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Measuring immunity
Measuring immunity

... killing capacity of AMPs How: Stimulate skin production of AMPs and swab skin surface Need: skin surface; adrenaline to induce proteins Equipment: Microplate reader or fluorometer or laminar flow hood ...
    Questions:    
    Questions:    

... Questions:   ...
Immune System
Immune System

... Insoluble Ant/Ab deposit in the microvasculature Ca /neutrophils---tissue damage ...
Riggs_Signal_Transduction-_PAMP_Presentation[1]
Riggs_Signal_Transduction-_PAMP_Presentation[1]

... Toll-Like Receptors activated by LPS to induce apoptosis ...
The Immune System
The Immune System

... • belongs to basic homeostatic mechanisms of organism • Its function is maintaining the integrity of organism by recognition of harmful from harmless, and by this way it protects organism against injurious matter of external and internal origin. ...
Sex and Behaviour * Immune Response to Parasites
Sex and Behaviour * Immune Response to Parasites

... The media’s role in the MMR controversy Many studies have concluded that the MMR vaccine is safe and only a few studies claim that it isn’t. However, this was not reflected by the media coverage. .The majority of coverage centred on the possibility of a link between the MMR vaccine and autism, whil ...
Monoclonal Antibodies In Hematology
Monoclonal Antibodies In Hematology

... necessitating close monitoring and observation. These adverse events have been summarized in Table IV . Though uncommon, severe or life threatening events have also been reported after rituximab administration with 2.9% deaths attributable to rituximab8. Respiratory complications are the commonest c ...
Pneumonitis
Pneumonitis

... oxygen and CO2 delivery. After approximately 7 days, a period of organization occurs and fibroblastic tissue fills the alveolar space and the intersitium. Alveoli eventually recover or progress to permanent fibrosis. Drugs may contribute to this pattern of toxicity by causing apoptosis of epithelial ...
Advanced Pharmacology-I (PHR5001) Lecture 12: Anti
Advanced Pharmacology-I (PHR5001) Lecture 12: Anti

... Muromonoab-CD3: Muromonoab-CD3 is used for the treatment of acute organ transplant rejection. It is effective in preventing graft rejection after kidney, heart or liver transplantation. Muromonoab-CD3 is effective in patients who after acute cardiac or liver allograft rejection do not respond to ste ...
B cell activation and antibody production
B cell activation and antibody production

... Applications of monoclonal antibody • Identification of phenotypic markers unique to particular cell types ...
Immune System Powerpoint
Immune System Powerpoint

... – T Cells (B.M. then thymus) ...
T cell
T cell

... NEGATIVE REGULATION IN THE IMMUNE SYSTEM 1. Decrease of antigen concentration in the course of the immune response 2. Inhibition of B lymphocyte activation - antibody feedback • Cross linking of BCR with FcRIIB (CD32) by antigen-antibody complex • ITIM-induced negative signaling of B cell activati ...
GENERAL CHARACTERIZATION OF THE
GENERAL CHARACTERIZATION OF THE

Type II Hypersensitivity: Antibody mediated cytotoxicity
Type II Hypersensitivity: Antibody mediated cytotoxicity

... • Both processes result in lysis of the Ab-coated cell • Clinical examples of Type II responses include: – Certain autoimmune diseases where Ab’s produced vs membrane Ag’s • Grave’s Disease – Ab’s produced vs thyroid hormone receptor • Myasthenia Gravis – Ab’s produced vs acetylcholine recpetors • A ...
5.3 KeyTerms
5.3 KeyTerms

Lymphocytes - Spark (e
Lymphocytes - Spark (e

... because they are produced during the pregnancy. NK cells are a part of the innate immune system and play a important role in defending the host from both tumors and virally infected cells. They are used to produce cytokines. These are a broad and loose category of small proteins that are important i ...
Slide 1
Slide 1

... • Class II molecules “present” peptides from molecules that are taken up from outside the cell via processes such as phagocytosis (known as exogenous processing pathway) • Together the peptide and MHC form a shape (3-D structure) that may match (complement) the surface of a T cell receptor • MHC cla ...
File - Westside High School Science Portal
File - Westside High School Science Portal

IMMUNOLOGY FINAL EXAM 1. A Major difference between using
IMMUNOLOGY FINAL EXAM 1. A Major difference between using

... E. The virus produces its own reverse transcriptase, which has served as a target for anti-HIV drugs. 31. Cytokines A. B. C. D. ...
PowerPoint
PowerPoint

... • Once activated these CTLs can kill target cells that have the same antigen-MHC-1 combination that originally activated the CTL • After bind target, CTL kills target cell via the perforin pathway and CD95 pathway ...
Lecture #23 - Suraj @ LUMS
Lecture #23 - Suraj @ LUMS

... • The body's capability to repel foreign substances and cells. • The nonspecific (innate) responses are the first line of defense - block the entry and spread of disease-causing agents. • Highly specific (adaptive) responses are the second line of defense and are tailored to an individual threat. • ...
Immune Compromised Infections
Immune Compromised Infections

... a defect in CD11 or CD18 peptides and consequently they cannot respond to C3b opsonin. Alternatively there may a defect in integrin molecules, LFA-1 or mac-1 arising from defective CD11a or CD11b peptides, respectively. These molecules are involved in diapedesis and hence defective neutrophils canno ...
Chapter 14 Lymphatic System Student outline
Chapter 14 Lymphatic System Student outline

... b. An activated B-cell proliferates when stimulated by a T-cell, enlarging its clone c. Some activated B-cells specialize into antibody producing plasma cells d. Antibodies react against the antigen-bearing agent 6. Types of antibodies-these are soluble proteins called ______________. a. The five ma ...
Immune
Immune

... have 1,25(OH)2D receptors; shifts response towards innate immunity rather than adaptive immunity (inhibits Th1 and Th17, enhances Th2 and Treg) – Ascorbic acid is 80x more concentrated in granulocytes than in plasma; is essential for T Cell maturation and division, and for phagocytosis; also importa ...


... The adaptive immune response allows the body to protect itself from a diverse set of pathogens. Key orchestrators of the adaptive immune response are T cells which recognize antigen through interactions between their T cell receptor (TCR) and antigen presenting cells. The TCR intracellular signaling ...
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Immunosuppressive drug

For a list of immunosuppressive drugs, see the transplant rejection page.Immunosuppressive drugs or immunosuppressive agents or antirejection medications are drugs that inhibit or prevent activity of the immune system. They are used in immunosuppressive therapy to: Prevent the rejection of transplanted organs and tissues (e.g., bone marrow, heart, kidney, liver) Treat autoimmune diseases or diseases that are most likely of autoimmune origin (e.g., rheumatoid arthritis, multiple sclerosis, myasthenia gravis, systemic lupus erythematosus, sarcoidosis, focal segmental glomerulosclerosis, Crohn's disease, Behcet's Disease, pemphigus, and ulcerative colitis). Treat some other non-autoimmune inflammatory diseases (e.g., long term allergic asthma control).A common side-effect of many immunosuppressive drugs is immunodeficiency, because the majority of them act non-selectively, resulting in increased susceptibility to infections and decreased cancer immunosurveillance. There are also other side-effects, such as hypertension, dyslipidemia, hyperglycemia, peptic ulcers, lipodystrophy, moon face, liver and kidney injury. The immunosuppressive drugs also interact with other medicines and affect their metabolism and action. Actual or suspected immunosuppressive agents can be evaluated in terms of their effects on lymphocyte subpopulations in tissues using immunohistochemistry.Immunosuppressive drugs can be classified into five groups: glucocorticoids cytostatics antibodies drugs acting on immunophilins other drugs.
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