The Role of Intracellular Neutral Lipid Hydrolases in Immune Cell
... comprehensive support, for the trust in my ideas throughout my PhD project and for always having an open door. I owe my gratitude to the thesis committee members Akos Heinemann, Achim Lass and Ruth Birner-Gruenberger for their critical advice and helpful comments. My special thanks go to the colleag ...
... comprehensive support, for the trust in my ideas throughout my PhD project and for always having an open door. I owe my gratitude to the thesis committee members Akos Heinemann, Achim Lass and Ruth Birner-Gruenberger for their critical advice and helpful comments. My special thanks go to the colleag ...
Optimal immune defence in the light of variation in lifespan
... looked for evidence for this pace of life hypothesis including meta-analyses (8, 9) and single studies with both nonspecific (10–12) and specific challenges and/or immune measures (13–17). When the more specific challenges or measures are used, evidence for the pace of life hypothesis is often found ...
... looked for evidence for this pace of life hypothesis including meta-analyses (8, 9) and single studies with both nonspecific (10–12) and specific challenges and/or immune measures (13–17). When the more specific challenges or measures are used, evidence for the pace of life hypothesis is often found ...
Guide to the Preparation of - Trace: Tennessee Research and
... from origin, largest X distance and largest Y distance were analyzed for each individual cell. Towards IL8, cells from GG genotype traveled further on an X axis and had higher X vs Y movement compared to CC genotype cells, meaning they moved more directly towards IL8. Our findings suggest lower F-ac ...
... from origin, largest X distance and largest Y distance were analyzed for each individual cell. Towards IL8, cells from GG genotype traveled further on an X axis and had higher X vs Y movement compared to CC genotype cells, meaning they moved more directly towards IL8. Our findings suggest lower F-ac ...
Medical monitoring: CD4 cell counts
... Immediately after HIV infection, the CD4 count is likely to fall several hundred cells below the previous normal level. The extent of this early drop and the level at which it stabilises are markers for the future risk of developing disease. Most people with HIV find that their CD4 count usually dec ...
... Immediately after HIV infection, the CD4 count is likely to fall several hundred cells below the previous normal level. The extent of this early drop and the level at which it stabilises are markers for the future risk of developing disease. Most people with HIV find that their CD4 count usually dec ...
Cell Therapy Systems brochure
... regulatory purposes. A Drug Master File is filed with the FDA. For Research Use or Manufacturing of Cell-, Gene- or Tissue-based Products. CAUTION: Not intended for direct administration into humans or animals. ...
... regulatory purposes. A Drug Master File is filed with the FDA. For Research Use or Manufacturing of Cell-, Gene- or Tissue-based Products. CAUTION: Not intended for direct administration into humans or animals. ...
Genetic analysis of innate immunity in resistance to
... inocula ranging from 103 to 108 yeasts having been tested.30 The LD50 for most C. albicans isolates tested in immunocompetent mice is between 104 and 106 yeasts. Both the strain of C. albicans and the growth conditions used have been shown to influence overall lethality during infection.32 The three ...
... inocula ranging from 103 to 108 yeasts having been tested.30 The LD50 for most C. albicans isolates tested in immunocompetent mice is between 104 and 106 yeasts. Both the strain of C. albicans and the growth conditions used have been shown to influence overall lethality during infection.32 The three ...
The function of tumour necrosis factor and receptors in models of
... the classic pro-inflammatory scenario, failure to regulate the production of TNF at a site of immunological injury may lead to chronic activation of innate immune cells and to chronic inflammatory responses, which may consequently lead to organ specific inflammatory pathology and tissue damage. Howe ...
... the classic pro-inflammatory scenario, failure to regulate the production of TNF at a site of immunological injury may lead to chronic activation of innate immune cells and to chronic inflammatory responses, which may consequently lead to organ specific inflammatory pathology and tissue damage. Howe ...
Nuclear factor κB (NF-κB)
... but not in pDCs [18–20]. These distinct expression patterns result in different cytokine production profiles following in vivo administration of TLR7 and TLR8 agonists. TLR7 stimulation of B cells induces differentiation and proliferation, but only a low level of cytokines, whereas stimulation of pD ...
... but not in pDCs [18–20]. These distinct expression patterns result in different cytokine production profiles following in vivo administration of TLR7 and TLR8 agonists. TLR7 stimulation of B cells induces differentiation and proliferation, but only a low level of cytokines, whereas stimulation of pD ...
2012 Program
... Internalization of group A Streptococcus (GAS) by epithelial cells may represent an important event in colonization of the human host. However, GAS must inhibit or delay the maturation of endolysosomal and/or autophagosomal compartments to avoid rapid intracellular degradation. The secreted pore-for ...
... Internalization of group A Streptococcus (GAS) by epithelial cells may represent an important event in colonization of the human host. However, GAS must inhibit or delay the maturation of endolysosomal and/or autophagosomal compartments to avoid rapid intracellular degradation. The secreted pore-for ...
