Drug Metabolism Test Results
... the tested individual. Absence of a detectable mutation does not exclude the possibility that the patient has a different drug metabolism phenotype due to harboring untested phenotypically important polymorphisms, drug-drug interactions, co-morbidities, lifestyle habits or other non-genetic factors ...
... the tested individual. Absence of a detectable mutation does not exclude the possibility that the patient has a different drug metabolism phenotype due to harboring untested phenotypically important polymorphisms, drug-drug interactions, co-morbidities, lifestyle habits or other non-genetic factors ...
comparative studies on the cytochrome p450
... Determination of Selegiline and Its Metabolites. Selegiline and its metabolites were analyzed by gas chromatography using nitrogen-selective detection. The assay method is described in detail elsewhere (Taavitsainen et al., 2000). Briefly, samples were made alkaline by adding potassium hydroxide and ...
... Determination of Selegiline and Its Metabolites. Selegiline and its metabolites were analyzed by gas chromatography using nitrogen-selective detection. The assay method is described in detail elsewhere (Taavitsainen et al., 2000). Briefly, samples were made alkaline by adding potassium hydroxide and ...
Uptake of Methotrexate, Aminopterin, and
... mg/kg) was somewhat less than at 1 hr. Much larger doses of Mtx were required to maintain inhibition for 18 hr. At this time , the o for Mtx was approximately 30 mg/kg, while those for MQ and aminopterin were 0.4 and 0.9 mg/kg, respectively. It is evident (Chart 2) that Mtx and MQ are roughly equipo ...
... mg/kg) was somewhat less than at 1 hr. Much larger doses of Mtx were required to maintain inhibition for 18 hr. At this time , the o for Mtx was approximately 30 mg/kg, while those for MQ and aminopterin were 0.4 and 0.9 mg/kg, respectively. It is evident (Chart 2) that Mtx and MQ are roughly equipo ...
Phosphodiesterase 5 inhibitors: are they cardioprotective?
... compartmentalization of cGMP derived from soluble and particulate guanylyl cyclase, Takimoto et al.24 found suppression of isoproterenol-stimulated increase in contractility by sildenafil which was prevented by pre-treatment with an inhibitor of protein kinase G, and also by inhibition of the NO syn ...
... compartmentalization of cGMP derived from soluble and particulate guanylyl cyclase, Takimoto et al.24 found suppression of isoproterenol-stimulated increase in contractility by sildenafil which was prevented by pre-treatment with an inhibitor of protein kinase G, and also by inhibition of the NO syn ...
trimethoprim and sulfamethoxazole are selective inhibitors of cyp2c8
... drug metabolism (i) can be predicted by the Ki value and the concentration of the inhibitor [I] around the metabolic enzyme in the liver using the following scaling model: i ⫽ [I]/([I] ⫹ Ki), assuming that the substrate concentration is much lower than its Km value (von Moltke et al., 1998). After o ...
... drug metabolism (i) can be predicted by the Ki value and the concentration of the inhibitor [I] around the metabolic enzyme in the liver using the following scaling model: i ⫽ [I]/([I] ⫹ Ki), assuming that the substrate concentration is much lower than its Km value (von Moltke et al., 1998). After o ...
Prodrugs for Amines
... membrane penetration by passive diffusion. The impact of this is amplified for the large number of amino drugs that are required to penetrate the blood brain barrier in order to reach their pharmacological targets. A second issue that can affect the development of amino drugs is instability. An exam ...
... membrane penetration by passive diffusion. The impact of this is amplified for the large number of amino drugs that are required to penetrate the blood brain barrier in order to reach their pharmacological targets. A second issue that can affect the development of amino drugs is instability. An exam ...
as a PDF
... use of cocktail method, and specific potent CYP2J2 inhibitor can also facilitate the evaluation of the role that CYP2J2 plays in liver microsomal metabolism and DDI in vivo. Several metabolic reactions have been reported to date to be primarily mediated by CYP2J2; these include astemizole O-demethyl ...
... use of cocktail method, and specific potent CYP2J2 inhibitor can also facilitate the evaluation of the role that CYP2J2 plays in liver microsomal metabolism and DDI in vivo. Several metabolic reactions have been reported to date to be primarily mediated by CYP2J2; these include astemizole O-demethyl ...
PPIs May Reduce Effectiveness Of Clopidogrel (PLAVIX®)
... Dunn SP, Macaulay TE, Brennan DM et al. Abstract 3999 :Baseline proton pump inhibitors use is associated with increased cardiovascular events with and without the use of clopidogrel in the CREDO trial. Circulation 2008;118:S_815. Pharmacist’s Letter. Do proton pump inhibitors decrease clopidogrel (P ...
