Review Article Amla (Emblica officinalis) – Medicinal Food and
... suggest that it has anti-viral properties and also functions as an anti-bacterial and anti-fungal agent. The gelatinous plum-sized Amla fruit contains naturally occurring vitamin, heat stable vitamin C. A clinical study on patients with pulmonary tuberculosis showed that the vitamin C contained in E ...
... suggest that it has anti-viral properties and also functions as an anti-bacterial and anti-fungal agent. The gelatinous plum-sized Amla fruit contains naturally occurring vitamin, heat stable vitamin C. A clinical study on patients with pulmonary tuberculosis showed that the vitamin C contained in E ...
Clinical pharmacology of anti-infectives and nonsteroidal_англ
... A. occurs primarily in patients under 30 years of age B. occurs with increased frequency in patients receiving concomitant ethambutol therapy C. *is probably due to the formation of a toxic hydrazine metabolite that binds to liver protein D. is frequently associated with allergic manifestations such ...
... A. occurs primarily in patients under 30 years of age B. occurs with increased frequency in patients receiving concomitant ethambutol therapy C. *is probably due to the formation of a toxic hydrazine metabolite that binds to liver protein D. is frequently associated with allergic manifestations such ...
PRODUCT MONOGRAPH PrCYKLOKAPRON* 500 mg Tranexamic
... reduction. After oral administration approximately 50% of the parent compound, 2% of the deaminated dicarboxylic acid, and 0.5% of the acetylated product are excreted. Tranexamic acid is eliminated by glomerular filtration, excretion being about 30% at one hour, 55% at three hours and 90% at 24 hour ...
... reduction. After oral administration approximately 50% of the parent compound, 2% of the deaminated dicarboxylic acid, and 0.5% of the acetylated product are excreted. Tranexamic acid is eliminated by glomerular filtration, excretion being about 30% at one hour, 55% at three hours and 90% at 24 hour ...
Non-steroidal anti- inflammatory drugs (NSAIDs)
... • It is given orally and is rapidly absorbed; ...
... • It is given orally and is rapidly absorbed; ...
2D SMARTCyp Reactivity-Based Site of Metabolism Prediction for
... starting with the X-ray structure of apo-CYP2D6. Docking simulations were performed on every conformer of the ensemble for many CYP2D6 substrates. When information from the docking simulations was combined with the estimated site reactivity of the substrates, reliable SOM predictions were achieved. ...
... starting with the X-ray structure of apo-CYP2D6. Docking simulations were performed on every conformer of the ensemble for many CYP2D6 substrates. When information from the docking simulations was combined with the estimated site reactivity of the substrates, reliable SOM predictions were achieved. ...
pantothenic acid: an overview focused on medical aspects
... isolated and extracted from liver by Williams and his colleagues in 1939, as an impure substance (about 40% pure). Thus, the initial isolation produced 3g of pantothenic acid from 250kg of sheep liver (26). In 1939, a partial synthesis of pantothenic acid was carried out independently by Williams in ...
... isolated and extracted from liver by Williams and his colleagues in 1939, as an impure substance (about 40% pure). Thus, the initial isolation produced 3g of pantothenic acid from 250kg of sheep liver (26). In 1939, a partial synthesis of pantothenic acid was carried out independently by Williams in ...
ANTIBACTERIAL AND SYNERGISTIC ACTIVITY OF ETHANOLIC AJWAIN (TRACHYSPERMUM
... The bioactive components from ajwain seed extract were analyzed by GC-MS HP 7890 system (Agilent technologies). The GC-system was equipped with capillary column with dimensions 30m X 0.25mm X 0.25μm. The program used for GC oven temperature was 5 min isothermal at 300ºC, followed by 90º-260ºC at a r ...
... The bioactive components from ajwain seed extract were analyzed by GC-MS HP 7890 system (Agilent technologies). The GC-system was equipped with capillary column with dimensions 30m X 0.25mm X 0.25μm. The program used for GC oven temperature was 5 min isothermal at 300ºC, followed by 90º-260ºC at a r ...
C 1 G
... The generation of pure metabolites can be achieved by organic synthesis, electrochemical oxidation of the parent drug or by biocatalysis using appropriate enzymes. The synthesis by organic chemistry is often complicated by the lack of appropriate synthetic routes for specific metabolites and may yie ...
