Phytochemicals for Diabetes Management
... and constituents. This practice may be attributed to the uncompromised cost and side effects of synthetic hypoglycemic agent. Although numerous synthetic drugs were developed for the treatment of diabetes mellitus but the safe and effective treatment paradigm is yet to be achieved [5]. WHO has recom ...
... and constituents. This practice may be attributed to the uncompromised cost and side effects of synthetic hypoglycemic agent. Although numerous synthetic drugs were developed for the treatment of diabetes mellitus but the safe and effective treatment paradigm is yet to be achieved [5]. WHO has recom ...
presentation source
... • Viagra acts competitively with cGMP at the active site of PDE 5. • So, if Viagra inhibits PDE 5, then there will be an accumulation of cGMP in smooth muscle cells until the Viagra is metabolized (mainly by cytochromes in hepatic metabolism). ...
... • Viagra acts competitively with cGMP at the active site of PDE 5. • So, if Viagra inhibits PDE 5, then there will be an accumulation of cGMP in smooth muscle cells until the Viagra is metabolized (mainly by cytochromes in hepatic metabolism). ...
Morphine - ISpatula
... positions (3 and 6) so we can form: morphine-3-glucoronide, morphine-6glucoronide or morphine-3,6- diglucoronides. * But what has been found in our bodies that morphine-3-glucoronide metabolite is not very stable as morphine-6-glucoronide, the bond between the aglycon and the sugar part (glucoronic ...
... positions (3 and 6) so we can form: morphine-3-glucoronide, morphine-6glucoronide or morphine-3,6- diglucoronides. * But what has been found in our bodies that morphine-3-glucoronide metabolite is not very stable as morphine-6-glucoronide, the bond between the aglycon and the sugar part (glucoronic ...
View eBook - Absorption Systems
... specific pharmacologic reagents and assay systems. Nearly all available transporter probe substrates and inhibitors interact with multiple transporters. Some transporters have multiple binding sites, which can result in substratedependent inhibition as has been reported for drug-metabolizing CYP enz ...
... specific pharmacologic reagents and assay systems. Nearly all available transporter probe substrates and inhibitors interact with multiple transporters. Some transporters have multiple binding sites, which can result in substratedependent inhibition as has been reported for drug-metabolizing CYP enz ...
Abstract
... circulation. So liver is at high risk of damage then other body organ (Samuel et al., 2012). The toxic agents which may damage the liver are drugs such as paracetamol, xenobiotics, viral infections, alcoholism and chemical agents (Ramchandara et al., 2007). That’s why the liver injury is one of the ...
... circulation. So liver is at high risk of damage then other body organ (Samuel et al., 2012). The toxic agents which may damage the liver are drugs such as paracetamol, xenobiotics, viral infections, alcoholism and chemical agents (Ramchandara et al., 2007). That’s why the liver injury is one of the ...
Antinociceptive effect of Ferula assa-foetida oleo-gum
... fraction consists of ferulic acid esters, free ferulic acid, umbelliferone and coumarin derivatives such as foetidin and kamolonol, farnesiferoles A, B and C (7). The compositions of its gum fraction are known to be glucose, galactose, L-arabinose, rhamnose and glucuronic acid (5). In recent studies ...
... fraction consists of ferulic acid esters, free ferulic acid, umbelliferone and coumarin derivatives such as foetidin and kamolonol, farnesiferoles A, B and C (7). The compositions of its gum fraction are known to be glucose, galactose, L-arabinose, rhamnose and glucuronic acid (5). In recent studies ...
Full-Text PDF
... thrombin in the coagulation cascade. Selective inhibition of FXa was unable to affect the pre-existing thrombin level, and activation and aggregation of the platelets reduced the risk of bleeding when compared with traditional anti-coagulants [2]. In addition, FXa plays a vital role in amplifying th ...
... thrombin in the coagulation cascade. Selective inhibition of FXa was unable to affect the pre-existing thrombin level, and activation and aggregation of the platelets reduced the risk of bleeding when compared with traditional anti-coagulants [2]. In addition, FXa plays a vital role in amplifying th ...
Enzyme Inhibition and Bioapplications
... active site in the ‘lock-key’ configuration. The 3D structure and conformation of active site permits very powerful enzyme inhibitors or substrate analogues to bind with enzyme molecule to make desirable product and accomplish the goal as pharmaceutical drug. Many drug classes and variants have been ...
