• Study Resource
  • Explore
    • Arts & Humanities
    • Business
    • Engineering & Technology
    • Foreign Language
    • History
    • Math
    • Science
    • Social Science

    Top subcategories

    • Advanced Math
    • Algebra
    • Basic Math
    • Calculus
    • Geometry
    • Linear Algebra
    • Pre-Algebra
    • Pre-Calculus
    • Statistics And Probability
    • Trigonometry
    • other →

    Top subcategories

    • Astronomy
    • Astrophysics
    • Biology
    • Chemistry
    • Earth Science
    • Environmental Science
    • Health Science
    • Physics
    • other →

    Top subcategories

    • Anthropology
    • Law
    • Political Science
    • Psychology
    • Sociology
    • other →

    Top subcategories

    • Accounting
    • Economics
    • Finance
    • Management
    • other →

    Top subcategories

    • Aerospace Engineering
    • Bioengineering
    • Chemical Engineering
    • Civil Engineering
    • Computer Science
    • Electrical Engineering
    • Industrial Engineering
    • Mechanical Engineering
    • Web Design
    • other →

    Top subcategories

    • Architecture
    • Communications
    • English
    • Gender Studies
    • Music
    • Performing Arts
    • Philosophy
    • Religious Studies
    • Writing
    • other →

    Top subcategories

    • Ancient History
    • European History
    • US History
    • World History
    • other →

    Top subcategories

    • Croatian
    • Czech
    • Finnish
    • Greek
    • Hindi
    • Japanese
    • Korean
    • Persian
    • Swedish
    • Turkish
    • other →
 
Profile Documents Logout
Upload
Immune Health - Naturally - Professional Complementary Health
Immune Health - Naturally - Professional Complementary Health

... the body in cases of bacterial gastroenteritis, inflammatory bowel diseases, urinary tract infection, and post-surgical infections. Glands that comprise the endocrine system interact with our immune systems in highly complex ways. Abnormalities of T-suppressor cells can result in autoimmune conditio ...
Lymphocytic hypophysitis: a rare or underestimated disease?
Lymphocytic hypophysitis: a rare or underestimated disease?

... granulomatous hypophysitis (GRH), and xanthomatous hypophysitis (XH). It is unclear whether these are truly distinct entities or only different expressions of the same disease, since they share clinical and radiological features and can only be distinguished from each ...
A dissection of T cell receptor signaling pathways
A dissection of T cell receptor signaling pathways

... The design of such supplements has been hindered by our limited mechanistic understanding of the effects of microgravity on T cell activation and function. The available data strongly implicates a defect in the ability of T cells to respond to antigenreceptor signals during exposure to microgravity ...
Research Projects 2016 - School of Chemistry and Molecular
Research Projects 2016 - School of Chemistry and Molecular

The Pseudomonas syringae Type III Effector
The Pseudomonas syringae Type III Effector

Epitope Specificity of Anti-Citrullinated Protein Antibodies
Epitope Specificity of Anti-Citrullinated Protein Antibodies

... The presence of ACPAs is associated with poor disease outcomes, such as increased disease activity, radiographic progression, disability and increased mortality [49–52]. In addition, studies find that the presence of ACPA in patients with early arthritis predicts disease progression, as ACPA-positiv ...
Restricted Biological Agents
Restricted Biological Agents

... Below is a list of agents restricted for export by the U.S. Government. Be aware that this list is not exhaustive but is limited to biological agents likely to be used at VUMC that have export control restrictions. ...
Document
Document

... body’s natural resistance and physical well being, resulting in optimum health. ...
Mucosal Immunity in Mycobacterial Infections  Anna Tjärnlund
Mucosal Immunity in Mycobacterial Infections Anna Tjärnlund

... presented to T cells. Mycobacteria appear to increase the retention of the tryptophan-aspartate containing coat (TACO) protein on the surface of the mycobacterial phagosome, thereby preventing phagosome-lysosome fusion (Ferrari et al., 1999). Moreover, characterization of mycobacterial phagosomes ha ...
To benefit from the full content of Nature Reviews Microbiology
To benefit from the full content of Nature Reviews Microbiology

Mesenchymal Stem Cells
Mesenchymal Stem Cells

... [12]. Many reports have also described MSCs as having immunosuppressive properties, specifically that MSCs can modulate many T-cell functions including cell activation [39, 40]. This suppression appears to be independent of MHC matching between the MSCs and the T cells. Some reports have demonstrate ...
Workshop summary Primary immunodeficiency diseases: An update
Workshop summary Primary immunodeficiency diseases: An update

... autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy, and immune dysregulation–polyendocrinopathy–enteropathy–X-linked in the table of diseases of immune regulation (Table IV). The updated classification takes into account that the clinical and immunologic spectrum of PIDs might be more va ...
Full Text - PDF - Donnish Journals
Full Text - PDF - Donnish Journals

... determination of human IFN-γ and IL-10 in serum of patient and control groups. Serum IFN-gamma level showed the distribution of serum levels of IFN-gamma in patients with VL and control group. The levels in the pretreated VL group were (60.87± 3.6) pg/ml higher than control (5.12± 0.98) pg/ml with a ...
Kirvan, et al (2003) Mimicry and Auto-antibody
Kirvan, et al (2003) Mimicry and Auto-antibody

