Histones Activate the NLRP3 Inflammasome in Kupffer Cells during
... cells, secreting cytokines, and recruiting other inflammatory cells, such as neutrophils and circulating monocytes (1). Because of their immune-triggering capability, responses driven by KCs are recognized as key mechanisms in liver I/R injury (3). Nucleotide-binding domain, leucine-rich repeat cont ...
... cells, secreting cytokines, and recruiting other inflammatory cells, such as neutrophils and circulating monocytes (1). Because of their immune-triggering capability, responses driven by KCs are recognized as key mechanisms in liver I/R injury (3). Nucleotide-binding domain, leucine-rich repeat cont ...
Saccharomyces boulardii effects on gastrointestinal diseases
... GG and probiotics mixtures) in the prevention of AAD and the treatment of Clostridium difficile-diseases. The authors concluded that the three types of probiotics significantly reduced the development of AAD but only S. boulardii was shown to be effective for Clostridium difficile-associated disease ...
... GG and probiotics mixtures) in the prevention of AAD and the treatment of Clostridium difficile-diseases. The authors concluded that the three types of probiotics significantly reduced the development of AAD but only S. boulardii was shown to be effective for Clostridium difficile-associated disease ...
VENEZUELAN EQUINE ENCEPHALITIS VIRUS REPLICON
... Vaccination is the most effective control measure in the fight against infectious diseases, and represents an opportunity to intercede in the spread of dangerous organisms through prophylactic intervention. Viral vectors, including alphavirus vectors, have proven to be powerful vaccine delivery vehi ...
... Vaccination is the most effective control measure in the fight against infectious diseases, and represents an opportunity to intercede in the spread of dangerous organisms through prophylactic intervention. Viral vectors, including alphavirus vectors, have proven to be powerful vaccine delivery vehi ...
alopecia_areata 2012
... is its creation of a milieu of relative immune privilege that normally renders unlikely an autoimmune attack on intrafollicularly expressed autoantigens.29-31 This relative immune privilege is established mainly by suppression of the surface molecules required for presenting autoantigens to CD8+ T l ...
... is its creation of a milieu of relative immune privilege that normally renders unlikely an autoimmune attack on intrafollicularly expressed autoantigens.29-31 This relative immune privilege is established mainly by suppression of the surface molecules required for presenting autoantigens to CD8+ T l ...
Alopecia Areata - New England Journal of Medicine
... is its creation of a milieu of relative immune privilege that normally renders unlikely an autoimmune attack on intrafollicularly expressed autoantigens.29-31 This relative immune privilege is established mainly by suppression of the surface molecules required for presenting autoantigens to CD8+ T l ...
... is its creation of a milieu of relative immune privilege that normally renders unlikely an autoimmune attack on intrafollicularly expressed autoantigens.29-31 This relative immune privilege is established mainly by suppression of the surface molecules required for presenting autoantigens to CD8+ T l ...
Innate immune lectins kill bacteria expressing blood group antigen
... The expression of ABO(H) blood group antigens causes deletion of cells that generate self-specific antibodies to these antigens but this deletion limits adaptive immunity toward pathogens bearing cognate blood group antigens. To explore potential defense mechanisms against such pathogens, given thes ...
... The expression of ABO(H) blood group antigens causes deletion of cells that generate self-specific antibodies to these antigens but this deletion limits adaptive immunity toward pathogens bearing cognate blood group antigens. To explore potential defense mechanisms against such pathogens, given thes ...
Tubules composed of non-structural protein
... Supervisor: Prof Henk Huismans, Department of Genetics, University of Pretoria For the degree MSc Non-structural protein, NS1 of African horse sickness virus is a hydrophobic protein of 63 kDa that spontaneously assembles into highly distinct tubular structures when expressed in mammalian or insect ...
... Supervisor: Prof Henk Huismans, Department of Genetics, University of Pretoria For the degree MSc Non-structural protein, NS1 of African horse sickness virus is a hydrophobic protein of 63 kDa that spontaneously assembles into highly distinct tubular structures when expressed in mammalian or insect ...
Molecular Evolution of FtsZ Protein Sequences Encoded Within the
... Visual inspection of all complete FtsZs revealed 154 sequences with putative 9-amino acid C-terminal motifs, all from Bacteria or Eukaryota. These motifs were used as a training set to construct a position-specific score matrix using the motif discovery tool Multiple EM for Motif Elicitation (MEME [B ...
... Visual inspection of all complete FtsZs revealed 154 sequences with putative 9-amino acid C-terminal motifs, all from Bacteria or Eukaryota. These motifs were used as a training set to construct a position-specific score matrix using the motif discovery tool Multiple EM for Motif Elicitation (MEME [B ...
Biological properties of extracellular vesicles and their physiological
... without the realization that this form of function or communication is a universally shared cell biological property. Specifically, EVs were observed as procoagulant platelet-derived particles in normal plasma, originally reported in 1946 by Chargaff and West (2) and referred to as ‘‘platelet dust’’ ...
... without the realization that this form of function or communication is a universally shared cell biological property. Specifically, EVs were observed as procoagulant platelet-derived particles in normal plasma, originally reported in 1946 by Chargaff and West (2) and referred to as ‘‘platelet dust’’ ...
