Immune Design Announces Treatment of First Patient in Phase 1
... “This trial will provide insights into the ability of ID-G100 to stimulate an immune response in patients with Merkel cell carcinoma,” said Shailender Bhatia, M.D., medical oncologist at Seattle Cancer Care Alliance, assistant professor, medical oncology division at the University of Washington Scho ...
... “This trial will provide insights into the ability of ID-G100 to stimulate an immune response in patients with Merkel cell carcinoma,” said Shailender Bhatia, M.D., medical oncologist at Seattle Cancer Care Alliance, assistant professor, medical oncology division at the University of Washington Scho ...
Document
... • Evidence for the importance of AICD in maintenance of self-tolerance: – Mice with mutations in Fas or Fas ligand develop a lupus-like autoimmune disease – Humans with mutations in Fas or enzymes involved in death receptor-induced apoptosis (caspases): the autoimmune lymphoproliferative syndrome (A ...
... • Evidence for the importance of AICD in maintenance of self-tolerance: – Mice with mutations in Fas or Fas ligand develop a lupus-like autoimmune disease – Humans with mutations in Fas or enzymes involved in death receptor-induced apoptosis (caspases): the autoimmune lymphoproliferative syndrome (A ...
The contrasting role of B7-H3 Kimberly A. Hofmeyer* , Anjana Ray*
... B7-H3 preferentially regulates CD4independent induction of CD8 CTL responses. B7-H3 action through T cell costimulation is also implied by the fact that rapamycin treatment induced permanent cardiac and islet allograft survival in B7-H3 knockout mice (17), indicating that B7-H3 functions to promote ...
... B7-H3 preferentially regulates CD4independent induction of CD8 CTL responses. B7-H3 action through T cell costimulation is also implied by the fact that rapamycin treatment induced permanent cardiac and islet allograft survival in B7-H3 knockout mice (17), indicating that B7-H3 functions to promote ...
T cells
... – are white blood cells that spend most of their time in the tissues and organs of the lymphatic system, – are responsible for adaptive immunity, and ...
... – are white blood cells that spend most of their time in the tissues and organs of the lymphatic system, – are responsible for adaptive immunity, and ...
BIOC39H – Immunology Winter 2012 Course Syllabus
... immune system and as such, this course aims to provide students with an appreciation of the interdisciplinary relationship between these subjects. This course is designed to introduce the molecular and cellular basis of the immune system. Topics covered include cells and tissues of the innate and ad ...
... immune system and as such, this course aims to provide students with an appreciation of the interdisciplinary relationship between these subjects. This course is designed to introduce the molecular and cellular basis of the immune system. Topics covered include cells and tissues of the innate and ad ...
BIOLOGICAL THERAPIES
... • It is complex system of cells and production of antibodies. • Can remember previous encounters with immunogens and mount responses on new challenges. • Differentiate between “self” and “foregion”. • In many cancers, may not recognize the cancer as “foregion” and the immune system does not act agai ...
... • It is complex system of cells and production of antibodies. • Can remember previous encounters with immunogens and mount responses on new challenges. • Differentiate between “self” and “foregion”. • In many cancers, may not recognize the cancer as “foregion” and the immune system does not act agai ...
Animal Diseases
... Panzootic: disease that spreads rapidly over a very large area and effects many animals in a short period of time (foot & mouth disease) ...
... Panzootic: disease that spreads rapidly over a very large area and effects many animals in a short period of time (foot & mouth disease) ...
Animal Diseases
... Panzootic: disease that spreads rapidly over a very large area and effects many animals in a short period of time (foot & mouth disease) ...
... Panzootic: disease that spreads rapidly over a very large area and effects many animals in a short period of time (foot & mouth disease) ...
Lymph - Dr. Victor Arai
... 6. Compare the primary immune response and the secondary immune response. 7. Discuss active and passive immunities, both naturally acquired and artificially acquired. 8. Explain the structure of an antibody. List the five classes of antibodies and their functions. Identify the ways antibodies functi ...
... 6. Compare the primary immune response and the secondary immune response. 7. Discuss active and passive immunities, both naturally acquired and artificially acquired. 8. Explain the structure of an antibody. List the five classes of antibodies and their functions. Identify the ways antibodies functi ...
LEARNING OBJECTIVES Genesis and General Characteristics of
... Leukopoiesis is hormonally stimulated by two families of cytokines (hematopoietic factors) – interleukins and colony-stimulating factors ...
