ABSTRACT - Johns Hopkins University
... strength of antigen activation (8). Galectin-3, therefore, is a ubiquitous protein that is involved in every step of the immune response. Galectin-3 and its role in the PDA tumor microenvironment Several studies have demonstrated a critical role for stromal elements in the development of cancer. Int ...
... strength of antigen activation (8). Galectin-3, therefore, is a ubiquitous protein that is involved in every step of the immune response. Galectin-3 and its role in the PDA tumor microenvironment Several studies have demonstrated a critical role for stromal elements in the development of cancer. Int ...
Is the decline of desert bighorn sheep from infectious disease the
... a much more direct approach to studying functional polymorphism within the MHC region. Speci®cally, here we examine the amount of variation for a class II (genes involved in recognizing extracellular antigens, including those from bacteria) MHC gene, DRB. This gene was chosen because it is the most ...
... a much more direct approach to studying functional polymorphism within the MHC region. Speci®cally, here we examine the amount of variation for a class II (genes involved in recognizing extracellular antigens, including those from bacteria) MHC gene, DRB. This gene was chosen because it is the most ...
NIH Public Access - Transcell Biologics
... Despite the well documented immunosuppressive effects of MSCs, recent literature described a dual role for MSCs as immunostimulatory cells as well [11]. As explained above, some studies have reported that MSC can upregulate expression of MHC II when exposed to low levels of inflammation and function ...
... Despite the well documented immunosuppressive effects of MSCs, recent literature described a dual role for MSCs as immunostimulatory cells as well [11]. As explained above, some studies have reported that MSC can upregulate expression of MHC II when exposed to low levels of inflammation and function ...
Divergent TLR7 and TLR9 signaling and type I interferon production
... (Flt3L), sorted the DCs for both subsets and then examined their morphology by electron microscopy (Fig. 1d). Sooty mangabey pDCs and mDCs showed the characteristic features of these cells described in humans and rhesus macaques15,16,20. The migration of activated and maturing DCs to lymph nodes is ...
... (Flt3L), sorted the DCs for both subsets and then examined their morphology by electron microscopy (Fig. 1d). Sooty mangabey pDCs and mDCs showed the characteristic features of these cells described in humans and rhesus macaques15,16,20. The migration of activated and maturing DCs to lymph nodes is ...
Role of complement in health and disease
... • Type III reaction: this reaction is due to excessive formation of immune complex (Ag‐Ab complex) which initiate an inflammatory reaction through the activation of complement system leading to tissue damage. • Localized reaction: in case of antibody excess or antigen antibody equivalence, lar ...
... • Type III reaction: this reaction is due to excessive formation of immune complex (Ag‐Ab complex) which initiate an inflammatory reaction through the activation of complement system leading to tissue damage. • Localized reaction: in case of antibody excess or antigen antibody equivalence, lar ...
Fundamentals of Immunology
... b. Secondary organs are site of co-ordination of information about pathogens and the subsequent activation of cells. 2. Innate versus adaptive cells: innate cells don’t rearrange genes, adaptive ones do. 3. Myeloid versus lymphoid cells: two general categories define by an early branching decision e ...
... b. Secondary organs are site of co-ordination of information about pathogens and the subsequent activation of cells. 2. Innate versus adaptive cells: innate cells don’t rearrange genes, adaptive ones do. 3. Myeloid versus lymphoid cells: two general categories define by an early branching decision e ...
Complement Opsonization of HIV-1 Enhances Endocytic Lectin and Integrin Receptor
... surface receptors) and uptake into the DC (uptake via endocytic events). When binding and uptake of C-HIV and C-IgG-HIV was evaluated against the levels for F-HIV, they showed significantly increased binding to IDC (C-HIV 60% p,0.0005, and C-IgGHIV 89% p,0.005) and MDC (C-HIV 28% p,0.0005, and CIgG- ...
... surface receptors) and uptake into the DC (uptake via endocytic events). When binding and uptake of C-HIV and C-IgG-HIV was evaluated against the levels for F-HIV, they showed significantly increased binding to IDC (C-HIV 60% p,0.0005, and C-IgGHIV 89% p,0.005) and MDC (C-HIV 28% p,0.0005, and CIgG- ...
A1 - Ummafrapp
... genotype, diet, and other possible influences on the microbiota. This allowed us to determine whether the indigenous microbiota in such mice had a stable baseline community structure and whether this community exhibited a consistent response following antibiotic administration. We employed a tag-seq ...
... genotype, diet, and other possible influences on the microbiota. This allowed us to determine whether the indigenous microbiota in such mice had a stable baseline community structure and whether this community exhibited a consistent response following antibiotic administration. We employed a tag-seq ...
A crucial role for B cells in neuroinvasive scrapie
... lymphoid organs to nervous tissue. Alternatively, the apparent protection of B-cell-deficient mice from prions administered i.p. may result from the absence of immunoglobulins. Complexing of PrPSc with antibodies may favour nucleation (a process proposed to underlie the formation of prion infectivit ...
... lymphoid organs to nervous tissue. Alternatively, the apparent protection of B-cell-deficient mice from prions administered i.p. may result from the absence of immunoglobulins. Complexing of PrPSc with antibodies may favour nucleation (a process proposed to underlie the formation of prion infectivit ...
THE FORGOTTEN THYMUS
... knows that the thymus gland has no function in adult life.' But the evidence accumulated over the last twenty years on the thymus gland's role in immunology is so overwhelming that it is hard for me to believe that there is not some unconscious factor working to deny it the recognition due to it." ( ...
... knows that the thymus gland has no function in adult life.' But the evidence accumulated over the last twenty years on the thymus gland's role in immunology is so overwhelming that it is hard for me to believe that there is not some unconscious factor working to deny it the recognition due to it." ( ...
Back to Basics: Regulation of the Gastrointestinal Functions
... formerly known as CCK-A (alimentary) receptor, which is distributed mainly in the alimentary tract, and CCK2, formerly known as CCK-B (brain) receptor, which is distributed mainly in the central nervous system. Sulfation (adding a sulfate group) of CCK affects the binding of the peptide to its recep ...
... formerly known as CCK-A (alimentary) receptor, which is distributed mainly in the alimentary tract, and CCK2, formerly known as CCK-B (brain) receptor, which is distributed mainly in the central nervous system. Sulfation (adding a sulfate group) of CCK affects the binding of the peptide to its recep ...
Plasma Levels of Neopterin and C-Reactive
... depletion is characteristic of HIV disease, subnormal CD4 cell levels can occur in other conditions [3], which may coexist in PLHIV. This includes active TB [4–6]; however the mechanisms involved in TB-related CD4 lymphocytopenia are unclear. In HIV infection, the main cause of CD4 cell depletion an ...
... depletion is characteristic of HIV disease, subnormal CD4 cell levels can occur in other conditions [3], which may coexist in PLHIV. This includes active TB [4–6]; however the mechanisms involved in TB-related CD4 lymphocytopenia are unclear. In HIV infection, the main cause of CD4 cell depletion an ...
Novel Royal Jelly Proteins Identified by Gel-Based and Gel
... extracted and separated by 1-DE followed by using MS compatible silver staining to visualize the protein bands, even the low abundant proteins (Figure 1). The entire lane was sliced into 12 fractions (marked by red boxes and numbered 112), and proteins in each fraction were identified by HPLC-Chip-Q ...
... extracted and separated by 1-DE followed by using MS compatible silver staining to visualize the protein bands, even the low abundant proteins (Figure 1). The entire lane was sliced into 12 fractions (marked by red boxes and numbered 112), and proteins in each fraction were identified by HPLC-Chip-Q ...