IOSR Journal of Dental and Medical Sciences (IOSR-JDMS)
... 2 Diabetes caused by insulin resistance is the commoner type comprising 90% of Diabetics1.Before the advent of modern medicine, the people of South India used Siddha system of medicine to combat this complex metabolic disorder recognized by them as Madhumegam and were protected from the onslaughts o ...
... 2 Diabetes caused by insulin resistance is the commoner type comprising 90% of Diabetics1.Before the advent of modern medicine, the people of South India used Siddha system of medicine to combat this complex metabolic disorder recognized by them as Madhumegam and were protected from the onslaughts o ...
Valproic acid metabolism and its effects
... Becker and Harris were the first to demonstrate the formation of valproyl-CoA, identifying this conjugate by HPLC analysis in extracts of the liver of rats treated with VPA (Becker and Harris 1983). Direct proof of VPA b-oxidation, including the subsequent reactions and metabolites, was obtained thr ...
... Becker and Harris were the first to demonstrate the formation of valproyl-CoA, identifying this conjugate by HPLC analysis in extracts of the liver of rats treated with VPA (Becker and Harris 1983). Direct proof of VPA b-oxidation, including the subsequent reactions and metabolites, was obtained thr ...
Aldehyde Oxidase Activity in Donor
... in vitro system theoretically contains the full complement of drugmetabolizing enzymes and cofactors in the liver. In addition, advancement of cryopreservation techniques has enabled easier access to hepatocytes. However, cytochrome P450 activities are the primary focus of enzyme characterization us ...
... in vitro system theoretically contains the full complement of drugmetabolizing enzymes and cofactors in the liver. In addition, advancement of cryopreservation techniques has enabled easier access to hepatocytes. However, cytochrome P450 activities are the primary focus of enzyme characterization us ...
T Th he eo
... of selectivity of theophylline for any of the PDE isoenzyme families, although it remains a possibility that unique PDE isoenzymes may be discovered that are more sensitive to theophylline. It is also possible that certain PDE isoenzymes are induced in asthmatic airways, and this may increase the se ...
... of selectivity of theophylline for any of the PDE isoenzyme families, although it remains a possibility that unique PDE isoenzymes may be discovered that are more sensitive to theophylline. It is also possible that certain PDE isoenzymes are induced in asthmatic airways, and this may increase the se ...
INHIBITION OF HERPES SIMPLEX VIRUS INFECTION WITH
... drugs against HSV has not resulted in widespread prevalence of drug resistant HSV strains. However, immunocompromised patients have higher incidence of drug resistant HSV and some current medical treatments result in attenuation of the immune system. Hence, as this type of immunosuppressant treatmen ...
... drugs against HSV has not resulted in widespread prevalence of drug resistant HSV strains. However, immunocompromised patients have higher incidence of drug resistant HSV and some current medical treatments result in attenuation of the immune system. Hence, as this type of immunosuppressant treatmen ...
Interactive Association of Drugs Binding to Human
... diffuse through the barriers constituted by endothelial cells into the organs where they are metabolized, biliary excretion or glomerular filtration in kidney [7,15,16]. The unbound drugs can also be distributed intracellularly via specific transport systems. Only free drug molecules interact with t ...
... diffuse through the barriers constituted by endothelial cells into the organs where they are metabolized, biliary excretion or glomerular filtration in kidney [7,15,16]. The unbound drugs can also be distributed intracellularly via specific transport systems. Only free drug molecules interact with t ...
anti-inflammatory, analgesic and antipyretic activities of the aqueous
... Abstract: The aqueous methanolic extract of stem part of Berberis calliobotrys (AMEBC) was evaluated for anti-inflammatory, analgesic and antipyretic activities in albino mice. Anti-inflammatory activity was evaluated by using carrageenan and albumin induced paw edema, while the analgesic effect was ...
... Abstract: The aqueous methanolic extract of stem part of Berberis calliobotrys (AMEBC) was evaluated for anti-inflammatory, analgesic and antipyretic activities in albino mice. Anti-inflammatory activity was evaluated by using carrageenan and albumin induced paw edema, while the analgesic effect was ...
-Lipoic Acid Supplements OVERVIEW Acetyl-L-Carnitine/
... Consumer Exposure: One source of human exposure to acetyl-L-carnitine and "-lipoic acid occurs from their ingestion in dietary supplements. These dietary supplements appeal to older persons as substances that rejuvenate the body by increasing available energy and mental acuity, although students and ...
