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To B or not to B: Pair use trout to study kidney's role in nurturing fish immune cells
To B or not to B: Pair use trout to study kidney's role in nurturing fish immune cells

... When humans are exposed to infectious bacteria or other foreign invaders, our immune system fights back using an incredibly diverse host of cells and molecules—B cells, T cells, macrophages, cytokines, and antibodies, among many others. As fellow vertebrates, fish produce and use the very same cells ...
Ch 15 Lymphatic, Ch 16 infection control
Ch 15 Lymphatic, Ch 16 infection control

...  Absorb digested fat at the intestinal villi Slide 12.1 ...
PD-L1 - Stem Cell Conferences
PD-L1 - Stem Cell Conferences

... is a critical regulator of activated T cell-cancer cell interactions, serving to defend tumor cells against (T cell-mediated) immune destruction. Pharmaceutical interest is high in PD-L1 antibody use in solid tumor chemo-therapy to render cancer cells susceptible to host killer T cell action. We hav ...
European Respiratory Society Annual Congress 2013
European Respiratory Society Annual Congress 2013

... Body: Virus-induced exacerbations of asthma, COPD and cystic fibrosis (CF) have recently been linked to an impaired innate immune response in epithelial cells. The impaired response to viral infection is characterized by reduced interferon production and increased viral replication. However, the und ...
Bacterial Structure
Bacterial Structure

... pathogens) are surrounded by a thick polysaccharide capsule. This is a loose jelly-like or mucus-like layer. It helps prevent immune system cells from reaching the bacteria, and it forms part of biofilms. ...
Innate Immune System
Innate Immune System

... lysosome to form a phagolysosome. The pathogen is then subject to a number of destructive factors including toxic enzymes such as DNAase and acid phosphatase, free radicals including H202, O2-, OH, acidic pH and Nitric Oxide. Some bacteria are able to ameliorate the actions of these factors: pneumoc ...
First Exam 2015
First Exam 2015

... Antigens and PAMP are targets for cells and/or soluble factors of the immune response and are recognized by different types of membrane receptors. Antigens and PAMP differ profoundly in the types of cells that respond to them as targets. Antigens and PAMP also differ profoundly in the type of immune ...
Author`s comment - Journal of Inflammation
Author`s comment - Journal of Inflammation

... macrophage pro-inflammatory cytokine release following apoptotic cell ingestion, for example when apoptotic neutrophils were coated with immune complexes, also profoundly influenced the rate of phagocytosis 1. Because phagocytosis was unaffected in the present study, we believe that the bound CRP is ...
Chapt07 Lecture 13ed Pt 1
Chapt07 Lecture 13ed Pt 1

... Red bone marrow: site for the origin of all types of blood cells Thymus: lymphatic tissue where T lymphocytes mature and learn to tell “self” from “nonself” ...
Cytokines In Health and Disease General Properties of Cytokines
Cytokines In Health and Disease General Properties of Cytokines

...  IL-12 and type I IFNs are most important for CTL response  After naïve T cell receives first two signals necessary for activation, a third signal from IL-12 (or type I IFNs) is required for further proliferation of CTLs  Effector CTLs acquire expression of perforin, granzymes and possibly CD95L ...
Chapter I Overview of Immunology
Chapter I Overview of Immunology

... Macrophage ingests antigen and displays portion on its surface. Helper T- Cell recognizes antigen on the surface of the macrophage and becomes active. Active Helper T-Cell activates Cytotoxic T-Cells and B-Cells. Cytotoxic T-Cells divide into Active Cytotoxic T-cells and Memory T – Cells. Active Cyt ...
allergiy.eng
allergiy.eng

... Development of drugs hypersensitivity has three stages: • conversion of drug’s substance into form that can interact with proteins; • conjugation of incomplete antigen with host protein that lead to formation of complete antigen; • immune reaction of the organism on certain drugprotein complex that ...
No Slide Title
No Slide Title

