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Mucosal IL-17 immunity in disease 12112012
Mucosal IL-17 immunity in disease 12112012

... T cells are CD4 lymphocytes participating in cell-mediated immunity, and play a critical role in immune-mediated diseases. T cells divide further into subclasses such as Th1, Th2, and Th17 that participate in mucosal immunity responses caused by extracellular pathogens and also play a role in autoim ...
Do all creatures possess an acquired immune system of some sort?
Do all creatures possess an acquired immune system of some sort?

Protein aggregation complicates the development of baculovirus-expressed African  horsesickness
Protein aggregation complicates the development of baculovirus-expressed African horsesickness

... & Taylor 1991 ). Nevertheless, all the remaining neurotropic cell culture-produced vaccine strains were subsequently replaced with fully cell culture-attenuated vaccine strains. Ever since, there have been problems with some of the AHSV vaccine strains. In 1990, a newly-attenuated serotype 5 vaccine ...
full text
full text

... of biofilm eradication, has also been reported. This antibiofilm effect is thought to be caused by a reduction in the production of matrix components, including polysaccharides [25]. Of all ...
REGULATORY MECHANISMS IN CELL-MEDIATED IMMUNE
REGULATORY MECHANISMS IN CELL-MEDIATED IMMUNE

... identifies essentially coincident populations. Factors which possess a binding site for the antigen used in their generation or exhibit antigen-specific suppression also generally express determinants encoded by genes of the major histocompatibility complex (I-9). The MHC product associated with eac ...
Hannah Akuffo Publications 1990 to 1999
Hannah Akuffo Publications 1990 to 1999

... Mingarini K, Ingemarsson K, Opoku N, Akuffo HO. A simple dot blot assay adaptable for field use in the diagnosis of onchocerciasis: preparation of an adult worm antigen fraction which enhances sensitivity and specificity. Trans R Soc Trop Med Hyg. 1994 MayJun;88(3):303-6. 36. Wolday D, Akuffo H, Bri ...
NOD2 Variants and Antibody Response to Microbial Antigens in
NOD2 Variants and Antibody Response to Microbial Antigens in

Part III, Endotoxin Test Concerns of Biologics
Part III, Endotoxin Test Concerns of Biologics

The microbiome mutiny hypothesis: can our microbiome turn against
The microbiome mutiny hypothesis: can our microbiome turn against

Subretinal space and vitreous cavity as immunologically
Subretinal space and vitreous cavity as immunologically

... tigen. Examination of the hematoxylin and eosin sections revealed that the grafts were well developed and differentiated, and located between the host neural retina and retinal pigment epithelium. Retinal grafts contained a dominant population of photoreceptor cells that formed rosettes (Fig. 3A). O ...
Mechanisms involved in regulation of MHC class I molecules in
Mechanisms involved in regulation of MHC class I molecules in

... species to the environment. These molecules are not only crucial for adaptive and innate immune responses against microorganisms and cancer cells but also play an important role in reproduction process and development of embryo during the preimplantation period. In the present study, we use murine e ...
Characterization of cell-mediated immune responses elicited
Characterization of cell-mediated immune responses elicited

... of T cells activated (or not) by orthotopic corneal grafts, the authors examined the development of delayed hypersensitivity (DH) to donor-specific alloantigens. Methods. Recipient BALB/c mice received orthotopic corneal allografts from donor mice that were MHC incompatible at MHC loci only, multipl ...
nk cell education and adhesion molecules
nk cell education and adhesion molecules

... MHC-I in otherwise normal cells. Recent evidence suggests that education is tunable and changes according to the net signaling input an individual NK cell receives. In paper I, we studied such retuning effects of NK cell education in different settings relevant to immunotherapy and asked whether the ...
Respiratory and Metabolic Impacts of Crustacean Immunity: Are
Respiratory and Metabolic Impacts of Crustacean Immunity: Are

... immune system is mediated largely by hemocytes, relying on suites of pattern recognition receptors, effector functions, and signaling pathways that parallel those of insects. In crustaceans, as in insects, the cardiovascular system facilitates movement of hemocytes and delivery of soluble immune fac ...
Immune profiling with next-generation sequencing
Immune profiling with next-generation sequencing

... Background In humans and closely related species, cellular immunity is mediated by T cells, which participate directly in the detection and neutralization of pathogenic threats. Essential to T-cell function are highly specialized extracellular receptors (T-cell receptors or TCRs) that selectively bi ...
Speciation accelerated and stabilized by pleiotropic major
Speciation accelerated and stabilized by pleiotropic major

