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Specific Immunity - Austin Community College
Specific Immunity - Austin Community College

... – portion of the antigen (ex. Amino acids) recognized by lymphocyte receptor ...
Taxonomy
Taxonomy

... Viruses- not considered living organisms; have to be inside a host cell to reproduce › A. contain DNA and RNA › B. diseases caused by viruses  HIV, chicken pox, Herpes, Flu (influenza) › C. Two ways of infecting cells  Lytic cycle  Lysogenic cycle ...
Document
Document

... What is the function of the immune system? What is a pathogen and how is it related to an antigen? What is the first line of defense? If a pathogen breaches a physical barrier in a human, what would happen next in the immune response? • What are toll-like receptors? Where do you find them? What is t ...
Department of Microbiology, Immunology and Tropical Medicine
Department of Microbiology, Immunology and Tropical Medicine

... initiation of CD8+ T cell response in the gut • Is NK-DC interaction critical for induction of robust CD8+ T cell immunity • Can long term central memory CD8+ T cell response be generated • What is the role of cytokines like IL-7 and IL-15 in the generation and maintenance of CD8+ T cell immunity in ...
Immune System
Immune System

... • TC cell releases perforin, a protein that forms pores in the target cell membrane; cell lysis and pathogen exposure to circulating antibodies ...
Immune System Lyrics (Parts 1 and 2)
Immune System Lyrics (Parts 1 and 2)

... To lymph nodes, where they bind with a Helper T Whose receptor is also complementary, To the antigen that the phagocyte’s displaying This is the connection for which we’ve been praying The Helper T grabs on with its CD4 protein, Which connects antigen presenting cell and Helper T And now the two cel ...
Integrated Science 2 Name: Per
Integrated Science 2 Name: Per

... 14. List the two different immune responses. ___________________________________________ 15. A protein that helps destroy pathogens is called a(an) ________________________________ 16. What happens once the body has been exposed to a pathogen? ________________________ _______________________________ ...
The Immune system
The Immune system

... complement and causes the lysis of cells. ...
PowerPoint
PowerPoint

... immune system – this allows for selective destruction of invading pathogens without destruction of host tissues – involves major histocompatibility complex ...
Lymphatic System
Lymphatic System

... particular T cell programmed to react with the antigen becomes activated – Macrophages phagocytize the antigen – Macrophages present it to the T cell ...
B-Cells - misslongscience
B-Cells - misslongscience

... The pathogens end up in a vesicle called ...
Role of the immune cells recognizing MHC-I like
Role of the immune cells recognizing MHC-I like

... immune cell infiltration, which is however not well characterized. We address the question of the recruitment and the role of non-conventional immune cell populations, NK, NKT and T gamma-delta lymphocytes infiltrating CNS in mouse experimental models such as olfactory axotomy and EAE. It was previo ...
Time course of immune response
Time course of immune response

... • Produced in response to an activating stimulus • Function by binding to a specific receptor • Usually soluble, but can be membrane associated • Can work locally or at a distance ...
Option D7: Antivirals
Option D7: Antivirals

... This is particularly the case with HIV which can lead to AIDS (acquired immune deficiency syndrome) ...
Immunity: Short- and Long
Immunity: Short- and Long

... Immunity: Short- and LongTerm Cell Memory Whenever T cells and B cells are activated, some become "memory" cells. ...
Immunocomputing - Carleton University
Immunocomputing - Carleton University

... – Proliferation and differentiation resulting from antigen activation of B cells – Autoimmune disease the result of autoreactive clones resistant to early elimination by self-antigens • The total number of lymphocytes kept relatively constant over time by regulation • Responsible for maintaining Ab ...
Name - Medical Mastermind Community
Name - Medical Mastermind Community

... B. T lymphocytes cells are derived from pluripotent hematopoietic stem cells in the bone marrow, and mature in the thymus. C. Neutrophils developing in the presence of MHC molecules undergo apoptosis. D. B lymphocytes are derived from pluripotent hematopoietic stem cells in the bone marrow, and unde ...
Dendritic cells
Dendritic cells