... Consumer Exposure: One source of human exposure to acetyl-L-carnitine and "-lipoic acid occurs from their ingestion in dietary supplements. These dietary supplements appeal to older persons as substances that rejuvenate the body by increasing available energy and mental acuity, although students and ...
clavamox amoxicillin and clavulanate potassium tablets usp
... ( Anaphylactic) reaction have been reported in patients on penicillin therapy. although anaphylaxis is more frequent following parenteral therapy, it has occurred in patients on oral penicillin. these reactions are more likely to occur in individuals with a history of penicillin hypersensitivity, wh ...
... ( Anaphylactic) reaction have been reported in patients on penicillin therapy. although anaphylaxis is more frequent following parenteral therapy, it has occurred in patients on oral penicillin. these reactions are more likely to occur in individuals with a history of penicillin hypersensitivity, wh ...
Morphine Glucuronidation and Glucosidation Represent
... excreted in trace amounts only. Thus, M-3-glucoside may contribute to the deficit in metabolite recovery observed in earlier studies. It is unknown whether the morphine glucosides are pharmacologically active, as are M3G and M6G (Frances et al., 1992; Milne et al., 1996). Drug and chemical glucosida ...
... excreted in trace amounts only. Thus, M-3-glucoside may contribute to the deficit in metabolite recovery observed in earlier studies. It is unknown whether the morphine glucosides are pharmacologically active, as are M3G and M6G (Frances et al., 1992; Milne et al., 1996). Drug and chemical glucosida ...
lactuca sativa linn. - Journal of Pharmaceutical and Scientific
... Plant origin drugs have played a vital role in the prevention and treatment of diseases in Unani medicine and it becomes popular day by day due to its low cost and less adverse effect. One such drug is Tukhme kahu (Seeds) belong to the family Asteraceae is an important herbal drugs which have hypogl ...
... Plant origin drugs have played a vital role in the prevention and treatment of diseases in Unani medicine and it becomes popular day by day due to its low cost and less adverse effect. One such drug is Tukhme kahu (Seeds) belong to the family Asteraceae is an important herbal drugs which have hypogl ...
Chemical, pharmacokinetic and pharmacodynamic properties of
... 2001), fluvastatin, pitavastatin and rosuvastatin are fully synthetic compounds, with elimination half-lives ranging from 1 h for fluvastatin to 19 h for rosuvastatin. Atorvastatin, simvastatin, lovastatin, fluvastatin, cerivastatin and pitavastatin are relatively lipophilic compounds. Lipophilic st ...
... 2001), fluvastatin, pitavastatin and rosuvastatin are fully synthetic compounds, with elimination half-lives ranging from 1 h for fluvastatin to 19 h for rosuvastatin. Atorvastatin, simvastatin, lovastatin, fluvastatin, cerivastatin and pitavastatin are relatively lipophilic compounds. Lipophilic st ...
Determination of hydrolyzed Gallic Acid content
... in the society [9-10]. It has been reported that tannins Biomed Res- India 2015 Volume 26 Issue 1 ...
... in the society [9-10]. It has been reported that tannins Biomed Res- India 2015 Volume 26 Issue 1 ...
CYP2B6, CYP2D6, and CYP3A4 Catalyze the Primary Oxidative
... Where inhibitor stocks were made using organic solvents, incubations containing equivalent solvent concentrations were used as controls. The incubation conditions were not altered from the kinetic analyses, except that the mechanism-based inhibitors diethyldithiocarbamate, thio-TEPA, furafylline, an ...
... Where inhibitor stocks were made using organic solvents, incubations containing equivalent solvent concentrations were used as controls. The incubation conditions were not altered from the kinetic analyses, except that the mechanism-based inhibitors diethyldithiocarbamate, thio-TEPA, furafylline, an ...
Inhibitory Effects of Fruit Juices on Cytochrome P450
... CYP2C9-mediated metabolism of diclofenac and tolbutamide in vitro. Bromelain inhibits CYP2C9 activity Bromelain is a mixture of cysteine proteases obtained from pineapple stems, and is also present in pineapple fruits.16) The mixture of cysteine proteases is different as between pineapple stems and f ...
... CYP2C9-mediated metabolism of diclofenac and tolbutamide in vitro. Bromelain inhibits CYP2C9 activity Bromelain is a mixture of cysteine proteases obtained from pineapple stems, and is also present in pineapple fruits.16) The mixture of cysteine proteases is different as between pineapple stems and f ...
distribution kinetics of salicylic acid in the dual
... salicyluric acid. Available data suggest that salicyluric acid and salicyl phenolic glucuronide can be reversibly metabolized back to salicylic acid (Morris, 1990). Nevertheless, more recent reports support the idea that salicylic acid is not metabolized (Hussein et al., 1994; Shetty et al., 1994) o ...
