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HSV-1
HSV-1

... Recurrences can be triggered by numerous environmental stimuli including a common cold, fever, severe sunburn, physical fatigue, emotional disturbance, trauma, gastrointestinal disturbances, menstruation, pregnancy, debilitating illnesses, or food allergy ...
slides - Smith Lab
slides - Smith Lab

... Inflammation leads to increase chemokine production • <24 hrs Neutrophils and immature Macrophages enter the cornea • 24-48 hrs Macrophages and Dendritic cells mature • 48 hrs NK cells enter the cornea • >48 hrs Dendritic cells travel to the DLN • 3-7 days Dendritic Cells Prime the T cell responses ...
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1 Defenders of the Body 2 Nonspecific Defenses 3 Specific

... – Entire clone is specific to this particular invader – These T cells then circulate throughout the body ...
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11.1 Antibody Production and Vaccination

... Mast cells are found in connective tissues. If stimulated by an infection they release histamine in the infected area.* ...
Course Objectives - Geisel School of Medicine
Course Objectives - Geisel School of Medicine

... Course  Objective Describe  the  cells,  products,  and  effector  responses  of  the  immune  system Describe  an  immune  response  from  initiation  to  resolution Describe  T  and  B  cell  receptor  diversity  and  antigen  recognition Expla ...
Investigating Leukocyte Dynamic Response to Stimuli in an - Q-bio
Investigating Leukocyte Dynamic Response to Stimuli in an - Q-bio

... information on the current state of the leukocytes which can lead to a more thorough understanding of a particular cell’s biology. II. RESULTS The integration of these two technologies has begun by means of offline experimental set-ups and steady-state analysis conditions in both yeast and T cell po ...
Chapter 1: MAJOR THEMES OF ANATOMY AND PHYSIOLOGY
Chapter 1: MAJOR THEMES OF ANATOMY AND PHYSIOLOGY

... • explain how lymph is formed and returned to the bloodstream; • name the major types of cells in the lymphatic system and state their functions; • name and describe the types of lymphatic tissues; and • describe the form and function of red bone marrow, thymus, lymph nodes, tonsils, and spleen. ...
Immune System notes fill-in
Immune System notes fill-in

... o Neutrophil, eosinophil, basophil, monocyte, lymphocyte function of (B lymphocyte & T lymphocyte) the thymus?  2. ______________ o Located below the _____________ o Larger in children, shrinks with age o Critical to immunity o Function: allows body to ______________ foreign tissues or invading ___ ...
Answer Key- Chapter 24 - Scarsdale Public Schools
Answer Key- Chapter 24 - Scarsdale Public Schools

... 28. AIDS patients end up suffering from _____________________ system is worn down by the HIV virus. 29. HIV is a retrovirus. This means it uses RNA as its molecule of heredity and has reverse transcriptase to make viral DNA from viral RNA. Briefly explain why this makes HIV much more likely to m ...
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Current Strategies in HIV-1 Vaccine Development Using

... of the specific B cells needed to fight HIV. Some cells from the clones become memory B cells, which response rapidly to any encounter with the same virus. Other cells from the clones mature into plasma cells and secrete antibodies to the virus. These antibodies bind to the virus and prevent it from ...
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Vaccines PPT - Alevelsolutions

... from the disease. 2. Vaccines can help avoid this. Vaccines contain antigens that cause your body to produce memory cells against a specific pathogen. Since the pathogen is dead it does not cause disease. 3. Herd immunity – since vaccines reduce the chances of getting a disease, those who are not va ...
MICROBIO320 EXAM 1-Fall 2009 Name 1 True/False (1 point each
MICROBIO320 EXAM 1-Fall 2009 Name 1 True/False (1 point each

... __T__10. Antigen is presented to T cell mainly in secondary lymphoid organs. __T__11. C3 is the most abundant complement component in the body. __T__12. T cell receptors are composed of constant and variable regions. __T__13. Mucosal membrane are collectively considered the largest anatomical barrie ...
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... How does the IS produce the required diversity of receptors? One source of this diversity: Lymphocyte receptors are constructed from inherited gene segments or libraries. The receptors are made by randomly recombining elements from different libraries, resulting in an exponential number of possible ...
The Importance of a Balanced Immune Response
The Importance of a Balanced Immune Response

... treat diseases such as asthma, arthritis and psoriasis. Unfortunately, long-term use of corticosteroids is known to produce complications such as cataracts, weight gain, increased cholesterol and brittle bones. Even severe allergies may need long-term treatment with intranasal corticosteroids, altho ...
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Fighting Disease Pathogen: a disease



... complexes. The complement proteins bind to the antigen– antibody complex and lyse cellular antigens or enhance the phagocytosis of noncellular antigens. ...
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Subset of CD4 Cells May Hold Key To Reaching HIV Cure

