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Handling Drug / Tube Feeding Interactions
Handling Drug / Tube Feeding Interactions

... interactions at your institution • Describe various techniques for avoiding potential drug / tube feeding interactions • Develop a method for avoiding potential drug / tube feeding interactions when specific recommendations are not available ...
Chapter_7
Chapter_7

... peptides. Filtering the database – If some properties of the sample protein(s) are known (like mass, pI, amino acid composition, species of origin), one can filter database sequences not satisfying these properties – However, using some of these can be risky if it is not taken into account that the ...
Bio251 07 HW2 1-26-0..
Bio251 07 HW2 1-26-0..

... Hydrophilic. The Oxygen atom attracts electrons much more forcefully than does a Hydrogen atom. In this way, oxygen is a strongly electronegative atom. As a result the O-H bond is said to be polarized, such that one of the atoms has a partial negative charge, and the other a partial positive charge. ...
Development of Software Package for Determining Protein Titration
Development of Software Package for Determining Protein Titration

... Adapted from Morikis et al ...
Membrane Proteins
Membrane Proteins

proteins
proteins

... ■ Four codons are particularly unique and have special importance in the assembly of amino acids into proteins. – AUG is called the “start codon”. It indicates where a ribosome should begin the assembly of a chain of amino acids to make a protein. – UAA, UGA, and UAG are all called “stop codons”. Li ...
The 92-kDa chitinase from Streptomyces olivaceoviridis contains a
The 92-kDa chitinase from Streptomyces olivaceoviridis contains a

... 1, the amino acid sequences of the three proteinases are identical. For comparison the Nterminal sequence of 92-kDa chitinase [2] is included in Table 1. Initially we had assumed that the instability of chitinases from S. olivaceoviridis was due to contamination with proteases. Later it was shown th ...
The GPI Transamidase Complex of Saccharomyces
The GPI Transamidase Complex of Saccharomyces

... nitrate, and the interesting bands were cut out and cut into small pieces with a scalpel. Then, 100 ␮l of 25 mM NH4HCO3 were added, gel pieces were agitated with a Vortex for 8 min, and the supernatant was discarded. Washing by agitation was reported using 100 ␮l of acetonitrile. Alternating washes ...
Title: Rescuing discarded spectra: Full - e
Title: Rescuing discarded spectra: Full - e

... of information due to the high percentage of unassigned spectra. To determine the causes behind this loss we have analyzed the proteome of one of the smallest living bacteria that can be grown axenically, Mycoplasma pneumoniae (729 ORFs). The proteome of M. pneumoniae cells, grown in defined media, ...
NMR IN DRUG DISCOVERY. FROM SCREENING TO STRUCTURE-BASED DESIGN OF
NMR IN DRUG DISCOVERY. FROM SCREENING TO STRUCTURE-BASED DESIGN OF

... important cross point, and is controlled by various pro and anti-apoptotic factors; we will cover this event in more detail later in this chapter (pg. 64). Among the polypeptides produced by mitochondria during apoptosis we find AIF (apoptosis inducing factor) and endonuclease G, both implicated in ...
Circadian Rhythm of Intestinal SucraseActivity in Rats
Circadian Rhythm of Intestinal SucraseActivity in Rats

... Clark (15). All assays were done in duplicate. Statistical evaluation of differences between means was done by t test. Determination of specific activity offree amino acids. Aliquots of individual mucosal homogenates containing 5 mg of protein were pooled for each time point after injection of ['4C] ...
Molecular Graphics for Ligand Binding Experiment
Molecular Graphics for Ligand Binding Experiment

Dynamics of Plasmodium falciparum enoyl‐ACP reductase and
Dynamics of Plasmodium falciparum enoyl‐ACP reductase and

2-7 Active-Site Geometry
2-7 Active-Site Geometry

Book Review Werner Callebaut and Diego Rasskin
Book Review Werner Callebaut and Diego Rasskin

... separation of processing modules, and argues instead for the idea of “vertical modularity”, defending the use of Berstein’s motor control theory as an alternative, aiming to reconstruct the hierarchical evolutionary mechanisms of mind and brain. Translations from Bernstein’s Russian originals are pr ...
General analysis of observed kinome profiles
General analysis of observed kinome profiles

... Pyruvate Dehydrogenase (PDH) are associated with decreased PDH activity [25], resulting in a lower conversion of pyruvate to acetyl-CoA necessary to drive the TCA/Krebs cycle [26]. These PDH phosphorylation profiles thus point to reduced substrate feeding into the TCA/Krebs cycle in the presence of ...
GEFs: master regulators of G
GEFs: master regulators of G

Alignment between domain region and whole enzyme
Alignment between domain region and whole enzyme

Function and biotechnology of extremophilic enzymes in low water
Function and biotechnology of extremophilic enzymes in low water

... functioning in harsh operational conditions has surged. A great deal of current effort is aimed at screening for new sources of novel enzymes capable of functioning in extreme conditions. The parallel development of sophisticated molecular biology tools has also enabled engineering of enzymes with n ...
Chapter 2 powerpoint file
Chapter 2 powerpoint file

...  Human Proteomics Initiative- determine all the types of proteins in the body. ...
Protein
Protein

... other peptidases specifically attack the linkages between the amino acids. These peptidases digest all the remaining dipeptides and tripeptides into individual amino acids for absorption into the bloodstream. Undigested protein Any parts of proteins that are not digested and absorbed in the small i ...
ELECTROPHORESIS
ELECTROPHORESIS

Sequence Entropy and the Absolute Rate of Amino Acid Substitutions
Sequence Entropy and the Absolute Rate of Amino Acid Substitutions

... specific stability contribution is small relative to the background contribution, so that this second term fulfills the role of the ‘thermal bath’ in statistical physics. This statistical mechanics formalism can now be applied to modeling the amino acid substitution rate. ...
Hydrogen Bonds and Hydrophobic Interactions of Porphyrins in
Hydrogen Bonds and Hydrophobic Interactions of Porphyrins in

... We found large number of hydrophobic interactions (3596) in porphyrin containing proteins. The results presented in Fig. (8A) show that the hydrophobic side chains make larger number of the interactions than side chains of charged and the polar amino acid. The backbone groups are not frequently invo ...
Folie 1 - FLI
Folie 1 - FLI

... Structural genomics consists in the determination of the three dimensional structure of all proteins of a given organism, by experimental methods such as X-ray crystallography, NMR spectroscopy or computational approaches such as homology modelling. As opposed to traditional structural biology, the ...
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Interactome



In molecular biology, an interactome is the whole set of molecular interactions in a particular cell. The term specifically refers to physical interactions among molecules (such as those among proteins, also known as protein-protein interactions) but can also describe sets of indirect interactions among genes (genetic interactions). Mathematically, interactomes are generally displayed as graphs.The word ""interactome"" was originally coined in 1999 by a group of French scientists headed by Bernard Jacq. Though interactomes may be described as biological networks, they should not be confused with other networks such as neural networks or food webs.
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