fucidin h - LEO Pharma
... bacterial protein synthesis. Such variants appear to be defective in that they grow more slowly than the parent strain, have a lower pathogenicity and subsequently revert to full sensitivity in the absence of fusidic acid. This type of mutation occurs at a high rate in vitro, but emergence of resist ...
... bacterial protein synthesis. Such variants appear to be defective in that they grow more slowly than the parent strain, have a lower pathogenicity and subsequently revert to full sensitivity in the absence of fusidic acid. This type of mutation occurs at a high rate in vitro, but emergence of resist ...
Pr FINACEA®
... doses where some maternal toxicity was noted. No teratogenic effects were observed. The embryofetal NOAEL was 32 times the MRHD based on BSA in rats, 6.5 times the MRHD based on BSA in rabbits and 19 times the MRHD based on BSA in monkeys. In a peri- and post-natal developmental study in rats where ...
... doses where some maternal toxicity was noted. No teratogenic effects were observed. The embryofetal NOAEL was 32 times the MRHD based on BSA in rats, 6.5 times the MRHD based on BSA in rabbits and 19 times the MRHD based on BSA in monkeys. In a peri- and post-natal developmental study in rats where ...
Effect of Oxidative Stress on AhpC Activity and Virulence in katG
... The search for anti TB drugs has been undergoing slow moving phase. Commercially available anti TB drugs have been used for 40 years. Drug resistant M.tuberculosis strain has emerged since many years, however, until recently new and potent anti TB drug have not yet discovered. Slow development of an ...
... The search for anti TB drugs has been undergoing slow moving phase. Commercially available anti TB drugs have been used for 40 years. Drug resistant M.tuberculosis strain has emerged since many years, however, until recently new and potent anti TB drug have not yet discovered. Slow development of an ...
study
... due to the inhibitory effect on commonly implicated bacteriae in burns. The ability of boa fat to inhibit the inflammatory responses produced in the croton oil-induced ear edema in the mice showed that it possesses antiinflammatory property which is probably mediated via inhibition of prostaglandins ...
... due to the inhibitory effect on commonly implicated bacteriae in burns. The ability of boa fat to inhibit the inflammatory responses produced in the croton oil-induced ear edema in the mice showed that it possesses antiinflammatory property which is probably mediated via inhibition of prostaglandins ...
Drug Review - Shodhganga
... to the application of heat or any vesicant alkaline solution as well as in bite of wild beasts and birds etc. and act beneficially in baths, unguents and lubrication Pharmacological Action : Sneha – because of qualities like Ushma, Tikshna, Vyavayi and Sukshma, reaches up to the microchannel levels, ...
... to the application of heat or any vesicant alkaline solution as well as in bite of wild beasts and birds etc. and act beneficially in baths, unguents and lubrication Pharmacological Action : Sneha – because of qualities like Ushma, Tikshna, Vyavayi and Sukshma, reaches up to the microchannel levels, ...
PROTECTIVE EFFECT OF NIGELLA SATIVA AGAINST ASPIRIN INDUCED GASTRIC DAMAGE IN RATS Original Article
... Methods: Ethanolic and aqueous extracts of Nigella sativa were prepared with the help of Soxhlet’s apparatus. Forty two wistar albino rats (150200g) of either sex were divided into seven groups of 6 each. Rats of group I and II were administered distilled water 0.5ml daily p.o for 5days, Group III w ...
... Methods: Ethanolic and aqueous extracts of Nigella sativa were prepared with the help of Soxhlet’s apparatus. Forty two wistar albino rats (150200g) of either sex were divided into seven groups of 6 each. Rats of group I and II were administered distilled water 0.5ml daily p.o for 5days, Group III w ...
IOSR Journal of Pharmacy and Biological Sciences (IOSR-JPBS)
... P.biglobosa showed the presence of phenols and tannins, studies indicated the presence of phenols and tannins in P.biglobosa [12, 20].Thin layer chromatography studies showed the confirmation of phenolic compounds like tannins and phenols Rf 0.78 and 0.97 values which were more close to the standard ...
... P.biglobosa showed the presence of phenols and tannins, studies indicated the presence of phenols and tannins in P.biglobosa [12, 20].Thin layer chromatography studies showed the confirmation of phenolic compounds like tannins and phenols Rf 0.78 and 0.97 values which were more close to the standard ...
Dipeptidyl peptidase4 inhibitors in the treatment of type 2
... Figure 2. Extent of plasma dipeptidyl peptidase (DPP)-4 activity in humans after DPP-4 inhibitor administration. (A) Vildagliptin, modified from He et al. [25]; (B) saxagliptin, modified from Boulton et al. [26]; (C) sitagliptin, modified from Bergman et al. [27]; (D) alogliptin, modified from Covin ...
