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Reish MAX
Reish MAX

... and longevity • stimulates the formation of antibodies • stimulates the ability of proliferation of immune cells • modulates the function of T cells and NK cells Wang SY, et al. International Journal of Cancer 1997;70(6):699-705. Lu Z, Lin ZB. 1994 International Symposium on Ganoderma Research, Octo ...
MicroReview Metal ion homeostasis and intracellular
MicroReview Metal ion homeostasis and intracellular

Mechanisms of viral emergence
Mechanisms of viral emergence

... infected hosts RNA viruses replicate as complex distributions of related genomes termed viral quasispecies. Here two out of multiple distributions are represented. Horizontal lines depict individual genomes and symbols on the lines represent different mutation types (transitions, transversions and s ...
Bloodless revolution
Bloodless revolution

... cells contrasts with the concept of paracrine nutrition of lymphoid cells, but is consistent with reports that blood-borne mononuclear cells from Crohn’s disease patients contain more, not less, n-3 polyunsaturated fatty acids. General defects in perinodal adipose tissue leading to impaired immune f ...
Full Text
Full Text

Regulatory T Helper Cells in Pregnancy and Tolerance Linköping University Post Print
Regulatory T Helper Cells in Pregnancy and Tolerance Linköping University Post Print

... development of organ-specific autoimmune diseases such as gastritis, oophoritis and thyroiditis. Notably, inflammatory disease was prevented by co-transfer of CD4+CD25+ cells. Subsequently it was shown that these cells migrate from thymus as a distinct cell subset32. In humans, the cell type corresp ...
A review of the human vs. porcine female genital tract
A review of the human vs. porcine female genital tract

... Full list of author information is available at the end of the article ...
The Immune System and Its Ecology - BU Blogs
The Immune System and Its Ecology - BU Blogs

Mannose-binding lectin binds to Ebola and Marburg envelope
Mannose-binding lectin binds to Ebola and Marburg envelope

Bee Propolis: Ancient Cure for Today`s Ailments
Bee Propolis: Ancient Cure for Today`s Ailments

... Propolis increased IFN-γ production leading to the antigen being presented on cells and the immune response starting to clear it faster. Mitogen infected cells did not show proliferation that would normally happen. Kept mitogen from working. ...
Examples of Supervisors and Research Projects (Wellcome)
Examples of Supervisors and Research Projects (Wellcome)

... signatures to understand cardiovascular disease mechanisms Metagenomics of the lung microbiome in health and disease Integrating complex data structures to identify subtypes of childhood asthma: a probabilistic machine learning approach New tools for analysis of short highly multivariate time series ...
PDF
PDF

... as a means to explore the role of the immune response in influenza viral dynamics. Our data affords us the opportunity to examine the relative importance and feasibility of different hypothesised mechanisms of the innate immune response, complementing the work of others who have studied how immunity ...
PATHOPHYSIOLOGY COURSE
PATHOPHYSIOLOGY COURSE

... antigen. The antibody is linked to an enzyme, and in the final step a substance (conjugate) is added that the enzyme can convert to some detectable signal. For example, in fluorescence ELISA, the antigen/antibody complex fluoresces upon exposure to light of the appropriate wavelength. Mechanisms of ...
Acute and chronic inflammation
Acute and chronic inflammation

Direct Delivery of Antigens to Dendritic Cells via Antibodies Specific
Direct Delivery of Antigens to Dendritic Cells via Antibodies Specific

... ensuring a full DC maturation (Figure 1a). This maturation process seems to be a critical step in the production of therapeutic moDCs, as the appropriate time point and the maturation cocktail composition determine the efficiency of the peptide-loaded moDCs to migrate into the patients’ lymph nodes ...
Department of Immunology, the Wenner-Gren Institute Stockholm University, Stockholm, Sweden Doctoral thesis
Department of Immunology, the Wenner-Gren Institute Stockholm University, Stockholm, Sweden Doctoral thesis

... of antibodies in the complex immune responses during a malaria infection. Our results suggest that the higher anti-malarial immune responses seen in the Fulani, are not due to a general hyper-responsiveness in this group, but neither a malaria specific response. Rather, the higher responses in the F ...
1. Apoptosis
1. Apoptosis

... characterized by defects in apoptosis leading to immortal clones of cells. Other malignancies have defects in the apoptotic regulatory pathways such as p53 (Kaufmann, 2001). Apoptosis plays an important role in the pathogenesis of cholesteatoma (Olszewska, 2005). The understanding of apoptosis has p ...
Full-Text PDF
Full-Text PDF

