Induced CD4+Foxp3+ Regulatory T Cells in Immune Tolerance
... a decisive factor in Helios expression on iTreg cells, rather than in nTreg or iTreg cell origin (30). In this case, the authors used T cells from TCR–transgenic RAG-deficient mice (which lack nTreg cells) and differentiated them to iTreg cells in vitro using TGF-β and IL-2 and two different activati ...
... a decisive factor in Helios expression on iTreg cells, rather than in nTreg or iTreg cell origin (30). In this case, the authors used T cells from TCR–transgenic RAG-deficient mice (which lack nTreg cells) and differentiated them to iTreg cells in vitro using TGF-β and IL-2 and two different activati ...
IOSR Journal of Pharmacy and Biological Sciences (IOSRJPBS)
... the immune system that can prevent autoimmunity [15], thus low levels of vitamin D may disrupt the regulation of the immune system. The involvement of vitamin D in the immune response demonstrates evidence that 1) the vitamin D receptors (VDR) are expressed in various of immune system cells, includi ...
... the immune system that can prevent autoimmunity [15], thus low levels of vitamin D may disrupt the regulation of the immune system. The involvement of vitamin D in the immune response demonstrates evidence that 1) the vitamin D receptors (VDR) are expressed in various of immune system cells, includi ...
Publications_files/Sabiiti et al review 2012
... relatively large focus on these novel, emerging models over the more established and well-used vertebrate systems in order to highlight potential avenues for exploiting new model systems for cryptococcal research. 4.1. Invertebrate Models. Invertebrates can be excellent models for disease. Advantage ...
... relatively large focus on these novel, emerging models over the more established and well-used vertebrate systems in order to highlight potential avenues for exploiting new model systems for cryptococcal research. 4.1. Invertebrate Models. Invertebrates can be excellent models for disease. Advantage ...
Slide 1
... • SSH indicated that septicemic E. coli strains have the ETT2 type of TTSS – ETT2sepsis • ETT2sepsis is degenerate but important for virulence • These results are the first demonstration of the importance of ETT2 in pathogenesis • The biological role of ETT2sepsis probably does not involve classical ...
... • SSH indicated that septicemic E. coli strains have the ETT2 type of TTSS – ETT2sepsis • ETT2sepsis is degenerate but important for virulence • These results are the first demonstration of the importance of ETT2 in pathogenesis • The biological role of ETT2sepsis probably does not involve classical ...
EFFECT OF SHORT TERM USE OF SEDATING AND NON-SEDATING ANTIHISTAMINES... WOUND HEALING AND IMMUNE RESPONSE IN RATS
... Antihistamines are widely incorporated and used in a variety of cold preparations, many of them considered over the counter medications; so they are used extensively without medical supervision or control. There is substantial evidence that a defect in innate effector functions of phagocytes (neutro ...
... Antihistamines are widely incorporated and used in a variety of cold preparations, many of them considered over the counter medications; so they are used extensively without medical supervision or control. There is substantial evidence that a defect in innate effector functions of phagocytes (neutro ...
PD-1 Blockade in Chronically HIV-1
... Inhibiting PD-1 signaling in vivo using mAbs to either PD-1 itself or its ligand PD-L1 during chronic LCMV infection dramatically enhanced virus-specific T cell number and function leading to a marked reduction in viral load [14]. The PD-1-PD-L1 pathway was subsequently found to play a major role in ...
... Inhibiting PD-1 signaling in vivo using mAbs to either PD-1 itself or its ligand PD-L1 during chronic LCMV infection dramatically enhanced virus-specific T cell number and function leading to a marked reduction in viral load [14]. The PD-1-PD-L1 pathway was subsequently found to play a major role in ...
Data and Results Graduate Physical and Life Sciences PhD Pharmacology
... modulates dopamine transporter function and dopamine neuron firing rates. Newly-developed compounds that specifically target TAAR1 have recently been investigated in animal models as candidate therapeutics for methamphetamine, cocaine and alcohol abuse. These studies involving classic behavioral mea ...
