse autoimmune, graft versus host and inflammatory diseases. Mycophenolate mofetil (MMF) is an anti-proliferative agent that targets lymphoid dependence on inosine monophosphate dehy ...
... Anti-proliferative agents that target lymphoid cells are common immunosuppressive agents used in the treatment of diverse autoimmune, graft versus host and inflammatory diseases. Mycophenolate mofetil (MMF) is an anti-proliferative agent that targets lymphoid dependence on inosine monophosphate dehy ...
Proceedings - Animal Nutrition Conference of Canada
... community, chose to focus on nutritional strategies to reduce the use of antimicrobials in animal production. Apart from the new legislative constraints that will force the industry to adapt and find new ways to maintain livestock profitability, there is also an opportunity for us to better understa ...
... community, chose to focus on nutritional strategies to reduce the use of antimicrobials in animal production. Apart from the new legislative constraints that will force the industry to adapt and find new ways to maintain livestock profitability, there is also an opportunity for us to better understa ...
Alice M. Nyakeriga RELATION OF NUTRITIONAL STATUS, IMMUNITY, HEMOGLOBINOPATHY AND
... expression of complex arrays of surface proteins, cluster of differentiation (CD) proteins: CD4+ T cells and CD8+ T cells. The CD4+ T cells or helper cells are MHC II restricted, help B cells and produce cytokines. These cells can further be grouped into Th1 and Th2 cells depending on which cytokine ...
... expression of complex arrays of surface proteins, cluster of differentiation (CD) proteins: CD4+ T cells and CD8+ T cells. The CD4+ T cells or helper cells are MHC II restricted, help B cells and produce cytokines. These cells can further be grouped into Th1 and Th2 cells depending on which cytokine ...
A Functional Study of the Drosophila Host Defense
... ymmärtämään paremmin myös ihmisen synnynnäistä immuunivastetta johtuen ...
... ymmärtämään paremmin myös ihmisen synnynnäistä immuunivastetta johtuen ...
Differential Host Immune Responses to Epidemic and Endemic
... Shigella dysenteriae type 1 causes devastating epidemics in developing countries with high case-fatality rates in all age-groups. The aim of the study was to compare host immune responses to epidemic (T2218) and endemic strains of S. dysenteriae type 1. Shigellacidal activity of serum from rabbits i ...
... Shigella dysenteriae type 1 causes devastating epidemics in developing countries with high case-fatality rates in all age-groups. The aim of the study was to compare host immune responses to epidemic (T2218) and endemic strains of S. dysenteriae type 1. Shigellacidal activity of serum from rabbits i ...
Immunological and Genetic Aspects of Narcolepsy
... Indeed, it is not clear whether the DQB1*06:02 allele acts alone, or in combination with other HLA variants to confer susceptibility, although additional HLA gene variants certainly modulate the DQB1*06:02 effects. The genes encoding DQB1 and DQA1 (encoding DQβ and DQα, respectively) are located adj ...
... Indeed, it is not clear whether the DQB1*06:02 allele acts alone, or in combination with other HLA variants to confer susceptibility, although additional HLA gene variants certainly modulate the DQB1*06:02 effects. The genes encoding DQB1 and DQA1 (encoding DQβ and DQα, respectively) are located adj ...
The impact of Toll-like receptor activation on - diss.fu
... in the central nervous system (CNS), predominantly expressed in microglia, the major immune cells of the brain. Increasing evidence suggests that, along with microglia-mediated neuroinflammation, TLRs play a crucial role in CNS pathologies such as infection, stroke and classical neurodegenerative di ...
... in the central nervous system (CNS), predominantly expressed in microglia, the major immune cells of the brain. Increasing evidence suggests that, along with microglia-mediated neuroinflammation, TLRs play a crucial role in CNS pathologies such as infection, stroke and classical neurodegenerative di ...
Cancer immunotherapy
Cancer immunotherapy (immuno-oncology) is the use of the immune system to treat cancer. Immunotherapies fall into three main groups: cellular, antibody and cytokine. They exploit the fact that cancer cells often have subtly different molecules on their surface that can be detected by the immune system. These molecules, known as cancer antigens, are most commonly proteins, but also include molecules such as carbohydrates. Immunotherapy is used to provoke the immune system into attacking the tumor cells by using these antigens as targets.Antibody therapies are the most successful immunotherapy, treating a wide range of cancers. Antibodies are proteins produced by the immune system that bind to a target antigen on the cell surface. In normal physiology the immune system uses them to fight pathogens. Each antibody is specific to one or a few proteins. Those that bind to cancer antigens are used to treat cancer. Cell surface receptors are common targets for antibody therapies and include the CD20, CD274, and CD279. Once bound to a cancer antigen, antibodies can induce antibody-dependent cell-mediated cytotoxicity, activate the complement system, or prevent a receptor from interacting with its ligand, all of which can lead to cell death. Multiple antibodies are approved to treat cancer, including Alemtuzumab, Ipilimumab, Nivolumab, Ofatumumab, and Rituximab.Cellular therapies, also known as cancer vaccines, usually involve the removal of immune cells from the blood or from a tumor. Immune cells specific for the tumor are activated, cultured and returned to the patient where the immune cells attack the cancer. Cell types that can be used in this way are natural killer cells, lymphokine-activated killer cells, cytotoxic T cells and dendritic cells. The only cell-based therapy approved in the US is Dendreon's Provenge, for the treatment of prostate cancer.Interleukin-2 and interferon-α are examples of cytokines, proteins that regulate and coordinate the behaviour of the immune system. They have the ability to enhance anti-tumor activity and thus can be used as cancer treatments. Interferon-α is used in the treatment of hairy-cell leukaemia, AIDS-related Kaposi's sarcoma, follicular lymphoma, chronic myeloid leukaemia and malignant melanoma. Interleukin-2 is used in the treatment of malignant melanoma and renal cell carcinoma.