... The generation of pure metabolites can be achieved by organic synthesis, electrochemical oxidation of the parent drug or by biocatalysis using appropriate enzymes. The synthesis by organic chemistry is often complicated by the lack of appropriate synthetic routes for specific metabolites and may yie ...
effects of cytochrome p450 enzyme inhibitors on the
... venlafaxine, produced only minor changes in the pharmacokinetics of venlafaxine. These studies show that an evident increase in the concentrations of NSAIDs may be expected, if they are used concomitantly with CYP inhibitors. However, as NSAIDs are generally well tolerated, use of single doses of NS ...
... venlafaxine, produced only minor changes in the pharmacokinetics of venlafaxine. These studies show that an evident increase in the concentrations of NSAIDs may be expected, if they are used concomitantly with CYP inhibitors. However, as NSAIDs are generally well tolerated, use of single doses of NS ...
EXTRA MURAL RESEARCH Search for Potential Anticancer Agents:
... we have reported previously12 the discrepancy in the drug contents of various marketed mother tinctures of Homeopathic preparations. Thus, it is better to make dilutions from their accurately measured drug contents and evaluation of anticancer activity of these ones. Due to non-availability of the m ...
... we have reported previously12 the discrepancy in the drug contents of various marketed mother tinctures of Homeopathic preparations. Thus, it is better to make dilutions from their accurately measured drug contents and evaluation of anticancer activity of these ones. Due to non-availability of the m ...
Volume 4, Supplement 1
... chemistry and biological advances in the fundamental and clinical study of antiviral diseases and their treatment. Areas covered include HIV, hepatitis B, hepatitis C and emerging viruses, co-infections, vaccines, animal models, pharmacology, microbicides, alternative therapies, viral dynamics and r ...
... chemistry and biological advances in the fundamental and clinical study of antiviral diseases and their treatment. Areas covered include HIV, hepatitis B, hepatitis C and emerging viruses, co-infections, vaccines, animal models, pharmacology, microbicides, alternative therapies, viral dynamics and r ...
Alkaloids Derived from Phenylalanine and Tyrosine
... of (-)-cathinone is qualitatively quite comparable to that of Damphetamine: it causes anorexia, hyperthermia, respiratory stimulation, mydriasis, arrhythmia, and hypertension. • This amine induces the release of catecholamines from storage. Its effects on the central nervous system depend in part on ...
... of (-)-cathinone is qualitatively quite comparable to that of Damphetamine: it causes anorexia, hyperthermia, respiratory stimulation, mydriasis, arrhythmia, and hypertension. • This amine induces the release of catecholamines from storage. Its effects on the central nervous system depend in part on ...
Is there a role for EGFR Tyrosine Kinase Inhibitors in recurrent
... Cohort A will include 32 patients at first recurrence with EGFRVIII mutations. Cohort B will include 32 patients at first recurrence with EGFR gene amplification but no EGFRVIII mutation ...
... Cohort A will include 32 patients at first recurrence with EGFRVIII mutations. Cohort B will include 32 patients at first recurrence with EGFR gene amplification but no EGFRVIII mutation ...
Strategies for in vitro Transporter Testing and
... Huang, et al. New Era in Drug Interaction Evaluation: US FDA Update on CYP Enzymes, Transporters, and the Guidance Process. J. Clin. Pharmacol. 48:662-670 (2008) ...
... Huang, et al. New Era in Drug Interaction Evaluation: US FDA Update on CYP Enzymes, Transporters, and the Guidance Process. J. Clin. Pharmacol. 48:662-670 (2008) ...
A treasure of medicinal herb - Anacyclus pyrethrum A review
... rooting. They can be inserted at any time from October to May. The foliage should be shortened to about 3 inches, when the cuttings will be ready for insertion in a bed of light, sandy soil. Plant very firmly, surface the bed with sand, and water in well. Shade is necessary while the cuttings are ro ...
... rooting. They can be inserted at any time from October to May. The foliage should be shortened to about 3 inches, when the cuttings will be ready for insertion in a bed of light, sandy soil. Plant very firmly, surface the bed with sand, and water in well. Shade is necessary while the cuttings are ro ...
... activity, is an antagonist at adenosine receptors, blockade of adenosine activity has been proposed as a possible mechanism for theophylline's effects in asthma [30]. In human bronchial smooth muscle, however, 8-phenyltheophylline - a methylxanthine adenosine antagonist with negligible PDE inhibitor ...
Pharmacology Objectives 7
... 2) Describe the mechanism of action for each class of diuretic. Osmotic Diuretics – Mannitol is filtered by the glomerulus and not reabsorbed thus exerting an osmotic action. Na+ reabsoption is impaired in the proximal tubule and thick ascending limb. Carbonic Anhydrase Inhibitors – Acetazolamide in ...