... modulates dopamine transporter function and dopamine neuron firing rates. Newly-developed compounds that specifically target TAAR1 have recently been investigated in animal models as candidate therapeutics for methamphetamine, cocaine and alcohol abuse. These studies involving classic behavioral mea ...
Expression of CD1d in human scalp skin and hair follicles: hair cycle
... Conclusions: These results suggest that CD1d plays a role in human scalp skin immunology and protection against lipid antigen rich infectious microbes. They also raise the question of whether keratinocytes of the immunoprivileged anagen hair follicle can present lipid antigens to natural killer T ce ...
... Conclusions: These results suggest that CD1d plays a role in human scalp skin immunology and protection against lipid antigen rich infectious microbes. They also raise the question of whether keratinocytes of the immunoprivileged anagen hair follicle can present lipid antigens to natural killer T ce ...
TLR3 Signaling in Macrophages Is Indispensable for the
... IFN-γ has been suggested to play a critical role in the control of EV71 infection [8,12]. To determine the cellular resources of IFN-γ production after EV71 infection, we cultured splenocytes from C57BL/6 mice with EV71M and analyzed IFN-γ production in the culture supernatants. We observed that the ...
... IFN-γ has been suggested to play a critical role in the control of EV71 infection [8,12]. To determine the cellular resources of IFN-γ production after EV71 infection, we cultured splenocytes from C57BL/6 mice with EV71M and analyzed IFN-γ production in the culture supernatants. We observed that the ...
Immunoinformatics: Towards an understanding of species
... First and foremost, I must wholeheartedly give thanks to my supervisor Dr. Mary O’Connell for all her support, enthusiasm, and dedication throughout my time at DCU. I cannot express in words how wonderful working alongside you has been and how truly difficult it was to leave. I know for certain that ...
... First and foremost, I must wholeheartedly give thanks to my supervisor Dr. Mary O’Connell for all her support, enthusiasm, and dedication throughout my time at DCU. I cannot express in words how wonderful working alongside you has been and how truly difficult it was to leave. I know for certain that ...
... TDI-induced asthma [40]. A role for suppressor T-cells in isocyanate-induced asthma has recently been confirmed [41]. We observed that the majority of T-cell clones derived from subjects with TDI-induced asthma are CD8+, capable of producing interleukin-5 (IL-5) but not interleukin-4 (IL-4). The fir ...
Mechanisms of Salivary Gland Secretory Dysfunction in Sjögren`s
... salivary gland (HSG) cells in vitro (Wang et al. 2009). In addition, TNF- can disrupt tight junction structure in salivary glands from SS patients, potentially resulting in secretory dysfunction (Ewert et al. 2010, ; Baker 2010). IL-18 and its inducer IL-12 are cytokines that play an important role ...
... salivary gland (HSG) cells in vitro (Wang et al. 2009). In addition, TNF- can disrupt tight junction structure in salivary glands from SS patients, potentially resulting in secretory dysfunction (Ewert et al. 2010, ; Baker 2010). IL-18 and its inducer IL-12 are cytokines that play an important role ...
Defense Mechanisms against Influenza Virus Infection in the
... of defense against virus infection. Viruses are initially detected and destroyed non-specifically by innate immune mechanisms, but if the viruses escape the early defense mechanisms, they are detected and eliminated specifically by adaptive immune mechanisms. The major adaptive immune mechanisms are ...
... of defense against virus infection. Viruses are initially detected and destroyed non-specifically by innate immune mechanisms, but if the viruses escape the early defense mechanisms, they are detected and eliminated specifically by adaptive immune mechanisms. The major adaptive immune mechanisms are ...
Comparison of a reverse transcription-polymerase chain
... was conducted, using CSFV grown in tissue culture and tonsil tissues from a CSFV-infected pig. For both infected tissues and tissue culture fluids, RT-PCR was ten times more sensitive than VI-IPA. Amounts as small as 0.6 infectious units per 100 mg of tissue were detected by RT-PCR, compared to 6 in ...
... was conducted, using CSFV grown in tissue culture and tonsil tissues from a CSFV-infected pig. For both infected tissues and tissue culture fluids, RT-PCR was ten times more sensitive than VI-IPA. Amounts as small as 0.6 infectious units per 100 mg of tissue were detected by RT-PCR, compared to 6 in ...
