Review Articles` Abstracts - source url
... Psoriasis is a chronic disease that can have substantial psychological and social impact on patient's life. Psoriasis has been shown to affect health-related Quality of Life to an extent similar to the effects of other chronic diseases such as depression, myocardial infarction, hypertension, etc. Th ...
... Psoriasis is a chronic disease that can have substantial psychological and social impact on patient's life. Psoriasis has been shown to affect health-related Quality of Life to an extent similar to the effects of other chronic diseases such as depression, myocardial infarction, hypertension, etc. Th ...
Pesticide residues in food – 1967
... chlordane in corn oil was increased for the 3 drugs reported (hexobarbital, aminopyrine and chlorpromazine). The increases for hexobarbital and aminopyrine were dose-related. In vivo hexobarbital response, measured by sleeping time of mice, 1, 3 and 8 days after single i.p. doses of 25 mg/kg body-we ...
... chlordane in corn oil was increased for the 3 drugs reported (hexobarbital, aminopyrine and chlorpromazine). The increases for hexobarbital and aminopyrine were dose-related. In vivo hexobarbital response, measured by sleeping time of mice, 1, 3 and 8 days after single i.p. doses of 25 mg/kg body-we ...
GPAT 2010 Question Paper
... (A) Carbon NMR is less sensitive than proton NMR (B) 12C nucleus is not magnetically active (C) Both 13C and *H have same spin quantum numbers (D) The gyromagnetic ratio of *H is lesser than that of1 C Ans. Q.33 In the TCA cycle, at which of the following enzyme-catalyzed steps, incorporation of ...
... (A) Carbon NMR is less sensitive than proton NMR (B) 12C nucleus is not magnetically active (C) Both 13C and *H have same spin quantum numbers (D) The gyromagnetic ratio of *H is lesser than that of1 C Ans. Q.33 In the TCA cycle, at which of the following enzyme-catalyzed steps, incorporation of ...
A review on pharmacological property of Mimusops elengi Linn.
... Prosopis juliflora, Punica granatum and Syzygium cumini have recorded significant antifungal activity against one or the other Aspergillus species tested [25]. Different solvent extracts of bark, fruits (fleshy portion) and leaves of Mimusops elengi were screened for their antifungal activity agains ...
... Prosopis juliflora, Punica granatum and Syzygium cumini have recorded significant antifungal activity against one or the other Aspergillus species tested [25]. Different solvent extracts of bark, fruits (fleshy portion) and leaves of Mimusops elengi were screened for their antifungal activity agains ...
Full-Text PDF
... carbohydrates, and small metabolite molecules) to reach the target sites [67]. The addition of a molecules) to reach the target sites [67]. The addition of a targeting moiety onto the surface of NP targeting moiety onto the surface of NP increases selective cellular binding and internalization incre ...
... carbohydrates, and small metabolite molecules) to reach the target sites [67]. The addition of a molecules) to reach the target sites [67]. The addition of a targeting moiety onto the surface of NP targeting moiety onto the surface of NP increases selective cellular binding and internalization incre ...
Synthesis and in vitro activities of a new antiviral duplex drug linking
... doses (IC50) against highly acyclovir (ACV)-resistant HSV isolates determined by a plaque reduction assay ranged between 1.87 and 4.59 lM. Using ganciclovir (GCV)-sensitive, GCV resistant and drug cross-resistant HCMV strains the IC50-values of AZT–lipid–PFA were between 2.78 and 1.18 lM. With regar ...
... doses (IC50) against highly acyclovir (ACV)-resistant HSV isolates determined by a plaque reduction assay ranged between 1.87 and 4.59 lM. Using ganciclovir (GCV)-sensitive, GCV resistant and drug cross-resistant HCMV strains the IC50-values of AZT–lipid–PFA were between 2.78 and 1.18 lM. With regar ...
Pharmacokinetic Interaction Between Prasugrel and Ritonavir
... the bioactivation of oxo-prasugrel to prasugrel AM is performed by CYP3A4 and 2–26% is performed by CYP2B6 [2]. In the present study, ritonavir was used to investigate the effect of the inhibition of CYP3A and possibly other CYPs on the prasugrel AM pharmacokinetics. In the present study, ritonavir ...
... the bioactivation of oxo-prasugrel to prasugrel AM is performed by CYP3A4 and 2–26% is performed by CYP2B6 [2]. In the present study, ritonavir was used to investigate the effect of the inhibition of CYP3A and possibly other CYPs on the prasugrel AM pharmacokinetics. In the present study, ritonavir ...
Download CV
... Thomas AJ, Olkowski JH, Vornov JJ, Slusher BS. “Toxicity induced by a polyglutamated folate analog is attenuated by NAALADase inhibition.” Brain Research, 1999, 843, 48-52 Tiffany CW, Lapidus RG, Merion A, Calvin DC, Slusher BS. “Characterization of the enzymatic activity of PSM: Comparison with bra ...
