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NYU_Lec1 - NDSU Computer Science
NYU_Lec1 - NDSU Computer Science

... Impact on Bioinformatics • Genomics produces high-throughput, highquality data, and bioinformatics provides the analysis and interpretation of these massive data sets. • It is impossible to separate genomics laboratory technologies from the computational tools required for data ...
Human Growth and Development Genetics
Human Growth and Development Genetics

... This type of mutant gene may either create an abnormality or fail to make something that is necessary. ...
AZBio Ch 13
AZBio Ch 13

... During transformation, a cell takes in DNA from outside the cell, and becomes part of the cell’s DNA. The foreign DNA is first joined to a small, circular DNA known as a plasmid. Plasmids are found naturally in some bacteria and have been very useful for DNA transfer. Why? The plasmid has a genetic ...
review-genetics-final-exam-2016
review-genetics-final-exam-2016

... 52. If an electrophoresis gel was used to separate DNA fragments and it ran from bottom to top, where would the longer fragments be located? 53. What charge does DNA carry and what evidence supports your answer? 54. Describe the step-by-step process of gel electrophoresis. ...
Biotechnology
Biotechnology

... Used for studying diseases and roles played by specific genes with a view to curing some human diseases Commonly used animals mice, roundworms and fruit flies Examples: 1. Goats engineered to produce high levels of human protein to dissolve blood clots. 2. Cows engineered to produce higher milk yiel ...


...  Law of Dominance -dominate alleles (capital letter) suppress recessive alleles (lowercase letter)  Law of Segregation -during fertilization gametes randomly pair to produce four sets of alleles (monohyrid)  TT=homozygous dominant, Tt=heterozygous, tt=homozygous recessive  Genotype is the combin ...
Unit topics - Kevan Kruger
Unit topics - Kevan Kruger

... ...
Xeroderma Pigmentosum(XP)
Xeroderma Pigmentosum(XP)

... How to help XP patients? • Some help for XP patients may be on the way in the form of skin creams that contain DNA repair enzymes. • The enzyme are contained in liposomes(脂质体) that can apparently penetrate (穿过) the outer layer of the skin and participate in repair pathways ...
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Methods Used in Medical and Population Genetics

... study rare, “Mendelian” diseases where a single genetic defect can cause illness. ...
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... Repeated cycles of heating and cooling stimulates the primers to attach to copies and copies of copies Result is exponential increase in number of copies of DNA ...
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... 4. The Human Genome Project is a unified effort to identify and determine the sequence of all genes found on the human chromosome. 5. The nucleus 6. Adenine, guanine, cytosine, thymine 7. The phosphate groups give DNA its acidic properties. 8. Blood, semen, saliva, hair follicular tissue, bone 9. Re ...
Genetics Session 5b_2016
Genetics Session 5b_2016

... So we would predict someone's height with a 95% confidence interval of about +/6cm. The top and bottom 10% of any sample are generally 1.6 standard deviation units above or below the average. For height that translates to 1.6*7*√(0.8) = 10cm, so individuals at the genetic tails will tend to be 20cm ...
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Bio_11_Rev

... responds by making defensive proteins called antibodies. The immune system creates a defense system against this form of the disease. •In the future, if the same pathogen enters the body, the antibodies are now there to combat the pathogen and stop it’s growth before it can cause a disease. The immu ...
Cell 103 Heredity and Society
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... 4. The cold viruses used in gene therapy for cystic fibrosis are genetically engineered so they cannot reproduce, and thus cannot cause a viral infection in the patient. Because of this, the therapy does not lead to a permanent cure for cystic fibrosis. Explain why this is the case. ...
CALL FOR PROPOSALS 2008
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... axeny, specific information on genome size (bibliographic references or techniques for estimation of size), G+C content, information on ploidy, polymorphism level (details and methods of estimation), repeat structure with details about how these are known, etc. ...
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... repressors. Those transposons can be activated under certain conditions – could be advantageous for the organism because it could induce rapid mutation.  They are found in between genes and introns.  They are inconspicuous – they insert one into another – so if a transposon goes into another – not ...
BioCY News January 2016 - Genetics, Development, and Cell
BioCY News January 2016 - Genetics, Development, and Cell

... 1988   by   a   group   working   on   E.   coli   at   Osaka   University   in   Japan.   The   scientists   noticed   odd   clusters  of  repeats  in  the  bacteria  but  it  wasn't  until  2005  that  they  got  the  first  inkling ...
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... • Some mutations result in genetic disease • If the mutation is recessive then it is possible for a person to be a carrier of the disease • The frequency of mutations are increased by mutagens • Some mutagens are carcinogens ...
Zoo/Bot 3333
Zoo/Bot 3333

... experiment. Four pairs of PCR primers were used to amplify DNA isolated from one man's somatic cells, and from 21 single sperm that he donated for this study. Each primer pair amplifies a different region of the human genome, referred to as genes A, B, C and D. Each of these amplified regions was th ...
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... Sequencing is no longer the primary need; data storage/retrieval and computational needs are outpacing everything else. How much data storage does 1 human genome require? About 1.5 GB (2 CDs) if your stored only one copy of each letter. For the raw format containing image files and base quality da ...
Lecture 20 Methodology for production of transgenic animals To
Lecture 20 Methodology for production of transgenic animals To

... Methodology for production of transgenic animals To date, there are three basic methods of producing transgenic animals: 1. DNA microinjection 2. Retrovirus-mediated gene transfer 3. Embryonic stem cell-mediated gene transfer Gene transfer by microinjection is the predominant method used to produce ...
Reproductive cloning
Reproductive cloning

... Some Eukaryotic Genomes ...
DNA Technology Tools Graphic Organizer KEY
DNA Technology Tools Graphic Organizer KEY

... Makes many copies of an Used for forensic entire region of DNA investigation and in medical testing. Animals that have Used to study diseases received DNA from some and ways to treat them, other organism to improve food supply, disease resistance, and human health. Plants that have received Creates ...
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Genome editing

Genome editing, or genome editing with engineered nucleases (GEEN) is a type of genetic engineering in which DNA is inserted, replaced, or removed from a genome using artificially engineered nucleases, or ""molecular scissors."" The nucleases create specific double-stranded break (DSBs) at desired locations in the genome, and harness the cell’s endogenous mechanisms to repair the induced break by natural processes of homologous recombination (HR) and nonhomologous end-joining (NHEJ). There are currently four families of engineered nucleases being used: Zinc finger nucleases (ZFNs), Transcription Activator-Like Effector Nucleases (TALENs), the CRISPR/Cas system, and engineered meganuclease re-engineered homing endonucleases.It is commonly practiced in genetic analysis that in order to understand the function of a gene or a protein function one interferes with it in a sequence-specific way and monitors its effects on the organism. However, in some organisms it is difficult or impossible to perform site-specific mutagenesis, and therefore more indirect methods have to be used, such as silencing the gene of interest by short RNA interference (siRNA) . Yet gene disruption by siRNA can be variable and incomplete. Genome editing with nucleases such as ZFN is different from siRNA in that the engineered nuclease is able to modify DNA-binding specificity and therefore can in principle cut any targeted position in the genome, and introduce modification of the endogenous sequences for genes that are impossible to specifically target by conventional RNAi. Furthermore, the specificity of ZFNs and TALENs are enhanced as two ZFNs are required in the recognition of their portion of the target and subsequently direct to the neighboring sequences.It was chosen by Nature Methods as the 2011 Method of the Year.
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