Molecular and Cellular Mechanisms of Reelin Signaling in the Adult
... The study of Reelin signaling and its role in cortical development is responsible for the large preponderance of known signaling mechanism. For that reason, section one will consist of an overview of cortical development followed by a more specific discussion of major and aspiring players in the Re ...
... The study of Reelin signaling and its role in cortical development is responsible for the large preponderance of known signaling mechanism. For that reason, section one will consist of an overview of cortical development followed by a more specific discussion of major and aspiring players in the Re ...
NEURAL MECHANISMS SUPPORTING THE LEARNING
... regulation in fear-related disorders (Davis, 1992; Kim & Jung, 2006; LeDoux, 2007; Maren, 2001; Milad et al., 2007). Pavlovian conditioning, often referred to as classical conditioning, is one of the oldest and most straightforward paradigms to study fear-related processes (Domjan, 2005; LeDoux, 199 ...
... regulation in fear-related disorders (Davis, 1992; Kim & Jung, 2006; LeDoux, 2007; Maren, 2001; Milad et al., 2007). Pavlovian conditioning, often referred to as classical conditioning, is one of the oldest and most straightforward paradigms to study fear-related processes (Domjan, 2005; LeDoux, 199 ...
ORAL UPF/ TESI DOCT Nicotine addiction phenotypes in a BAC transgenic mouse
... The present Doctoral Thesis has been devoted to study genetic vulnerability in nicotine addiction. Specifically, we focus on the cluster CHRNA5/A3/B4 of human chromosome 15, which human genetic studies have identified as a strong candidate for nicotine dependence and smoking-related behaviours. This ...
... The present Doctoral Thesis has been devoted to study genetic vulnerability in nicotine addiction. Specifically, we focus on the cluster CHRNA5/A3/B4 of human chromosome 15, which human genetic studies have identified as a strong candidate for nicotine dependence and smoking-related behaviours. This ...
Propagation of tau pathology in Alzheimer`s disease
... in its intercellular transfer is of great interest. The phosphorylation state and length of extracellular tau have been reported in numerous studies, but obtaining a global picture is difficult since different epitopes were analyzed in various model systems. Analysis of tau in human CSF found that l ...
... in its intercellular transfer is of great interest. The phosphorylation state and length of extracellular tau have been reported in numerous studies, but obtaining a global picture is difficult since different epitopes were analyzed in various model systems. Analysis of tau in human CSF found that l ...
Myelin and White Matter
... On the same axon, adjacent myelin segments belong to different oligodendrocytes. A single oligodendrocyte provides the myelin for many internodal segments of different axons simultaneously. One oligodendrocyte can be responsible for the production and maintenance of up to 40 nerve fibers (Fig. 1.9). ...
... On the same axon, adjacent myelin segments belong to different oligodendrocytes. A single oligodendrocyte provides the myelin for many internodal segments of different axons simultaneously. One oligodendrocyte can be responsible for the production and maintenance of up to 40 nerve fibers (Fig. 1.9). ...
Neuronal uptake and propagation of a rare phosphorylated high-molecular-weight tau
... that is taken up by neurons may provide a platform for tau pathology spreading. Better understanding of the molecular basis of tau propagation is key to preventing progression from early mild memory impairment to full cognitive deterioration and dementia. Recent studies showed that cellular tau upta ...
... that is taken up by neurons may provide a platform for tau pathology spreading. Better understanding of the molecular basis of tau propagation is key to preventing progression from early mild memory impairment to full cognitive deterioration and dementia. Recent studies showed that cellular tau upta ...
Early Thiamine Deficiency
... to press, neither the authors nor the editors nor the publisher can accept any legal responsibility for any errors or omissions that may be made. The publisher makes no warranty, express or implied, with respect to the material contained herein. Printed on acid-free paper springer.com ...
... to press, neither the authors nor the editors nor the publisher can accept any legal responsibility for any errors or omissions that may be made. The publisher makes no warranty, express or implied, with respect to the material contained herein. Printed on acid-free paper springer.com ...
thesis - ETDA
... dystonia, which results in larger cortical representation areas of the affected body parts and that may affect inhibition (Hallett M, 1998). While many theories are currently being discussed in the literature, very few are consistently supported by findings in dystonic patients. This could mean that ...
... dystonia, which results in larger cortical representation areas of the affected body parts and that may affect inhibition (Hallett M, 1998). While many theories are currently being discussed in the literature, very few are consistently supported by findings in dystonic patients. This could mean that ...
1 - Test Bank
... 39. Recent evidence suggests that glial cells and astrocytes may play an important role in ________. a. learning and memory b. endocrine functioning c. maturation and aging d. growth and metabolic regulation Answer: a Difficulty: 3 Page Reference: 43 Topic: Neurons: The Messengers Skill: F ...