... been identifying people shortly after they become infected and then encouraging them to start ARVs immediately. It typically takes 3 weeks after infection for people to test positive on standard screens for viral proteins and antibodies, but Ananworanich uses more sensitive tests that can identify i ...
Human Immunodeficiency Virus
Human Immunodeficiency Virus

... • AIDS – fourth and last stage –immune system no longer able to defend against virus • definition of AIDS –all HIV-infected individuals who has fewer than 200 CD4+ T cells/microliter of blood or a CD4+ cell percentage of lymphocytes of less than 14 ...
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Module #

... The immune response responds at the site of the infection and at the lymph nodes away from the infection. We can understand the immune response by following the course of an infection.  Barriers: Most pathogens are kept outside of the body by protective mechanisms such as tears, stomach acid and ci ...
Chapter 2
Chapter 2

... T helper cells ○ CD4 glycoprotein ○ “help” activation of B cells, TC cells, ...
슬라이드 제목 없음
슬라이드 제목 없음

... The lymphocyte is an agranular cell with very clear cytoplasm which stains pale blue. Its nucleus is very large for the size of the cell and stains dark purple. This cell is much smaller than the three granulocytes (which are all about the same size). These cells play an important role in our immune ...
Chapter 18
Chapter 18

... • Some antibodies are soluble proteins that travel free in blood and lymph. Others are integral membrane proteins on B cells. • When a pathogen invades the body, it may be detected by and bound by a B cell whose membrane antibody fits one of its potential antigenic determinants. • This binding activ ...
Pathogenic Mechanisms of Uveitis
Pathogenic Mechanisms of Uveitis

... to posterior uveitis may be an excellent example of the effects of epitope spreading. Through tissue damage, cryptic or hidden epitopes on the same molecule will be suddenly presented to the immune system. The end result is that every target antigen generally contains several epitopes, each of which ...
Exam 2 2016 Answers
Exam 2 2016 Answers

... 33. Why is a live virus thought to elicit both cell mediated immunity and humoral immunity while killed virus only provokes a humoral response? a. viral antigens stimulate all immune cells b. proliferating viruses do not kill macrophages c. proliferating virus can activate the cytotoxic T cells to k ...
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Adaptive immune system



The adaptive immune system, also known as the acquired immune or, more rarely, as the specific immune system, is a subsystem of the overall immune system that is composed of highly specialized, systemic cells and processes that eliminate or prevent pathogen growth. The adaptive immune system is one of the two main immunity strategies found in vertebrates (the other being the innate immune system). Adaptive immunity creates immunological memory after an initial response to a specific pathogen, leads to an enhanced response to subsequent encounters with that pathogen. This process of acquired immunity is the basis of vaccination. Like the innate system, the adaptive system includes both humoral immunity components and cell-mediated immunity components.Unlike the innate immune system, the adaptive immune system is highly specific to a specific pathogen. Adaptive immunity can also provide long-lasting protection: for example; someone who recovers from measles is now protected against measles for their lifetime but in other cases it does not provide lifetime protection: for example; chickenpox. The adaptive system response destroys invading pathogens and any toxic molecules they produce. Sometimes the adaptive system is unable to distinguish foreign molecules, the effects of this may be hayfever, asthma or any other allergies. Antigens are any substances that elicit the adaptive immune response. The cells that carry out the adaptive immune response are white blood cells known as lymphocytes. Two main broad classes—antibody responses and cell mediated immune response—are also carried by two different lymphocytes (B cells and T cells). In antibody responses, B cells are activated to secrete antibodies, which are proteins also known as immunoglobulins. Antibodies travel through the bloodstream and bind to the foreign antigen causing it to inactivate, which does not allow the antigen to bind to the host.In acquired immunity, pathogen-specific receptors are ""acquired"" during the lifetime of the organism (whereas in innate immunity pathogen-specific receptors are already encoded in the germline). The acquired response is called ""adaptive"" because it prepares the body's immune system for future challenges (though it can actually also be maladaptive when it results in autoimmunity).The system is highly adaptable because of somatic hypermutation (a process of accelerated somatic mutations), and V(D)J recombination (an irreversible genetic recombination of antigen receptor gene segments). This mechanism allows a small number of genes to generate a vast number of different antigen receptors, which are then uniquely expressed on each individual lymphocyte. Because the gene rearrangement leads to an irreversible change in the DNA of each cell, all progeny (offspring) of that cell inherit genes that encode the same receptor specificity, including the memory B cells and memory T cells that are the keys to long-lived specific immunity.A theoretical framework explaining the workings of the acquired immune system is provided by immune network theory. This theory, which builds on established concepts of clonal selection, is being applied in the search for an HIV vaccine.
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