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Advances in Natural and Applied Sciences, 9(4) April 2015, Pages: 39-42
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Advances in Natural and Applied Sciences
ISSN:1995-0772 EISSN: 1998-1090
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Study of Impact of Prolactin in Women Ages 20 to 40 years in Model of Menstruation
period and Infertility Referred to Razmjo Moqadam Lab in Zahrdan City
1
Ali Sanjarani, 2Z. Irani, 3SaideIzadi Far, 4Salehe Ghanbari, 5Fethullah Hussain Dadi, 6M. Mirzade
1.3.5.
Undergraduate students of Laboratory of Islamic Azad University of Zahedan Branch and member of Young Researchers Club, Islamic
Azad University, Iran zahedan Branch, Iran
2
Supervisor of Reference Laboratory biochemistry MA student of Zahedan, Iran
4
Student Laboratory Science, Islamic Azad University, Iran zahedan branch, Iran
6
Expert of Reference Laboratory, Iran
ARTICLE INFO
Article history:
Received 4 September 2014
Received in revised form 24 November
2014
Accepted 8 December 2014
Available online 10 January 2015
Keywords:
prolactin, the pattern of menstruation,
infertility and Zahedan.
ABSTRACT
Background and Aim: PRL (Prolactin) is Name of the pituitary gland secretes a
hormone in the body of women during pregnancy and breastfeeding and driving making
milk in women .increasing these hormones in the female body, creating difficulties for
women's health. This study aimed to investigate the Model of prolactin effect
menstruation and infertility in women ages 20 to 40 years in Razmjoo Moghadam
laboratory of zahedan city that is done in the first six months of 2014. Methods: this is
a cross-sectional study and randomly selected 50 patients referred for testing prolactin
levels were evaluated as Grft.ps after filling out these questionnaires by the ELISA
method for measuring serum prolactin full data were analyzed by using SPSS software.
Results: Serum levels of prolactin in the age group -20-25 years, was about 3/47, and in
the age group of 25-30 years 2/57 and for age group 30-35 years 1/ 89, 40-35 years was
2/26. Results showed the mean serum levels of three age groups, show significant
differences (P = 0.01). Conclusion: 90% of women complain with overactive secretion
of prolactin in breast milk or infertility, menstrual cessation. If prolactin begin before
menstrual period the onset of menstrual adults may refer to lab without lack of
beginning of menstrual .prolactin is cause 15-20% of secondary amenorrhea.
© 2015 AENSI Publisher All rights reserved.
To Cite This Article: Ali Sanjarani, Z. Irani, SaideIzadi Far, Salehe Ghanbari, Fethullah Hussain Dadi, M. Mirzade, Study of Impact of
Prolactin in Women Ages 20 to 40 years in Model of Menstruationperiod and Infertility Referred to Razmjo Moqadam Lab in Zahrdan City.
Adv. in Nat. Appl. Sci., 9(4): 39-42, 2015
INTRODUCTION
PRL (Prolactin) is the Name of hormone in a woman's body that is produced by the pituitary gland during
pregnancy and it is stimulant of making milk in women. Increasing testosterone, prolactin making some health
problems in women. Role of Prolactin is not known in men but a blood estrogen level in women is higher than
in men. During pregnancy greatly increases the amount of hormone in the blood of women and two to three
weeks to return to normal after delivery. Breast feeding stimulates the secretion of prolactin and it will continue
to Pituitary of it. Prolactin also seems to be involved in the expression of sexual desire and call it the hormone of
love (Love hormone) (Jara, et al., Jacobi, 20012.
Hormone-releasing and inhibiting factors affecting the hypothalamic control Factors that affect the amount
of hormone-releasing factor inhibits most of the day and at night more resonant mode of the day Also, breast
sucking, nipple stimulation, intercourse, stress, hypoglycemia (low blood sugar), and strenuous physical activity
in women increases hormone secretion (Walker, 2001).Before puberty and pregnancy hormones estrogen and
growth hormone, insulin and other hormones in the adrenal glands and increase breast growth of breast milk
glands are involved. Many patients with high levels of prolactin, the average period of no real middle period, but
others just luteal phase progesterone production is less than normal. When working full prolactin due to lack of
ovulation or interfere with ovulation. With the normalization of prolactin after drug treatment of ovarian
function returned to normal in most patients (Jimena, 1998; Leaños-Miranda, 2006).
One of prolactin, thyroid disorders associated with primary hyperparathyroidism. When hypothyroidism is
clinically apparent, although in some cases there are no diagnostic trouble thyroid levels are normal, but the
TSH level is high, in order to compensate for primary hypothyroidism occurs subclinical (Elbourne,
Corresponding Author: Ali Sanjarani, Undergraduate students of Laboratory of Islamic Azad University of Zahedan
Branch and member of Young Researchers Club, Islamic Azad University, Iran zahedan Branch.
40
Ali Sanjarani et al, 2015
Advances in Natural and Applied Sciences, 9(4) April 2015, Pages: 39-42
1998).Appropriate treatment for patients with mild elevations in TSH, prolactin, thyroid hormone replacement is
normal TSH and prolactin response and return to normal ovarian cycle plays (Peeva, 2006).