... Figure 2. Extent of plasma dipeptidyl peptidase (DPP)-4 activity in humans after DPP-4 inhibitor administration. (A) Vildagliptin, modified from He et al. [25]; (B) saxagliptin, modified from Boulton et al. [26]; (C) sitagliptin, modified from Bergman et al. [27]; (D) alogliptin, modified from Covin ...
Inhaled loop diuretics as potential ... asthmatic drugs - *
... the studies detailed above, or in a controlled study in which specific airway resistance and forced expiratory volume in one second were monitored for 5 h in a group of asthmatic patients with airway obstruction highly reversible after inhalation of fenoterol [64]. In a more recent study, frusemide ...
... the studies detailed above, or in a controlled study in which specific airway resistance and forced expiratory volume in one second were monitored for 5 h in a group of asthmatic patients with airway obstruction highly reversible after inhalation of fenoterol [64]. In a more recent study, frusemide ...
Perspective Herb–Drug Interactions: Challenges and Opportunities
... inhibition, the interaction can persist after removal of the perpetrator since recovery of enzyme activity depends on de novo protein synthesis (Grimm et al., 2009). Inhibition of Protein-Mediated Flux. Compared with metabolismbased interactions, mechanistic information about transporter-based inter ...
... inhibition, the interaction can persist after removal of the perpetrator since recovery of enzyme activity depends on de novo protein synthesis (Grimm et al., 2009). Inhibition of Protein-Mediated Flux. Compared with metabolismbased interactions, mechanistic information about transporter-based inter ...
KIRGANELIA RETICULATA CARRAGEENAN
... permission from IAEC of the Bundelkhand University, India. (Reference number BU/Pharm/IAEC/12/026). In- vivo Anti- inflammatory activity by Carrageenan- induced rat paw oedema model The method of Winter et al [9]; was used to evaluate antiinflammatory activity with some minor modifications. The rats ...
... permission from IAEC of the Bundelkhand University, India. (Reference number BU/Pharm/IAEC/12/026). In- vivo Anti- inflammatory activity by Carrageenan- induced rat paw oedema model The method of Winter et al [9]; was used to evaluate antiinflammatory activity with some minor modifications. The rats ...
Spotlight on the microbes that produce heat shock protein 90
... Since these discoveries of Hsp90 as the target of the benzoquinone ansamycins and RAD, several other natural compounds—including a number derived from medicinal plants—have been found to bind, and inhibit, this chaperone (table 1). Each of these is now providing a lead for further drug development [ ...
... Since these discoveries of Hsp90 as the target of the benzoquinone ansamycins and RAD, several other natural compounds—including a number derived from medicinal plants—have been found to bind, and inhibit, this chaperone (table 1). Each of these is now providing a lead for further drug development [ ...
IOSR Journal of Pharmacy and Biological Sciences (IOSR-JPBS) e-ISSN: 2278-3008, p-ISSN:2319-7676.
... out by using Eddy’s Hotplate method and acetic acid-induced writhing test and Anti inflammatory study was evaluated by Cotton pellet granuloma method and by plethysmometer method. The result of the analgesic activity evaluated using hot plate method revealed that the reaction time for mice was signi ...
... out by using Eddy’s Hotplate method and acetic acid-induced writhing test and Anti inflammatory study was evaluated by Cotton pellet granuloma method and by plethysmometer method. The result of the analgesic activity evaluated using hot plate method revealed that the reaction time for mice was signi ...
chapter one
... blood from infected human hosts. The parasites multiply in the stomach-wall of the mosquito, and then migrate through her body to infect the salivary glands. When the infected mosquito feeds on human blood, it injects saliva containing the malaria parasites into the human host and the cycle starts a ...
... blood from infected human hosts. The parasites multiply in the stomach-wall of the mosquito, and then migrate through her body to infect the salivary glands. When the infected mosquito feeds on human blood, it injects saliva containing the malaria parasites into the human host and the cycle starts a ...
Full Text
... interactions with proteins of the blood coagulation cascade (Capila and Linhardt 2002; Munoz and Linhardt 2004). Four types of bacterial heparin/HS lyases have been identified. Heparinase I (HepI) is specific for heparin and cleaves the bond on the nonreducing end of iduronic acid, heparinase III (Hep ...
... interactions with proteins of the blood coagulation cascade (Capila and Linhardt 2002; Munoz and Linhardt 2004). Four types of bacterial heparin/HS lyases have been identified. Heparinase I (HepI) is specific for heparin and cleaves the bond on the nonreducing end of iduronic acid, heparinase III (Hep ...
