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FST 123 - Enzymology Homework IS `13
FST 123 - Enzymology Homework IS `13

... c. What predictions can you make about the results of a native PAGE at pH 7.6 (State any assumptions you might need to make about the % acrylamide in the gel.) d. Sketch the elution profile of these proteins from a carboxymethyl cellulose ion exchange chromatography column, run at pH 6.25 (with a sa ...
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HonBio Chapter 3 notes

...  This is done by means of an enzymemediated dehydration synthesis.  A polypeptide chain contains hundreds or thousands of amino acids.  The amino acid sequence causes the polypeptide to assume a particular shape  The shape of a protein determines its specific function. ...
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... Define super-secondary protein structures, motifs and domains. Explain the role of domains in terms of the functional components of proteins Motifs: Each individual protein has a segment that binds to the DNA molecules, and a different segment that binds to its partner protein; DNA binding is highly ...
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Two-hybrid screening



Two-hybrid screening (also known as yeast two-hybrid system or Y2H) is a molecular biology technique used to discover protein–protein interactions (PPIs) and protein–DNA interactions by testing for physical interactions (such as binding) between two proteins or a single protein and a DNA molecule, respectively.The premise behind the test is the activation of downstream reporter gene(s) by the binding of a transcription factor onto an upstream activating sequence (UAS). For two-hybrid screening, the transcription factor is split into two separate fragments, called the binding domain (BD) and activating domain (AD). The BD is the domain responsible for binding to the UAS and the AD is the domain responsible for the activation of transcription. The Y2H is thus a protein-fragment complementation assay.
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