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Studies on the Genetic Basis of P k, P and P1 Blood Group Antigen
Studies on the Genetic Basis of P k, P and P1 Blood Group Antigen

Atlantic salmon type I interferons: Protection against virus infection in
Atlantic salmon type I interferons: Protection against virus infection in

... attacked by several viruses, which represent a continuous threat to the aquaculture industry and cause large economic losses. Infectious salmon anemia (ISA) is caused by ISA virus (ISAV), which belong to the Orthomyxoviridae family (3). Fish infected by this disease show anaemia in blood system and ...
the complement system
the complement system

... Moreover, the factor P designated for Properdin, is a glycoprotein which once was thought to be an activating agent in classical pathway. It is now shown that factor P helps in binding Bb to C3 and stabilizing C3b, Bb complex. Complexes between two or more proteins, for instance, C3b and Bb are repr ...
Exosomes, your body`s answer to immune health
Exosomes, your body`s answer to immune health

... to correlate with disease states (3,11). It has been widely reported that exosomes can transport miRNAs that are functional in recipient cells, thereby mediating cell-tocell communication. Therefore, miRNAs might display a protective role in attenuating inflammation or modulating the immune response ...
Anti-Terrorism, Crime and Security Act (Pathogens and Toxins)
Anti-Terrorism, Crime and Security Act (Pathogens and Toxins)

... premises holding scheduled material. Principal Investigators should contact their SSA and the UBSO before using any material on this list (so that the premises can be inspected and NaCTSO notified) or when any information previously given changes. ...
Mucosal Immunology
Mucosal Immunology

anthrax-poster
anthrax-poster

... affected meat, though this form of anthrax infection is a rarity in the United States. Cutaneous anthrax, the most common manifestation and least lethal, is contracted through an opening in the skin, upon which the spores enter. When anthrax spores are inhaled, the deadliest form of transmission, th ...
Signatures in HIV-1 Infection Reveals Stage
Signatures in HIV-1 Infection Reveals Stage

chapter 5 complement
chapter 5 complement

... causes cholera) by immune sera, and found that the ability of an immune serum to lyse its targets was lost upon heating (e.g., at 56° C for 30 min). This ability to cause lysis was also lost after simple storage of the serum for a few days at room temperature. Bordet showed that such heating did not ...
Thermal ablation of tumours: biological
Thermal ablation of tumours: biological

... These immune cell subsets have also been observed in distant, untreated tumours26, as well as peripherally in the bloodstream27–29 in both patients and animals; these results suggest an overall immune activation by RFA. Mechanical cell damage that is caused by heat-induced necrosis releases various ...
A novel adenosine A receptor antagonist optimized for high potency
A novel adenosine A receptor antagonist optimized for high potency

... environment and restored cytokine production even in the presence of high concentrations of A2A agonists. Furthermore, our compound was able to potently increase CD8 T cell cytotoxicity in a cytotoxicity assay with CD8 T cells as effectors and cancer cells as targets. These results suggest that iTeo ...
Obstacles to ideal anti-HIV antibody-dependent cellular cytotoxicity
Obstacles to ideal anti-HIV antibody-dependent cellular cytotoxicity

... in slow progressors [19], and immunodeficiency virus-infected macaques that have slow progressing infections sustain higher ADCC responses than animals with more rapid disease progression [20]. Furthermore, and perhaps most impressive, elegant experiments have revealed that some of the protection con ...
CD39 is involved in mediating suppression by Mycobacterium bovis
CD39 is involved in mediating suppression by Mycobacterium bovis

N E W S L E T T E R - Australasian Society for Immunology
N E W S L E T T E R - Australasian Society for Immunology

... Newsletter. It hasn’t been my goal to specifically increase the size of the Newsletter, but I suppose it is the natural effect of trying to tell more of the story of ASI and its members. And with 1000 intelligent and active members, there’s lots to tell. It’s slightly ironic, however, that as the Ne ...
Regulatory T-lymphocytes in asthma REVIEW A.J.M. van Oosterhout* and N. Bloksma
Regulatory T-lymphocytes in asthma REVIEW A.J.M. van Oosterhout* and N. Bloksma

... rodents. nTreg cells express a normal a/b TCR repertoire and can be activated by anti-CD3 [24, 26, 27]. It has been shown that nTreg cells have a high TCR affinity for self-peptides that might be encountered in the periphery, which may explain the constitutive expression of the activation marker, CD ...
IgG2 subclass isotype antibody and intrauterine
IgG2 subclass isotype antibody and intrauterine

