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Supplementary Figure 4 - PowerPoint (327 KB )
Supplementary Figure 4 - PowerPoint (327 KB )

... the C. elegans total protein lysates. Adult wild-type animals (N2) were fed with bacteria expressing dsRNA against ZK287.5 (the C. elegans homologue of RBX1) for three days, and the protein lysates were probed with RBX1 antibodies at 1:2000 dilution. Compared with lysates from untreated animals, a b ...
Aalborg Universitet Molecular Pathogenesis of Spondyloarthritis Carlsen, Thomas Gelsing
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... this thesis. Several hypotheses are retrieved from the literature, which since the discovery of the susceptibility gene HLA-B27 have moved from interest in the antigenic presentation of peptides to CD8+ T cells and autoimmune reactions born from protein homology to exploring the presence of single n ...
The Immune System
The Immune System

... to a billion different epitopes -- even artificially made molecules • Explanation for great diversity of receptors is genetic recombination of few hundred small gene segments • Each B or T cell has its own unique set of gene segments that codes its unique antigen receptor in the cell membrane ...
Rumen Function - Causeway Produce Agency
Rumen Function - Causeway Produce Agency

... Kenneth Bruerton PhD 11 August 2011 ...
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... B- and T-cell tumors that are derived from specific stages of their normal differentiation pathways. The diagnosis and classification of these tumors relies heavily on tests that detect lineage-specific antigens (B-cell, T-cell, and NK-cell markers) ;  Immunohistochemistry  Flow cytometry Analysis ...
PhD Course Work in Indian Institute of Chemical Biology
PhD Course Work in Indian Institute of Chemical Biology

... Advanced/ modern synthetic reaction Heck reaction, radical reaction, sonogisera reaction, Suzuki-coupling, aryl amination, aryl-etherification reaction, ring-closing metatheses, Pausand khan reaction, Chemical and biochemical approach for the synthesis of deoxyribonucleic acid (DNA); solid phase syn ...
The Lymphatic System and Immunity
The Lymphatic System and Immunity

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Immune Cells - Morgan Community College

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AP Biology Summer Assignment

... acquired immune system learns to identify what is foreign and uses antibodies to rapidly ‘tag’ pathogens so that the phagocytes and other immune cells can quickly identify and destroy intruders. Sometimes the immune system ...
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投影片 1 - National Cheng Kung University
投影片 1 - National Cheng Kung University

... complement activation, and leukocyte infiltration occurred only in the glomeruli of exotoxin B-hyperimmunized mice. One particular anti-exotoxin B monoclonal antibody, 10G, was cross-reactive with kidney endothelial cells and it caused kidney injury and proteinuria when infused into mice. This cross ...
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... • Inpatient—may be required with severe secondary infections, low red-blood cell count (known as “anemia”), or extreme weight loss with muscle wasting (known as “cachexia”) until condition is stable • Blood transfusions—emergency support; multiple transfusions may be necessary; vaccination of donor ...
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The role of autoantibodies in health and disease

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1. dia - immunology.unideb.hu
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Microbial physiology
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Molecular mimicry

Molecular mimicry is defined as the theoretical possibility that sequence similarities between foreign and self-peptides are sufficient to result in the cross-activation of autoreactive T or B cells by pathogen-derived peptides. Despite the promiscuity of several peptide sequences which can be both foreign and self in nature, a single antibody or TCR (T cell receptor) can be activated by even a few crucial residues which stresses the importance of structural homology in the theory of molecular mimicry. Upon the activation of B or T cells, it is believed that these ""peptide mimic"" specific T or B cells can cross-react with self-epitopes, thus leading to tissue pathology (autoimmunity). Molecular mimicry is a phenomenon that has been just recently discovered as one of several ways in which autoimmunity can be evoked. A molecular mimicking event is, however, more than an epiphenomenon despite its low statistical probability of occurring and these events have serious implications in the onset of many human autoimmune disorders. In the past decade the study of autoimmunity, the failure to recognize self antigens as ""self,"" has grown immensely. Autoimmunity is a result of a loss of immunological tolerance, the ability for an individual to discriminate between self and non-self. Growth in the field of autoimmunity has resulted in more and more frequent diagnosis of autoimmune diseases. Consequently, recent data show that autoimmune diseases affect approximately 1 in 31 people within the general population. Growth has also led to a greater characterization of what autoimmunity is and how it can be studied and treated. With an increased amount of research, there has been tremendous growth in the study of the several different ways in which autoimmunity can occur, one of which is molecular mimicry. The mechanism by which pathogens have evolved, or obtained by chance, similar amino acid sequences or the homologous three-dimensional crystal structure of immunodominant epitopes remains a mystery.
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