... 39. Recent evidence suggests that glial cells and astrocytes may play an important role in ________. a. learning and memory b. endocrine functioning c. maturation and aging d. growth and metabolic regulation Answer: a Difficulty: 3 Page Reference: 43 Topic: Neurons: The Messengers Skill: F ...
stimulant treatment history predicts frontal-striatal
... Segal, 1997; Volkow et al., 2001). Magnetic resonance imaging (MRI) techniques offer non-‐invasive, accessible, and versatile tools to study stimulant effects in the developing human brain. Especially functional MRI studies investigating acute st ...
... Segal, 1997; Volkow et al., 2001). Magnetic resonance imaging (MRI) techniques offer non-‐invasive, accessible, and versatile tools to study stimulant effects in the developing human brain. Especially functional MRI studies investigating acute st ...
Role of brain-derived neurotrophic factor in Huntington`s disease
... The fact that BDNF has survival promoting activity on the striatal neurons that die in HD has led to the idea that reduced endogenous trophic support may contribute to disease onset and/or progression. This hypothesis has aroused interest in BDNF and/or BDNF mimetics as potential therapeutic agents, ...
... The fact that BDNF has survival promoting activity on the striatal neurons that die in HD has led to the idea that reduced endogenous trophic support may contribute to disease onset and/or progression. This hypothesis has aroused interest in BDNF and/or BDNF mimetics as potential therapeutic agents, ...
ﻧﺘﺎﯾﺞ داوری ﻣﻘﺎﻻت ﭼﻬﺎرﻣﯿﻦ ﮐﻨﮕﺮه ﻋﻠﻮم اﻋﺼﺎب ﭘﺎﯾﻪ و ﺑﺎ
... Delayed-coupled neuronal networks yield stimulus-dependent synchronization and communication channels Transplantation of very small embryonic like stem cells to spinal cord injury rat model promotes movement recovery Interference Control In Elderly Bilinguals: Appearances Can Be Misleading ...
... Delayed-coupled neuronal networks yield stimulus-dependent synchronization and communication channels Transplantation of very small embryonic like stem cells to spinal cord injury rat model promotes movement recovery Interference Control In Elderly Bilinguals: Appearances Can Be Misleading ...
Test Bank 1
... c. the missing half is eventually regenerated d. it leads to permanent, severe disabilities Answer: a Difficulty: 3 Page Reference: 41 Topic: Introduction Skill: F 3. In regards to the brain, the term “plasticity” refers to ________. a. easily broken or “cracked” b. ability to adapt to new condition ...
... c. the missing half is eventually regenerated d. it leads to permanent, severe disabilities Answer: a Difficulty: 3 Page Reference: 41 Topic: Introduction Skill: F 3. In regards to the brain, the term “plasticity” refers to ________. a. easily broken or “cracked” b. ability to adapt to new condition ...
Kaczkurkin_umn_0130E_14221
... interest, there have been a number of studies in recent years on fear conditioning in anxiety patients. This chapter will provide an integrative review of fear-conditioning theories and research related to specific anxiety disorders to elucidate the relationship between fear conditioning and patholo ...
... interest, there have been a number of studies in recent years on fear conditioning in anxiety patients. This chapter will provide an integrative review of fear-conditioning theories and research related to specific anxiety disorders to elucidate the relationship between fear conditioning and patholo ...
What clinical disorders tell us about the neural
... inclusive, attempting to describe features common among a group of patients with similar symptoms, whereas scientific studies tend to be exclusive, focusing on one or a few differences between experimental and control subjects. Finally, basic scientists often study saccades in several species (e.g. ...
... inclusive, attempting to describe features common among a group of patients with similar symptoms, whereas scientific studies tend to be exclusive, focusing on one or a few differences between experimental and control subjects. Finally, basic scientists often study saccades in several species (e.g. ...
Curriculum Vitae - Laureate Institute for Brain Research
... I am a Professor in Residence in the Department of Psychiatry at the University of California San Diego (UCSD) and the Director of Telemental Health at the Veterans Affairs San Diego Health Care System (VASDHS). My research focuses on the interface between interoception, i.e. the processing of senso ...
... I am a Professor in Residence in the Department of Psychiatry at the University of California San Diego (UCSD) and the Director of Telemental Health at the Veterans Affairs San Diego Health Care System (VASDHS). My research focuses on the interface between interoception, i.e. the processing of senso ...
Full-Text PDF
... high concentrations [11]. Yet, thrombin has been demonstrated within the central nervous system (CNS) in rat and human specimens under physiological conditions [12]. Additionally, main thrombin regulatory factors such as FX, protease nexin-1 (PN-1), AT III and thrombin-activated receptors have been ...
... high concentrations [11]. Yet, thrombin has been demonstrated within the central nervous system (CNS) in rat and human specimens under physiological conditions [12]. Additionally, main thrombin regulatory factors such as FX, protease nexin-1 (PN-1), AT III and thrombin-activated receptors have been ...
