CURRICULUM VITAE - University of Oxford
... trial. More recently, in collaboration with Professor Cerundolo, we have found that allergens generate neolipids which are novel ligands for CD1a, and can be presented to CD1arestricted T cells from human skin. We believe that this is an important finding, not only for CD1a and Langerhans cell biolo ...
... trial. More recently, in collaboration with Professor Cerundolo, we have found that allergens generate neolipids which are novel ligands for CD1a, and can be presented to CD1arestricted T cells from human skin. We believe that this is an important finding, not only for CD1a and Langerhans cell biolo ...
viruses
... respectively) and incubated at 37 °C in a 5% CO2 atmosphere. After 12 hours, the medium was replaced with two-fold serially diluted Epimedium koreanum Nakai (50 aL/well). At 12 hour post treatment (hpt), the cells were washed with PBS once and infected using DMEM containing 1% FBS. RAW264.7 cells we ...
... respectively) and incubated at 37 °C in a 5% CO2 atmosphere. After 12 hours, the medium was replaced with two-fold serially diluted Epimedium koreanum Nakai (50 aL/well). At 12 hour post treatment (hpt), the cells were washed with PBS once and infected using DMEM containing 1% FBS. RAW264.7 cells we ...
as a PDF
... were largely unknown. Toll like receptors (TLRs) have emerged as key transducers of type I IFN during viral infections by recognizing various viral components. Furthermore, much progress has been made in defining the signaling pathways downstream of TLRs for type I IFN production. TLR7 and TLR9 have ...
... were largely unknown. Toll like receptors (TLRs) have emerged as key transducers of type I IFN during viral infections by recognizing various viral components. Furthermore, much progress has been made in defining the signaling pathways downstream of TLRs for type I IFN production. TLR7 and TLR9 have ...
Phenotypic Markers Distinguished by Their Cytokine Profiles and T
... either at 8 days postinfection to study activated T cell responses at the peak of the effector T cell response, or at 280 –300 days p.i. to study memory T cell responses. Fig. 1 shows FACS analysis of IFN-g production by these two T cell populations following direct ex vivo stimulation with the immu ...
... either at 8 days postinfection to study activated T cell responses at the peak of the effector T cell response, or at 280 –300 days p.i. to study memory T cell responses. Fig. 1 shows FACS analysis of IFN-g production by these two T cell populations following direct ex vivo stimulation with the immu ...
Relative ability of ovine follicle stimulating hormone and
... The primary objective of the current study was to understand whether antibodies capable of sequestering FSH circulating in vivo are also able to inhibit FSH response in vitro and if so the mechanism by which this is achieved. All studies carried out hitherto on bioneutralization of endogenous FSH ha ...
... The primary objective of the current study was to understand whether antibodies capable of sequestering FSH circulating in vivo are also able to inhibit FSH response in vitro and if so the mechanism by which this is achieved. All studies carried out hitherto on bioneutralization of endogenous FSH ha ...
Cytokines
... The Complexity of Cytokine-Receptor Signaling and Effects What cytokine is being made? When is it being made? At what concentration? How long will it be around? Is it being modified by other proteins? Activated? Degraded? What other cytokines are being made? Do they affect the first cytokine? Do t ...
... The Complexity of Cytokine-Receptor Signaling and Effects What cytokine is being made? When is it being made? At what concentration? How long will it be around? Is it being modified by other proteins? Activated? Degraded? What other cytokines are being made? Do they affect the first cytokine? Do t ...
bt 6602 immunology dr.r.b.narayanan
... Development, maturation, activation and differentiation of T-cells and B-cells. TCR. Antibodies - Structure and Functions. Antibodies - Genes and Generation of diversity. Antigen-Antibody reactions. Antigen presenting cells. Major histocompatibility complex. Regulation of T-cell and B-cell responses ...
... Development, maturation, activation and differentiation of T-cells and B-cells. TCR. Antibodies - Structure and Functions. Antibodies - Genes and Generation of diversity. Antigen-Antibody reactions. Antigen presenting cells. Major histocompatibility complex. Regulation of T-cell and B-cell responses ...
Mammalian Stem Cells - National Human Neural Stem Cell Resource
... Another clear example of actively proliferating long-term HSCs is in the fetal liver. In fact, fetal liver HSCs are even more potent in long-term reconstitution assays than adult HSCs (36). Mobilization of HSCs by cyclophosphamide and granulocyte colony-stimulating factor also result in proliferatio ...
... Another clear example of actively proliferating long-term HSCs is in the fetal liver. In fact, fetal liver HSCs are even more potent in long-term reconstitution assays than adult HSCs (36). Mobilization of HSCs by cyclophosphamide and granulocyte colony-stimulating factor also result in proliferatio ...
Complement-induced regulatory T cells suppress T
... were used to isolate peripheral CD4⫹ T lymphocytes or monocytes, respectively. Monoclonal Abs to human CD3 (HIT3a), CD4 (RPA-T4), CD45RA (HI100), and CD45RO (UCHL1), labeled with FITC, PE, allophycocyanin, or PerCP, were used for cell sorting and obtained from BD Bioscience. Primary-labeled mAbs to ...