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Full-Text PDF
... hypothetically ensures that infectious virions are not lost to redundant infection events. In addition, CD4 downregulation promotes viral egress by preventing the binding of newly synthesized gp120 protein to CD4 within the vesicular system prior to virion assembly [30] or at the cell surface where ...
... hypothetically ensures that infectious virions are not lost to redundant infection events. In addition, CD4 downregulation promotes viral egress by preventing the binding of newly synthesized gp120 protein to CD4 within the vesicular system prior to virion assembly [30] or at the cell surface where ...
Sleeping sickness and the central nervous system* V.W. PENTREATH P.J. BAUGH
... cells, which become a target for the immune response (Pepin & Milord 1991). Alternatively, the response may be due to the incomplete killing of trypanosomes behind the blood-brain barrier, which then provoke the reactive encephalopathy (Jennings, Hunter, Kennedy & Murray 1993). Neuro-immune changes ...
... cells, which become a target for the immune response (Pepin & Milord 1991). Alternatively, the response may be due to the incomplete killing of trypanosomes behind the blood-brain barrier, which then provoke the reactive encephalopathy (Jennings, Hunter, Kennedy & Murray 1993). Neuro-immune changes ...
Locusts increase carbohydrate consumption to protect against a
... et al., 2009; Smilanich et al., 2011), known as ‘‘therapeutic medication’’ (de Roode and Lefevre, 2012). Therapeutic self-medication does not necessarily rely on the consumption of chemical substances, but may also be facilitated through the interaction between nutrition and physiological immune res ...
... et al., 2009; Smilanich et al., 2011), known as ‘‘therapeutic medication’’ (de Roode and Lefevre, 2012). Therapeutic self-medication does not necessarily rely on the consumption of chemical substances, but may also be facilitated through the interaction between nutrition and physiological immune res ...
Disease ecology meets ecological immunology
... during the winter months. In humans, vitamin D deficiency caused by limited exposure to sunlight has been linked with a higher incidence of respiratory infections and lower expression of antimicrobial peptides (Cannell et al. 2006). For example, one study of pneumococcal disease in humans showed that ...
... during the winter months. In humans, vitamin D deficiency caused by limited exposure to sunlight has been linked with a higher incidence of respiratory infections and lower expression of antimicrobial peptides (Cannell et al. 2006). For example, one study of pneumococcal disease in humans showed that ...
T/F HIV-1 Bx11 - International AIDS Society
... T-cells The increased immune sensing pDC maturation during pDC/lymphocyte cross talk efficient innate immune responses and may be of able to control viral infection might IFN-αpromote induction was not inhibited following VRC01 inhibition HIV-1 or IDV treatment (72h PI, HIV-1Bx11, n = 3 donors) (me ...
... T-cells The increased immune sensing pDC maturation during pDC/lymphocyte cross talk efficient innate immune responses and may be of able to control viral infection might IFN-αpromote induction was not inhibited following VRC01 inhibition HIV-1 or IDV treatment (72h PI, HIV-1Bx11, n = 3 donors) (me ...
The Emerging Role of Metagenomics in the Diagnosis of Infectious
... technically generate whole-genome sequence data of microbes, not limited to certain regions of the microbe genome in traditional approach. The metagenomics-based identification result would reflect the comprehensive characteristics of microbes in the sample without bias, as shown by the Human Microb ...
... technically generate whole-genome sequence data of microbes, not limited to certain regions of the microbe genome in traditional approach. The metagenomics-based identification result would reflect the comprehensive characteristics of microbes in the sample without bias, as shown by the Human Microb ...
The Most Cunning Parasite From an Immunological Perspective
... complement proteins from attaching to their surfaces. They can even release molecules that act as decoys, telling the killer proteins to leave them alone. They are able release other proteins that are able to protect them from being eaten, although how exactly this is accomplished is still unknown. ...
... complement proteins from attaching to their surfaces. They can even release molecules that act as decoys, telling the killer proteins to leave them alone. They are able release other proteins that are able to protect them from being eaten, although how exactly this is accomplished is still unknown. ...