... Leukopoiesis is hormonally stimulated by two families of cytokines (hematopoietic factors) – interleukins and colony-stimulating factors ...
the programme
... SM Kaech (New Haven) Regulation of T cell responses during viral infection JA Berzofsky (Maryland) Strategies and mechanisms for induction of mucosal T-cell immunity DE Speiser (Lausanne) Optimizing human T cell responses against cancer M Boer (Leiden) (Short talk) CD39 is involved in mediating supp ...
... SM Kaech (New Haven) Regulation of T cell responses during viral infection JA Berzofsky (Maryland) Strategies and mechanisms for induction of mucosal T-cell immunity DE Speiser (Lausanne) Optimizing human T cell responses against cancer M Boer (Leiden) (Short talk) CD39 is involved in mediating supp ...
Hematopoiesis Hematopoiesis Hematopoiesis Apoptosis
... • Lack TCR of T cells or sIg of B cells • Unique surface markers: CD16 (FcγRIII) and CD56 • Action similar to Tc (CD8+) cells • Role: destroys tumor cells and virus-infected cells • Recognition due to altered expression of MHC-I and ADCC (Ab-dependent cell cytotoxicity) • NK1-T cell: T cell and NK c ...
... • Lack TCR of T cells or sIg of B cells • Unique surface markers: CD16 (FcγRIII) and CD56 • Action similar to Tc (CD8+) cells • Role: destroys tumor cells and virus-infected cells • Recognition due to altered expression of MHC-I and ADCC (Ab-dependent cell cytotoxicity) • NK1-T cell: T cell and NK c ...
CELLULAR IMMUNE RESPONSE
... • Antibody response to T (cell) dependent antigens – Ig receptors on B cell recognize Ag but cross-linking inadequate to activate cell – Therefore need second signal from T helper cell; thus – 1) Ag binds to Ig receptor on B cell as above – 2) Some bound Ag internalized, processed and presented in M ...
... • Antibody response to T (cell) dependent antigens – Ig receptors on B cell recognize Ag but cross-linking inadequate to activate cell – Therefore need second signal from T helper cell; thus – 1) Ag binds to Ig receptor on B cell as above – 2) Some bound Ag internalized, processed and presented in M ...
Infectious Disease PPT worksheet
... Washing hands with soap and warm water, regularly. Treating open wounds with ____________________ ointment and properly covering the wound. Public sanitation such as water treatment plants. 15.____________________ - Drugs made from alter Microbes or their poisons injected or given by mouth to produc ...
... Washing hands with soap and warm water, regularly. Treating open wounds with ____________________ ointment and properly covering the wound. Public sanitation such as water treatment plants. 15.____________________ - Drugs made from alter Microbes or their poisons injected or given by mouth to produc ...
No Slide Title
... There is structural variation in antibody heavy chain constant regions. These variations are critical for effector functions and are achieved in two different ways, RNA splicing and DNA switch recombination. The signals regulating these changes come from antigen binding to the B cell receptor and an ...
... There is structural variation in antibody heavy chain constant regions. These variations are critical for effector functions and are achieved in two different ways, RNA splicing and DNA switch recombination. The signals regulating these changes come from antigen binding to the B cell receptor and an ...
Chapter 22: The Lymphatic System and Immunity
... clones that are available for swift response if a 2nd exposure should occur reside in lymphatic tissues Co-stimulation of Cytotoxic T lymphocytes (Fig 22.16) any cell (except RBCs) processes an antigen and presents it on its surface with MHC-I could possibly be an APC that is also presenting same an ...
... clones that are available for swift response if a 2nd exposure should occur reside in lymphatic tissues Co-stimulation of Cytotoxic T lymphocytes (Fig 22.16) any cell (except RBCs) processes an antigen and presents it on its surface with MHC-I could possibly be an APC that is also presenting same an ...
Editorial: Bacterial Exotoxins: How Bacteria Fight the Immune System
... pathways, resulting in adjustment of the host immune response to infection and modification of inflammatory responses both locally and systemically (1, 2). Exotoxins can be single polypeptides or heteromeric protein complexes that act on different parts of the cells. At the cell surface, they may in ...
... pathways, resulting in adjustment of the host immune response to infection and modification of inflammatory responses both locally and systemically (1, 2). Exotoxins can be single polypeptides or heteromeric protein complexes that act on different parts of the cells. At the cell surface, they may in ...
Tracking movement of immune cells identifies key first steps in
... a component of the innate immune system, which iimmunol.aaj2195 is then displayed on the inner walls of adjacent blood vessels. C5a directly initiates the adherence of neutrophils to the vessel walls through interaction with the C5a receptor on neutrophils, Provided by Massachusetts General Hospital ...
... a component of the innate immune system, which iimmunol.aaj2195 is then displayed on the inner walls of adjacent blood vessels. C5a directly initiates the adherence of neutrophils to the vessel walls through interaction with the C5a receptor on neutrophils, Provided by Massachusetts General Hospital ...