... infections with Haemophilus influenzae, Neisseria meningitides and Streptococcus pnemoniae, thus proving the tolerance of IgG2 against such pathogens4. Though the predominant subclass isotype antibody produced in response to polysaccharide and capsular antigens is IgG2, because of lack of its corres ...
Texas Tech University Health Science Center School of Medicine
Texas Tech University Health Science Center School of Medicine

... D. C3b released was in an inert form and unable to be activated E. IgE is involved and stimulated the classical pathway of complement activation 971/ 24. In the final stage of a correctly performed complement fixation test, when the antibody (anti-sheep red blood cell) coated sheep red blood cells u ...
Aging, Persistent Viral Infections, and Immunosenescence: Can
Aging, Persistent Viral Infections, and Immunosenescence: Can

Glycosaminoglycan-binding microbial proteins in tissue adhesion
Glycosaminoglycan-binding microbial proteins in tissue adhesion

... ECM-associated molecules and cell-surface glycoconjugates. Cell-surface extracts of micro-organisms binding 1251-labelledGAG molecules or solubilised virus proteins can be used in similar inhibition assays. The use of glycosidases, as described above, is helpful. Such experiments should also be perf ...
A review on transfer factor an immune modulator
A review on transfer factor an immune modulator

... been reported so far with transfer factor,35 and valuable when administered orally as well as by injection.17,36 Long-term oral administration is convenient,37 safe38,39 and easily accepted37 by infants, elderly people who are at the risk for numerous infections. Dresseler and Rosenfield40 reported, ...
poster template - Argos Therapeutics
poster template - Argos Therapeutics

... AGS-003, an autologous dendritic cell (DC) immunotherapy has recently been evaluated in combination with sunitinib in AGS-003-006, an open label phase 2 trial for treatment of patients with newly diagnosed, unfavorable-risk, metastatic renal cell carcinoma (mRCC). The mechanism of action (MOA) of AG ...
SYLVIA ELLINGER, RUDI GLOCKSHUBER, GERHARD JAHN, 1
SYLVIA ELLINGER, RUDI GLOCKSHUBER, GERHARD JAHN, 1

... Expression of HIV gag antigens cloned into pROS. For the expression of HIV gag proteins in E. coli, the 1.7-kilobase Ssti-Bcll fragment of BH10 (residues 681 to 2464, Fig. 2), containing the entire gag gene of HIV type 1, was cloned between the SstI and BamHI sites of the poly linker region of pUC19 ...
Hepatitis B virus: from immunobiology to
Hepatitis B virus: from immunobiology to

... Several studies have clearly shown a correlation between vigorous and multi-specific CD8 + T-cell responses and HBV clearance (Table 1). The central role of CD8 + T-cells has been further confirmed by depletion studies [47]. In acute self-limiting infection, HBV-DNA falls rapidly after the peak of v ...
Type I interferons in anticancer immunity
Type I interferons in anticancer immunity

The origin and role of innate lymphoid cells in the lung | Military
The origin and role of innate lymphoid cells in the lung | Military

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Molecular mimicry

Molecular mimicry is defined as the theoretical possibility that sequence similarities between foreign and self-peptides are sufficient to result in the cross-activation of autoreactive T or B cells by pathogen-derived peptides. Despite the promiscuity of several peptide sequences which can be both foreign and self in nature, a single antibody or TCR (T cell receptor) can be activated by even a few crucial residues which stresses the importance of structural homology in the theory of molecular mimicry. Upon the activation of B or T cells, it is believed that these ""peptide mimic"" specific T or B cells can cross-react with self-epitopes, thus leading to tissue pathology (autoimmunity). Molecular mimicry is a phenomenon that has been just recently discovered as one of several ways in which autoimmunity can be evoked. A molecular mimicking event is, however, more than an epiphenomenon despite its low statistical probability of occurring and these events have serious implications in the onset of many human autoimmune disorders. In the past decade the study of autoimmunity, the failure to recognize self antigens as ""self,"" has grown immensely. Autoimmunity is a result of a loss of immunological tolerance, the ability for an individual to discriminate between self and non-self. Growth in the field of autoimmunity has resulted in more and more frequent diagnosis of autoimmune diseases. Consequently, recent data show that autoimmune diseases affect approximately 1 in 31 people within the general population. Growth has also led to a greater characterization of what autoimmunity is and how it can be studied and treated. With an increased amount of research, there has been tremendous growth in the study of the several different ways in which autoimmunity can occur, one of which is molecular mimicry. The mechanism by which pathogens have evolved, or obtained by chance, similar amino acid sequences or the homologous three-dimensional crystal structure of immunodominant epitopes remains a mystery.
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