Identification of signaling pathways important for Borrelia burgdorferi
... protein portion, which is exposed to the external environment, is highly variable. There are over 130 different genes that appear to encode lipoproteins, with only a few having been described to have some virulence ...
... protein portion, which is exposed to the external environment, is highly variable. There are over 130 different genes that appear to encode lipoproteins, with only a few having been described to have some virulence ...
Untitled
... requiring prior exposure and are a key component of the innate immune system. Antibodies, by contrast, are produced only after infection, and are specific for the infecting pathogen. The antibodies present in a given person therefore directly reflect the infections to which he or she has been expose ...
... requiring prior exposure and are a key component of the innate immune system. Antibodies, by contrast, are produced only after infection, and are specific for the infecting pathogen. The antibodies present in a given person therefore directly reflect the infections to which he or she has been expose ...
Leukocyte surface antigen CD47
... human Th1 T-cell differentiation by blocking production of IL12 (Avice et al. 2001). In the same study this effect was corroborated using human antibodies against CD47, showing that this peptide regulates CD47-mediated development of Th1 cells with potential implications of CD47 in immune response. ...
... human Th1 T-cell differentiation by blocking production of IL12 (Avice et al. 2001). In the same study this effect was corroborated using human antibodies against CD47, showing that this peptide regulates CD47-mediated development of Th1 cells with potential implications of CD47 in immune response. ...
NIH Public Access Author Manuscript The immune system and cardiac repair Abstract
... The TLRs represent a family of pattern recognition receptors that serve to recognize molecular patterns associated with pathogens and, upon binding of their ligands, induce activation of several kinases and NF-κB. Endogenous ligands from damaged tissues, including heat shock proteins, hyaluronan and ...
... The TLRs represent a family of pattern recognition receptors that serve to recognize molecular patterns associated with pathogens and, upon binding of their ligands, induce activation of several kinases and NF-κB. Endogenous ligands from damaged tissues, including heat shock proteins, hyaluronan and ...
Molecular cloning and expression analysis of the STAT1 gene from
... Results: A DNA fragment containing the conserved SH2 domain was amplified by RT-PCR using degenerate primers designed based on the highly conserved sequences in the SH2 domains of the zebrafish and mammalian STAT1. The complete cDNA sequence was obtained by 5' and 3' RACE. The flounder STAT1 transcr ...
... Results: A DNA fragment containing the conserved SH2 domain was amplified by RT-PCR using degenerate primers designed based on the highly conserved sequences in the SH2 domains of the zebrafish and mammalian STAT1. The complete cDNA sequence was obtained by 5' and 3' RACE. The flounder STAT1 transcr ...
Chapter_008
... T cells in the graft are mature and capable of cellmediated destruction tissues within the recipient Not a problem if patient is immunocompetent ...
... T cells in the graft are mature and capable of cellmediated destruction tissues within the recipient Not a problem if patient is immunocompetent ...
Full text in pdf format
... ABSTRACT: The first step of the pathogenesis of many infectious diseases is the colonisation of the mucosal surface by the pathogen. Bacterial colonisation of the mucosal surface is promoted by adherence to high molecular weight mucus glycoproteins. We examined the effect of carp intestinal mucus gl ...
... ABSTRACT: The first step of the pathogenesis of many infectious diseases is the colonisation of the mucosal surface by the pathogen. Bacterial colonisation of the mucosal surface is promoted by adherence to high molecular weight mucus glycoproteins. We examined the effect of carp intestinal mucus gl ...
Immune Responses In Vitro and In Vivo Oligodeoxynucleotide for
... motif followed by a poly C tail, which is highly active with a phosphodiester backbone, is essentially inactive with a phosphorothioate backbone. In contrast, murine leukocytes are strongly activated by phosphorothioate ODN containing just one optimal murine motif. This argues for differences in the ...
... motif followed by a poly C tail, which is highly active with a phosphodiester backbone, is essentially inactive with a phosphorothioate backbone. In contrast, murine leukocytes are strongly activated by phosphorothioate ODN containing just one optimal murine motif. This argues for differences in the ...
Full-Text PDF
... Phage display technology is a widely used method for the selection of peptides, antibodies and alternative scaffolds [1–6], whereas oligopeptide phage display for the identification of immunogenic proteins is, to date, not widely spread. The fundamental technology was invented in 1985 by George P. S ...
... Phage display technology is a widely used method for the selection of peptides, antibodies and alternative scaffolds [1–6], whereas oligopeptide phage display for the identification of immunogenic proteins is, to date, not widely spread. The fundamental technology was invented in 1985 by George P. S ...
Comparison of Phenology and Pathogen Prevalence, Including
... (E.S., unpublished data). At each site, the predominant tick-borne diseases are Lyme and anaplasmosis. In addition, soldier populations at the three installations are standardized in several ways that facilitate comparisons. All three installations are field training facilities used primarily by Res ...
... (E.S., unpublished data). At each site, the predominant tick-borne diseases are Lyme and anaplasmosis. In addition, soldier populations at the three installations are standardized in several ways that facilitate comparisons. All three installations are field training facilities used primarily by Res ...