High prolactin:
Among the types of prolactinoma, micro Prolactin are more common in women. While Macro adenomas
mostly seen in men. Prolactin in women can cause hyperthyroidism gonadal gonadotropin deficiency, leading to
the lack of estrogen. Trephine Ganado is natural and decreasing sexual steroids (Alvarez-Nemegyei, 1998).
Prolactin secretion in pulsed Ganado Trephine to inhibit the LH surge stops in the middle of the cycle that leads
to the lack of ovulation. In men with high testosterone levels are decreased prolactin .increasing blood prolactin
is a common disease of every hundred people with it. 10 to 40 percent of women who start after the monthly
period, a monthly period will be cut, an increase in blood prolactin (Walker, 2001). About 75 percent of women
whose menstrual periods associated with the secretion of milk from the breasts, have increased blood prolactin.
30% of patient’s have Prolactin-secreting tumor in pituitary (Kraemer, 2005).
Methods:
This cross-sectional study carried out on 50 female person between the ages of 20 and 40 years who
attended to Razmjo moqadam laboratory for prolactin test in Zahedan .After random selection the participants
filled questionnaires and for literal person staff filled by face to face form. Furthermore, blood samples were
taken from these people and transferred to the laboratory serum samples and hormonal part were measured by
ELISA method. So Data were analyzed by using SPSS statistical software.
Findings:
Out of 50 patients, 26 (52%) of 20 to 25 years, 11 (22%) of 25 to 30 years, 8 (16%) of 30 to 35, and 5
(10%) of 35 to 40 years.13 (26%) were single and 37 (74%) were married. Among these 39 patients (78%) had
abnormal menstruation.14 (28%) had abnormal discharge of milk from the breast .These 50 patients, 11 (22%)
patients with kidney disease and 3 (6%) Hypothyroidism were stigmatized.8 (21.6%), had history of infertility.
Among these 19 number of them (4/51%) of the blend (near) were reluctant. Reluctant in the sex ratio increase
the age has been shown in figure 1.
32 (64%) patients with headache, double vision, and 32 (64%) number of them had symptoms such as acne
and excess hair on the face. Acne and facial hair on the basis of marital status is shown in figure 2.
Fig. 2: Acne and facial hair on the basis of marital status.
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Ali Sanjarani et al, 2015
Advances in Natural and Applied Sciences, 9(4) April 2015, Pages: 39-42
14 (28%) were nausea, sedation and Drug nerves were taking. Sedative drugs, nervous, nausea, based on
ethnicity, mean age is shown in figure 3.
Fig. 3: sedative drugs, nervous, nausea, based on ethnicity, mean age.
Discussion:
Regardless of the cause of hyperprolactinemia clinical features of this disorder are similar. Menstrual
disorders and infertility in women with prolactinoma are often diagnosed earlier (Di Luigi, 2003). This is in
contrast to men who go with decreased libido and impotence. 90% of women with a prolific production of breast
milk secretion of prolactin and infertility menstrual cut complain.
If prolactinoma menstrual period begins before the onset of menstrual adults may attend before begging of
first menstrual period.Prolactin cause of 15-20% of secondary amenorrhea. Lack of ovulation is associated with
infertility (Pullinen, 2002). Secretion of milk or galactorrhea may coincide, after menstrual disorders and May
sometimes cause clinically not apparent and only be diagnosed with breast examination. Estrogen deficiency
may cause Autopen, vaginal dryness, hot flashes and irritability feeling (Fry, 1998)) .prolactin adrenal androgen
production, stimulates and increases androgen can cause weight gain and hair.Prolactin may be associated with
anxiety and depression. These symptoms often do not draw attention to the diagnosis of prolactinoma highly
effective role, in many cases, as long as blurred vision, headaches and hypopituitarism caused the delay.
Several factors such as different physiological conditions (pregnancy - stress nipple stimulation) of some
drugs (phenothiazine .What methyl Dope- cimetidine- Metoclopramide) pathological condition
(hypothyroidism, chronic renal failure, chest lesions) were prolactin secretion under effect However, the
prolactin levels are high 200 ng / dl usually implies the presence of elevated prolactin MRI should be performed
to confirm the diagnosis (Baker, 2006). medicine therapy by agonist do pamine medication, BromeCrip tine or
CaberGuilin gonadal function returns fertility in most patients. Dopamine agonists in a significant number of
patients with adenomas macro to shrink the tumor. In patients with visual field defects or neurological
symptoms and medical therapy in patients who cannot tolerate surgery Asfenoeedal transformer is necessary
(Cumming, 1989).
In this study, individuals studied, 21 (42%) of Sistani and 27 (54%) Bloch and 27 (54%) person under
Diploma, 11 (22%) diplomas, 4 (8%) of upper Diploma and 8 (16%) of BA and more than that among these 3
(6%) were employees and 36 (72%) number of them were housewives
ACKNOWLEDGEMENT
Thereby respected professors’ lab personnel of Razmjoo moqadam in zahdan city greatly appreciated that
help us to carry out this study.
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Ali Sanjarani et al, 2015
Advances in Natural and Applied Sciences, 9(4) April 2015, Pages: 39-42
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