... active site in the ‘lock-key’ configuration. The 3D structure and conformation of active site permits very powerful enzyme inhibitors or substrate analogues to bind with enzyme molecule to make desirable product and accomplish the goal as pharmaceutical drug. Many drug classes and variants have been ...
Pharmacological Effects
... diets, exercise less, and smoke more than Americans. However, their mortality from cardiovascular diseases is much lower than in the USA or in most other Western societies. Polyphenolic constituents in red wine have been found to be cardioprotective and their consumption is likely to explain the “Fr ...
... diets, exercise less, and smoke more than Americans. However, their mortality from cardiovascular diseases is much lower than in the USA or in most other Western societies. Polyphenolic constituents in red wine have been found to be cardioprotective and their consumption is likely to explain the “Fr ...
Drug effects on acetic acid-depressed locomotor
... E-mail address: [email protected] (G.W. Stevenson). ...
... E-mail address: [email protected] (G.W. Stevenson). ...
An investigation of protective formulations containing
... It is well known that feces and urine are two factors that affect the skin in a negative way and together they can cause skin irritation, dermatitis. The biggest difference between an adult skin a ...
... It is well known that feces and urine are two factors that affect the skin in a negative way and together they can cause skin irritation, dermatitis. The biggest difference between an adult skin a ...
The effects of combinations of a green tea extract and... active ingredient thereof, with standard antiretroviral drugs
... compliance, severe adverse effects and drug resistance. Therefore, the focus of current research is the development of new antiretroviral drugs, improved treatment strategies and the discovery of new drugs derived from plants. Green tea (GT) and its active constituent epigallocatechin gallate (EGCg) ...
... compliance, severe adverse effects and drug resistance. Therefore, the focus of current research is the development of new antiretroviral drugs, improved treatment strategies and the discovery of new drugs derived from plants. Green tea (GT) and its active constituent epigallocatechin gallate (EGCg) ...
contents - Médecins d`Afrique
... subjects was used to predict AUC in patients with renal or hepatic impairment. Methods: Two sets of simulated plasma concentration versus time data for 2 antihypertensive drugs and measured plasma concentration versus time data for 2 representative drugs (A and B) were used in the analysis. Results ...
... subjects was used to predict AUC in patients with renal or hepatic impairment. Methods: Two sets of simulated plasma concentration versus time data for 2 antihypertensive drugs and measured plasma concentration versus time data for 2 representative drugs (A and B) were used in the analysis. Results ...
Symposium Report Correlating Structure and Function of Drug
... garnered largely from structures determined by X-ray crystallography. Building on approaches used to determine the first structure of a membrane cytochrome P450 in 2000 (Williams et al., 2000), structures are now available for most major human drug-metabolizing P450 enzymes (Fig. 1). A synthesis of ...
... garnered largely from structures determined by X-ray crystallography. Building on approaches used to determine the first structure of a membrane cytochrome P450 in 2000 (Williams et al., 2000), structures are now available for most major human drug-metabolizing P450 enzymes (Fig. 1). A synthesis of ...
Clinical Implications of Dihydropyrimidine
... Clinical Consequences of Modulation of DPD Activity The importance of DPD to the clinical pharmacology of 5-FU has been further established by several recent observations (Table 1) that demonstrate that DPD can account for much of the variability that has been noted in clinical studies with 5-FU. Th ...
... Clinical Consequences of Modulation of DPD Activity The importance of DPD to the clinical pharmacology of 5-FU has been further established by several recent observations (Table 1) that demonstrate that DPD can account for much of the variability that has been noted in clinical studies with 5-FU. Th ...
BoNT_A Presentation UMass Dartmouth 081029
... Efficacy in vitro, & in neuronal cell culture or synaptosomes ...
... Efficacy in vitro, & in neuronal cell culture or synaptosomes ...
Statins Transport, side effects and cytoxicity_Rev2
... Km 0.77, 0.73, 2.84 (μM) and Vmax 6.61, 2.29, 24.27 (pmol/mg protein/min) respectively. Lovastatin acid, simvastatin acid and pravastatin acid were found to be specific OATP1B1 inhibitors. Pravastatin almost completely inhibits the uptake of atorvastatin by OATP1B1 (75%) with only a minor effect on ...
... Km 0.77, 0.73, 2.84 (μM) and Vmax 6.61, 2.29, 24.27 (pmol/mg protein/min) respectively. Lovastatin acid, simvastatin acid and pravastatin acid were found to be specific OATP1B1 inhibitors. Pravastatin almost completely inhibits the uptake of atorvastatin by OATP1B1 (75%) with only a minor effect on ...