... from a Sydenham chorea patient. Human hybridomas established from fusions of peripheral blood mononuclear cells with the K6H6/B5 cell line resulted in three monoclonal antibodies (24.3.1, 31.1.1 and 37.2.1) that reacted strongly with glutaraldehyde-fixed, whole-cell type 5 S. pyogenes18. Monoclonal ...
Viruses - Sign In
Viruses - Sign In

... up of cells and be able to live independently, then viruses are not alive. However, when they are able to infect living cells, vi¬ ruses can grow, reproduce, regulate gene expression, and even evolve. Viruses have so many of the characteristics of living things that it seems only fair to consider th ...
Methylation - The Hoffman Centre for Integrative Medicine
Methylation - The Hoffman Centre for Integrative Medicine

... optimally,   then   tissues   function   properly.   When   tissues   function   optimally,   then   organs   and   glands   function  properly,  and  when  that  occurs,  the  body  can  live  in  excellent  health.  Seems  simple  enough.   ...
T Cell Expression of MyD88 Is + CD4 Essential for Normal Resolution of
T Cell Expression of MyD88 Is + CD4 Essential for Normal Resolution of

... mouse model (reviewed in Ref. 40). In humans, loss-of-function mutations in MyD88 (41) and IRAK4 (42) have been associated with the development of severe and potentially fatal bacterial infections in children. The importance of MyD88 in promoting adaptive immune responses to pathogens in murine mode ...
Dendritic cells in progressive renal disease: some answers, many
Dendritic cells in progressive renal disease: some answers, many

Whey and Glutathione - Part III
Whey and Glutathione - Part III

... cells at low concentrations. Finally, and most importantly, a fairly recent clinical study with cancer patients showed a regression in some patient's tumors when fed whey protein concentrate at 30 grams per day. Whey and Glutathione New research using whey protein concentrate led researchers to a di ...
Full-Text PDF
Full-Text PDF

... The biological role for CA125 is still under investigation though several studies have demonstrated a relationship between CA125 and the immune system. In 2003 Kui Wong et al. proposed a role in immunity based upon the characterization of the N-oligosaccharide structures identified on CA125 [7]. Thi ...
Introduction to Diagnostic and Therapeutic Monoclonal Antibodies
Introduction to Diagnostic and Therapeutic Monoclonal Antibodies

... routinely follows is to first be introduced in specialized situations that do not involve radiolabeling. Then, as the safety of each antibody product is established, uses targeting the specific site with radiolabeled diagnostic and therapeutic versions become viable. This has been the case for sever ...
Transcript
Transcript

Structure analysis of DNA relaxases, the key enzymes of bacterial
Structure analysis of DNA relaxases, the key enzymes of bacterial

... at around 42°C. CD spectra measured at 20°C showed 30 % α-helix and 13 % β-sheet for TraA and 27 % α-helix and 18 % β-sheet content for the truncated protein. Upon DNAbinding an enhanced secondary structure content and increased thermal stability was observed for the TraAN246 protein suggesting an i ...
ReishiMax Product Training
ReishiMax Product Training

... and longevity • stimulates the formation of antibodies • stimulates the ability of proliferation of immune cells • modulates the function of T cells and NK cells Wang SY, et al. International Journal of Cancer 1997;70(6):699-705. Lu Z, Lin ZB. 1994 International Symposium on Ganoderma Research, Octo ...
Reish MAX
Reish MAX

... and longevity • stimulates the formation of antibodies • stimulates the ability of proliferation of immune cells • modulates the function of T cells and NK cells Wang SY, et al. International Journal of Cancer 1997;70(6):699-705. Lu Z, Lin ZB. 1994 International Symposium on Ganoderma Research, Octo ...
< 1 ... 53 54 55 56 57 58 59 60 61 ... 514 >

Molecular mimicry

Molecular mimicry is defined as the theoretical possibility that sequence similarities between foreign and self-peptides are sufficient to result in the cross-activation of autoreactive T or B cells by pathogen-derived peptides. Despite the promiscuity of several peptide sequences which can be both foreign and self in nature, a single antibody or TCR (T cell receptor) can be activated by even a few crucial residues which stresses the importance of structural homology in the theory of molecular mimicry. Upon the activation of B or T cells, it is believed that these ""peptide mimic"" specific T or B cells can cross-react with self-epitopes, thus leading to tissue pathology (autoimmunity). Molecular mimicry is a phenomenon that has been just recently discovered as one of several ways in which autoimmunity can be evoked. A molecular mimicking event is, however, more than an epiphenomenon despite its low statistical probability of occurring and these events have serious implications in the onset of many human autoimmune disorders. In the past decade the study of autoimmunity, the failure to recognize self antigens as ""self,"" has grown immensely. Autoimmunity is a result of a loss of immunological tolerance, the ability for an individual to discriminate between self and non-self. Growth in the field of autoimmunity has resulted in more and more frequent diagnosis of autoimmune diseases. Consequently, recent data show that autoimmune diseases affect approximately 1 in 31 people within the general population. Growth has also led to a greater characterization of what autoimmunity is and how it can be studied and treated. With an increased amount of research, there has been tremendous growth in the study of the several different ways in which autoimmunity can occur, one of which is molecular mimicry. The mechanism by which pathogens have evolved, or obtained by chance, similar amino acid sequences or the homologous three-dimensional crystal structure of immunodominant epitopes remains a mystery.
  • studyres.com © 2025
  • DMCA
  • Privacy
  • Terms
  • Report