Slide 1
... FIGURE 41.7 Suppressive pathways of Treg cells. Tolerogenic dendritic cells, together with regulatory cytokines and other immunedeviating agents, control Treg cell activation and proliferation. Cytokines G-CSF, GM-CSF, IL-4, and IL-10, together with IDO and HLA-G, regulate dendritic cell differenti ...
... FIGURE 41.7 Suppressive pathways of Treg cells. Tolerogenic dendritic cells, together with regulatory cytokines and other immunedeviating agents, control Treg cell activation and proliferation. Cytokines G-CSF, GM-CSF, IL-4, and IL-10, together with IDO and HLA-G, regulate dendritic cell differenti ...
Evolutionary aspects of allorecognition
... During evolution various solutions that meet this demand have been selected within the different phyla. First, large families of germline genes encoding the receptors can be generated by multiple duplications. Some of these are used in allorecognition, for example polymorphic Immunoglobulin superfam ...
... During evolution various solutions that meet this demand have been selected within the different phyla. First, large families of germline genes encoding the receptors can be generated by multiple duplications. Some of these are used in allorecognition, for example polymorphic Immunoglobulin superfam ...
AP® BIOLOGY 2007 SCORING GUIDELINES (Form B)
... In part (a) the student received 3 points: 1 point for recognizing that the skin provides a barrier to most organisms; 1 point for stating that there are antibacterial agents in saliva and mucus; and 1 point for describing the role of macrophages. The student earned 3 points in part (b): 1 point for ...
... In part (a) the student received 3 points: 1 point for recognizing that the skin provides a barrier to most organisms; 1 point for stating that there are antibacterial agents in saliva and mucus; and 1 point for describing the role of macrophages. The student earned 3 points in part (b): 1 point for ...
... stimulate the specific immune response. Phagocytes recognise surface antigen molecules on pathogens and destroy them by phagocytosis. NK cells induce the pathogen to produce self-destructive enzymes in apoptosis. I can describe specific cellular defences. I can describe immune surveillance as a rang ...
Adaptive immune system
The adaptive immune system, also known as the acquired immune or, more rarely, as the specific immune system, is a subsystem of the overall immune system that is composed of highly specialized, systemic cells and processes that eliminate or prevent pathogen growth. The adaptive immune system is one of the two main immunity strategies found in vertebrates (the other being the innate immune system). Adaptive immunity creates immunological memory after an initial response to a specific pathogen, leads to an enhanced response to subsequent encounters with that pathogen. This process of acquired immunity is the basis of vaccination. Like the innate system, the adaptive system includes both humoral immunity components and cell-mediated immunity components.Unlike the innate immune system, the adaptive immune system is highly specific to a specific pathogen. Adaptive immunity can also provide long-lasting protection: for example; someone who recovers from measles is now protected against measles for their lifetime but in other cases it does not provide lifetime protection: for example; chickenpox. The adaptive system response destroys invading pathogens and any toxic molecules they produce. Sometimes the adaptive system is unable to distinguish foreign molecules, the effects of this may be hayfever, asthma or any other allergies. Antigens are any substances that elicit the adaptive immune response. The cells that carry out the adaptive immune response are white blood cells known as lymphocytes. Two main broad classes—antibody responses and cell mediated immune response—are also carried by two different lymphocytes (B cells and T cells). In antibody responses, B cells are activated to secrete antibodies, which are proteins also known as immunoglobulins. Antibodies travel through the bloodstream and bind to the foreign antigen causing it to inactivate, which does not allow the antigen to bind to the host.In acquired immunity, pathogen-specific receptors are ""acquired"" during the lifetime of the organism (whereas in innate immunity pathogen-specific receptors are already encoded in the germline). The acquired response is called ""adaptive"" because it prepares the body's immune system for future challenges (though it can actually also be maladaptive when it results in autoimmunity).The system is highly adaptable because of somatic hypermutation (a process of accelerated somatic mutations), and V(D)J recombination (an irreversible genetic recombination of antigen receptor gene segments). This mechanism allows a small number of genes to generate a vast number of different antigen receptors, which are then uniquely expressed on each individual lymphocyte. Because the gene rearrangement leads to an irreversible change in the DNA of each cell, all progeny (offspring) of that cell inherit genes that encode the same receptor specificity, including the memory B cells and memory T cells that are the keys to long-lived specific immunity.A theoretical framework explaining the workings of the acquired immune system is provided by immune network theory. This theory, which builds on established concepts of clonal selection, is being applied in the search for an HIV vaccine.