... Thomas AJ, Olkowski JH, Vornov JJ, Slusher BS. “Toxicity induced by a polyglutamated folate analog is attenuated by NAALADase inhibition.” Brain Research, 1999, 843, 48-52 Tiffany CW, Lapidus RG, Merion A, Calvin DC, Slusher BS. “Characterization of the enzymatic activity of PSM: Comparison with bra ...
Mechanistic Studies on Metabolic Interactions between Gemfibrozil
... and GENTEST, whereas those from beagle dogs (9 –11 kg) were prepared in house as described previously (Prueksaritanont et al., 1997) and were pooled from four to six animals before use. In Vivo Studies. All studies were reviewed and approved by the Merck Research Laboratories Institutional Animal Ca ...
... and GENTEST, whereas those from beagle dogs (9 –11 kg) were prepared in house as described previously (Prueksaritanont et al., 1997) and were pooled from four to six animals before use. In Vivo Studies. All studies were reviewed and approved by the Merck Research Laboratories Institutional Animal Ca ...
Hepatotoxicity in rats induced by aqueous extract of
... serum ALT or AST levels significantly [31]; the effect of CYP450 level was not taken into account in the previous animal experiments. If the level of CYP450 has an effect on PMR related rat liver injury, a high dose may show a more pronounced effect, and the high dose was adopted in this study. Thir ...
... serum ALT or AST levels significantly [31]; the effect of CYP450 level was not taken into account in the previous animal experiments. If the level of CYP450 has an effect on PMR related rat liver injury, a high dose may show a more pronounced effect, and the high dose was adopted in this study. Thir ...
Urinary Hydrocodone and Metabolite Distributions in
... been reported to be 134- and 23-fold, respectively (12). Hydromorphone inter- and intrasubject variability is 51- and 27-fold, respectively (12). Numerous factors are known to influence inter- and intrasubject variability of hydrocodone and metabolites. Plasma concentrations of hydromorphone are hig ...
... been reported to be 134- and 23-fold, respectively (12). Hydromorphone inter- and intrasubject variability is 51- and 27-fold, respectively (12). Numerous factors are known to influence inter- and intrasubject variability of hydrocodone and metabolites. Plasma concentrations of hydromorphone are hig ...
Journal home page: http://www.iajpr.com/index.php/en/ INDO
... male albino rats and proposed AML may be useful in the long-term management of diabetes. There was a decrease in blood glucose at the end of 4 weeks in treated animals compared with diabetic rats. There was an increase in erythrocyte GSH and a decrease in MDA in treated animals. [6] Narender T et al ...
... male albino rats and proposed AML may be useful in the long-term management of diabetes. There was a decrease in blood glucose at the end of 4 weeks in treated animals compared with diabetic rats. There was an increase in erythrocyte GSH and a decrease in MDA in treated animals. [6] Narender T et al ...
Wrightia tinctoria R. Br. - Journal of Coastal Life Medicine
... The mature powdered pod showed the presence of cooccurrence of β-amyrin, ursolic acid and oleanolic acid along with β-sitosterol[77]. The wrightial, a new terpene and other phyto constituets such as cycloartenone, cycloeucalenol, β-amyrin and β-sitosterol were isolated from methanol extract of the i ...
... The mature powdered pod showed the presence of cooccurrence of β-amyrin, ursolic acid and oleanolic acid along with β-sitosterol[77]. The wrightial, a new terpene and other phyto constituets such as cycloartenone, cycloeucalenol, β-amyrin and β-sitosterol were isolated from methanol extract of the i ...
Lemon Balm - Longwood Herbal Task Force
... placebo twice daily for 14 days. Sleep quality improved during and after the trial for those taking the Euvegal Forte. Additionally, a significant improvement in the “feeling of well being” for the Euvegal Forte group occurred during and after the trial compared to the placebo group. The severity of ...
... placebo twice daily for 14 days. Sleep quality improved during and after the trial for those taking the Euvegal Forte. Additionally, a significant improvement in the “feeling of well being” for the Euvegal Forte group occurred during and after the trial compared to the placebo group. The severity of ...
Medical importance of Cupressus sempervirens
... The essential oils isolated from Tunisian Cupressus sempervirens were ranged from 0.1 to 0.65% depending on the part of the plant analyzed. The greatest yields were in cones and leaves (0.65 and 0.43%, respectively) and the oil was lowest in the branches (0.1%). 52 compounds were identified accounti ...
... The essential oils isolated from Tunisian Cupressus sempervirens were ranged from 0.1 to 0.65% depending on the part of the plant analyzed. The greatest yields were in cones and leaves (0.65 and 0.43%, respectively) and the oil was lowest in the branches (0.1%). 52 compounds were identified accounti ...
PDF - Pharmacological Reviews
... 1. The multiple drug-effect equation . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 2. The combination index theorem and plot . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 3. The general equation for combi ...
... 1. The multiple drug-effect equation . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 2. The combination index theorem and plot . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 3. The general equation for combi ...