... we would expect that the two new host species differ only in their MHC genetics. Being undistinguishable otherwise, they would be cryptic species (Mayr 1977). Many such cryptic but yet undetected species may exist. For example, Blais et al. (2007) investigated the role of MHC class II in two cichl ...
Veterinary Microbiology and Preventive Medicine (V MPM) Iowa State University – 2013-2014 1
Veterinary Microbiology and Preventive Medicine (V MPM) Iowa State University – 2013-2014 1

... An examination of humoral and cellular immune function as well as the interaction of the cells and factors of the immune system that result in health and disease. Micro 475L optional. Credit for either Micro 575 or V MPM 520, but not both, may be applied toward graduation. V MPM 586. Medical Bacteri ...
Licentiate thesis from the Department of Immunology,
Licentiate thesis from the Department of Immunology,

... strains. Multiplicity of infection (MOI) is known as an indicator of immune status. However, whether high or low MOI are good or bad for the development of immunity to malaria is still not clear. Our second study aimed to examine the MOI in asymptomatic children aged 2-10 years and to relate it to t ...
Diversity, Sources, and Detection of Human Bacterial Pathogens in
Diversity, Sources, and Detection of Human Bacterial Pathogens in

... Intracellular associations of bacteria with protozoan and algal hosts have been described in natural and clinical settings and may represent an additional source of pathogens in marine environments. Colonization of amoeboid hosts has been observed for several human bacterial pathogens including Myco ...
The ontogeny of the common carp (Cyprinus carpio L.) immune system
The ontogeny of the common carp (Cyprinus carpio L.) immune system

... species are quantitatively the most important1. A major problem accompanying this vast increase is the occurrence of infectious diseases, which causes high losses in cultured fish, especially larvae and juveniles. Knowledge on the ontogeny of the immune system is imperative to design preventive meas ...
Origin of Anti-tumor Immunity Failure in Mammals
Origin of Anti-tumor Immunity Failure in Mammals

... the evolution of the immune system in vertebrates, and also cleared the pathway towards reaching further relevant presumptions and conclusions. The mechanisms for defending the host against foreign invaders are present in all multicellular organisms in different forms. For example, in all invertebra ...
Photochemotherapy induces the apoptosis of - HAL
Photochemotherapy induces the apoptosis of - HAL

... pinocytosis and FITC-ovalbumine (FITC-OVA) as a model of macropinocytosis. After 3-hours incubation at 37°C, more than 90% of the monocytes efficiently engulfed LY and FITC-OVA (Figure 2). The PUVA treatment neither affected the percentage of positive cells nor the intensity of labeling, meaning tha ...
4. Treatment of pyoderma gangrenosum usually involves systemic
4. Treatment of pyoderma gangrenosum usually involves systemic

... Pyoderma gangrenosum is a neutrophilic dermatosis that may be idiopathic or associated with an underlying disease. It is the result of an exaggerated response to specific and non-specific stimuli. First-line treatment is with a steroid, usually prednisone. In this case report, a 25-year-old man pres ...


... anti-CD3 and anti-ICAM-1 mAb enhances the production of IL-4 [50]. Interestingly, costimulation with anti-ICAM1 and anti-CD3 protects T-cell allergen-specific clones from apoptosis induced by anti-CD3 [50]. Helper activity for B-cells Interaction between LFA-1 expressed on B-cells and ICAM-1 on acti ...
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Molecular mimicry

Molecular mimicry is defined as the theoretical possibility that sequence similarities between foreign and self-peptides are sufficient to result in the cross-activation of autoreactive T or B cells by pathogen-derived peptides. Despite the promiscuity of several peptide sequences which can be both foreign and self in nature, a single antibody or TCR (T cell receptor) can be activated by even a few crucial residues which stresses the importance of structural homology in the theory of molecular mimicry. Upon the activation of B or T cells, it is believed that these ""peptide mimic"" specific T or B cells can cross-react with self-epitopes, thus leading to tissue pathology (autoimmunity). Molecular mimicry is a phenomenon that has been just recently discovered as one of several ways in which autoimmunity can be evoked. A molecular mimicking event is, however, more than an epiphenomenon despite its low statistical probability of occurring and these events have serious implications in the onset of many human autoimmune disorders. In the past decade the study of autoimmunity, the failure to recognize self antigens as ""self,"" has grown immensely. Autoimmunity is a result of a loss of immunological tolerance, the ability for an individual to discriminate between self and non-self. Growth in the field of autoimmunity has resulted in more and more frequent diagnosis of autoimmune diseases. Consequently, recent data show that autoimmune diseases affect approximately 1 in 31 people within the general population. Growth has also led to a greater characterization of what autoimmunity is and how it can be studied and treated. With an increased amount of research, there has been tremendous growth in the study of the several different ways in which autoimmunity can occur, one of which is molecular mimicry. The mechanism by which pathogens have evolved, or obtained by chance, similar amino acid sequences or the homologous three-dimensional crystal structure of immunodominant epitopes remains a mystery.
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