... Dunn SP, Macaulay TE, Brennan DM et al. Abstract 3999 :Baseline proton pump inhibitors use is associated with increased cardiovascular events with and without the use of clopidogrel in the CREDO trial. Circulation 2008;118:S_815. Pharmacist’s Letter. Do proton pump inhibitors decrease clopidogrel (P ...
the PDF
... Excellent papers on the preclinical characterization of rivastigmine were communicated [97–102]. Extensive literature exists on the clinical trial results of rivastigmine in AD (in chronological order) [103–112]. Rivastigmine at doses of up to 12 mg/day had useful efficacy in patients with mild-mode ...
... Excellent papers on the preclinical characterization of rivastigmine were communicated [97–102]. Extensive literature exists on the clinical trial results of rivastigmine in AD (in chronological order) [103–112]. Rivastigmine at doses of up to 12 mg/day had useful efficacy in patients with mild-mode ...
Anaplastic lymphoma kinase (ALK) - Blue Ridge Institute for Medical
... Anaplastic lymphoma kinase was first described in 1994 as the NPM-ALK fusion protein that is expressed in the majority of anaplastic large-cell lymphomas. ALK is a receptor protein-tyrosine kinase that was more fully characterized in 1997. Physiological ALK participates in embryonic nervous system de ...
... Anaplastic lymphoma kinase was first described in 1994 as the NPM-ALK fusion protein that is expressed in the majority of anaplastic large-cell lymphomas. ALK is a receptor protein-tyrosine kinase that was more fully characterized in 1997. Physiological ALK participates in embryonic nervous system de ...
PORTULACA OLERACEA PHARMACOLOGICAL POTENTIAL Review Article
... The fatty acid content in P. oleracea ranged from 1.5 to 2.5 mg/g of fresh mass in leaves, 0.6 to 0.9 mg/g in stems and 80 to 170 mg/g in seeds. The β-carotene content ranged from 22 to 30 mg/g fresh mass in leaves. Longer-chain omega-3 fatty acids were not detected [32]. α-Linolenic acid accounted ...
... The fatty acid content in P. oleracea ranged from 1.5 to 2.5 mg/g of fresh mass in leaves, 0.6 to 0.9 mg/g in stems and 80 to 170 mg/g in seeds. The β-carotene content ranged from 22 to 30 mg/g fresh mass in leaves. Longer-chain omega-3 fatty acids were not detected [32]. α-Linolenic acid accounted ...
Oleo-gum-resin of Ferula asafoetida: A traditional culinary spice with
... locomotor motor activity meter for analgesic and sedative activity. He used diazepam as a reference anxiolytic agent. The results showed a dose-dependent anxiolytic and analgesic activity of aqueous extract of asafoetida, with a mild sedative effect in high doses in rodents at dose of 250mg/kg and 5 ...
... locomotor motor activity meter for analgesic and sedative activity. He used diazepam as a reference anxiolytic agent. The results showed a dose-dependent anxiolytic and analgesic activity of aqueous extract of asafoetida, with a mild sedative effect in high doses in rodents at dose of 250mg/kg and 5 ...
ISOLATION AND IDENTIFICATION OF NAPHTHOQUINONES EUCLEA NATALENSIS WITH ACTIVITY AGAINST
... extracts derived from over 10,500 samples for activity against the human immunodeficiency virus (HIV); 2320 of these extracts were of medicinal plant origin. Approximately 18% of the total number of extracts showed significant anti-HIV activity of which four plant-derived compounds are in preclinica ...
... extracts derived from over 10,500 samples for activity against the human immunodeficiency virus (HIV); 2320 of these extracts were of medicinal plant origin. Approximately 18% of the total number of extracts showed significant anti-HIV activity of which four plant-derived compounds are in preclinica ...
Analgesic and Anti-inflammatory Activities of Ethanolic Root Extract
... The ethanolic root extract of Swertia chirata was chosen for pharmacological screening and analgesic and anti-inflammatory activities in animal models. The anti-inflammatory activity was assessed using the carrageenan-induced rat paw edema model. The analgesic effect was measured in mice using the a ...
... The ethanolic root extract of Swertia chirata was chosen for pharmacological screening and analgesic and anti-inflammatory activities in animal models. The anti-inflammatory activity was assessed using the carrageenan-induced rat paw edema model. The analgesic effect was measured in mice using the a ...
Evaluation of Diuretic activity of aqueous and alcoholic rhizomes
... followed by Dennetts test. The comparison made for the urine volume, concentration of electrolytes. P<0.05 is considered as moderately significant, p<0.01 is considered as highly significant. The present study revealed that alcoholic and aqueous extracts of Costus peciosus Linn significantly increas ...
... followed by Dennetts test. The comparison made for the urine volume, concentration of electrolytes. P<0.05 is considered as moderately significant, p<0.01 is considered as highly significant. The present study revealed that alcoholic and aqueous extracts of Costus peciosus Linn significantly increas ...
week5
... Binding free energies can be calculated accurately from umbrella sampling MD simulations. For selectivity, one could use the free energy perturbation (FEP) method (computationally cheaper). ...