... Some implications of the danger hypothesis • There is no window for tolerance induction in neonates • Neonatal T cells are not intrinsically tolerant but the neonatal environment predisposes to tolerance • Antigens induce tolerance or immunity depending upon the ability of the immune system to sens ...
T-cell development in the thymus
T-cell development in the thymus

... positive selection, in the cortex. DP cells interact with self-antigens in the context of major histocompatabilty complex (MHC) class I or class II molecules. Those cells that engage antigen/MHC with an appropriate affinity survive, whereas those cells that interact with a weaker affinity die by apo ...
The Immune System and Disease Chapter 40 Page 1030
The Immune System and Disease Chapter 40 Page 1030

Transcriptional noise in CD4+ cells
Transcriptional noise in CD4+ cells

... Project description: The numbers of mRNAs and proteins that are found in a cell are usually low, amounting to less than one hundred for most types of mRNA. The statistical distributions of these among the cells of an otherwise identical population feature high variances. Yet, cells function reliably ...
幻灯片 1 - Shandong University
幻灯片 1 - Shandong University

... • Tolerance is antigenic specific and results from the recognition of antigens by specific lymphocytes. • Normal individuals are tolerant of their own antigens(self antigen)----- Self-tolerance. • Foreign antigens may be administered in ways that preferentially inhibit immune response by inducing to ...
MHC
MHC

... • Fold around the peptide to increase stability of the complex •The captured peptides contribute to the stabilization of the complex • Use a small number of anchor residues to tether the peptide - this allows different sequences between anchors and different lengths of peptides ...
PowerPoint Presentation - I. Introduction to class
PowerPoint Presentation - I. Introduction to class

... ACTIVITY OF OTHER CELLS OF THE IMMUNE SYSTEM. • DEFENSE AGAINST: • BACTERIA AND VIRUSES THAT ARE INSIDE HOST CELLS AND ARE INACCESSIBLE TO ANTIBODIES. • FUNGI, PROTOZOA, AND WORMS ...
Lines of Defense - Trinity Christian School
Lines of Defense - Trinity Christian School

< 1 ... 466 467 468 469 470 471 472 473 474 ... 514 >

Molecular mimicry

Molecular mimicry is defined as the theoretical possibility that sequence similarities between foreign and self-peptides are sufficient to result in the cross-activation of autoreactive T or B cells by pathogen-derived peptides. Despite the promiscuity of several peptide sequences which can be both foreign and self in nature, a single antibody or TCR (T cell receptor) can be activated by even a few crucial residues which stresses the importance of structural homology in the theory of molecular mimicry. Upon the activation of B or T cells, it is believed that these ""peptide mimic"" specific T or B cells can cross-react with self-epitopes, thus leading to tissue pathology (autoimmunity). Molecular mimicry is a phenomenon that has been just recently discovered as one of several ways in which autoimmunity can be evoked. A molecular mimicking event is, however, more than an epiphenomenon despite its low statistical probability of occurring and these events have serious implications in the onset of many human autoimmune disorders. In the past decade the study of autoimmunity, the failure to recognize self antigens as ""self,"" has grown immensely. Autoimmunity is a result of a loss of immunological tolerance, the ability for an individual to discriminate between self and non-self. Growth in the field of autoimmunity has resulted in more and more frequent diagnosis of autoimmune diseases. Consequently, recent data show that autoimmune diseases affect approximately 1 in 31 people within the general population. Growth has also led to a greater characterization of what autoimmunity is and how it can be studied and treated. With an increased amount of research, there has been tremendous growth in the study of the several different ways in which autoimmunity can occur, one of which is molecular mimicry. The mechanism by which pathogens have evolved, or obtained by chance, similar amino acid sequences or the homologous three-dimensional crystal structure of immunodominant epitopes remains a mystery.
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