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Lec. 2 Antigens, Immunogens, Epitopes, and Haptens
Lec. 2 Antigens, Immunogens, Epitopes, and Haptens

Company Overview - Peregrine Pharmaceuticals, Inc.
Company Overview - Peregrine Pharmaceuticals, Inc.

... growing commercial biomanufacturing business that provides a comprehensive range of process development, high quality cGMP clinical and commercial manufacturing services for Peregrine and other biotechnology and biopharmaceutical companies. With over 15 years of experience producing monoclonal antib ...
The Immune Response
The Immune Response

... • Bacteria invade and are engulfed by macrophages • Macrophage takes portion of bacteria and positions it in its cell membrane as antigens • Special WBC called helper T-cells bind to these antigens and become ‘activated” • The T-cells then bind to B-cells causing them to divide and produce plasma ce ...
Humoral immune response
Humoral immune response

... • prevailing antibody of primary immune response • high-effective agglutinant and cytolytic agent • usually isohaemagglutinins and natural antibodies ...
When They Say There`s No Hope: Nutritional Approaches to
When They Say There`s No Hope: Nutritional Approaches to

... (optimal ranges: men < 0.55 mg/L, women < 1.5 mg/L), which are often followed with disease-specific diagnostic tests; the fluorescent antinuclear antibody test (FANA); and the erythrocyte sedimentation rate (ESR) test (non-diagnostic; detects/monitors tissue death and ADs that present vague/minimal ...
Lymphocytes - MBBS Students Club
Lymphocytes - MBBS Students Club

... Clones of Lymphocytes • All the different lymphocytes capable of forming one specifity of antibodies or T lymphocytes are called a clone of lymphocytes • On surface of B cells membrane highly specific 100,000 Abs and on surface of T cells membrane highly specific “surface receptor proteins” or “T c ...
body defenses
body defenses

Groups of adhesive molecules
Groups of adhesive molecules

... Tumor necrosis factors – induction of apoptosis ...
Secondary Lymphoid Organs of the Immune System
Secondary Lymphoid Organs of the Immune System

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 T cells are involved with the host response to infection... αβ T cells, traditional MHC-restricted recognition of

...  T cells are involved with the host response to infection and autoimmunity. Unlike conventional αβ T cells, traditional MHC-restricted recognition of  ligands has not been identified. Furthermore, few  ligands have been verified and the conditions under which these ligands are induced remain i ...
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... 2. Lymphocytes, in a high concenration, will cause what to expand? a) the heart b) the bone marrow c) the spleen d) the lymph nodes ...
Antigen bonds on immune cells Jun Allard:
Antigen bonds on immune cells Jun Allard:

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Immune System

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Immune System
Immune System

... are coated with mucus; Mucus traps airborne pathogens & swept into the digestive system to be destroyed 3. Inflammation - Occurs when pathogens do enter the body (usually through skin); Blood vessels near wound expand; WBC leak from the vessels to invade the infected tissues; Phagocytes (wbc) engulf ...
Immune Defense notes part 2 fill-in
Immune Defense notes part 2 fill-in

... C. Types of WBCs (White Blood Cells)  ________________ - “eat” & destroy pathogens o Macrophages, Neurtophils, Monocytes  Eosinphils – deal with ________________ infections  Basophils – involved in ________________ reactions ...
Worm therapy: Multiple Sclerosis
Worm therapy: Multiple Sclerosis

... Prevalence (and exposure) of parasites in highlysanitized countries might indeed explain low prevalence of MS Links between some steps of the immune mechanisms Role of genetics? Diet? ...
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... 9. The hypersensitivity – Gell–Coombs classification ...
Inflammation & the Immune Response Unit VIII
Inflammation & the Immune Response Unit VIII

... An antigen is a substance that elicits an immune response Mostly comprised of protein A foreign substance that invades the body is called an antigen All cells have antigen unique to that individual allowing the body to recognize itself ...
the body`s defenses
the body`s defenses

... The cells of the immune system can distinguish between different kinds of pathogens. The immune system cells react to each kind of pathogen with a defense targeted to that pathogen ...
Immune Disorders notes
Immune Disorders notes

...  If they enter the fetus’ blood supply they can cause inappropriate immune reaction ...
Cytokine - Chemotaxis Group
Cytokine - Chemotaxis Group

... • Synery : combined effetc of two or more cytokines is higher than the simple summary of the individual effects • Antagonism : cytokines can block each other e.g. IL-4 and IFN-g. • Multifunctionality: (pluripotent , pleiotrope) several cytokines possess more, different effects on the diverse target ...
Cytokine - Chemotaxis Group
Cytokine - Chemotaxis Group

... • Synery : combined effetc of two or more cytokines is higher than the simple summary of the individual effects • Antagonism : cytokines can block each other e.g. IL-4 and IFN-g. • Multifunctionality: (pluripotent , pleiotrope) several cytokines possess more, different effects on the diverse target ...
CBE Seminar - Chemical Engineering, University of Delaware
CBE Seminar - Chemical Engineering, University of Delaware

... Cytokines constitute a large class of secreted proteins that signal through membraneembedded receptors to orchestrate all aspects of the immune response. Their critical role in immune regulation has motivated the therapeutic use of cytokines to treat a range of diseases including autoimmune disorder ...
APO-4: Microbes and you: who will win the war
APO-4: Microbes and you: who will win the war

... _____ Antigen breakdown products bind major histocompatibility complexprotein and are "displayed" on B cell surface. _____ T cell secretes cytokines which stimulate B cell. _____ Antigen-antibody complex is internalized and processed. _____ Helper T cell binds antigen via its T-cell receptor. _____ ...
35-2 Defense Against Infection Worksheet
35-2 Defense Against Infection Worksheet

... 10. A substance that triggers the immune response is known as a (n) 11. The main role of immune-system cells. ...
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Immunosuppressive drug

For a list of immunosuppressive drugs, see the transplant rejection page.Immunosuppressive drugs or immunosuppressive agents or antirejection medications are drugs that inhibit or prevent activity of the immune system. They are used in immunosuppressive therapy to: Prevent the rejection of transplanted organs and tissues (e.g., bone marrow, heart, kidney, liver) Treat autoimmune diseases or diseases that are most likely of autoimmune origin (e.g., rheumatoid arthritis, multiple sclerosis, myasthenia gravis, systemic lupus erythematosus, sarcoidosis, focal segmental glomerulosclerosis, Crohn's disease, Behcet's Disease, pemphigus, and ulcerative colitis). Treat some other non-autoimmune inflammatory diseases (e.g., long term allergic asthma control).A common side-effect of many immunosuppressive drugs is immunodeficiency, because the majority of them act non-selectively, resulting in increased susceptibility to infections and decreased cancer immunosurveillance. There are also other side-effects, such as hypertension, dyslipidemia, hyperglycemia, peptic ulcers, lipodystrophy, moon face, liver and kidney injury. The immunosuppressive drugs also interact with other medicines and affect their metabolism and action. Actual or suspected immunosuppressive agents can be evaluated in terms of their effects on lymphocyte subpopulations in tissues using immunohistochemistry.Immunosuppressive drugs can be classified into five groups: glucocorticoids cytostatics antibodies drugs acting on immunophilins other drugs.
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