... were used to isolate peripheral CD4⫹ T lymphocytes or monocytes, respectively. Monoclonal Abs to human CD3 (HIT3a), CD4 (RPA-T4), CD45RA (HI100), and CD45RO (UCHL1), labeled with FITC, PE, allophycocyanin, or PerCP, were used for cell sorting and obtained from BD Bioscience. Primary-labeled mAbs to ...
Fighting Intestinal Infections with Immunobiotic Lactic Acid Bacteria
... clinical disease in human and animal hosts. The molecular tools available to study Salmonella as well as suitable animal models for salmonellosis, have provided optimal conditions to drive scientists to generate a large expansion of our knowledge about the pathogenesis of Salmonella-induced enteroco ...
... clinical disease in human and animal hosts. The molecular tools available to study Salmonella as well as suitable animal models for salmonellosis, have provided optimal conditions to drive scientists to generate a large expansion of our knowledge about the pathogenesis of Salmonella-induced enteroco ...
Interaction between tumour-infiltrating B cells and T cells controls
... inflammatory conditions, including cancer.8 Multiple costimulatory and coinhibitory molecules that are expressed on T cells have been the recent targets of a new generation of immunotherapies, such as anti-CTLA-4, anti-PD-1/PD-L1 or anti-OX40 antibodies, which aim to enhance the local antitumour immu ...
... inflammatory conditions, including cancer.8 Multiple costimulatory and coinhibitory molecules that are expressed on T cells have been the recent targets of a new generation of immunotherapies, such as anti-CTLA-4, anti-PD-1/PD-L1 or anti-OX40 antibodies, which aim to enhance the local antitumour immu ...
Immune memory in CD4+ CD45RA+ T cells
... limiting dilution following 10 days of bulk culture with D. pteronyssinus antigen. Sixty-eight clones were obtained from CD4+ CD45RO+ and 24 from CD4+ CD45RA+ T cells. All clones were CD3+ CD4+ CD45RO+ and proliferated in response to D. pteronyssinus antigens. Of 40 clones tested, none responded to ...
... limiting dilution following 10 days of bulk culture with D. pteronyssinus antigen. Sixty-eight clones were obtained from CD4+ CD45RO+ and 24 from CD4+ CD45RA+ T cells. All clones were CD3+ CD4+ CD45RO+ and proliferated in response to D. pteronyssinus antigens. Of 40 clones tested, none responded to ...
Precision Calf Nutrition
... a. Plasma protein is a functional protein which can both increase intestinal health and provide dietary protein. b. Other alternative proteins such as soy and wheat protein can be processed to reduce anti-nutritional properties, included in milk replacer, and result in somewhat comparable calf perf ...
... a. Plasma protein is a functional protein which can both increase intestinal health and provide dietary protein. b. Other alternative proteins such as soy and wheat protein can be processed to reduce anti-nutritional properties, included in milk replacer, and result in somewhat comparable calf perf ...
Licentiate thesis from the Department of Immunology,
... animals. It has evolved throughout the years, and its complex network of cells and molecules can distinguish between invading pathogens and the body’s own cells. Traditionally, the immune responses raised to an invading pathogen are divided into innate immune responses and adaptive immune responses. ...
... animals. It has evolved throughout the years, and its complex network of cells and molecules can distinguish between invading pathogens and the body’s own cells. Traditionally, the immune responses raised to an invading pathogen are divided into innate immune responses and adaptive immune responses. ...
Predicting pathogen-specific CD8 T cell immune responses
... cytoplasm. The WR strain of vaccinia used in this study is a vaccinal strain that was adapted to the mouse [18]. Despite their importance, T cell mechanisms involved in a vaccinia infection were not thoroughly studied [4]. However, smallpox vaccines could be improved, since the existing vaccines are ...
... cytoplasm. The WR strain of vaccinia used in this study is a vaccinal strain that was adapted to the mouse [18]. Despite their importance, T cell mechanisms involved in a vaccinia infection were not thoroughly studied [4]. However, smallpox vaccines could be improved, since the existing vaccines are ...
the role of dual specificity phosphatase
... the host against pathogens (Delves and Roitt, 2000a, b). Fundamentally, immune responses against microbes are classified either as innate or adaptive immune responses. Innate immune responses serve as a first line of defense against infections. However, they are not specific and are not usually suff ...
... the host against pathogens (Delves and Roitt, 2000a, b). Fundamentally, immune responses against microbes are classified either as innate or adaptive immune responses. Innate immune responses serve as a first line of defense against infections. However, they are not specific and are not usually suff ...
Immune response of the small intestinal mucosa in children with
... expressed at lower levels in CD patients compared to controls. In addition, IELs expressing RAG1 were less abundant in CD patients compared to controls. The levels of these two indicators stayed low in treated CD patients, suggesting that impaired capacity of ETCM is an inherent feature of CD. Seco ...
... expressed at lower levels in CD patients compared to controls. In addition, IELs expressing RAG1 were less abundant in CD patients compared to controls. The levels of these two indicators stayed low in treated CD patients, suggesting that impaired capacity of ETCM is an inherent feature of CD. Seco ...