RITE Answers 2007
... Anesthesia over the perineal area ("saddle anesthesia") in conjuction with loss of sphincter tone and erectile dysfunction can be caused by a lesion of the lower cauda equina or the conus medularis. The region of sensory abnormality is in the S2 to S5 dermatomes. There is no weakness noted indicatin ...
... Anesthesia over the perineal area ("saddle anesthesia") in conjuction with loss of sphincter tone and erectile dysfunction can be caused by a lesion of the lower cauda equina or the conus medularis. The region of sensory abnormality is in the S2 to S5 dermatomes. There is no weakness noted indicatin ...
1
... characterized by symptoms of inattention, hyperactivity and impulsivity. Converging data from different studies point to ADHD abnormalities in fronto-striatal circuits. Structural neuroimaging studies partially support fronto-striatal abnormalities and suggest an important role of the cerebellum. Ho ...
... characterized by symptoms of inattention, hyperactivity and impulsivity. Converging data from different studies point to ADHD abnormalities in fronto-striatal circuits. Structural neuroimaging studies partially support fronto-striatal abnormalities and suggest an important role of the cerebellum. Ho ...
Here follows a list of recently published papers
... http://t.co/avwjFHZA7z Deficiency of prion protein: impaired autophagic flux in neurons http://bit.ly/1mFLiM3 CA3 size predicts the precision of memory recall http://bit.ly/1mukcG9 " A Role for Tac2, NkB, and Nk3 Receptor in Normal and Dysregulated Fear Memory Consolidation http://www.cell.com/neuro ...
... http://t.co/avwjFHZA7z Deficiency of prion protein: impaired autophagic flux in neurons http://bit.ly/1mFLiM3 CA3 size predicts the precision of memory recall http://bit.ly/1mukcG9 " A Role for Tac2, NkB, and Nk3 Receptor in Normal and Dysregulated Fear Memory Consolidation http://www.cell.com/neuro ...
sleep disturbances associated with neuropsychiatric disease
... Mechanisms Underlying Behavioral State Changes: Evidence from Human Sleep Imaging Studies The advent of brain imaging methods that can be used to study the functional neuroanatomy of human sleep has recently created a venue for linking preclinical work with human sleep electrophysiology. Findings fr ...
... Mechanisms Underlying Behavioral State Changes: Evidence from Human Sleep Imaging Studies The advent of brain imaging methods that can be used to study the functional neuroanatomy of human sleep has recently created a venue for linking preclinical work with human sleep electrophysiology. Findings fr ...
Glutamine deficiency in the prefrontal cortex increases depressive
... levels of Glu and Gln would be affected by astrocyte loss and dysregulation of the Glu–Gln cycle and that depressive-like behaviours would be closely related to the level of changes in Glu and Gln. Methods: We used liquid chromatography to measure Glu and Gln concentrations in the prefrontal cortex ...
... levels of Glu and Gln would be affected by astrocyte loss and dysregulation of the Glu–Gln cycle and that depressive-like behaviours would be closely related to the level of changes in Glu and Gln. Methods: We used liquid chromatography to measure Glu and Gln concentrations in the prefrontal cortex ...
Anatomy of Neuropsychiatry : The New Anatomy of the
... not only from new methods of exploring the brain, including new neuroanatomical staining techniques and brain imaging methods in humans, but also from a need to unite our knowledge of brain function and structure with clinical observations. The task is to enable an integration of brain-behavior rela ...
... not only from new methods of exploring the brain, including new neuroanatomical staining techniques and brain imaging methods in humans, but also from a need to unite our knowledge of brain function and structure with clinical observations. The task is to enable an integration of brain-behavior rela ...
Apparent Loss and Hypertrophy of Interneurons in a Mouse Model
... that are characteristic for each form of NCL (Santavuori, 1988; Goebel, 1995, 1997). Biochemical studies of these deposits in CLN2, CLN3, and CLN4 have shown that the major protein component is subunit c of the mitochondrial ATPase (Hall et al., 1991; Kominami et al., 1992; Palmer et al., 1992). In ...
... that are characteristic for each form of NCL (Santavuori, 1988; Goebel, 1995, 1997). Biochemical studies of these deposits in CLN2, CLN3, and CLN4 have shown that the major protein component is subunit c of the mitochondrial ATPase (Hall et al., 1991; Kominami et al., 1992; Palmer et al., 1992). In ...
Chronic Use and Cognitive Functioning and Mental Health
... Studies of attentional deficits among individuals who use cannabis chronically have also yielded mixed results. Specifically, an fMRI study that compared those who use cannabis chronically to controls during a visual-attention task showed no differences in task performance. However, individuals who ...
... Studies of attentional deficits among individuals who use cannabis chronically have also yielded mixed results. Specifically, an fMRI study that compared those who use cannabis chronically to controls during a visual-attention task showed no differences in task performance. However, individuals who ...