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Runx1t1- Exploring its role as a transcriptional regulator in the dorsal root ganglion neuron specification Aditya Harisankar One of the most complex issues in developmental neurobiology is to understand how diversity in the nervous system is created. A classic model system in which to address this question is the peripheral nervous system. Sensory neurons of the dorsal root ganglion are located along the spinal cord; they derive during development from common progenitor cells which differentiate into many types of neurons that are mediating sensory information (touch, pain, heat, cold, and proprioception) from the body to the central nervous system. This differentiation process is orchestrated by specific molecular factors. Recent work from the laboratory identified the expression of Runx1t1 – a factor that regulates gene expression – in the dorsal root ganglion during embryonic development. In this project, I am trying to identify when exactly and in which type of neurons Runx1t1is expressed in the developing dorsal root ganglion. My results show that the expression of Runx1t1 is very strong during embryonic development, at a time when different types of neurons are being specified. In the future, we are planning to understand the function of Runx1t1in specifying different types of sensory neurons and in the physiology of the sensory system in general. Together with providing new insights into the sensory system field, these studies will also help contributing to new knowledge in understanding the process of neuronal development. P Degree project E 45hp, 1BG355 Division of Molecular Neurobiology, Department of Medical Biochemistry and Biophysics, Karolinska Institute, Stockholm Supervisor: Asst. Prof.Dr. Francois Lallemend