... CoA) reductase (meva1onate:NADP oxidoreductase, E.C. 1.1.1.34),the rate-limiting step in cholesterol biosynthesis, is suppressed (8-1 1). Ursodeoxycholic acid has recently been reported to also reduce the stimulated biliary secretion of cholesterol (12). There is presently no information on the effe ...
carbapenam and monobactam - Home
... Meropenem is not hydrolyzed by DHP-I and is resistant to most β-lactamases, including a few carbapenemases that hydrolyze ...
... Meropenem is not hydrolyzed by DHP-I and is resistant to most β-lactamases, including a few carbapenemases that hydrolyze ...
Guideline on the investigation of drug interactions - EMA
... Pharmacodynamic interactions may be caused by a large variety of mechanisms. It is therefore not possible to give detailed guidance for pharmacodynamic interaction studies. The studies needed should be determined on a case-by-case basis. The potential for pharmacodynamic interactions should be consi ...
... Pharmacodynamic interactions may be caused by a large variety of mechanisms. It is therefore not possible to give detailed guidance for pharmacodynamic interaction studies. The studies needed should be determined on a case-by-case basis. The potential for pharmacodynamic interactions should be consi ...
The Penicillins - Available Courses
... 4. Piperacillin + tazobactam (Zosyn® - Aventis) a. Extended spectrum. Indications are as follows: i. Appendicitis or peritonitis caused by b-lactamase-producing E. coli or Bacteroides fragilis ii. Uncomplicated & complicated skin and skin structure infections caused by piperacillin-resistant b-lacta ...
... 4. Piperacillin + tazobactam (Zosyn® - Aventis) a. Extended spectrum. Indications are as follows: i. Appendicitis or peritonitis caused by b-lactamase-producing E. coli or Bacteroides fragilis ii. Uncomplicated & complicated skin and skin structure infections caused by piperacillin-resistant b-lacta ...
EVALUATION OF ANTIULCER ACTIVITY OF ETHANOLIC EXTRACT OF LEAVES OF... NEGUNDO ON PYLORUS LIGATURE INDUCED AND ASPIRIN INDUCED ULCER IN...
... the equilibrium is disturbed either by enhanced aggressiveness or by lessened mucosal resistance [2]. Drugs that affect acid and enhance defensive mechanisms are available. Of late, the concept is now changing from chemical pH to microbial Hp (pH= acidity, Hp= H.pylori)[3]. Flood gates of research o ...
... the equilibrium is disturbed either by enhanced aggressiveness or by lessened mucosal resistance [2]. Drugs that affect acid and enhance defensive mechanisms are available. Of late, the concept is now changing from chemical pH to microbial Hp (pH= acidity, Hp= H.pylori)[3]. Flood gates of research o ...
Folic Acid - Council for Responsible Nutrition
... adverse effects at doses of 1 to 1.25 mg folic acid. There is no record of adverse effects caused by food polyglutamyl folates, perhaps because of the lower bioavailability and/or the limited range of intakes observed. No studies have been done with elevated doses of purified polyglutamyl folates. T ...
... adverse effects at doses of 1 to 1.25 mg folic acid. There is no record of adverse effects caused by food polyglutamyl folates, perhaps because of the lower bioavailability and/or the limited range of intakes observed. No studies have been done with elevated doses of purified polyglutamyl folates. T ...
Valproic acid metabolism and its effects on mitochondrial fatty acid
... Becker and Harris were the first to demonstrate the formation of valproyl-CoA, identifying this conjugate by HPLC analysis in extracts of the liver of rats treated with VPA (Becker and Harris 1983). Direct proof of VPA b-oxidation, including the subsequent reactions and metabolites, was obtained thr ...
... Becker and Harris were the first to demonstrate the formation of valproyl-CoA, identifying this conjugate by HPLC analysis in extracts of the liver of rats treated with VPA (Becker and Harris 1983). Direct proof of VPA b-oxidation, including the subsequent reactions and metabolites, was obtained thr ...
Review of studies on flukicide residues in cows` milk and
... IRISH JOURNAL OF AGRICULTURAL AND FOOD RESEARCH, VOL. 52, NO. 2, 2013 Table 1. Transfer of flukicide residues from milk to curd, whey and cheese ...
... IRISH JOURNAL OF AGRICULTURAL AND FOOD RESEARCH, VOL. 52, NO. 2, 2013 Table 1. Transfer of flukicide residues from milk to curd, whey and cheese ...