... associated with elevated production of antibodies and transitional B cells [30]. At the same time, a polymorphism in the gene of the tyrosine phosphatase PTPN22 (C1858T), which is associated with SLE susceptibility, leads to a substitution of a tryptophan to an arginine (R620W) which reduces the bin ...
Activators - U of M wiki
Activators - U of M wiki

... Activation of C5 and the Terminal Complement Pathway  C5 is cleaved by either the Classical Pathway C5 convertase (C4b2aC3b) or by the Alternative Pathway C5 convertase (C3bBbC3b) into 2 fragments: C5a and C5b.  Cleavage of C5 is the last enzymatic step  C5b binds to a target and then interacts ...
D9 -Tetrahydrocannabinol attenuates allogeneic host-versus
D9 -Tetrahydrocannabinol attenuates allogeneic host-versus

... been shown to trigger potent immunosuppression. Despite such studies, the role of cannabinoids in transplantation, specifically to prevent allograft rejection, has not, to our knowledge, been investigated previously. In the current study, we tested the effect of THC on the suppression of HvGD as wel ...
Pinto, A. K., A. M. Jamieson, D. H. Raulet, and A. B. Hill. 2007. The role of NKG2D signaling in inhibition of cytotoxic T-lymphocyte lysis by the Murine cytomegalovirus immunoevasin m152/gp40. J. Viro 81:12564-12571 .
Pinto, A. K., A. M. Jamieson, D. H. Raulet, and A. B. Hill. 2007. The role of NKG2D signaling in inhibition of cytotoxic T-lymphocyte lysis by the Murine cytomegalovirus immunoevasin m152/gp40. J. Viro 81:12564-12571 .

... CTL lysis appears greater than would be expected based on its impact on cell surface major histocompatibility complex (MHC) class I. In addition to MHC class I, m152/gp40 also downregulates the RAE-1 family of NKG2D ligands, which can provide costimulation for CD8 T cells. We hypothesized that m152/ ...
Document
Document

...  Tumor necrosis factor, IL-2, and interferons may kill cancer cells.  Immunotoxins link poisons with an monoclonal antibody ...
General Characteristics
General Characteristics

... MYCOPLASMA & UREPLASMA LAB DIAGNOSIS Culture : “Fried egg” colonies on specialized medium  Cold Agglutinin detection A titer of 1:128 or higher – indicates recent infection TREATMENT Tetracycline OR Spectinomycin ...
Virology: Research and Treatment
Virology: Research and Treatment

... two years following inoculation.16 Numerous studies in squirrel monkeys found that early in infection, the peripheral lymphocytes, spleen, and lymph nodes were major reservoirs for HTLV-1.17–19 It was also determined that infection of squirrel monkeys with HTLV-1 could be divided into two phases of ...
Programação detalhada
Programação detalhada

... are the first cells to differentiate from the embryo, and ultimately form the fetal component of the placenta. Trophoblast cells are the only cells derived from the blastocyst that are in direct contact with maternal blood, and therefore play an essential role in protecting the fetus from attack fro ...
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Molecular mimicry

Molecular mimicry is defined as the theoretical possibility that sequence similarities between foreign and self-peptides are sufficient to result in the cross-activation of autoreactive T or B cells by pathogen-derived peptides. Despite the promiscuity of several peptide sequences which can be both foreign and self in nature, a single antibody or TCR (T cell receptor) can be activated by even a few crucial residues which stresses the importance of structural homology in the theory of molecular mimicry. Upon the activation of B or T cells, it is believed that these ""peptide mimic"" specific T or B cells can cross-react with self-epitopes, thus leading to tissue pathology (autoimmunity). Molecular mimicry is a phenomenon that has been just recently discovered as one of several ways in which autoimmunity can be evoked. A molecular mimicking event is, however, more than an epiphenomenon despite its low statistical probability of occurring and these events have serious implications in the onset of many human autoimmune disorders. In the past decade the study of autoimmunity, the failure to recognize self antigens as ""self,"" has grown immensely. Autoimmunity is a result of a loss of immunological tolerance, the ability for an individual to discriminate between self and non-self. Growth in the field of autoimmunity has resulted in more and more frequent diagnosis of autoimmune diseases. Consequently, recent data show that autoimmune diseases affect approximately 1 in 31 people within the general population. Growth has also led to a greater characterization of what autoimmunity is and how it can be studied and treated. With an increased amount of research, there has been tremendous growth in the study of the several different ways in which autoimmunity can occur, one of which is molecular mimicry. The mechanism by which pathogens have evolved, or obtained by chance, similar amino acid sequences or the homologous three-dimensional crystal structure of immunodominant epitopes remains a mystery.
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