The mutation patterns in B-cell immunoglobulin receptors reflect the
... cells also undergo isotype switching (e.g. from IgM to IgG) which allows for different effector functions. Unlike naive B cells that start with a BCR in the unmutated germline state, B memory cells that are reactivated through exposure to recurrent and related infections usually begin with a mutated ...
... cells also undergo isotype switching (e.g. from IgM to IgG) which allows for different effector functions. Unlike naive B cells that start with a BCR in the unmutated germline state, B memory cells that are reactivated through exposure to recurrent and related infections usually begin with a mutated ...
Neutrophils in tuberculosis
... Factor (TNF) [30]. Sometimes the reverse may happen; ingestion of apoptotic cell with pathogen may result in pro inflammatory effect [30]. This may be due to expression of heat shock proteins [31] or activation of macrophages by neutrophil proteases. Phagocytosis of apoptotic cell may produce anti/p ...
... Factor (TNF) [30]. Sometimes the reverse may happen; ingestion of apoptotic cell with pathogen may result in pro inflammatory effect [30]. This may be due to expression of heat shock proteins [31] or activation of macrophages by neutrophil proteases. Phagocytosis of apoptotic cell may produce anti/p ...
Chapter 1 - Baboola Sumo
... the body to specific organs. Moreover, disease microbes often concentrate in specific organs, which suggests they they also may restrict their own location in the body. Traveling through the body to a specific organ or tissue is termed homing, and homing of course requires molecular machinery. This ...
... the body to specific organs. Moreover, disease microbes often concentrate in specific organs, which suggests they they also may restrict their own location in the body. Traveling through the body to a specific organ or tissue is termed homing, and homing of course requires molecular machinery. This ...
this PDF file - Smart Science Technology
... immune homeostasis scheme, answers to which will offer new insight in the field of immunology. To cite this article: Indira Guha, et al. Macrophage as a mediator of immune response: Sustenance of immune homeostasis.Macrophage 2015;2: e709. doi: 10.14800/ Macrophage.709. ...
... immune homeostasis scheme, answers to which will offer new insight in the field of immunology. To cite this article: Indira Guha, et al. Macrophage as a mediator of immune response: Sustenance of immune homeostasis.Macrophage 2015;2: e709. doi: 10.14800/ Macrophage.709. ...
Antibodies and IL-3 support helminth-induced basophil
... restore basophilia in these mice. Supplementation of immune serum in IL-4Rα−/− mice completely restored H. polygyrus bakeriinduced basophilia (Fig. 4C). Importantly, no soluble IL-3 could be detected in immune serum, indicating that it was the antibody component that was responsible for the observed ...
... restore basophilia in these mice. Supplementation of immune serum in IL-4Rα−/− mice completely restored H. polygyrus bakeriinduced basophilia (Fig. 4C). Importantly, no soluble IL-3 could be detected in immune serum, indicating that it was the antibody component that was responsible for the observed ...
Software Modeling of the Complement System and its role in
... I am indebted to my supervisor Dr. Jugal K. Kalita for helping me define my topic in this thesis and having been of invaluable assistance in my endeavors. He has given me constant support and guidance through out. I would like to thank Dr. Karen Newell and Dr. Maria Augusteijn for agreeing to be my ...
... I am indebted to my supervisor Dr. Jugal K. Kalita for helping me define my topic in this thesis and having been of invaluable assistance in my endeavors. He has given me constant support and guidance through out. I would like to thank Dr. Karen Newell and Dr. Maria Augusteijn for agreeing to be my ...
Coinfection with Hepatitis C Virus among HIV-1
... addition to other acquired immunodeficiency syndrome (AIDS)related complications. In areas of the world where highly active antiretroviral therapy (HAART) is available, following AIDSrelated complications, chronic infection with HCV has now become the leading cause of death among HIV-1-infected indi ...
... addition to other acquired immunodeficiency syndrome (AIDS)related complications. In areas of the world where highly active antiretroviral therapy (HAART) is available, following AIDSrelated complications, chronic infection with HCV has now become the leading cause of death among HIV-1-infected indi ...
Major Histocompatibility Complex Heterozygosity Reduces Fitness
... linked genes. We did not determine the parentage for the pups, but the markers enabled us to determine whether the mother was MHC homozygous or heterozygous. Statistical analyses: We always tested the data for assumptions of normality and equality of variances before conducting parametric tests. The ...
... linked genes. We did not determine the parentage for the pups, but the markers enabled us to determine whether the mother was MHC homozygous or heterozygous. Statistical analyses: We always tested the data for assumptions of normality and equality of variances before conducting parametric tests. The ...
on MHC & Leukemia Associations in Humans
... The borderland of embryogenesis and carcinogenesis. MHC-linked genes affecting development and their possible relationship to the development of cancer Biochim Biophys Acta 1984;738(3):93-102 ...
... The borderland of embryogenesis and carcinogenesis. MHC-linked genes affecting development and their possible relationship to the development of cancer Biochim Biophys Acta 1984;738(3):93-102 ...