Determination and Characterization of a Cannabinoid Receptor in
... by a G protein. The binding was also sensitive to MgCI2 and CaCI2. Binding of [3H]CP-55,940 was displaced by cannabinoid drugs in the following order of potency: CP-55,940 ...
... by a G protein. The binding was also sensitive to MgCI2 and CaCI2. Binding of [3H]CP-55,940 was displaced by cannabinoid drugs in the following order of potency: CP-55,940 ...
Managing Drug Interactions
... • H2Blockers follow the same rules as H1Blockers; Cimetidine is the most potent inhibitor, ranitidine to a lesser degree, and famotidine slightly lesser. Mnemonic: “cim>ran>fam” ...
... • H2Blockers follow the same rules as H1Blockers; Cimetidine is the most potent inhibitor, ranitidine to a lesser degree, and famotidine slightly lesser. Mnemonic: “cim>ran>fam” ...
Potential Anti-HIV Activity of Jatropha curcas Linn. Leaf Extracts
... jatropham and jatrophone, are reported from other species of Jatropha [8]. The plant has also been homoeopathically used for cold sweats, colic, collapse, cramps, cyanosis, diarrhoea, leg cramps [7,8]. Some other potential antimicrobial activity of Jatropha curcas Linn. have also been found [9,10]. ...
... jatropham and jatrophone, are reported from other species of Jatropha [8]. The plant has also been homoeopathically used for cold sweats, colic, collapse, cramps, cyanosis, diarrhoea, leg cramps [7,8]. Some other potential antimicrobial activity of Jatropha curcas Linn. have also been found [9,10]. ...
Angiotensin-Converting Enzyme Inhibitor-Induced
... and the thromboxane receptor antagonist picotamide (not available in the United States).24 In open-label, uncontrolled studies, agents shown to suppress ACE inhibitor-induced cough include the ␥-aminobutyric acid agonist baclofen,25 the thromboxane synthetase inhibitor ozagrel,26 and aspirin, 500 mg ...
... and the thromboxane receptor antagonist picotamide (not available in the United States).24 In open-label, uncontrolled studies, agents shown to suppress ACE inhibitor-induced cough include the ␥-aminobutyric acid agonist baclofen,25 the thromboxane synthetase inhibitor ozagrel,26 and aspirin, 500 mg ...
The Role of Ligand Efficiency Measures in Drug Discovery
... entropy may not be as significant as is commonly believed. In contrast to size, both lipophilic enthalpy and lipophilic entropy efficiencies tend to decrease with increasing lipophilicity (see Supplementary Figure S1). For individual protein targets, lipophilic ligand efficiency (LLE or LipE, Box 1) ...
... entropy may not be as significant as is commonly believed. In contrast to size, both lipophilic enthalpy and lipophilic entropy efficiencies tend to decrease with increasing lipophilicity (see Supplementary Figure S1). For individual protein targets, lipophilic ligand efficiency (LLE or LipE, Box 1) ...
A review of toxicity from topical salicylic acid - E
... salicylic acid can be found in the body even after The level at which salicylic toxicity begins is 35 application of low concentrations in hydrophilic mg/dL.6 The half-life of salicylic acid can range from ointment.9 Using cutaneous microdialysis, it was 2 to 12 hours depending on the dose. If 16 g ...
... salicylic acid can be found in the body even after The level at which salicylic toxicity begins is 35 application of low concentrations in hydrophilic mg/dL.6 The half-life of salicylic acid can range from ointment.9 Using cutaneous microdialysis, it was 2 to 12 hours depending on the dose. If 16 g ...
1. Immediate 2. Delayed 3. Cumulative
... but it illustrates a very simple principle -- “If the dose of a drug is doubled then the duration of response will increase by one half-life.” The duration of response means the time that the drug effect is above a pre-defined critical value e.g. the time above 50% of Emax. With a low dose (blue lin ...
... but it illustrates a very simple principle -- “If the dose of a drug is doubled then the duration of response will increase by one half-life.” The duration of response means the time that the drug effect is above a pre-defined critical value e.g. the time above 50% of Emax. With a low dose (blue lin ...
Thiazide and Thiazide
... 1) The 2-position can tolerate small alkyl groups as CH3. 2) Substitutents in the 3-position determine the potency and duration of action of the thiazides. 3) Saturation of C-N bond between the 3 and 4 positions of the benzothiadiazine-1,1-dioxide nucleus increases the potency of this class of diure ...
... 1) The 2-position can tolerate small alkyl groups as CH3. 2) Substitutents in the 3-position determine the potency and duration of action of the thiazides. 3) Saturation of C-N bond between the 3 and 4 positions of the benzothiadiazine-1,1-dioxide nucleus increases the potency of this class of diure ...