... PRESENTING CELL BY ENDOCYTOSIS • DIGEST IN PHAGOLYSOSOME • FRAGMENTS COMBINE WITH PREFORMED MHC CLASS II • DISPLAYED ON PLASMA MEMBRANE • RECOGNIZED BY CD4 + CELLS ...
Ch. 16 Outline
Ch. 16 Outline

Immunology Basics Biology Lecture PowerPoint
Immunology Basics Biology Lecture PowerPoint

... ________trigger the hypothalamus to increase body’s core temperature. ...
coronaviruses-sars - Biomedic Generation
coronaviruses-sars - Biomedic Generation

... be inhibited by fusion/entry inhibitors. HIV is uncoated inside the cell and reverse transcriptase copies genomic RNA into DNA, making errors at a frequence of about one per replication cycle. Reverse transcriptase inhibitors were the first class of HIV inhibitors to be used as drugs. Viral DNA can ...
PDF (126KB)
PDF (126KB)

... various mechanisms that could play a role in modulating undesirable autoimmune responses. The IgG molecules in IVIg have various immunosuppressive effects, which are attributed to the Fc portion or antigen recognition region. Herein, I focus on the immunosuppressive effects of IVIg on activated B ce ...
Posttranslational Modifications of Proteins in Type 1 Diabetes: The
Posttranslational Modifications of Proteins in Type 1 Diabetes: The

Methodic_students_3
Methodic_students_3

A VLP-based Platform for Vaccine Discovery
A VLP-based Platform for Vaccine Discovery

Document
Document

... Live pathogen selected or genetically modified causes no disease or only mild disease. ...
lecture-4_theraeutic_vaccine_immune-based
lecture-4_theraeutic_vaccine_immune-based

Diseases
Diseases

... • Some beneficial effects for pathogen, however: - Evaporative cooling - Pathogen dispersal ...
Microbiology
Microbiology

...  Target cells are self-cells carrying endogenous antigens  Activated into cytotoxic T lymphocytes (CTLs)  CTLs recognize Ag + MHC I  Induce apoptosis in target cell ...
Notes-Blood and Immunity
Notes-Blood and Immunity

... response and disease resistance. Fluid that is forced out of the bloodstream during normal circulation is filtered through lymph nodes to remove bacteria, abnormal cells and other matter. This fluid is then transported back into the bloodstream via the lymph vessels. Lymph only moves in one directio ...
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Molecular mimicry

Molecular mimicry is defined as the theoretical possibility that sequence similarities between foreign and self-peptides are sufficient to result in the cross-activation of autoreactive T or B cells by pathogen-derived peptides. Despite the promiscuity of several peptide sequences which can be both foreign and self in nature, a single antibody or TCR (T cell receptor) can be activated by even a few crucial residues which stresses the importance of structural homology in the theory of molecular mimicry. Upon the activation of B or T cells, it is believed that these ""peptide mimic"" specific T or B cells can cross-react with self-epitopes, thus leading to tissue pathology (autoimmunity). Molecular mimicry is a phenomenon that has been just recently discovered as one of several ways in which autoimmunity can be evoked. A molecular mimicking event is, however, more than an epiphenomenon despite its low statistical probability of occurring and these events have serious implications in the onset of many human autoimmune disorders. In the past decade the study of autoimmunity, the failure to recognize self antigens as ""self,"" has grown immensely. Autoimmunity is a result of a loss of immunological tolerance, the ability for an individual to discriminate between self and non-self. Growth in the field of autoimmunity has resulted in more and more frequent diagnosis of autoimmune diseases. Consequently, recent data show that autoimmune diseases affect approximately 1 in 31 people within the general population. Growth has also led to a greater characterization of what autoimmunity is and how it can be studied and treated. With an increased amount of research, there has been tremendous growth in the study of the several different ways in which autoimmunity can occur, one of which is molecular mimicry. The mechanism by which pathogens have evolved, or obtained by chance, similar amino acid sequences or the homologous three-dimensional crystal structure of immunodominant epitopes remains a mystery.
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