... 2) Describe the mechanism of action for each class of diuretic. Osmotic Diuretics – Mannitol is filtered by the glomerulus and not reabsorbed thus exerting an osmotic action. Na+ reabsoption is impaired in the proximal tubule and thick ascending limb. Carbonic Anhydrase Inhibitors – Acetazolamide in ...
Genetically modified yeasts as a new oral drug delivery system: from
... interleukin-10 (IL-10), a strong anti-inflammatory cytokine, in a localised manner by the action of recombinant Lactococcus lactis (L. lactis). A recent phase I clinical trial has reported that the treatment of Crohn’s disease patients with L. lactis secreting human IL-10 was safe and allowed a decr ...
... interleukin-10 (IL-10), a strong anti-inflammatory cytokine, in a localised manner by the action of recombinant Lactococcus lactis (L. lactis). A recent phase I clinical trial has reported that the treatment of Crohn’s disease patients with L. lactis secreting human IL-10 was safe and allowed a decr ...
Inhibition and induction of human cytochrome P450 (CYP) enzymes
... A phenom enon that cannot be overemphasized in the ® eld of xenobiotic metabolism is interindividual variability, which results in very individualized patterns of enzyme composition and hence metabolic activities. Permanent determinants causing variability are genetic factors, which result in pharma ...
... A phenom enon that cannot be overemphasized in the ® eld of xenobiotic metabolism is interindividual variability, which results in very individualized patterns of enzyme composition and hence metabolic activities. Permanent determinants causing variability are genetic factors, which result in pharma ...
The impact of penicillin on therapeutic outcomes
... cancer,autoͲimmunediseases,newvaccines,etc.aredependentonthesamemicrobialstrain selectionandlargeͲscalechemicalengineeringmethodsthatwerefirstpioneeredforpenicillin. • ThedevelopmentofpenicillinduringWorldWarIImarkedafundamentalchangeinthe p p g g relationshipb ...
... cancer,autoͲimmunediseases,newvaccines,etc.aredependentonthesamemicrobialstrain selectionandlargeͲscalechemicalengineeringmethodsthatwerefirstpioneeredforpenicillin. • ThedevelopmentofpenicillinduringWorldWarIImarkedafundamentalchangeinthe p p g g relationshipb ...
of aspirin
... inactivation of cyclooxygenase because they have little or no capacity for protein biosynthesis and thus cannot regenerate the cyclooxygenase enzyme. • In practical terms, this means that a single dose of aspirin will inhibit the platelet cyclooxygenase for the life of the platelet (8 to 11 days); i ...
... inactivation of cyclooxygenase because they have little or no capacity for protein biosynthesis and thus cannot regenerate the cyclooxygenase enzyme. • In practical terms, this means that a single dose of aspirin will inhibit the platelet cyclooxygenase for the life of the platelet (8 to 11 days); i ...
Martindale: The Complete Drug Reference
... starch into dextrins and sugars. They are given orally in conditions of pancreatic exocrine deficiency such as pancreatitis and cystic fibrosis. They are available in the form of powder, capsules containing powder or enteric-coated granules (which may be opened before use and the contents sprinkled ...
... starch into dextrins and sugars. They are given orally in conditions of pancreatic exocrine deficiency such as pancreatitis and cystic fibrosis. They are available in the form of powder, capsules containing powder or enteric-coated granules (which may be opened before use and the contents sprinkled ...
a review on the pharmacology of embelia ribes burm.f.
... side effects, but they are still the basis of drugs that are vital for treatment of disorders such as cancer or diabetes, one such classical example is the modified form of the compound acetylsalicylic acid more commonly known as aspirin was the first modern drug that was born from the nature’s medi ...
... side effects, but they are still the basis of drugs that are vital for treatment of disorders such as cancer or diabetes, one such classical example is the modified form of the compound acetylsalicylic acid more commonly known as aspirin was the first modern drug that was born from the nature’s medi ...
PHARMACOLOGICAL SCREENING AND EVALUATION OF ANTI-PEPTIC ULCER PROPERTY OF Research Article
... Plants constitute a major remedy in the traditional medical system. The practice continues today due to their biomedical benefits, non toxic nature, their easy access and a place in cultural benefits. In the present scenario, medicinal plants have been used as a source of drugs and as a potential so ...
... Plants constitute a major remedy in the traditional medical system. The practice continues today due to their biomedical benefits, non toxic nature, their easy access and a place in cultural benefits. In the present scenario, medicinal plants have been used as a source of drugs and as a potential so ...