... salicyluric acid. Available data suggest that salicyluric acid and salicyl phenolic glucuronide can be reversibly metabolized back to salicylic acid (Morris, 1990). Nevertheless, more recent reports support the idea that salicylic acid is not metabolized (Hussein et al., 1994; Shetty et al., 1994) o ...
Review of Shirish (Albizia lebbeck) therapeutic properties
... The phytochemical profile of this plant reveals the Bark contains 7-11% tannins; d-catechin d-leucocyanidin and it yield 7 compds. Including frieedlan-3-one-and y-sitosterol. The leaves contain echinocystic acid and it yield flavon, vicenin II and β-sitosterol. Flowers yield triterponiodssapononslab ...
... The phytochemical profile of this plant reveals the Bark contains 7-11% tannins; d-catechin d-leucocyanidin and it yield 7 compds. Including frieedlan-3-one-and y-sitosterol. The leaves contain echinocystic acid and it yield flavon, vicenin II and β-sitosterol. Flowers yield triterponiodssapononslab ...
Factors leading to PPI overuse Despite FDA alerts/concerns of PPI
... it removes the burning sensation. Abrupt withdrawal may lead to an acid rebound effect, so a gradual reduction may be required. A pharmacist can play key role in monitoring the progress of a controlled, gradual tapering off of PPIs. In cases where abrupt discontinuation failed, tapering was proven t ...
... it removes the burning sensation. Abrupt withdrawal may lead to an acid rebound effect, so a gradual reduction may be required. A pharmacist can play key role in monitoring the progress of a controlled, gradual tapering off of PPIs. In cases where abrupt discontinuation failed, tapering was proven t ...
patrick_tb_ch22
... Type: multiple choice question Title: Chapter 22 Question 04 04) What type of histamine receptor is associated with the dilation of blood vessels? Feedback: There are two main types of histamine receptor, H1 and H2. H3 and H4 receptors do not exist. The H1 receptor is targeted by traditional antihis ...
... Type: multiple choice question Title: Chapter 22 Question 04 04) What type of histamine receptor is associated with the dilation of blood vessels? Feedback: There are two main types of histamine receptor, H1 and H2. H3 and H4 receptors do not exist. The H1 receptor is targeted by traditional antihis ...
Histopathological evaluation of gastro protective effect of Berberis
... Abstract: The present study was carried out to investigate the antiulcer activity of Berberis vulgaris (Zereshk) seeds in albino mice. After acclimatization, animals were divided into six equal groups. Aspirin 150mg/kg was used to induce gastric ulcer in all groups except normal control. Omeprazole ...
... Abstract: The present study was carried out to investigate the antiulcer activity of Berberis vulgaris (Zereshk) seeds in albino mice. After acclimatization, animals were divided into six equal groups. Aspirin 150mg/kg was used to induce gastric ulcer in all groups except normal control. Omeprazole ...
Pharmacognosy of Coccinia grandis: a review
... bacteria as compared with hexane and water extracts. Leaf hexane extract is more effective than water extract against gram positive and gram negative bacteria. Ethanol extract of stem is more effective against Pseudomonas aeruginosa (9 mm zone of inhibition) whereas ethyl acetate extract and hexane ...
... bacteria as compared with hexane and water extracts. Leaf hexane extract is more effective than water extract against gram positive and gram negative bacteria. Ethanol extract of stem is more effective against Pseudomonas aeruginosa (9 mm zone of inhibition) whereas ethyl acetate extract and hexane ...
PRODUCT MONOGRAPH PrCYKLOKAPRON* 500 mg Tranexamic
... reduction. After oral administration approximately 50% of the parent compound, 2% of the deaminated dicarboxylic acid, and 0.5% of the acetylated product are excreted. Tranexamic acid is eliminated by glomerular filtration, excretion being about 30% at one hour, 55% at three hours and 90% at 24 hour ...
... reduction. After oral administration approximately 50% of the parent compound, 2% of the deaminated dicarboxylic acid, and 0.5% of the acetylated product are excreted. Tranexamic acid is eliminated by glomerular filtration, excretion being about 30% at one hour, 55% at three hours and 90% at 24 hour ...