... Binding free energies can be calculated accurately from umbrella sampling MD simulations. For selectivity, one could use the free energy perturbation (FEP) method (computationally cheaper). ...
New Hepatitis C Therapies: The Toolbox, Strategies, and
... Nevertheless, second-generation NS3-4A protease inhibitors select resistant variants that also are selected by first-generation compounds, including variants with substitutions at position A156, which are unlikely to replicate at high levels in vivo, and variants with substitutions at position D168, ...
... Nevertheless, second-generation NS3-4A protease inhibitors select resistant variants that also are selected by first-generation compounds, including variants with substitutions at position A156, which are unlikely to replicate at high levels in vivo, and variants with substitutions at position D168, ...
Pharmaceuticals - Sites @ Suffolk University
... ProstaglandinF2α is used extensively today in cattle breeding. Prostaglandin E1 is used to induce labor to terminate pregnancy. Prostaglandins have also been used clinically to lower or raise blood pressure and are being tested for a wide variety of therapeutic uses. Body areas which are inflamed an ...
... ProstaglandinF2α is used extensively today in cattle breeding. Prostaglandin E1 is used to induce labor to terminate pregnancy. Prostaglandins have also been used clinically to lower or raise blood pressure and are being tested for a wide variety of therapeutic uses. Body areas which are inflamed an ...
... isolated human bronchi, in vivo LTE4 is approximately one tenth as potent as LTD, but with a longer duration of action [25]. LTC4 and LTD4 are also potent stimulants of mucous glycoproteins from human airways in vitro [26, 27]. In vivo, they enhance secretion of mucus [28], and stimulate secretion o ...
Clinical Pharmacology of Boceprevir (BOC): Metabolism
... • Many drugs are CYP3A4 inhibitors o These interactions are understood and managed appropriately o CYP3A4 substrate drugs with toxicities often dose-titrated as standard practice o Many drug classes include alternatives that are not CYP3A4 substrates o No interaction with drugs metabolized by other ...
... • Many drugs are CYP3A4 inhibitors o These interactions are understood and managed appropriately o CYP3A4 substrate drugs with toxicities often dose-titrated as standard practice o Many drug classes include alternatives that are not CYP3A4 substrates o No interaction with drugs metabolized by other ...
CALPAIN: TRANSITIONING FROM THE USE OF THE
... Figure 1.2. The catalytic triad of papain, Ca2+-free m-calpain and µI-II. ........................................ 7 Figure 1.3. Calcium-induced conformational change of m-calpain................................................. 9 Figure 1.4. Domain structure of CAST and its interaction with calpain ...
... Figure 1.2. The catalytic triad of papain, Ca2+-free m-calpain and µI-II. ........................................ 7 Figure 1.3. Calcium-induced conformational change of m-calpain................................................. 9 Figure 1.4. Domain structure of CAST and its interaction with calpain ...
THESPESIA POPULNEA LINN. Review Article MOHINI A. PHANSE*,
... The nitric oxide method reveals that the standard drug i. e. ascorbic acid shows good results when compared to ethanolic extract of T. populnea. Antioxidants help to neutralize free radicals, which are unstable molecules that are linked to the development of a number of degenerative diseases such as ...
... The nitric oxide method reveals that the standard drug i. e. ascorbic acid shows good results when compared to ethanolic extract of T. populnea. Antioxidants help to neutralize free radicals, which are unstable molecules that are linked to the development of a number of degenerative diseases such as ...
... The pituitary adenylate cyclase-activating peptides (PACAPs) are vasoactive intestinal peptide (VIP)-like neuropeptides existing in a 38 and a 27-amino acid residue form [1, 2], named PACAP-38 and PACAP-27, respectively, with an identical 1–27 amino acid sequence. Immunoreactivity for PACAPs has bee ...
Herb -Drug Interactions –An Update on Synergistic Interactions
... the form of dietary supplements are being consumed along with modern allopathic drugs [1,2]. This is particularly true for geriatric patients who consume a number of medications simultaneously. The consumption of herbal drugs is often associated with a general belief that these drugs are relatively ...
... the form of dietary supplements are being consumed along with modern allopathic drugs [1,2]. This is particularly true for geriatric patients who consume a number of medications simultaneously. The consumption of herbal drugs is often associated with a general belief that these drugs are relatively ...
Structural and functional validation of S
... I would like to acknowledge the following individuals and institutions: My supervisor, Prof. L Birkholtz, for her support, guidance and insight during this project, as well as all the conference, research and collaborative opportunities she provided me. My co-supervisor, Prof. A. I. Louw, for always ...
... I would like to acknowledge the following individuals and institutions: My supervisor, Prof. L Birkholtz, for her support, guidance and insight during this project, as well as all the conference, research and collaborative opportunities she provided me. My co-supervisor, Prof. A. I. Louw, for always ...