... 45 Å in depth spanning both sides of the bilayer [25]. LEWELL [29] has calculated the dimensions of the beta2adrenoceptor to be 18×33×45 Å. The peptide backbone of the individual alpha-helices is approximately 5 Å in diameter, and the helices are thought to be separated by approximately 10 Å. A sche ...
MORUS ALBA Review Article BANDNA DEVI, NEHA SHARMA, DINESH KUMAR, KAMAL JEET*
... Morus alba extract indifferent doses increased the levels of serum immunoglobulin and prevented the mortality induced by bovine Pasteurella multocida in mice. It also increased the circulating antibody titre in indirect haemagglutination test. On the other hand, it showed significant increase in the ...
... Morus alba extract indifferent doses increased the levels of serum immunoglobulin and prevented the mortality induced by bovine Pasteurella multocida in mice. It also increased the circulating antibody titre in indirect haemagglutination test. On the other hand, it showed significant increase in the ...
The effect of anticholinergic drugs on the
... Schrager (1961). He found that the tyrosine estimation used by Glass to determine the mucoprotein and mucoproteose content was a measure of the proteinous material only, and the tyrosine of the mucoprotein related chiefly to the pepsin content of that fraction. Grossberg et al. (1950) determined the ...
... Schrager (1961). He found that the tyrosine estimation used by Glass to determine the mucoprotein and mucoproteose content was a measure of the proteinous material only, and the tyrosine of the mucoprotein related chiefly to the pepsin content of that fraction. Grossberg et al. (1950) determined the ...
Exploitation of Bile Acid Transport Systems in Prodrug Design
... stoichiometry of Na+:bile acid is identified of being 2:1 [54]. The second uptake system is Na+independent and involves several members of the organic anion transporting polypeptide (OATP) family. Three OATPs, which are expressed in the liver and accept bile salts as substrates, have been cloned. Th ...
... stoichiometry of Na+:bile acid is identified of being 2:1 [54]. The second uptake system is Na+independent and involves several members of the organic anion transporting polypeptide (OATP) family. Three OATPs, which are expressed in the liver and accept bile salts as substrates, have been cloned. Th ...
(MMP)-2 and - UTHSC Digital Commons
... synthesized in 1919 during World War I, the drug was prescribed for many soldiers because of its stimulatory and performance-enhancing properties.1 It was not until 1959, that the Food and Drug Administration (FDA) banned amphetamine-based inhalers because of their potential for abuse. Currently the ...
... synthesized in 1919 during World War I, the drug was prescribed for many soldiers because of its stimulatory and performance-enhancing properties.1 It was not until 1959, that the Food and Drug Administration (FDA) banned amphetamine-based inhalers because of their potential for abuse. Currently the ...
Histones Differentially Modulate the Anticoagulant and
... activity against FXa and thrombin, LMWHs showing a preference for FXa, and pentasaccharide being specific for FXa. It is renowned that cationic proteins can interact with UFH by electrostatic forces and neutralize its activity, as in the case of protamine sulfate, which is indeed used as heparin ant ...
... activity against FXa and thrombin, LMWHs showing a preference for FXa, and pentasaccharide being specific for FXa. It is renowned that cationic proteins can interact with UFH by electrostatic forces and neutralize its activity, as in the case of protamine sulfate, which is indeed used as heparin ant ...
An overview of interactions between grapefruit juice and drugs ReView Abstract
... interaction between grapefruit juice and felodipine.8 Since this observation, much research has focused on the mechanisms of drug-grapefruit juice interactions and the medications that interact with the juice.9 Many more drugs have shown enhanced oral bioavailability when consumed with grapefruit ju ...
... interaction between grapefruit juice and felodipine.8 Since this observation, much research has focused on the mechanisms of drug-grapefruit juice interactions and the medications that interact with the juice.9 Many more drugs have shown enhanced oral bioavailability when consumed with grapefruit ju ...
pharmacology basic principles
... PHARMACOLOGY BASIC PRINCIPLES Drug: a molecule that when introduced into body alters body’s functions by interaction at molecular level; most are molecular weight 100-1000, which allows efficient absorption and distribution; 25% of drugs are chiral (stereoisomeric) Xenobiotics: chemicals not synthes ...
... PHARMACOLOGY BASIC PRINCIPLES Drug: a molecule that when introduced into body alters body’s functions by interaction at molecular level; most are molecular weight 100-1000, which allows efficient absorption and distribution; 25% of drugs are chiral (stereoisomeric) Xenobiotics: chemicals not synthes ...
Pharmacologically Active Drug Metabolites: Impact on Drug
... Address correspondence to: Dr. R. Scott Obach, Pfizer Inc., Eastern Point Rd., Groton, CT 06340. E-mail: [email protected] dx.doi.org/10.1124/pr.111.005439. ...
... Address correspondence to: Dr. R. Scott Obach, Pfizer Inc., Eastern Point Rd., Groton, CT 06340. E-mail: [email protected] dx.doi.org/10.1124/pr.111.005439. ...